Acsl3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acsl3
Entrez Gene ID	114024
Full Name	acyl-CoA synthetase long-chain family member 3
Synonyms	Acs3,Facl3
General protein information	Preferred Names acyl-CoA synthetase long-chain family member 3 Names long-chain-fatty-acid--CoA ligase 3 LACS 3 brain acyl-CoA synthetase II fatty acid Coenzyme A ligase, long chain 3 long-chain acyl-CoA synthetase 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q34
Summary	catalyzes initial reaction of fatty acid metabolism to produce Acyl-CoA; plays a key role in lipid metabolism; may mediate the synthesis of brain lipids [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_057107.1	NP_476448.1	long-chain-fatty-acid--CoA ligase 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ACSL3	XP_001166511.1
	ACSL3	XP_001108365.2
Arabidopsis thaliana (thale cress)	LACS8	NP_178516.1
Gallus gallus (chicken)	ACSL3	XP_422625.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003623	XP_003436540.1
Xenopus tropicalis (tropical clawed frog)	acsl4	NP_001090679.1
Canis lupus familiaris (dog)	ACSL3	XP_851617.1
Bos taurus (cattle)	ACSL3	NP_001192397.1
Mus musculus (house mouse)	Acsl3	NP_083093.2
Danio rerio (zebrafish)	acsl3a	NP_001038593.1
Oryza sativa (rice)	Os05g0317200	NP_001055177.1
Homo sapiens (human)	ACSL3	NP_976251.1
Rattus norvegicus (Norway rat)	Acsl3	NP_476448.1
Drosophila melanogaster (fruit fly)	Acsl	NP_724695.1
Danio rerio (zebrafish)	acsl3b	NP_001139404.1

Gene Ontology
Bibliography

Related articles in PubMed

Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids.
Klett EL, Chen S, Yechoor A, Lih FB, Coleman RA
Journal of lipid research58(5)884-894(2017 May)

Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness.
Shang Y, Das S, Rabold R, Sham JS, Mitzner W, Tang WY
American journal of respiratory cell and molecular biology49(2)279-87(2013 Aug)

Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.
Pei Z, Fraisl P, Shi X, Gabrielson E, Forss-Petter S, Berger J, Watkins PA
PloS one8(7)e69392(2013)

Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7.
Fujimoto Y, Itabe H, Sakai J, Makita M, Noda J, Mori M, Higashi Y, Kojima S, Takano T
Biochimica et biophysica acta1644(1)47-59(2004 Feb)

Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation.
Benani A, Vol C, Heurtaux T, Asensio C, Dau?a M, Lapicque F, Netter P, Minn A
The European journal of neuroscience18(7)1904-14(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

novel role for ACSL3 in mediating transcriptional control of hepatic lipogenesis
Title: Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity.

The following Acsl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acsl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42522	NM_057107.1 Latest version!	Rattus norvegicus acyl-CoA synthetase long-chain family member 3 (Acsl3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acsl3 ( NM_057107.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476448.1 Rattus norvegicus acyl-CoA synthetase long-chain family member 3 (Acsl3), mRNA.

Price & Availability↑

CloneID	ORa42522
Clone ID Related Accession (Same CDS sequence)	NM_057107.1
Accession Version	NM_057107.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2163bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	long-chain-fatty-acid--CoA ligase 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D30666.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D30666.1 [ECO:0000332] ##Evidence-Data-END##

