Kynu cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kynu
Entrez Gene ID	116682
Full Name	kynureninase
General protein information	Preferred Names kynureninase Names kynureninase L-kynurenine hydrolase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q12
Summary	enzyme involved in the biosynthesis of NAD cofactors from tryptophan [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006234138.2	XP_006234200.1	kynureninase isoform X1
XM_008761695.2	XP_008759917.1	kynureninase isoform X2
NM_053902.2	NP_446354.1	kynureninase

Pathways from BioSystems

Homologies

Homo sapiens (human)	KYNU	NP_003928.1
Gallus gallus (chicken)	KYNU	XP_004943069.1
Saccharomyces cerevisiae (baker's yeast)	BNA5	NP_013332.1
Eremothecium gossypii	AGOS_AGL098W	NP_986569.2
Bos taurus (cattle)	KYNU	NP_001178237.1
Pan troglodytes (chimpanzee)	KYNU	XP_003309314.1
	KYNU	XP_002798909.1
Mus musculus (house mouse)	Kynu	NP_081828.1
Caenorhabditis elegans (roundworm)	C15H9.7	NP_509023.1
Canis lupus familiaris (dog)	KYNU	XP_541027.3
Rattus norvegicus (Norway rat)	Kynu	NP_446354.1
Neurospora crassa	NCU00463	XP_956782.2

Gene Ontology
Bibliography

Related articles in PubMed

NAD Deficiency, Congenital Malformations, and Niacin Supplementation.
Shi H, Enriquez A, Rapadas M, Martin EMMA, Wang R, Moreau J, Lim CK, Szot JO, Ip E, Hughes JN, Sugimoto K, Humphreys DT, McInerney-Leo AM, Leo PJ, Maghzal GJ, Halliday J, Smith J, Colley A, Mark PR, Collins F, Sillence DO, Winlaw DS, Ho JWK, Guillemin GJ, Brown MA, Kikuchi K, Thomas PQ, Stocker R, Giannoulatou E, Chapman G, Duncan EL, Sparrow DB, Dunwoodie SL
The New England journal of medicine377(6)544-552(2017 08)

The kynurenine pathway and neurodegenerative disease.
Maddison DC, Giorgini F
Seminars in cell & developmental biology40134-41(2015 Apr)

Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase.
Christensen M, Duno M, Lund AM, Skovby F, Christensen E
Journal of inherited metabolic disease30(2)248-55(2007 Apr)

The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats.
Comai S, Costa CV, Ragazzi E, Bertazzo A, Allegri G
Clinica chimica acta; international journal of clinical chemistry360(1-2)67-80(2005 Oct)

Expression of kynurenine aminotransferase in the subplate of the rat and its possible role in the regulation of programmed cell death.
Csillik AE, Okuno E, Csillik B, Knyih?r E, V?csei L
Cerebral cortex (New York, N.Y. : 1991)12(11)1193-201(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Kynurenine aminotransferase is expressed in the neurons of the transient subplate zone during prenatal development of the cerebral cortex and may play a role in regulating programmed neuronal cell death.
Title: Expression of kynurenine aminotransferase in the subplate of the rat and its possible role in the regulation of programmed cell death.

Spontaneously hypertensive rats have a missense mutation in KAT-1
Title: A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats.

Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.
Title: Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.

The following Kynu gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kynu cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa11003	NM_053902.2 Latest version!	Rattus norvegicus kynureninase (Kynu), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa25827	XM_006234138.2 Latest version!	Rattus norvegicus kynureninase (Kynu), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa44035	XM_008761695.2 Latest version!	Rattus norvegicus kynureninase (Kynu), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kynu ( NM_053902.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446354.1 Rattus norvegicus kynureninase (Kynu), mRNA.

