MTNR1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MTNR1A
Entrez Gene ID	4543
Full Name	melatonin receptor 1A
Synonyms	MEL-1A-R,MT1
General protein information	Preferred Names melatonin receptor 1A Names melatonin receptor type 1A mel1a receptor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q35.2
Summary	This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008].
Disorder MIM:	600665

mRNA and Protein(s)

mRNA	Protein	Name
NM_005958.3	NP_005949.1	melatonin receptor type 1A
XM_011532002.3	XP_011530304.1	melatonin receptor type 1A isoform X1
NM_005958.4	NP_005949.1	melatonin receptor type 1A
XM_011532002.2	XP_011530304.1	melatonin receptor type 1A isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MTNR1A	XP_526799.1
Rattus norvegicus (Norway rat)	Mtnr1a	NP_446128.1
Danio rerio (zebrafish)	mtnr1aa	NP_571468.1
Canis lupus familiaris (dog)	MTNR1A	XP_540019.3
Bos taurus (cattle)	MTNR1A	XP_002698702.1
Gallus gallus (chicken)	MTNR1A	NP_990693.1
Xenopus tropicalis (tropical clawed frog)	mtnr1a	XP_002940910.1
	MTNR1A	XP_001090972.1
Danio rerio (zebrafish)	LOC565718	XP_694081.2
Homo sapiens (human)	MTNR1A	NP_005949.1
Mus musculus (house mouse)	Mtnr1a	NP_032665.1

Gene Ontology
Bibliography

Related articles in PubMed

Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.
Owino S, S?nchez-Breta?o A, Tchio C, Cecon E, Karamitri A, Dam J, Jockers R, Piccione G, Noh HL, Kim T, Kim JK, Baba K, Tosini G
Journal of pineal research(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

There were no statistically significant differences in the distribution of MTNR1A rs2119882 and MTNR1B rs4753426 genotypes and alleles between women with gestational diabetes and healthy pregnant women.
Title: MTNR1A and MTNR1B gene polymorphisms in women with gestational diabetes.

findings suggest that a variant near MTNR1A may be associated with job-related exhaustion in shift workers
Title: Common Genetic Variation Near Melatonin Receptor 1A Gene Linked to Job-Related Exhaustion in Shift Workers.

By integrating genetic and epigenetic data, we identified that a differentially methylated CpG site within the melatonin receptor 1A (MTNR1A) gene mediates the effect of a paternally transmitted genetic variant on the comorbidity of asthma and AR. This study provides a novel insight into the role of epigenetic mechanisms in patients with allergic respiratory diseases.
Title: DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.

One single nucleotide polymorphism (SNP), rs713224, located near the brain-expressed melatonin receptor (MTNR1A) gene, was associated with the somatic complaints domain of depression symptoms. [Meta-Analysis]
Title: Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies.

rs2119882 polymorphism was associated with polycystic ovary syndrome in Han Chinese. A significant difference in transmission of allele C of rs2119882 was found between obese and non-obese women with PCOS.
Title: Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese.

The following MTNR1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MTNR1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17234	NM_005958.4 Latest version!	Homo sapiens melatonin receptor 1A (MTNR1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu59093	XM_011532002.3 Latest version!	Homo sapiens melatonin receptor 1A (MTNR1A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OHu17234	NM_005958.3	Homo sapiens melatonin receptor 1A (MTNR1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu59093	XM_011532002.2	Homo sapiens melatonin receptor 1A (MTNR1A), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MTNR1A ( NM_005958.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005949.1 Homo sapiens melatonin receptor 1A (MTNR1A), mRNA.