ATGAATAACC ACGTATCTTC AACACCGTCT ACCATGAAGC TAAAACAAAC CATCCACCCC 
ATACTTTTAT ATTTCATACA TTTTATAATA TCACTCTATA CTATTTTAAC ATACATCCCA 
TTTTATTTTT TGTGTGAGTC AAAACAAGAG AAACCAAACC ACATTAAAGC AAAGCCTGTC 
AGTTCAAAAC CGGACTCTGC ATACAGGTCT GTCAACAGTA TGGATGGCTT AGCTTCAGTA 
TTGTATCCTG GCTGCGACAC ACTTGATAAA GTTTTTATGT ATGCAAAAAA CAAATTTAAG 
GACAAAAGAC TATTGGGAAC ACGTGAGATT TTGAATGAGG AAGATGAAAT ACAACCAAAT 
GGAAAGGTTT TTAAAAAGGT TATTCTGGGG CACTATAATT GGCTTTCCTA TGAAGATGTC 
TTCATTCGAG CCCTCGATTT TGGAAATGGG TTACAAATGT TGGGCCAGAA GCCGAAGGCC 
AACATCGCCA TCTTTTGTGA GACCAGGGCT GAGTGGATGA TTGCTGCGCA GGCGTGTTTC 
ATGTACAACT TCCAGCTTGT TACACTGTAT GCGACTCTGG GAGGTCCAGC CATTGTCCAT 
GGACTGAATG AGACAGAGGT GACCAACATC ATTACTAGTA AAGAACTCCT GCAAACAAAG 
CTGAAGGATA TCGTCTCTTT GGTCCCACGT CTGCGGCATA TCATTACTGT TGATGGGAAG 
CCTCCAACCT GGTCTGAGTT CCCCAAGGGC GTCATTGTAC ACACCATGGC TGCAGTGCAG 
GCTCTAGGAG TAAAGGCTGA CGTGGACAAG AAAGCTCACA GCAAACCACT GCCCTCAGAT 
ATTGCAGTAA TCATGTACAC AAGTGGATCC ACAGGAATTC CAAAGGGAGT CATGATCTCA 
CACAGCAACA TCATTGCCTC TATAACGGGG ATGGCGAGAA GGATTCCAAG ACTGGGAGAG 
GAAGATGTAT ACATTGGATA TTTGCCCCTG GCACATGTTC TAGAATTAAG CGCTGAGCTT 
GTGTGTCTTT CTCATGGATG CCGGATTGGC TACTCTTCAC CACAGACATT AGCAGATCAG 
TCTTCAAAAA TAAAGAAAGG AAGCAAAGGA GACACATCCG TTCTGAAGCC CACGCTGATG 
GCAGCTGTGC CGGAAATCAT GGATCGGATC TACAAAAATG TCATGAATAA AGTGAATGAA 
ATGAGTGCTT TTCAACGAAA CTTGTTTATT TTGGCATATA ATTATAAGAT GGAGCAGATT 
TCAAAAGGGT GTAGTACCCC GCTGTGTGAC CGCTTTGTTT TCCGGAATGT CCGAAGGCTG 
CTGGGTGGAA ATATTCGCGT TTTATTGTGC GGTGGTGCTC CACTTTCTGC AACGACACAG 
CGATTCATGA ATATCTGCTT CTGTTGTCCC GTTGGCCAGG GGTATGGACT CACAGAATCT 
ACTGGGGCTG GAACAATTAC AGAAGTGTGG GACTACAATA CCGGCAGAGT GGGAGCACCA 
TTAGTTTGCT GTGAAATCAA ATTAAAGAAC TGGGAGGAAG GTGGCTATTT TAATACTGAC 
AAACCACATC CCAGAGGTGA AATTCTGATT GGTGGCCAAA ATGTGACAAT GGGGTACTAC 
AAAAATGAAG CAAAAACAAA GGCCGATTTC TTTGAAGATG AAAACGGACA GAGGTGGCTG 
TGCACTGGCG ATATTGGAGA GTTTGACCCT GATGGCTGCC TCAAGATCAT TGATCGTAAA 
AAGGACCTTG TGAAACTACA GGCAGGAGAG TATGTTTCTC TAGGCAAAGT TGAGGCAGCT 
TTGAAGAACC TCCCACTGAT AGATAACATT TGTGCATATG CAAACAGTTA CCATTCTTAC 
GTAATTGGAT TTGTTGTGCC AAATCAAAAG GAACTTACGG AGCTAGCTAG AACGAAAGGA 
TTTAACGGAA CTTGGGAAGA GCTGTGTAAC AGCAGTGAAA TGGAAAACGA GGTCCTTAAA 
GTGCTTTCTG AGGCTGCTAT TTCAGCAAGT CTGGAAAAGT TTGAAATCCC ACTGAAAATT 
CGTTTGAGCC CTGACCCATG GACTCCCGAA ACTGGTCTGG TGACTGATGC CTTCAAGTTG 
AAACGTAAAG AACTTAAAAC ACACTACCAG GCAGACATTG AGCGGATGTA CGGAAGAAAA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476448.1
CDS	49..2211
Translation	MNNHVSSTPSTMKLKQTIHPILLYFIHFIISLYTILTYIPFYFLCESKQEKPNHIKAKPVSSKPDSAYRSVNSMDGLASVLYPGCDTLDKVFMYAKNKFKDKRLLGTREILNEEDEIQPNGKVFKKVILGHYNWLSYEDVFIRALDFGNGLQMLGQKPKANIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHGLNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGVIVHTMAAVQALGVKADVDKKAHSKPLPSDIAVIMYTSGSTGIPKGVMISHSNIIASITGMARRIPRLGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSVLKPTLMAAVPEIMDRIYKNVMNKVNEMSAFQRNLFILAYNYKMEQISKGCSTPLCDRFVFRNVRRLLGGNIRVLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESTGAGTITEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQNVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFDPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLIDNICAYANSYHSYVIGFVVPNQKELTELARTKGFNGTWEELCNSSEMENEVLKVLSEAAISASLEKFEIPLKIRLSPDPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK

Target ORF information:

RefSeq Version	NM_057107.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus acyl-CoA synthetase long-chain family member 3 (Acsl3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057107.1

ORF Insert Sequence:

ATGAATAACC ACGTATCTTC AACACCGTCT ACCATGAAGC TAAAACAAAC CATCCACCCC 
ATACTTTTAT ATTTCATACA TTTTATAATA TCACTCTATA CTATTTTAAC ATACATCCCA 
TTTTATTTTT TGTGTGAGTC AAAACAAGAG AAACCAAACC ACATTAAAGC AAAGCCTGTC 
AGTTCAAAAC CGGACTCTGC ATACAGGTCT GTCAACAGTA TGGATGGCTT AGCTTCAGTA 
TTGTATCCTG GCTGCGACAC ACTTGATAAA GTTTTTATGT ATGCAAAAAA CAAATTTAAG 
GACAAAAGAC TATTGGGAAC ACGTGAGATT TTGAATGAGG AAGATGAAAT ACAACCAAAT 
GGAAAGGTTT TTAAAAAGGT TATTCTGGGG CACTATAATT GGCTTTCCTA TGAAGATGTC 
TTCATTCGAG CCCTCGATTT TGGAAATGGG TTACAAATGT TGGGCCAGAA GCCGAAGGCC 
AACATCGCCA TCTTTTGTGA GACCAGGGCT GAGTGGATGA TTGCTGCGCA GGCGTGTTTC 
ATGTACAACT TCCAGCTTGT TACACTGTAT GCGACTCTGG GAGGTCCAGC CATTGTCCAT 
GGACTGAATG AGACAGAGGT GACCAACATC ATTACTAGTA AAGAACTCCT GCAAACAAAG 
CTGAAGGATA TCGTCTCTTT GGTCCCACGT CTGCGGCATA TCATTACTGT TGATGGGAAG 
CCTCCAACCT GGTCTGAGTT CCCCAAGGGC GTCATTGTAC ACACCATGGC TGCAGTGCAG 
GCTCTAGGAG TAAAGGCTGA CGTGGACAAG AAAGCTCACA GCAAACCACT GCCCTCAGAT 
ATTGCAGTAA TCATGTACAC AAGTGGATCC ACAGGAATTC CAAAGGGAGT CATGATCTCA 
CACAGCAACA TCATTGCCTC TATAACGGGG ATGGCGAGAA GGATTCCAAG ACTGGGAGAG 
GAAGATGTAT ACATTGGATA TTTGCCCCTG GCACATGTTC TAGAATTAAG CGCTGAGCTT 
GTGTGTCTTT CTCATGGATG CCGGATTGGC TACTCTTCAC CACAGACATT AGCAGATCAG 
TCTTCAAAAA TAAAGAAAGG AAGCAAAGGA GACACATCCG TTCTGAAGCC CACGCTGATG 
GCAGCTGTGC CGGAAATCAT GGATCGGATC TACAAAAATG TCATGAATAA AGTGAATGAA 
ATGAGTGCTT TTCAACGAAA CTTGTTTATT TTGGCATATA ATTATAAGAT GGAGCAGATT 
TCAAAAGGGT GTAGTACCCC GCTGTGTGAC CGCTTTGTTT TCCGGAATGT CCGAAGGCTG 
CTGGGTGGAA ATATTCGCGT TTTATTGTGC GGTGGTGCTC CACTTTCTGC AACGACACAG 
CGATTCATGA ATATCTGCTT CTGTTGTCCC GTTGGCCAGG GGTATGGACT CACAGAATCT 