Price & Availability↑

CloneID	ORa11003
Clone ID Related Accession (Same CDS sequence)	NM_053902.2
Accession Version	NM_053902.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1395bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	kynureninase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U68168.1. On Aug 30, 2012 this sequence version replaced NM_053902.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U68168.1, BC078762.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689597 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCT CGCCTCTTGA GCTACCAGTT GATGCAGTGC GGCGCATCGC GGCTGAACTC 
AATTGTGACC CAACCGATGA GAGGGTGGCT CTCCGCTTGG ATGAGGAAGA TAAACTGAAG 
CGTTTTAAGG ACTGTTTTTA TATCCCCAAA ATGCGGGACC TGCCTTCAAT TGATCTATCT 
TTAGTGAATG AGGATGATAA TGCCATCTAT TTCCTGGGAA ATTCCCTTGG TCTTCAACCG 
AAGATGGTTA AAACATACCT GGAGGAAGAG CTAGATAAGT GGGCCAAAAT AGGAGCCTAT 
GGCCATGAGG TAGGGAAACG TCCTTGGATT ATAGGAGATG AGAGCATTGT AACCCTTATG 
AAGGACATTG TAGGAGCCCA TGAGAAAGAA ATAGCTCTAA TGAATGCTTT GACTGTTAAT 
TTACATCTCC TGCTGTTATC ATTCTTTAAG CCTACACCAA AGCGGCACAA AATTCTTCTA 
GAAGCCAAAG CCTTCCCTTC TGATCATTAT GCGATCGAGT CACAGATTCA ACTTCATGGA 
CTTGATGTTG AGAAAAGTAT GCGGATGATA AAGCCACGAG AGGGGGAAGA GACCTTAAGA 
ATGGAGGACA TACTGGAAGT AATTGAGAAG GAAGGAGACT CAATTGCTGT GGTCCTGTTC 
AGTGGCCTGC ACTTTTATAC TGGACAGCTG TTCAACATTC CTGCCATTAC ACAAGCCGGA 
CATGCAAAGG GCTGTTTTGT TGGCTTTGAC CTAGCGCATG CGGTTGGAAA TGTTGAACTC 
CACTTACATG ACTGGGATGT TGACTTTGCC TGCTGGTGCT CCTACAAGTA TTTAAATTCA 
GGAGCTGGAG GTCTGGCTGG TGCCTTCATC CATGAGAAAC ACGCTCACAC GATCAAGCCA 
GCGTTAGTGG GATGGTTCGG CCATGAACTC AGTACAAGAT TTAACATGGA TAACAAACTA 
CAATTAATCC CCGGGGTCAA TGGATTCCGA ATTTCCAACC CTCCCATTCT GTTGGTCTGC 
TCCTTGCATG CCAGTTTAGA GATCTTTCAG CAAGCAACTA TGACTGCGCT GAGGAGAAAA 
TCCATTCTGC TGACAGGTTA TCTGGAATAC TTGCTCAAAC ATTACCATGG CGGAAATGAC 
ACAGAAAACA AGAGGCCAGT TGTGAACATA ATCACCCCAT CCAGAGCAGA GGAACGAGGC 
TGCCAGCTGA CACTGACCTT TTCCATTTCC AAGAAAGGCG TTTTTAAGGA ACTAGAAAAA 
AGAGGAGTCG TCTGTGACAA GCGAGAACCA GAAGGCATCC GGGTGGCCCC GGTTCCTCTC 
TATAATTCTT TCCATGATGT TTATAAGTTC ATCAGACTGC TTACTGCCAT ACTCGACTCT 
ACAGAAAGAA ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446354.1
CDS	51..1445
Translation	MEPSPLELPVDAVRRIAAELNCDPTDERVALRLDEEDKLKRFKDCFYIPKMRDLPSIDLSLVNEDDNAIYFLGNSLGLQPKMVKTYLEEELDKWAKIGAYGHEVGKRPWIIGDESIVTLMKDIVGAHEKEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMIKPREGEETLRMEDILEVIEKEGDSIAVVLFSGLHFYTGQLFNIPAITQAGHAKGCFVGFDLAHAVGNVELHLHDWDVDFACWCSYKYLNSGAGGLAGAFIHEKHAHTIKPALVGWFGHELSTRFNMDNKLQLIPGVNGFRISNPPILLVCSLHASLEIFQQATMTALRRKSILLTGYLEYLLKHYHGGNDTENKRPVVNIITPSRAEERGCQLTLTFSISKKGVFKELEKRGVVCDKREPEGIRVAPVPLYNSFHDVYKFIRLLTAILDSTERN

