Rap2a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rap2a
Entrez Gene ID	114560
Full Name	RAP2A, member of RAS oncogene family
General protein information	Preferred Names RAP2A, member of RAS oncogene family Names ras-related protein Rap-2a RAS related protein 2a inverted question mark rap2A-like protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15q24
Summary	human homolog is a GTPase and member of the RAS oncogene family [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053741.1	NP_446193.1	ras-related protein Rap-2a

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells.
Emery AC, Xu W, Eiden MV, Eiden LE
The Journal of biological chemistry292(29)12220-12231(2017 07)

Rap2A links intestinal cell polarity to brush border formation.
Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL
Nature cell biology14(8)793-801(2012 Aug)

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.
Kawabe H, Neeb A, Dimova K, Young SM Jr, Takeda M, Katsurabayashi S, Mitkovski M, Malakhova OA, Zhang DE, Umikawa M, Kariya K, Goebbels S, Nave KA, Rosenmund C, Jahn O, Rhee J, Brose N
Neuron65(3)358-72(2010 Feb)

Rap2 function requires palmitoylation and recycling endosome localization.
Uechi Y, Bayarjargal M, Umikawa M, Oshiro M, Takei K, Yamashiro Y, Asato T, Endo S, Misaki R, Taguchi T, Kariya K
Biochemical and biophysical research communications378(4)732-7(2009 Jan)

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.
Taira K, Umikawa M, Takei K, Myagmar BE, Shinzato M, Machida N, Uezato H, Nonaka S, Kariya K
The Journal of biological chemistry279(47)49488-96(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that Rap2A is the obligate effector for Epac2 in mediating growth arrest and reversal of neurite extension through activation of MAP kinase signaling via protein phosphorylation/farnesylation in neuroendocrine cells. (Rap2A = RAS oncogene family member Rap2A; Epac2 = guanine nucleotide exchange factor Epac2)
Title: Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells.

The following Rap2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rap2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41920	NM_053741.1 Latest version!	Rattus norvegicus RAP2A, member of RAS oncogene family (Rap2a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rap2a ( NM_053741.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446193.1 Rattus norvegicus RAP2A, member of RAS oncogene family (Rap2a), mRNA.

Price & Availability↑

CloneID	ORa41920
Clone ID Related Accession (Same CDS sequence)	NM_053741.1
Accession Version	NM_053741.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	ras-related protein Rap-2a
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY037826.1. ##Evidence-Data-START## Transcript exon combination :: AY037826.1 [ECO:0000332] ##Evidence-Data-END##

ATGCGCGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGGG TAGGCAAATC CGCCCTGACC 
GTGCAGTTCG TGACCGGCAC CTTCATTGAG AAATACGACC CCACCATCGA GGACTTCTAC 
CGCAAGGAGA TCGAGGTGGA CTCGTCGCCT TCGGTGTTGG AGATCCTGGA CACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTG 
GTCTACAGCC TGGTCAACCA GCAGAGCTTC CAGGATATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446193.1
CDS	6..323
Translation	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKR

Target ORF information:

RefSeq Version	NM_053741.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus RAP2A, member of RAS oncogene family (Rap2a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053741.1

ORF Insert Sequence:

ATGCGCGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGGG TAGGCAAATC CGCCCTGACC 
GTGCAGTTCG TGACCGGCAC CTTCATTGAG AAATACGACC CCACCATCGA GGACTTCTAC 
CGCAAGGAGA TCGAGGTGGA CTCGTCGCCT TCGGTGTTGG AGATCCTGGA CACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTG 
GTCTACAGCC TGGTCAACCA GCAGAGCTTC CAGGATATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells.
The Journal of biological chemistry292(29)12220-12231(2017 07)
Emery AC,Xu W,Eiden MV,Eiden LE

Rap2A links intestinal cell polarity to brush border formation.
Nature cell biology14(8)793-801(2012 Aug)
Gloerich M,ten Klooster JP,Vliem MJ,Koorman T,Zwartkruis FJ,Clevers H,Bos JL

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.
Neuron65(3)358-72(2010 Feb)
Kawabe H,Neeb A,Dimova K,Young SM Jr,Takeda M,Katsurabayashi S,Mitkovski M,Malakhova OA,Zhang DE,Umikawa M,Kariya K,Goebbels S,Nave KA,Rosenmund C,Jahn O,Rhee J,Brose N

Rap2 function requires palmitoylation and recycling endosome localization.
Biochemical and biophysical research communications378(4)732-7(2009 Jan)
Uechi Y,Bayarjargal M,Umikawa M,Oshiro M,Takei K,Yamashiro Y,Asato T,Endo S,Misaki R,Taguchi T,Kariya K

The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton.
The Journal of biological chemistry279(47)49488-96(2004 Nov)
Taira K,Umikawa M,Takei K,Myagmar BE,Shinzato M,Machida N,Uezato H,Nonaka S,Kariya K

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Rap2a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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