Price & Availability↑

CloneID	OHu17234
Clone ID Related Accession (Same CDS sequence)	NM_005958.3 , NM_005958.4
Accession Version	NM_005958.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	melatonin receptor type 1A
Comment

ATGCAGGGCA ACGGCAGCGC GCTGCCCAAC GCCTCCCAGC CCGTGCTCCG CGGGGACGGC 
GCGCGGCCCT CGTGGCTGGC GTCCGCCCTG GCCTGCGTCC TCATCTTCAC CATCGTGGTG 
GACATCCTGG GCAACCTCCT GGTCATCCTG TCGGTGTATC GGAACAAGAA GCTCAGGAAC 
GCAGGAAACA TCTTTGTGGT GAGCTTAGCG GTGGCAGACC TGGTGGTGGC CATTTATCCG 
TACCCGTTGG TGCTGATGTC GATATTTAAC AACGGGTGGA ACCTGGGCTA TCTGCACTGC 
CAAGTCAGTG GGTTCCTGAT GGGCCTGAGC GTCATCGGCT CCATATTCAA CATCACCGGC 
ATCGCCATCA ACCGCTACTG CTACATCTGC CACAGTCTCA AGTACGACAA ACTGTACAGC 
AGCAAGAACT CCCTCTGCTA CGTGCTCCTC ATATGGCTCC TGACGCTGGC GGCCGTCCTG 
CCCAACCTCC GTGCAGGGAC TCTCCAGTAC GACCCGAGGA TCTACTCGTG CACCTTCGCC 
CAGTCCGTCA GCTCCGCCTA CACCATCGCC GTGGTGGTTT TCCACTTCCT CGTCCCCATG 
ATCATAGTCA TCTTCTGTTA CCTGAGAATA TGGATCCTGG TTCTCCAGGT CAGACAGAGG 
GTGAAACCTG ACCGCAAACC CAAACTGAAA CCACAGGACT TCAGGAATTT TGTCACCATG 
TTTGTGGTTT TTGTCCTTTT TGCCATTTGC TGGGCTCCTC TGAACTTCAT TGGCCTGGCC 
GTGGCCTCTG ACCCCGCCAG CATGGTGCCT AGGATCCCAG AGTGGCTGTT TGTGGCCAGT 
TACTACATGG CGTATTTCAA CAGCTGCCTC AATGCCATTA TATACGGGCT ACTGAACCAA 
AATTTCAGGA AGGAATACAG GAGAATTATA GTCTCGCTCT GTACAGCCAG GGTGTTCTTT 
GTGGACAGCT CTAACGACGT GGCCGATAGG GTTAAATGGA AACCGTCTCC ACTGATGACC 
AACAATAATG TAGTAAAGGT GGACTCCGTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005949.1
Translation	MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV

Target ORF information:

RefSeq Version	NM_005958.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens melatonin receptor 1A (MTNR1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005958.3

ORF Insert Sequence:

ATGCAGGGCA ACGGCAGCGC GCTGCCCAAC GCCTCCCAGC CCGTGCTCCG CGGGGACGGC 
GCGCGGCCCT CGTGGCTGGC GTCCGCCCTG GCCTGCGTCC TCATCTTCAC CATCGTGGTG 
GACATCCTGG GCAACCTCCT GGTCATCCTG TCGGTGTATC GGAACAAGAA GCTCAGGAAC 
GCAGGAAACA TCTTTGTGGT GAGCTTAGCG GTGGCAGACC TGGTGGTGGC CATTTATCCG 
TACCCGTTGG TGCTGATGTC GATATTTAAC AACGGGTGGA ACCTGGGCTA TCTGCACTGC 
CAAGTCAGTG GGTTCCTGAT GGGCCTGAGC GTCATCGGCT CCATATTCAA CATCACCGGC 
ATCGCCATCA ACCGCTACTG CTACATCTGC CACAGTCTCA AGTACGACAA ACTGTACAGC 
AGCAAGAACT CCCTCTGCTA CGTGCTCCTC ATATGGCTCC TGACGCTGGC GGCCGTCCTG 
CCCAACCTCC GTGCAGGGAC TCTCCAGTAC GACCCGAGGA TCTACTCGTG CACCTTCGCC 
CAGTCCGTCA GCTCCGCCTA CACCATCGCC GTGGTGGTTT TCCACTTCCT CGTCCCCATG 
ATCATAGTCA TCTTCTGTTA CCTGAGAATA TGGATCCTGG TTCTCCAGGT CAGACAGAGG 
GTGAAACCTG ACCGCAAACC CAAACTGAAA CCACAGGACT TCAGGAATTT TGTCACCATG 
TTTGTGGTTT TTGTCCTTTT TGCCATTTGC TGGGCTCCTC TGAACTTCAT TGGCCTGGCC 
GTGGCCTCTG ACCCCGCCAG CATGGTGCCT AGGATCCCAG AGTGGCTGTT TGTGGCCAGT 
TACTACATGG CGTATTTCAA CAGCTGCCTC AATGCCATTA TATACGGGCT ACTGAACCAA 
AATTTCAGGA AGGAATACAG GAGAATTATA GTCTCGCTCT GTACAGCCAG GGTGTTCTTT 
GTGGACAGCT CTAACGACGT GGCCGATAGG GTTAAATGGA AACCGTCTCC ACTGATGACC 
AACAATAATG TAGTAAAGGT GGACTCCGTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTNR1A ( NM_005958.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005949.1 Homo sapiens melatonin receptor 1A (MTNR1A), mRNA.

