CCR5 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCR5
Entrez Gene ID	735311
Full Name	C-C motif chemokine receptor 5
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)

mRNA and Protein(s)

mRNA	Protein	Name
XM_015131082.1	XP_014986568.1	C-C chemokine receptor type 5 isoform X1
XM_015131082.2	XP_014986568.1	C-C chemokine receptor type 5 isoform X1
NM_001042773.3	NP_001036238.2	C-C chemokine receptor type 5
NM_001309402.1	NP_001296331.1	C-C chemokine receptor type 5

Pathways from BioSystems

Homologies

	CCR5	NP_001036238.2
Canis lupus familiaris (dog)	CCR5	NP_001012342.2
Bos taurus (cattle)	CCR5	NP_001011672.2
Pan troglodytes (chimpanzee)	CCR5	NP_001009046.1
Mus musculus (house mouse)	Ccr5	NP_034047.2
Rattus norvegicus (Norway rat)	Ccr5	NP_446412.2
Danio rerio (zebrafish)	LOC100004988	XP_001344151.1
Homo sapiens (human)	CCR5	NP_001093638.1
Danio rerio (zebrafish)	LOC100005081	XP_001344220.4
Danio rerio (zebrafish)	LOC100004625	XP_001343879.1
Xenopus tropicalis (tropical clawed frog)	LOC101731980	XP_004915406.1

Gene Ontology
Bibliography

Related articles in PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.
Kelly KM, Tocchetti CG, Lyashkov A, Tarwater PM, Bedja D, Graham DR, Beck SE, Metcalf Pate KA, Queen SE, Adams RJ, Paolocci N, Mankowski JL
Journal of the American Heart Association3(2)e000874(2014 Apr)

A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
Van Rompay KK, Hunter Z, Jayashankar K, Peabody J, Montefiori D, LaBranche CC, Keele BF, Jensen K, Abel K, Chackerian B
Journal of virology88(4)2011-24(2014 Feb)

Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques.
Yan G, Zhang G, Fang X, Zhang Y, Li C, Ling F, Cooper DN, Li Q, Li Y, van Gool AJ, Du H, Chen J, Chen R, Zhang P, Huang Z, Thompson JR, Meng Y, Bai Y, Wang J, Zhuo M, Wang T, Huang Y, Wei L, Li J, Wang Z, Hu H, Yang P, Le L, Stenson PD, Li B, Liu X, Ball EV, An N, Huang Q, Zhang Y, Fan W, Zhang X, Li Y, Wang W, Katze MG, Su B, Nielsen R, Yang H, Wang J, Wang X, Wang J
Nature biotechnology29(11)1019-23(2011 Oct)

TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection.
Minang JT, Trivett MT, Barsov EV, Del Prete GQ, Trubey CM, Thomas JA, Gorelick RJ, Piatak M Jr, Ott DE, Ohlen C
Virology409(1)132-40(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CCR5 inhibition may provide a cardioprotective benefit in SIV infection by preventing cardiomyocyte CCR5 signaling.
Title: CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.

A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
Title: A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.

CCR5 downregulation on CD4(+) T cells by TCR activation has no measurable effect on susceptibility to SAIDS.
Title: TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection.

CD4 and CD8 T cells are more vulnerable to SIV infection, indicating the the ability to express CCR5 may activate and hassten T cell death by SIV infection in vitro.
Title: Peripheral blood CD4 and CD8 double-positive T cells of rhesus macaques become vulnerable to Simian Immunodeficiency Virus by in vitro stimulation due to the induction of CCR5.

Virus recovered from CA28 plasma (SHIV(CA28NP)) used both CCR5 and CXCR4 for entry, but the virus recovered from lymph node (SHIV(CA28NL)) used CXCR4 almost exclusively
Title: Different mutational pathways to CXCR4 coreceptor switch of CCR5-using simian-human immunodeficiency virus.

