Mtnr1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mtnr1a
Entrez Gene ID	114211
Full Name	melatonin receptor 1A
General protein information	Preferred Names melatonin receptor 1A Names melatonin receptor type 1A mel-1A-R mel1a melatonin receptor mel1a receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q11
Summary	G-protein coupled receptor for melatonin; involved in circardian rhythm and reproductive function [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053676.2	NP_446128.1	melatonin receptor type 1A

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MTNR1A	XP_526799.1
Rattus norvegicus (Norway rat)	Mtnr1a	NP_446128.1
Danio rerio (zebrafish)	mtnr1aa	NP_571468.1
Canis lupus familiaris (dog)	MTNR1A	XP_540019.3
Bos taurus (cattle)	MTNR1A	XP_002698702.1
Gallus gallus (chicken)	MTNR1A	NP_990693.1
Xenopus tropicalis (tropical clawed frog)	mtnr1a	XP_002940910.1
	MTNR1A	XP_001090972.1
Danio rerio (zebrafish)	LOC565718	XP_694081.2
Homo sapiens (human)	MTNR1A	NP_005949.1
Mus musculus (house mouse)	Mtnr1a	NP_032665.1

Gene Ontology
Bibliography

Related articles in PubMed

Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells.
Sheng WL, Chen WY, Yang XL, Zhong YM, Weng SJ
PloS one10(2)e0117967(2015)

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis.
Zhang Y, Cook A, Kim J, Baranov SV, Jiang J, Smith K, Cormier K, Bennett E, Browser RP, Day AL, Carlisle DL, Ferrante RJ, Wang X, Friedlander RM
Neurobiology of disease5526-35(2013 Jul)

Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth.
Hill SM, Cheng C, Yuan L, Mao L, Jockers R, Dauchy B, Blask DE
Current aging science6(1)125-33(2013 Feb)

Immunohistochemical and biomolecular identification of melatonin 1a and 1b receptors in rat vestibular nuclei.
Ahn SK, Khalmuratova R, Hah YS, Jeon SY, Hur DG, Kang HS, Balaban CD
Auris, nasus, larynx39(5)479-83(2012 Oct)

Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets.
M?hlbauer E, Albrecht E, Bazwinsky-Wutschke I, Peschke E
Journal of pineal research52(4)446-59(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We demonstrated the co-existence of MT1 and MT2 receptors in all melanopsin-positive M1 ipRGCs, and the expression of MT1 and MT2 receptors in these cells could be seen as early as the day of birth (P0).
Title: Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells.

The present study demonstrates, for the first time, that MT1a receptors are localized and expressed in rat vestibular nuclei. This study provides additional insight into the role of melatonin receptors during vestibular signal processing.
Title: Immunohistochemical and biomolecular identification of melatonin 1a and 1b receptors in rat vestibular nuclei.

Data indicate that fetal adrenal gland showed circadian expression of Bmal-1 and Per-2 as well as of Mt1 and Egr-1.
Title: A circadian clock entrained by melatonin is ticking in the rat fetal adrenal.

MT1 might play an important role in the pathogenesis of acute necrotizing pancreatitis. Expression was down-regulated as the severity of the disease increased.
Title: [The expression of melatonin MT1 receptor in acute necrotizing pancreatitis rats and the protective effects of melatonin].

N-nitroso-N-methylurea disrupted and dietary methylselenocysteine significantly increased the expression of MTNR1A in mammary glands of Fischer 344 rats
Title: Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo.

The following Mtnr1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mtnr1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10282	NM_053676.2 Latest version!	Rattus norvegicus melatonin receptor 1A (Mtnr1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mtnr1a ( NM_053676.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446128.1 Rattus norvegicus melatonin receptor 1A (Mtnr1a), mRNA.

Price & Availability↑

CloneID	ORa10282
Clone ID Related Accession (Same CDS sequence)	NM_053676.2
Accession Version	NM_053676.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Rattus norvegicus(Norway rat)
Product	melatonin receptor type 1A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB377274.1. On Aug 30, 2012 this sequence version replaced NM_053676.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB377274.1, AF130341.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642599, SAMN02642618 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGGCA ATGTCAGCGA GCTTCTCAAC GCCTCTCAGC AGGCTCCAGG CGGCGGGGAG 
GAAATAAGAT CGCGGCCGTC GTGGCTGGCC TCTACACTGG CCTTCATCCT CATCTTTACT 
ATCGTGGTGG ACATCCTGGG CAACCTGCTG GTCATCCTGT CTGTGTATCG CAACAAGAAG 
CTCAGGAACG CAGGGAATAT ATTTGTGGTG AGTTTAGCTG TGGCAGACCT CGTGGTGGCT 
ATTTACCCAT TTCCCTTGGC GCTGACGTCT ATACTTAACA ATGGATGGAA CCTGGGATAT 
CTGCATTGTC AAGTTAGTGC CTTCCTAATG GGCCTGAGTG TCATTGGCTC GGTATTCAAC 
ATCACCGGGA TCGCTATGAA CCGCTACTGC TACATTTGCC ACAGTCTCAA GTATGATAGG 
ATATACAGTA ACAAGAATTC CCTGTGCTAC GTGTTCCTGA TATGGACACT GACACTCATA 
GCCATCATGC CCAACCTGCA AACCGGAACT CTCCAGTACG ACCCCCGGAT CTACTCCTGT 
ACCTTCACCC AGTCCGTCAG CTCGGCGTAC ACGATTGCCC TGGTGGTTTT CCATTTCGTA 
GTTCCAATGA TTATTGTCAC TTTCTGCTAC TTAAGGATAT GGATCCTGGT TCTTCAGGTC 
AGACGGAGGG TGAAACCGGA CAGCAAACCC AAACTGAAGC CGCAGGACTT CAGGAACTTT 
GTCACCATGT TTGTAGTTTT TGTACTTTTT GCCCTGTGCT GGGCCCCACT CAACTTCATA 
GGTCTTATTG TGGCCTCAGA TCCGGCCGCC ATGGCCCCCA GGATCCCGGA GTGGCTCTTC 
GTGGCTAGTT ACTACCTGGC GTATTTCAAC AGCTGCCTCA ACGCAATCAT ATACGGACTA 
CTGAACCAAA ATTTCAGAAA GGAGTACAAG AGGATTATCA TCTCACTGTG CACAGCTAAG 
ATGTTCTTTG TGGACAGTTC AAATGATGCA GCAGATAAGA TTAAATGTAA GCCCTCTCCA 
CTAATAACCA ATAATAATTT AATAAAGGTG GACTCTGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446128.1
CDS	206..1267
Translation	MKGNVSELLNASQQAPGGGEEIRSRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPFPLALTSILNNGWNLGYLHCQVSAFLMGLSVIGSVFNITGIAMNRYCYICHSLKYDRIYSNKNSLCYVFLIWTLTLIAIMPNLQTGTLQYDPRIYSCTFTQSVSSAYTIALVVFHFVVPMIIVTFCYLRIWILVLQVRRRVKPDSKPKLKPQDFRNFVTMFVVFVLFALCWAPLNFIGLIVASDPAAMAPRIPEWLFVASYYLAYFNSCLNAIIYGLLNQNFRKEYKRIIISLCTAKMFFVDSSNDAADKIKCKPSPLITNNNLIKVDSV