Price & Availability↑

CloneID	OHu17234
Clone ID Related Accession (Same CDS sequence)	NM_005958.3 , NM_005958.4
Accession Version	NM_005958.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	melatonin receptor type 1A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC126297.1 and BC074946.2. On Dec 11, 2015 this sequence version replaced NM_005958.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC126297.1, SRR1660805.196710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307161.5/ ENSP00000302811.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGCAGGGCA ACGGCAGCGC GCTGCCCAAC GCCTCCCAGC CCGTGCTCCG CGGGGACGGC 
GCGCGGCCCT CGTGGCTGGC GTCCGCCCTG GCCTGCGTCC TCATCTTCAC CATCGTGGTG 
GACATCCTGG GCAACCTCCT GGTCATCCTG TCGGTGTATC GGAACAAGAA GCTCAGGAAC 
GCAGGAAACA TCTTTGTGGT GAGCTTAGCG GTGGCAGACC TGGTGGTGGC CATTTATCCG 
TACCCGTTGG TGCTGATGTC GATATTTAAC AACGGGTGGA ACCTGGGCTA TCTGCACTGC 
CAAGTCAGTG GGTTCCTGAT GGGCCTGAGC GTCATCGGCT CCATATTCAA CATCACCGGC 
ATCGCCATCA ACCGCTACTG CTACATCTGC CACAGTCTCA AGTACGACAA ACTGTACAGC 
AGCAAGAACT CCCTCTGCTA CGTGCTCCTC ATATGGCTCC TGACGCTGGC GGCCGTCCTG 
CCCAACCTCC GTGCAGGGAC TCTCCAGTAC GACCCGAGGA TCTACTCGTG CACCTTCGCC 
CAGTCCGTCA GCTCCGCCTA CACCATCGCC GTGGTGGTTT TCCACTTCCT CGTCCCCATG 
ATCATAGTCA TCTTCTGTTA CCTGAGAATA TGGATCCTGG TTCTCCAGGT CAGACAGAGG 
GTGAAACCTG ACCGCAAACC CAAACTGAAA CCACAGGACT TCAGGAATTT TGTCACCATG 
TTTGTGGTTT TTGTCCTTTT TGCCATTTGC TGGGCTCCTC TGAACTTCAT TGGCCTGGCC 
GTGGCCTCTG ACCCCGCCAG CATGGTGCCT AGGATCCCAG AGTGGCTGTT TGTGGCCAGT 
TACTACATGG CGTATTTCAA CAGCTGCCTC AATGCCATTA TATACGGGCT ACTGAACCAA 
AATTTCAGGA AGGAATACAG GAGAATTATA GTCTCGCTCT GTACAGCCAG GGTGTTCTTT 
GTGGACAGCT CTAACGACGT GGCCGATAGG GTTAAATGGA AACCGTCTCC ACTGATGACC 
AACAATAATG TAGTAAAGGT GGACTCCGTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005949.1
CDS	203..1255
Translation	MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV

Target ORF information:

RefSeq Version	NM_005958.4
Organism	Homo sapiens(human)
Definition	Homo sapiens melatonin receptor 1A (MTNR1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005958.4

ORF Insert Sequence:

ATGCAGGGCA ACGGCAGCGC GCTGCCCAAC GCCTCCCAGC CCGTGCTCCG CGGGGACGGC 
GCGCGGCCCT CGTGGCTGGC GTCCGCCCTG GCCTGCGTCC TCATCTTCAC CATCGTGGTG 
GACATCCTGG GCAACCTCCT GGTCATCCTG TCGGTGTATC GGAACAAGAA GCTCAGGAAC 
GCAGGAAACA TCTTTGTGGT GAGCTTAGCG GTGGCAGACC TGGTGGTGGC CATTTATCCG 
TACCCGTTGG TGCTGATGTC GATATTTAAC AACGGGTGGA ACCTGGGCTA TCTGCACTGC 
CAAGTCAGTG GGTTCCTGAT GGGCCTGAGC GTCATCGGCT CCATATTCAA CATCACCGGC 
ATCGCCATCA ACCGCTACTG CTACATCTGC CACAGTCTCA AGTACGACAA ACTGTACAGC 
AGCAAGAACT CCCTCTGCTA CGTGCTCCTC ATATGGCTCC TGACGCTGGC GGCCGTCCTG 
CCCAACCTCC GTGCAGGGAC TCTCCAGTAC GACCCGAGGA TCTACTCGTG CACCTTCGCC 
CAGTCCGTCA GCTCCGCCTA CACCATCGCC GTGGTGGTTT TCCACTTCCT CGTCCCCATG 
ATCATAGTCA TCTTCTGTTA CCTGAGAATA TGGATCCTGG TTCTCCAGGT CAGACAGAGG 
GTGAAACCTG ACCGCAAACC CAAACTGAAA CCACAGGACT TCAGGAATTT TGTCACCATG 
TTTGTGGTTT TTGTCCTTTT TGCCATTTGC TGGGCTCCTC TGAACTTCAT TGGCCTGGCC 
GTGGCCTCTG ACCCCGCCAG CATGGTGCCT AGGATCCCAG AGTGGCTGTT TGTGGCCAGT 
TACTACATGG CGTATTTCAA CAGCTGCCTC AATGCCATTA TATACGGGCT ACTGAACCAA 
AATTTCAGGA AGGAATACAG GAGAATTATA GTCTCGCTCT GTACAGCCAG GGTGTTCTTT 
GTGGACAGCT CTAACGACGT GGCCGATAGG GTTAAATGGA AACCGTCTCC ACTGATGACC 
AACAATAATG TAGTAAAGGT GGACTCCGTT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTNR1A ( XM_011532002.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530304.1 Homo sapiens melatonin receptor 1A (MTNR1A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59093
Clone ID Related Accession (Same CDS sequence)	XM_011532002.3 , XM_011532002.2
Accession Version	XM_011532002.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	melatonin receptor type 1A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011532002.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGATAT TTAACAACGG GTGGAACCTG GGCTATCTGC ACTGCCAAGT CAGTGGGTTC 
CTGATGGGCC TGAGCGTCAT CGGCTCCATA TTCAACATCA CCGGCATCGC CATCAACCGC 
TACTGCTACA TCTGCCACAG TCTCAAGTAC GACAAACTGT ACAGCAGCAA GAACTCCCTC 
TGCTACGTGC TCCTCATATG GCTCCTGACG CTGGCGGCCG TCCTGCCCAA CCTCCGTGCA 
GGGACTCTCC AGTACGACCC GAGGATCTAC TCGTGCACCT TCGCCCAGTC CGTCAGCTCC 
GCCTACACCA TCGCCGTGGT GGTTTTCCAC TTCCTCGTCC CCATGATCAT AGTCATCTTC 
TGTTACCTGA GAATATGGAT CCTGGTTCTC CAGGTCAGAC AGAGGGTGAA ACCTGACCGC 
AAACCCAAAC TGAAACCACA GGACTTCAGG AATTTTGTCA CCATGTTTGT GGTTTTTGTC 
CTTTTTGCCA TTTGCTGGGC TCCTCTGAAC TTCATTGGCC TGGCCGTGGC CTCTGACCCC 
GCCAGCATGG TGCCTAGGAT CCCAGAGTGG CTGTTTGTGG CCAGTTACTA CATGGCGTAT 
TTCAACAGCT GCCTCAATGC CATTATATAC GGGCTACTGA ACCAAAATTT CAGGAAGGAA 
TACAGGAGAA TTATAGTCTC GCTCTGTACA GCCAGGGTGT TCTTTGTGGA CAGCTCTAAC 
GACGTGGCCG ATAGGGTTAA ATGGAAACCG TCTCCACTGA TGACCAACAA TAATGTAGTA 
AAGGTGGACT CCGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530304.1
CDS	539..1336
Translation	MSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV

Target ORF information:

RefSeq Version	XM_011532002.3
Organism	Homo sapiens(human)
Definition	Homo sapiens melatonin receptor 1A (MTNR1A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532002.3

ORF Insert Sequence:

ATGTCGATAT TTAACAACGG GTGGAACCTG GGCTATCTGC ACTGCCAAGT CAGTGGGTTC 
CTGATGGGCC TGAGCGTCAT CGGCTCCATA TTCAACATCA CCGGCATCGC CATCAACCGC 
TACTGCTACA TCTGCCACAG TCTCAAGTAC GACAAACTGT ACAGCAGCAA GAACTCCCTC 
TGCTACGTGC TCCTCATATG GCTCCTGACG CTGGCGGCCG TCCTGCCCAA CCTCCGTGCA 
GGGACTCTCC AGTACGACCC GAGGATCTAC TCGTGCACCT TCGCCCAGTC CGTCAGCTCC 
GCCTACACCA TCGCCGTGGT GGTTTTCCAC TTCCTCGTCC CCATGATCAT AGTCATCTTC 
TGTTACCTGA GAATATGGAT CCTGGTTCTC CAGGTCAGAC AGAGGGTGAA ACCTGACCGC 
AAACCCAAAC TGAAACCACA GGACTTCAGG AATTTTGTCA CCATGTTTGT GGTTTTTGTC 
CTTTTTGCCA TTTGCTGGGC TCCTCTGAAC TTCATTGGCC TGGCCGTGGC CTCTGACCCC 
GCCAGCATGG TGCCTAGGAT CCCAGAGTGG CTGTTTGTGG CCAGTTACTA CATGGCGTAT 
TTCAACAGCT GCCTCAATGC CATTATATAC GGGCTACTGA ACCAAAATTT CAGGAAGGAA 
TACAGGAGAA TTATAGTCTC GCTCTGTACA GCCAGGGTGT TCTTTGTGGA CAGCTCTAAC 
GACGTGGCCG ATAGGGTTAA ATGGAAACCG TCTCCACTGA TGACCAACAA TAATGTAGTA 
AAGGTGGACT CCGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MTNR1A ( XM_011532002.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530304.1 Homo sapiens melatonin receptor 1A (MTNR1A), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59093
Clone ID Related Accession (Same CDS sequence)	XM_011532002.3 , XM_011532002.2
Accession Version	XM_011532002.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 798bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	melatonin receptor type 1A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532002.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGATAT TTAACAACGG GTGGAACCTG GGCTATCTGC ACTGCCAAGT CAGTGGGTTC 
CTGATGGGCC TGAGCGTCAT CGGCTCCATA TTCAACATCA CCGGCATCGC CATCAACCGC 
TACTGCTACA TCTGCCACAG TCTCAAGTAC GACAAACTGT ACAGCAGCAA GAACTCCCTC 
TGCTACGTGC TCCTCATATG GCTCCTGACG CTGGCGGCCG TCCTGCCCAA CCTCCGTGCA 
GGGACTCTCC AGTACGACCC GAGGATCTAC TCGTGCACCT TCGCCCAGTC CGTCAGCTCC 
GCCTACACCA TCGCCGTGGT GGTTTTCCAC TTCCTCGTCC CCATGATCAT AGTCATCTTC 
TGTTACCTGA GAATATGGAT CCTGGTTCTC CAGGTCAGAC AGAGGGTGAA ACCTGACCGC 
AAACCCAAAC TGAAACCACA GGACTTCAGG AATTTTGTCA CCATGTTTGT GGTTTTTGTC 
CTTTTTGCCA TTTGCTGGGC TCCTCTGAAC TTCATTGGCC TGGCCGTGGC CTCTGACCCC 
GCCAGCATGG TGCCTAGGAT CCCAGAGTGG CTGTTTGTGG CCAGTTACTA CATGGCGTAT 
TTCAACAGCT GCCTCAATGC CATTATATAC GGGCTACTGA ACCAAAATTT CAGGAAGGAA 
TACAGGAGAA TTATAGTCTC GCTCTGTACA GCCAGGGTGT TCTTTGTGGA CAGCTCTAAC 
GACGTGGCCG ATAGGGTTAA ATGGAAACCG TCTCCACTGA TGACCAACAA TAATGTAGTA 
AAGGTGGACT CCGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530304.1
CDS	539..1336
Translation	MSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV

Target ORF information:

RefSeq Version	XM_011532002.2
Organism	Homo sapiens(human)
Definition	Homo sapiens melatonin receptor 1A (MTNR1A), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532002.2

ORF Insert Sequence:

ATGTCGATAT TTAACAACGG GTGGAACCTG GGCTATCTGC ACTGCCAAGT CAGTGGGTTC 
CTGATGGGCC TGAGCGTCAT CGGCTCCATA TTCAACATCA CCGGCATCGC CATCAACCGC 
TACTGCTACA TCTGCCACAG TCTCAAGTAC GACAAACTGT ACAGCAGCAA GAACTCCCTC 
TGCTACGTGC TCCTCATATG GCTCCTGACG CTGGCGGCCG TCCTGCCCAA CCTCCGTGCA 
GGGACTCTCC AGTACGACCC GAGGATCTAC TCGTGCACCT TCGCCCAGTC CGTCAGCTCC 
GCCTACACCA TCGCCGTGGT GGTTTTCCAC TTCCTCGTCC CCATGATCAT AGTCATCTTC 
TGTTACCTGA GAATATGGAT CCTGGTTCTC CAGGTCAGAC AGAGGGTGAA ACCTGACCGC 
AAACCCAAAC TGAAACCACA GGACTTCAGG AATTTTGTCA CCATGTTTGT GGTTTTTGTC 
CTTTTTGCCA TTTGCTGGGC TCCTCTGAAC TTCATTGGCC TGGCCGTGGC CTCTGACCCC 
GCCAGCATGG TGCCTAGGAT CCCAGAGTGG CTGTTTGTGG CCAGTTACTA CATGGCGTAT 
TTCAACAGCT GCCTCAATGC CATTATATAC GGGCTACTGA ACCAAAATTT CAGGAAGGAA 
TACAGGAGAA TTATAGTCTC GCTCTGTACA GCCAGGGTGT TCTTTGTGGA CAGCTCTAAC 
GACGTGGCCG ATAGGGTTAA ATGGAAACCG TCTCCACTGA TGACCAACAA TAATGTAGTA 
AAGGTGGACT CCGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.
Journal of pineal research(2017 Dec)
Owino S,S?nchez-Breta?o A,Tchio C,Cecon E,Karamitri A,Dam J,Jockers R,Piccione G,Noh HL,Kim T,Kim JK,Baba K,Tosini G

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MTNR1A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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