Target ORF information:

RefSeq Version	NM_053902.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus kynureninase (Kynu), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053902.2

ORF Insert Sequence:

ATGGAGCCCT CGCCTCTTGA GCTACCAGTT GATGCAGTGC GGCGCATCGC GGCTGAACTC 
AATTGTGACC CAACCGATGA GAGGGTGGCT CTCCGCTTGG ATGAGGAAGA TAAACTGAAG 
CGTTTTAAGG ACTGTTTTTA TATCCCCAAA ATGCGGGACC TGCCTTCAAT TGATCTATCT 
TTAGTGAATG AGGATGATAA TGCCATCTAT TTCCTGGGAA ATTCCCTTGG TCTTCAACCG 
AAGATGGTTA AAACATACCT GGAGGAAGAG CTAGATAAGT GGGCCAAAAT AGGAGCCTAT 
GGCCATGAGG TAGGGAAACG TCCTTGGATT ATAGGAGATG AGAGCATTGT AACCCTTATG 
AAGGACATTG TAGGAGCCCA TGAGAAAGAA ATAGCTCTAA TGAATGCTTT GACTGTTAAT 
TTACATCTCC TGCTGTTATC ATTCTTTAAG CCTACACCAA AGCGGCACAA AATTCTTCTA 
GAAGCCAAAG CCTTCCCTTC TGATCATTAT GCGATCGAGT CACAGATTCA ACTTCATGGA 
CTTGATGTTG AGAAAAGTAT GCGGATGATA AAGCCACGAG AGGGGGAAGA GACCTTAAGA 
ATGGAGGACA TACTGGAAGT AATTGAGAAG GAAGGAGACT CAATTGCTGT GGTCCTGTTC 
AGTGGCCTGC ACTTTTATAC TGGACAGCTG TTCAACATTC CTGCCATTAC ACAAGCCGGA 
CATGCAAAGG GCTGTTTTGT TGGCTTTGAC CTAGCGCATG CGGTTGGAAA TGTTGAACTC 
CACTTACATG ACTGGGATGT TGACTTTGCC TGCTGGTGCT CCTACAAGTA TTTAAATTCA 
GGAGCTGGAG GTCTGGCTGG TGCCTTCATC CATGAGAAAC ACGCTCACAC GATCAAGCCA 
GCGTTAGTGG GATGGTTCGG CCATGAACTC AGTACAAGAT TTAACATGGA TAACAAACTA 
CAATTAATCC CCGGGGTCAA TGGATTCCGA ATTTCCAACC CTCCCATTCT GTTGGTCTGC 
TCCTTGCATG CCAGTTTAGA GATCTTTCAG CAAGCAACTA TGACTGCGCT GAGGAGAAAA 
TCCATTCTGC TGACAGGTTA TCTGGAATAC TTGCTCAAAC ATTACCATGG CGGAAATGAC 
ACAGAAAACA AGAGGCCAGT TGTGAACATA ATCACCCCAT CCAGAGCAGA GGAACGAGGC 
TGCCAGCTGA CACTGACCTT TTCCATTTCC AAGAAAGGCG TTTTTAAGGA ACTAGAAAAA 
AGAGGAGTCG TCTGTGACAA GCGAGAACCA GAAGGCATCC GGGTGGCCCC GGTTCCTCTC 
TATAATTCTT TCCATGATGT TTATAAGTTC ATCAGACTGC TTACTGCCAT ACTCGACTCT 
ACAGAAAGAA ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kynu ( XM_006234138.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234200.1 Rattus norvegicus kynureninase (Kynu), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25827
Clone ID Related Accession (Same CDS sequence)	XM_006234138.2