Target ORF information:

RefSeq Version	NM_053676.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus melatonin receptor 1A (Mtnr1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053676.2

ORF Insert Sequence:

ATGAAGGGCA ATGTCAGCGA GCTTCTCAAC GCCTCTCAGC AGGCTCCAGG CGGCGGGGAG 
GAAATAAGAT CGCGGCCGTC GTGGCTGGCC TCTACACTGG CCTTCATCCT CATCTTTACT 
ATCGTGGTGG ACATCCTGGG CAACCTGCTG GTCATCCTGT CTGTGTATCG CAACAAGAAG 
CTCAGGAACG CAGGGAATAT ATTTGTGGTG AGTTTAGCTG TGGCAGACCT CGTGGTGGCT 
ATTTACCCAT TTCCCTTGGC GCTGACGTCT ATACTTAACA ATGGATGGAA CCTGGGATAT 
CTGCATTGTC AAGTTAGTGC CTTCCTAATG GGCCTGAGTG TCATTGGCTC GGTATTCAAC 
ATCACCGGGA TCGCTATGAA CCGCTACTGC TACATTTGCC ACAGTCTCAA GTATGATAGG 
ATATACAGTA ACAAGAATTC CCTGTGCTAC GTGTTCCTGA TATGGACACT GACACTCATA 
GCCATCATGC CCAACCTGCA AACCGGAACT CTCCAGTACG ACCCCCGGAT CTACTCCTGT 
ACCTTCACCC AGTCCGTCAG CTCGGCGTAC ACGATTGCCC TGGTGGTTTT CCATTTCGTA 
GTTCCAATGA TTATTGTCAC TTTCTGCTAC TTAAGGATAT GGATCCTGGT TCTTCAGGTC 
AGACGGAGGG TGAAACCGGA CAGCAAACCC AAACTGAAGC CGCAGGACTT CAGGAACTTT 
GTCACCATGT TTGTAGTTTT TGTACTTTTT GCCCTGTGCT GGGCCCCACT CAACTTCATA 
GGTCTTATTG TGGCCTCAGA TCCGGCCGCC ATGGCCCCCA GGATCCCGGA GTGGCTCTTC 
GTGGCTAGTT ACTACCTGGC GTATTTCAAC AGCTGCCTCA ACGCAATCAT ATACGGACTA 
CTGAACCAAA ATTTCAGAAA GGAGTACAAG AGGATTATCA TCTCACTGTG CACAGCTAAG 
ATGTTCTTTG TGGACAGTTC AAATGATGCA GCAGATAAGA TTAAATGTAA GCCCTCTCCA 
CTAATAACCA ATAATAATTT AATAAAGGTG GACTCTGTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Co-expression of two subtypes of melatonin receptor on rat M1-type intrinsically photosensitive retinal ganglion cells.
PloS one10(2)e0117967(2015)
Sheng WL,Chen WY,Yang XL,Zhong YM,Weng SJ

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis.
Neurobiology of disease5526-35(2013 Jul)
Zhang Y,Cook A,Kim J,Baranov SV,Jiang J,Smith K,Cormier K,Bennett E,Browser RP,Day AL,Carlisle DL,Ferrante RJ,Wang X,Friedlander RM

Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth.
Current aging science6(1)125-33(2013 Feb)
Hill SM,Cheng C,Yuan L,Mao L,Jockers R,Dauchy B,Blask DE

Immunohistochemical and biomolecular identification of melatonin 1a and 1b receptors in rat vestibular nuclei.
Auris, nasus, larynx39(5)479-83(2012 Oct)
Ahn SK,Khalmuratova R,Hah YS,Jeon SY,Hur DG,Kang HS,Balaban CD

Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets.
Journal of pineal research52(4)446-59(2012 May)
M?hlbauer E,Albrecht E,Bazwinsky-Wutschke I,Peschke E

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Mtnr1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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