ACTGGGGCTG GAACAATTAC AGAAGTGTGG GACTACAATA CCGGCAGAGT GGGAGCACCA 
TTAGTTTGCT GTGAAATCAA ATTAAAGAAC TGGGAGGAAG GTGGCTATTT TAATACTGAC 
AAACCACATC CCAGAGGTGA AATTCTGATT GGTGGCCAAA ATGTGACAAT GGGGTACTAC 
AAAAATGAAG CAAAAACAAA GGCCGATTTC TTTGAAGATG AAAACGGACA GAGGTGGCTG 
TGCACTGGCG ATATTGGAGA GTTTGACCCT GATGGCTGCC TCAAGATCAT TGATCGTAAA 
AAGGACCTTG TGAAACTACA GGCAGGAGAG TATGTTTCTC TAGGCAAAGT TGAGGCAGCT 
TTGAAGAACC TCCCACTGAT AGATAACATT TGTGCATATG CAAACAGTTA CCATTCTTAC 
GTAATTGGAT TTGTTGTGCC AAATCAAAAG GAACTTACGG AGCTAGCTAG AACGAAAGGA 
TTTAACGGAA CTTGGGAAGA GCTGTGTAAC AGCAGTGAAA TGGAAAACGA GGTCCTTAAA 
GTGCTTTCTG AGGCTGCTAT TTCAGCAAGT CTGGAAAAGT TTGAAATCCC ACTGAAAATT 
CGTTTGAGCC CTGACCCATG GACTCCCGAA ACTGGTCTGG TGACTGATGC CTTCAAGTTG 
AAACGTAAAG AACTTAAAAC ACACTACCAG GCAGACATTG AGCGGATGTA CGGAAGAAAA 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids.
Journal of lipid research58(5)884-894(2017 May)
Klett EL,Chen S,Yechoor A,Lih FB,Coleman RA

Epigenetic alterations by DNA methylation in house dust mite-induced airway hyperresponsiveness.
American journal of respiratory cell and molecular biology49(2)279-87(2013 Aug)
Shang Y,Das S,Rabold R,Sham JS,Mitzner W,Tang WY

Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.
PloS one8(7)e69392(2013)
Pei Z,Fraisl P,Shi X,Gabrielson E,Forss-Petter S,Berger J,Watkins PA

Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7.
Biochimica et biophysica acta1644(1)47-59(2004 Feb)
Fujimoto Y,Itabe H,Sakai J,Makita M,Noda J,Mori M,Higashi Y,Kojima S,Takano T

Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation.
The European journal of neuroscience18(7)1904-14(2003 Oct)
Benani A,Vol C,Heurtaux T,Asensio C,Dau?a M,Lapicque F,Netter P,Minn A

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Acsl3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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