Accession Version	XM_006234138.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	kynureninase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006234138.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCCT CGCCTCTTGA GCTACCAGTT GATGCAGTGC GGCGCATCGC GACTGAACTC 
AATTGTGACC CAACCGATGA GAGGGTGGCT CTCCGCTTGG ATGAGGAAGA TAAACTGAAG 
CGTTTTAAGG ACTGTTTTTA TATCCCCAAA ATGCGGGACC TGCCTTCAAT TGATCTATCT 
TTAGTGAATG AGGATGATAA TGCCATCTAT TTCCTGGGAA ATTCCCTTGG TCTTCAACCG 
AAGATGGTTA AAACATACCT GGAGGAAGAG CTAGATAAGT GGGCCAAAAT AGGAGCCTAT 
GGCCATGAGG TAGGGAAACG TCCTTGGATT ATAGGAGATG AGAGCATTGT AAGCCTTATG 
AAGGACATTG TAGGAGCCCA TGAGAAAGAA ATAGCTCTAA TGAATGCTTT GACTGTTAAT 
TTACATCTCC TGCTGTTATC ATTCTTTAAG CCTACACCAA AGCGGCACAA AATTCTTCTA 
GAAGCCAAAG CCTTCCCTTC TGATCATTAT GCGATCGAGT CACAGATTCA ACTTCATGGA 
CTTGATGTTG AGAAAAGTAT GCGGATGATA AAGCCACGAG AGGGCTGTTT TGTTGGCTTT 
GACCTAGCGC ATGCGGTTGG AAATGTTGAA CTCCACTTAC ATGACTGGGA TGTTGACTTT 
GCCTGCTGGT GCTCCTACAA GTATTTAAAT TCAGGAGCTG GAGGTCTGGC TGGTGCCTTC 
ATCCATGAGA AACACGCTCA CACGATCAAG CCAGCGTTAG TGGGATGGTT CGGCCATGAA 
CTCAGTACAA GATTTAACAT GGATAACAAA CTACAATTAA TCCCCGGGGT CAATGGATTC 
CGAATTTCCA ACCCTCCCAT TCTGTTGGTC TGCTCCTTGC ATGCCAGTTT AGAGATCTTT 
CAGCAAGCAA CTATGACTGC GCTGAGGAGA AAATCCATTC TGCTGACAGG TTATCTGGAA 
TACTTGCTCA AACATTACCA TGGCGGAAAT GACACAGAAA ACAAGAGGCC AGTTGTGAAC 
ATAATCACCC CATCCAGAGC AGAGGAACGA GGCTGCCAGC TGACACTGAC CTTTTCCATT 
TCCAAGAAAG GCGTTTTTAA GGAACTAGAA AAAAGAGGAG TCGTCTGTGA CAAGCGAGAA 
CCAGAAGGCA TCCGGGTGGC CCCGGTTCCT CTCTATAATT CTTTCCATGA TGTTTATAAG 
TTCATCAGAC TGCTTACTGC CATACTCGAC TCTACAGAAA GAAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234200.1
CDS	114..1361
Translation	MEPSPLELPVDAVRRIATELNCDPTDERVALRLDEEDKLKRFKDCFYIPKMRDLPSIDLSLVNEDDNAIYFLGNSLGLQPKMVKTYLEEELDKWAKIGAYGHEVGKRPWIIGDESIVSLMKDIVGAHEKEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMIKPREGCFVGFDLAHAVGNVELHLHDWDVDFACWCSYKYLNSGAGGLAGAFIHEKHAHTIKPALVGWFGHELSTRFNMDNKLQLIPGVNGFRISNPPILLVCSLHASLEIFQQATMTALRRKSILLTGYLEYLLKHYHGGNDTENKRPVVNIITPSRAEERGCQLTLTFSISKKGVFKELEKRGVVCDKREPEGIRVAPVPLYNSFHDVYKFIRLLTAILDSTERN

