Cited2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cited2
Entrez Gene ID	114490
Full Name	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Synonyms	Mrg1
General protein information	Preferred Names Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 Names cbp/p300-interacting transactivator 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p12
Summary	a transcription factor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053698.2	NP_446150.1	cbp/p300-interacting transactivator 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CITED2	NP_001161861.2
Mus musculus (house mouse)	Cited2	NP_034958.2
Gallus gallus (chicken)	CITED2	NP_996726.1
Pan troglodytes (chimpanzee)	CITED2	XP_003950972.1
Danio rerio (zebrafish)	cited2	NP_001006045.1
Canis lupus familiaris (dog)	CITED2	XP_850158.1
Bos taurus (cattle)	CITED2	NP_001069287.1
Rattus norvegicus (Norway rat)	Cited2	NP_446150.1
Xenopus tropicalis (tropical clawed frog)	cited2	NP_001001196.1

Gene Ontology
Bibliography

Related articles in PubMed

Cited2 participates in cardiomyocyte apoptosis and maternal diabetes-induced congenital heart abnormality.
Su D, Song JX, Gao Q, Guan L, Li Q, Shi C, Ma X
Biochemical and biophysical research communications479(4)887-892(2016 Oct)

MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2.
Clark AL, Naya FJ
The Journal of biological chemistry290(38)23162-72(2015 Sep)

CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression.
Li Q, Pan H, Guan L, Su D, Ma X
Biochemical and biophysical research communications423(4)895-9(2012 Jul)

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.
Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela T, Moffat J, Hudson TJ, Sladek R
Physiological genomics44(2)183-97(2012 Feb)

Physiological loading of joints prevents cartilage degradation through CITED2.
Leong DJ, Li YH, Gu XI, Sun L, Zhou Z, Nasser P, Laudier DM, Iqbal J, Majeska RJ, Schaffler MB, Goldring MB, Cardoso L, Zaidi M, Sun HB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology25(1)182-91(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gestational diabetes mellitus is a risk factor for abnormal heart development. Cited2 expression decreased in the heart tissues of diabetic-exposed embryos comparing with the control.
Title: Cited2 participates in cardiomyocyte apoptosis and maternal diabetes-induced congenital heart abnormality.

MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2.
Title: MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2.

Studies identify a novel regulatory pathway involving CITED2 and p38delta, which may be critical for the maintenance of articular cartilage integrity under normal physical activity levels.
Title: Physiological loading of joints prevents cartilage degradation through CITED2.

These results indicate that Cited2 and Akap12 are silenced in radiation-induced osteosarcomas, and therefore are novel candidate tumor-suppressor genes of this tumor.
Title: Silencing of Cited2 and Akap12 genes in radiation-induced rat osteosarcomas.

CITED2 is a critical upstream regulator of fracture healing. The suppression of CITED2 early after fracture may allow an optimal initiation of the healing response.
Title: Identification of CITED2 as a negative regulator of fracture healing.

The following Cited2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cited2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10342	NM_053698.2 Latest version!	Rattus norvegicus Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (Cited2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cited2 ( NM_053698.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446150.1 Rattus norvegicus Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (Cited2), mRNA.

Price & Availability↑

CloneID	ORa10342
Clone ID Related Accession (Same CDS sequence)	NM_053698.2
Accession Version	NM_053698.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 810bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	cbp/p300-interacting transactivator 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC087005.1. On Dec 26, 2004 this sequence version replaced NM_053698.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC087005.1, AF361476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGACC ATATGATGGC CATGAACCAC GGTCGCTTCC CCGACGGCAC CAACGGGCTG 
CACCACCACC CTGCCCACCG CATGGGCATG GGGCAGTTCC CGAGCCCGCA TCACCACCAG 
CAGCAGCAGC CCCAGCACGC CTTCAACGCC CTCATGGGCG AGCACATACA CTACGGCGCG 
GGCAACATGA ATGCCACGAG CGGCATCAGG CACGCCATGG GGCCGGGGAC TGTGAACGGG 
GGGCACCCCC CGAGCGCTCT GGCCCCGGCC GCCAGGTTTA ACAACTCCCA GTTCATGGGT 
CCCCCTGTGG CCAGCCAGGG AGGCTCCCTG CCGGCCAGCA TGCAGCTGCA GAAGCTCAAC 
AACCAGTATT TCAACCATCA CCCCTACCCC CACAACCACT ACATGCCGGA TTTGCACCCC 
GCTGCAGGCC ACCAGATGAA CGGGACAAAC CAGCACTTCC GAGATTGCAA CCCCAAGCAC 
AGTGGAGGCA GCAGCACCCC TGGCGGCGCG GGTGGCAGCG GCACCCCCGG CGGCTCCGGC 
GGCACCTCGG GCGGCGCGGG TGGCAGCAGC GCGGGCGGCA GTGGCGGTGG CAGCACCATG 
CCCGCCTCGG TGGCTCACGT CCCCGCGGCA ATGCTGCCGC CCAATGTCAT AGACACTGAT 
TTCATCGACG AGGAAGTGCT TATGTCCTTA GTGATAGAGA TGGGTTTGGA CCGCATCAAG 
GAGCTGCCAG AACTCTGGCT GGGCCAAAAT GAGTTTGATT TTATGACGGA CTTCGTGTGC 
AAACAGCAGC CCAGCAGAGT CAGCTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446150.1
CDS	235..1044
Translation	MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGAGGSGTPGGSGGTSGGAGGSSAGGSGGGSTMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC

Target ORF information:

RefSeq Version	NM_053698.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (Cited2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053698.2

ORF Insert Sequence:

ATGGCAGACC ATATGATGGC CATGAACCAC GGTCGCTTCC CCGACGGCAC CAACGGGCTG 
CACCACCACC CTGCCCACCG CATGGGCATG GGGCAGTTCC CGAGCCCGCA TCACCACCAG 
CAGCAGCAGC CCCAGCACGC CTTCAACGCC CTCATGGGCG AGCACATACA CTACGGCGCG 
GGCAACATGA ATGCCACGAG CGGCATCAGG CACGCCATGG GGCCGGGGAC TGTGAACGGG 
GGGCACCCCC CGAGCGCTCT GGCCCCGGCC GCCAGGTTTA ACAACTCCCA GTTCATGGGT 
CCCCCTGTGG CCAGCCAGGG AGGCTCCCTG CCGGCCAGCA TGCAGCTGCA GAAGCTCAAC 
AACCAGTATT TCAACCATCA CCCCTACCCC CACAACCACT ACATGCCGGA TTTGCACCCC 
GCTGCAGGCC ACCAGATGAA CGGGACAAAC CAGCACTTCC GAGATTGCAA CCCCAAGCAC 
AGTGGAGGCA GCAGCACCCC TGGCGGCGCG GGTGGCAGCG GCACCCCCGG CGGCTCCGGC 
GGCACCTCGG GCGGCGCGGG TGGCAGCAGC GCGGGCGGCA GTGGCGGTGG CAGCACCATG 
CCCGCCTCGG TGGCTCACGT CCCCGCGGCA ATGCTGCCGC CCAATGTCAT AGACACTGAT 
TTCATCGACG AGGAAGTGCT TATGTCCTTA GTGATAGAGA TGGGTTTGGA CCGCATCAAG 
GAGCTGCCAG AACTCTGGCT GGGCCAAAAT GAGTTTGATT TTATGACGGA CTTCGTGTGC 
AAACAGCAGC CCAGCAGAGT CAGCTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cited2 participates in cardiomyocyte apoptosis and maternal diabetes-induced congenital heart abnormality.
Biochemical and biophysical research communications479(4)887-892(2016 Oct)
Su D,Song JX,Gao Q,Guan L,Li Q,Shi C,Ma X

MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2.
The Journal of biological chemistry290(38)23162-72(2015 Sep)
Clark AL,Naya FJ

CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression.
Biochemical and biophysical research communications423(4)895-9(2012 Jul)
Li Q,Pan H,Guan L,Su D,Ma X

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation.
Physiological genomics44(2)183-97(2012 Feb)
Rajan S,Chu Pham Dang H,Djambazian H,Zuzan H,Fedyshyn Y,Ketela T,Moffat J,Hudson TJ,Sladek R

Physiological loading of joints prevents cartilage degradation through CITED2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology25(1)182-91(2011 Jan)
Leong DJ,Li YH,Gu XI,Sun L,Zhou Z,Nasser P,Laudier DM,Iqbal J,Majeska RJ,Schaffler MB,Goldring MB,Cardoso L,Zaidi M,Sun HB

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Cited2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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