Target ORF information:

RefSeq Version	XM_006234138.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus kynureninase (Kynu), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234138.2

ORF Insert Sequence:

ATGGAGCCCT CGCCTCTTGA GCTACCAGTT GATGCAGTGC GGCGCATCGC GACTGAACTC 
AATTGTGACC CAACCGATGA GAGGGTGGCT CTCCGCTTGG ATGAGGAAGA TAAACTGAAG 
CGTTTTAAGG ACTGTTTTTA TATCCCCAAA ATGCGGGACC TGCCTTCAAT TGATCTATCT 
TTAGTGAATG AGGATGATAA TGCCATCTAT TTCCTGGGAA ATTCCCTTGG TCTTCAACCG 
AAGATGGTTA AAACATACCT GGAGGAAGAG CTAGATAAGT GGGCCAAAAT AGGAGCCTAT 
GGCCATGAGG TAGGGAAACG TCCTTGGATT ATAGGAGATG AGAGCATTGT AAGCCTTATG 
AAGGACATTG TAGGAGCCCA TGAGAAAGAA ATAGCTCTAA TGAATGCTTT GACTGTTAAT 
TTACATCTCC TGCTGTTATC ATTCTTTAAG CCTACACCAA AGCGGCACAA AATTCTTCTA 
GAAGCCAAAG CCTTCCCTTC TGATCATTAT GCGATCGAGT CACAGATTCA ACTTCATGGA 
CTTGATGTTG AGAAAAGTAT GCGGATGATA AAGCCACGAG AGGGCTGTTT TGTTGGCTTT 
GACCTAGCGC ATGCGGTTGG AAATGTTGAA CTCCACTTAC ATGACTGGGA TGTTGACTTT 
GCCTGCTGGT GCTCCTACAA GTATTTAAAT TCAGGAGCTG GAGGTCTGGC TGGTGCCTTC 
ATCCATGAGA AACACGCTCA CACGATCAAG CCAGCGTTAG TGGGATGGTT CGGCCATGAA 
CTCAGTACAA GATTTAACAT GGATAACAAA CTACAATTAA TCCCCGGGGT CAATGGATTC 
CGAATTTCCA ACCCTCCCAT TCTGTTGGTC TGCTCCTTGC ATGCCAGTTT AGAGATCTTT 
CAGCAAGCAA CTATGACTGC GCTGAGGAGA AAATCCATTC TGCTGACAGG TTATCTGGAA 
TACTTGCTCA AACATTACCA TGGCGGAAAT GACACAGAAA ACAAGAGGCC AGTTGTGAAC 
ATAATCACCC CATCCAGAGC AGAGGAACGA GGCTGCCAGC TGACACTGAC CTTTTCCATT 
TCCAAGAAAG GCGTTTTTAA GGAACTAGAA AAAAGAGGAG TCGTCTGTGA CAAGCGAGAA 
CCAGAAGGCA TCCGGGTGGC CCCGGTTCCT CTCTATAATT CTTTCCATGA TGTTTATAAG 
TTCATCAGAC TGCTTACTGC CATACTCGAC TCTACAGAAA GAAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kynu ( XM_008761695.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008759917.1 Rattus norvegicus kynureninase (Kynu), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa44035
Clone ID Related Accession (Same CDS sequence)	XM_008761695.2
Accession Version	XM_008761695.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	kynureninase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008761695.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCCT CGCCTCTTGA GCTACCAGTT GATGCAGTGC GGCGCATCGC GACTGAACTC 
AATTGTGACC CAACCGATGA GAGGGTGGCT CTCCGCTTGG ATGAGGAAGA TAAACTGAAG 
CGTTTTAAGG ACTGTTTTTA TATCCCCAAA ATGCGGGACC TGCCTTCAAT TGATCTATCT 
TTAGTGAATG AGGATGATAA TGCCATCTAT TTCCTGGGAA ATTCCCTTGG TCTTCAACCG 
AAGATGGTTA AAACATACCT GGAGGAAGAG CTAGATAAGT GGGCCAAAAT AGGAGCCTAT 
GGCCATGAGG TAGGGAAACG TCCTTGGATT ATAGGAGATG AGAGCATTGT AAGCCTTATG 
AAGGACATTG TAGGAGCCCA TGAGAAAGAA ATAGCTCTAA TGAATGCTTT GACTGTTAAT 
TTACATCTCC TGCTGTTATC ATTCTTTAAG CCTACACCAA AGCGGCACAA AATTCTTCTA 
GAAGCCAAAG CCTTCCCTTC TGATCATTAT GCGATCGAGT CACAGATTCA ACTTCATGGA 
CTTGATGTTG AGAAAAGTAT GCGGATGATA AAGCCACGAG AGGGGGAAGA GACCTTAAGA 
ATGGAGGACA TACTGGAAGT AATTGAGAAG GAAGGAGACT CAATTGCTGT GGTCCTGTTC 
AGTGGCCTGC ACTTTTATAC TGGACAGCTG TTCAACATTC CTGCCATTAC ACAAGCCGGA 
CATGCAAAGG GCTGTTTTGT TGGCTTTGAC CTAGCGCATG CGGTTGGAAA TGTTGAACTC 
CACTTACATG ACTGGGATGT TGACTTTGCC TGCTGGTGCT CCTACAAGTA TTTAAATTCA 
GGAGCTGGAG GTCTGGCTGG TGCCTTCATC CATGAGAAAC ACGCTCACAC GATCAAGCCA 
GCATCAATAA TTAAATATGG CAAGTCTCAC TGTATATCTG ATCTTACTGA ATATCCATCT 
AAGGTCTCCG TGTTTTTTCA TGTGAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008759917.1
CDS	114..1103
Translation	MEPSPLELPVDAVRRIATELNCDPTDERVALRLDEEDKLKRFKDCFYIPKMRDLPSIDLSLVNEDDNAIYFLGNSLGLQPKMVKTYLEEELDKWAKIGAYGHEVGKRPWIIGDESIVSLMKDIVGAHEKEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMIKPREGEETLRMEDILEVIEKEGDSIAVVLFSGLHFYTGQLFNIPAITQAGHAKGCFVGFDLAHAVGNVELHLHDWDVDFACWCSYKYLNSGAGGLAGAFIHEKHAHTIKPASIIKYGKSHCISDLTEYPSKVSVFFHVS

Target ORF information:

RefSeq Version	XM_008761695.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus kynureninase (Kynu), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008761695.2

ORF Insert Sequence:

ATGGAGCCCT CGCCTCTTGA GCTACCAGTT GATGCAGTGC GGCGCATCGC GACTGAACTC 
AATTGTGACC CAACCGATGA GAGGGTGGCT CTCCGCTTGG ATGAGGAAGA TAAACTGAAG 
CGTTTTAAGG ACTGTTTTTA TATCCCCAAA ATGCGGGACC TGCCTTCAAT TGATCTATCT 
TTAGTGAATG AGGATGATAA TGCCATCTAT TTCCTGGGAA ATTCCCTTGG TCTTCAACCG 
AAGATGGTTA AAACATACCT GGAGGAAGAG CTAGATAAGT GGGCCAAAAT AGGAGCCTAT 
GGCCATGAGG TAGGGAAACG TCCTTGGATT ATAGGAGATG AGAGCATTGT AAGCCTTATG 
AAGGACATTG TAGGAGCCCA TGAGAAAGAA ATAGCTCTAA TGAATGCTTT GACTGTTAAT 
TTACATCTCC TGCTGTTATC ATTCTTTAAG CCTACACCAA AGCGGCACAA AATTCTTCTA 
GAAGCCAAAG CCTTCCCTTC TGATCATTAT GCGATCGAGT CACAGATTCA ACTTCATGGA 
CTTGATGTTG AGAAAAGTAT GCGGATGATA AAGCCACGAG AGGGGGAAGA GACCTTAAGA 
ATGGAGGACA TACTGGAAGT AATTGAGAAG GAAGGAGACT CAATTGCTGT GGTCCTGTTC 
AGTGGCCTGC ACTTTTATAC TGGACAGCTG TTCAACATTC CTGCCATTAC ACAAGCCGGA 
CATGCAAAGG GCTGTTTTGT TGGCTTTGAC CTAGCGCATG CGGTTGGAAA TGTTGAACTC 
CACTTACATG ACTGGGATGT TGACTTTGCC TGCTGGTGCT CCTACAAGTA TTTAAATTCA 
GGAGCTGGAG GTCTGGCTGG TGCCTTCATC CATGAGAAAC ACGCTCACAC GATCAAGCCA 
GCATCAATAA TTAAATATGG CAAGTCTCAC TGTATATCTG ATCTTACTGA ATATCCATCT 
AAGGTCTCCG TGTTTTTTCA TGTGAGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NAD Deficiency, Congenital Malformations, and Niacin Supplementation.
The New England journal of medicine377(6)544-552(2017 08)
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Kynu cDNA ORF clone, Rattus norvegicus(Norway rat)

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