The following CCR5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCR5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMb24180	NM_001309402.1 Latest version!	Macaca mulatta C-C motif chemokine receptor 5 (CCR5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OMb24180	NM_001042773.3 Latest version!	Macaca mulatta C-C motif chemokine receptor 5 (CCR5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OMb28605	XM_015131082.2 Latest version!	Macaca mulatta C-C motif chemokine receptor 5 (CCR5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
View Old Accession Versions >>
OMb28605	XM_015131082.1	Macaca mulatta chemokine (C-C motif) receptor 5 (CCR5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCR5 ( NM_001042773.3 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001036238.2 Macaca mulatta C-C motif chemokine receptor 5 (CCR5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMb24180
Clone ID Related Accession (Same CDS sequence)	NM_001042773.3 , NM_001309402.1
Accession Version	NM_001042773.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-04
Organism	Macaca mulatta(Rhesus monkey)
Product	C-C chemokine receptor type 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ902537.1 and DQ499963.1. On May 29, 2015 this sequence version replaced NM_001042773.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGGACTATC AAGTGTCAAG TCCAACCTAT GACATCGATT ATTATACATC GGAACCCTGC 
CAAAAAATCA ATGTGAAACA AATCGCAGCC CGCCTCCTGC CTCCGCTCTA CTCACTGGTG 
TTCATCTTTG GTTTTGTGGG CAACATACTG GTCGTCCTCA TCCTGATAAA CTGCAAAAGG 
CTGAAAAGCA TGACTGACAT CTACCTGCTC AACCTGGCCA TCTCTGACCT GCTTTTCCTT 
CTTACTGTCC CCTTCTGGGC TCACTATGCT GCTGCCCAGT GGGACTTTGG AAATACAATG 
TGTCAACTCT TGACAGGGCT CTATTTTATA GGCTTCTTCT CTGGAATCTT CTTCATCATC 
CTCCTGACAA TCGATAGGTA CCTGGCTATC GTCCATGCTG TGTTTGCTTT AAAAGCCAGG 
ACAGTCACCT TTGGGGTGGT GACAAGTGTG ATCACTTGGG TGGTGGCTGT GTTTGCCTCT 
CTCCCAGGAA TCATCTTTAC CAGATCTCAG AGAGAAGGTC TTCATTACAC CTGCAGCTCT 
CATTTTCCAT ACAGTCAGTA TCAATTCTGG AAGAATTTTC AGACATTAAA GATGGTCATC 
TTGGGGCTGG TCCTGCCGCT GCTTGTCATG GTCATCTGCT ACTCGGGAAT CCTGAAAACT 
CTGCTTCGGT GTCGAAACGA GAAGAAGAGG CACAGGGCTG TGAGGCTTAT CTTCACCATC 
ATGATTGTTT ATTTTCTCTT CTGGGCTCCC TACAACATTG TCCTTCTCCT GAACACCTTC 
CAGGAGTTCT TTGGCCTGAA TAATTGCAGT AGCTCTAACA GGTTGGACCA AGCCATGCAG 
GTGACAGAGA CTCTTGGGAT GACACACTGC TGCATCAACC CCATCATCTA TGCCTTCGTC 
GGGGAGAAGT TCAGAAACTA CCTCTTAGTC TTCTTCCAAA AGCACATTGC CAAACGCTTC 
TGCAAATGCT GTTCCATTTT CCAGCAAGAG GCTCCCGAGC GAGCAAGTTC AGTTTACACC 
CGATCCACTG GGGAGCAGGA AATATCTGTG GGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036238.2
CDS	233..1291
Translation	MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPYSQYQFWKNFQTLKMVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Target ORF information:

RefSeq Version	NM_001042773.3
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta C-C motif chemokine receptor 5 (CCR5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042773.3

ORF Insert Sequence:

ATGGACTATC AAGTGTCAAG TCCAACCTAT GACATCGATT ATTATACATC GGAACCCTGC 
CAAAAAATCA ATGTGAAACA AATCGCAGCC CGCCTCCTGC CTCCGCTCTA CTCACTGGTG 
TTCATCTTTG GTTTTGTGGG CAACATACTG GTCGTCCTCA TCCTGATAAA CTGCAAAAGG 
CTGAAAAGCA TGACTGACAT CTACCTGCTC AACCTGGCCA TCTCTGACCT GCTTTTCCTT 
CTTACTGTCC CCTTCTGGGC TCACTATGCT GCTGCCCAGT GGGACTTTGG AAATACAATG 
TGTCAACTCT TGACAGGGCT CTATTTTATA GGCTTCTTCT CTGGAATCTT CTTCATCATC 
CTCCTGACAA TCGATAGGTA CCTGGCTATC GTCCATGCTG TGTTTGCTTT AAAAGCCAGG 
ACAGTCACCT TTGGGGTGGT GACAAGTGTG ATCACTTGGG TGGTGGCTGT GTTTGCCTCT 
CTCCCAGGAA TCATCTTTAC CAGATCTCAG AGAGAAGGTC TTCATTACAC CTGCAGCTCT 
CATTTTCCAT ACAGTCAGTA TCAATTCTGG AAGAATTTTC AGACATTAAA GATGGTCATC 
TTGGGGCTGG TCCTGCCGCT GCTTGTCATG GTCATCTGCT ACTCGGGAAT CCTGAAAACT 
CTGCTTCGGT GTCGAAACGA GAAGAAGAGG CACAGGGCTG TGAGGCTTAT CTTCACCATC 
ATGATTGTTT ATTTTCTCTT CTGGGCTCCC TACAACATTG TCCTTCTCCT GAACACCTTC 
CAGGAGTTCT TTGGCCTGAA TAATTGCAGT AGCTCTAACA GGTTGGACCA AGCCATGCAG 
GTGACAGAGA CTCTTGGGAT GACACACTGC TGCATCAACC CCATCATCTA TGCCTTCGTC 
GGGGAGAAGT TCAGAAACTA CCTCTTAGTC TTCTTCCAAA AGCACATTGC CAAACGCTTC 
TGCAAATGCT GTTCCATTTT CCAGCAAGAG GCTCCCGAGC GAGCAAGTTC AGTTTACACC 
CGATCCACTG GGGAGCAGGA AATATCTGTG GGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCR5 ( NM_001309402.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001296331.1 Macaca mulatta C-C motif chemokine receptor 5 (CCR5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMb24180
Clone ID Related Accession (Same CDS sequence)	NM_001042773.3 , NM_001309402.1
Accession Version	NM_001309402.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-04
Organism	Macaca mulatta(Rhesus monkey)
Product	C-C chemokine receptor type 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JU480013.1 and DQ499963.1. Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: JU480013.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688317, SAMEA4688318 [ECO:0000348] ##Evidence-Data-END##

ATGGACTATC AAGTGTCAAG TCCAACCTAT GACATCGATT ATTATACATC GGAACCCTGC 
CAAAAAATCA ATGTGAAACA AATCGCAGCC CGCCTCCTGC CTCCGCTCTA CTCACTGGTG 
TTCATCTTTG GTTTTGTGGG CAACATACTG GTCGTCCTCA TCCTGATAAA CTGCAAAAGG 
CTGAAAAGCA TGACTGACAT CTACCTGCTC AACCTGGCCA TCTCTGACCT GCTTTTCCTT 
CTTACTGTCC CCTTCTGGGC TCACTATGCT GCTGCCCAGT GGGACTTTGG AAATACAATG 
TGTCAACTCT TGACAGGGCT CTATTTTATA GGCTTCTTCT CTGGAATCTT CTTCATCATC 
CTCCTGACAA TCGATAGGTA CCTGGCTATC GTCCATGCTG TGTTTGCTTT AAAAGCCAGG 
ACAGTCACCT TTGGGGTGGT GACAAGTGTG ATCACTTGGG TGGTGGCTGT GTTTGCCTCT 
CTCCCAGGAA TCATCTTTAC CAGATCTCAG AGAGAAGGTC TTCATTACAC CTGCAGCTCT 
CATTTTCCAT ACAGTCAGTA TCAATTCTGG AAGAATTTTC AGACATTAAA GATGGTCATC 
TTGGGGCTGG TCCTGCCGCT GCTTGTCATG GTCATCTGCT ACTCGGGAAT CCTGAAAACT 
CTGCTTCGGT GTCGAAACGA GAAGAAGAGG CACAGGGCTG TGAGGCTTAT CTTCACCATC 
ATGATTGTTT ATTTTCTCTT CTGGGCTCCC TACAACATTG TCCTTCTCCT GAACACCTTC 
CAGGAGTTCT TTGGCCTGAA TAATTGCAGT AGCTCTAACA GGTTGGACCA AGCCATGCAG 
GTGACAGAGA CTCTTGGGAT GACACACTGC TGCATCAACC CCATCATCTA TGCCTTCGTC 
GGGGAGAAGT TCAGAAACTA CCTCTTAGTC TTCTTCCAAA AGCACATTGC CAAACGCTTC 
TGCAAATGCT GTTCCATTTT CCAGCAAGAG GCTCCCGAGC GAGCAAGTTC AGTTTACACC 
CGATCCACTG GGGAGCAGGA AATATCTGTG GGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001296331.1
CDS	38..1096
Translation	MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPYSQYQFWKNFQTLKMVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Target ORF information:

RefSeq Version	NM_001309402.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta C-C motif chemokine receptor 5 (CCR5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001309402.1

ORF Insert Sequence:

ATGGACTATC AAGTGTCAAG TCCAACCTAT GACATCGATT ATTATACATC GGAACCCTGC 
CAAAAAATCA ATGTGAAACA AATCGCAGCC CGCCTCCTGC CTCCGCTCTA CTCACTGGTG 
TTCATCTTTG GTTTTGTGGG CAACATACTG GTCGTCCTCA TCCTGATAAA CTGCAAAAGG 
CTGAAAAGCA TGACTGACAT CTACCTGCTC AACCTGGCCA TCTCTGACCT GCTTTTCCTT 
CTTACTGTCC CCTTCTGGGC TCACTATGCT GCTGCCCAGT GGGACTTTGG AAATACAATG 
TGTCAACTCT TGACAGGGCT CTATTTTATA GGCTTCTTCT CTGGAATCTT CTTCATCATC 
CTCCTGACAA TCGATAGGTA CCTGGCTATC GTCCATGCTG TGTTTGCTTT AAAAGCCAGG 
ACAGTCACCT TTGGGGTGGT GACAAGTGTG ATCACTTGGG TGGTGGCTGT GTTTGCCTCT 
CTCCCAGGAA TCATCTTTAC CAGATCTCAG AGAGAAGGTC TTCATTACAC CTGCAGCTCT 
CATTTTCCAT ACAGTCAGTA TCAATTCTGG AAGAATTTTC AGACATTAAA GATGGTCATC 
TTGGGGCTGG TCCTGCCGCT GCTTGTCATG GTCATCTGCT ACTCGGGAAT CCTGAAAACT 
CTGCTTCGGT GTCGAAACGA GAAGAAGAGG CACAGGGCTG TGAGGCTTAT CTTCACCATC 
ATGATTGTTT ATTTTCTCTT CTGGGCTCCC TACAACATTG TCCTTCTCCT GAACACCTTC 
CAGGAGTTCT TTGGCCTGAA TAATTGCAGT AGCTCTAACA GGTTGGACCA AGCCATGCAG 
GTGACAGAGA CTCTTGGGAT GACACACTGC TGCATCAACC CCATCATCTA TGCCTTCGTC 
GGGGAGAAGT TCAGAAACTA CCTCTTAGTC TTCTTCCAAA AGCACATTGC CAAACGCTTC 
TGCAAATGCT GTTCCATTTT CCAGCAAGAG GCTCCCGAGC GAGCAAGTTC AGTTTACACC 
CGATCCACTG GGGAGCAGGA AATATCTGTG GGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCR5 ( XM_015131082.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> XP_014986568.1 Macaca mulatta chemokine (C-C motif) receptor 5 (CCR5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMb28605
Clone ID Related Accession (Same CDS sequence)	XM_015131082.1 , XM_015131082.2
Accession Version	XM_015131082.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-12-20
Organism	Macaca mulatta(Rhesus monkey)
Product	C-C chemokine receptor type 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014804632.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Macaca mulatta Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTGATT TGCACAACTC ATCTGCCAGA AGAGCTGAGA CATCCGTTCC CCTACAAGAA 
ACTCTCCCTG GGTGGAACAA GATGGACTAT CAAGTGTCAA GTCCAACCTA TGACATCGAT 
TATTATACAT CGGAACCCTG CCAAAAAATC AATGTGAAAC AAATCGCAGC CCGCCTCCTG 
CCTCCGCTCT ACTCACTGGT GTTCATCTTT GGTTTTGTGG GCAACATACT GGTCGTCCTC 
ATCCTGATAA ACTGCAAAAG GCTGAAAAGC ATGACTGACA TCTACCTGCT CAACCTGGCC 
ATCTCTGACC TGCTTTTCCT TCTTACTGTC CCCTTCTGGG CTCACTATGC TGCTGCCCAG 
TGGGACTTTG GAAATACAAT GTGTCAACTC TTGACAGGGC TCTATTTTAT AGGCTTCTTC 
TCTGGAATCT TCTTCATCAT CCTCCTGACA ATCGATAGGT ACCTGGCTAT CGTCCATGCT 
GTGTTTGCTT TAAAAGCCAG GACAGTCACC TTTGGGGTGG TGACAAGTGT GATCACTTGG 
GTGGTGGCTG TGTTTGCCTC TCTCCCAGGA ATCATCTTTA CCAGATCTCA GAGAGAAGGT 
CTTCATTACA CCTGCAGCTC TCATTTTCCA TACAGTCAGT ATCAATTCTG GAAGAATTTT 
CAGACATTAA AGATGGTCAT CTTGGGGCTG GTCCTGCCGC TGCTTGTCAT GGTCATCTGC 
TACTCGGGAA TCCTGAAAAC TCTGCTTCGG TGTCGAAACG AGAAGAAGAG GCACAGGGCT 
GTGAGGCTTA TCTTCACCAT CATGATTGTT TATTTTCTCT TCTGGGCTCC CTACAACATT 
GTCCTTCTCC TGAACACCTT CCAGGAGTTC TTTGGCCTGA ATAATTGCAG TAGCTCTAAC 
AGGTTGGACC AAGCCATGCA GGTGACAGAG ACTCTTGGGA TGACACACTG CTGCATCAAC 
CCCATCATCT ATGCCTTCGT CGGGGAGAAG TTCAGAAACT ACCTCTTAGT CTTCTTCCAA 
AAGCACATTG CCAAACGCTT CTGCAAATGC TGTTCCATTT TCCAGCAAGA GGCTCCCGAG 
CGAGCAAGTT CAGTTTACAC CCGATCCACT GGGGAGCAGG AAATATCTGT GGGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_014986568.1
CDS	207..1346
Translation	MIDLHNSSARRAETSVPLQETLPGWNKMDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPYSQYQFWKNFQTLKMVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Target ORF information:

RefSeq Version	XM_015131082.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta chemokine (C-C motif) receptor 5 (CCR5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015131082.1

ORF Insert Sequence:

ATGATTGATT TGCACAACTC ATCTGCCAGA AGAGCTGAGA CATCCGTTCC CCTACAAGAA 
ACTCTCCCTG GGTGGAACAA GATGGACTAT CAAGTGTCAA GTCCAACCTA TGACATCGAT 
TATTATACAT CGGAACCCTG CCAAAAAATC AATGTGAAAC AAATCGCAGC CCGCCTCCTG 
CCTCCGCTCT ACTCACTGGT GTTCATCTTT GGTTTTGTGG GCAACATACT GGTCGTCCTC 
ATCCTGATAA ACTGCAAAAG GCTGAAAAGC ATGACTGACA TCTACCTGCT CAACCTGGCC 
ATCTCTGACC TGCTTTTCCT TCTTACTGTC CCCTTCTGGG CTCACTATGC TGCTGCCCAG 
TGGGACTTTG GAAATACAAT GTGTCAACTC TTGACAGGGC TCTATTTTAT AGGCTTCTTC 
TCTGGAATCT TCTTCATCAT CCTCCTGACA ATCGATAGGT ACCTGGCTAT CGTCCATGCT 
GTGTTTGCTT TAAAAGCCAG GACAGTCACC TTTGGGGTGG TGACAAGTGT GATCACTTGG 
GTGGTGGCTG TGTTTGCCTC TCTCCCAGGA ATCATCTTTA CCAGATCTCA GAGAGAAGGT 
CTTCATTACA CCTGCAGCTC TCATTTTCCA TACAGTCAGT ATCAATTCTG GAAGAATTTT 
CAGACATTAA AGATGGTCAT CTTGGGGCTG GTCCTGCCGC TGCTTGTCAT GGTCATCTGC 
TACTCGGGAA TCCTGAAAAC TCTGCTTCGG TGTCGAAACG AGAAGAAGAG GCACAGGGCT 
GTGAGGCTTA TCTTCACCAT CATGATTGTT TATTTTCTCT TCTGGGCTCC CTACAACATT 
GTCCTTCTCC TGAACACCTT CCAGGAGTTC TTTGGCCTGA ATAATTGCAG TAGCTCTAAC 
AGGTTGGACC AAGCCATGCA GGTGACAGAG ACTCTTGGGA TGACACACTG CTGCATCAAC 
CCCATCATCT ATGCCTTCGT CGGGGAGAAG TTCAGAAACT ACCTCTTAGT CTTCTTCCAA 
AAGCACATTG CCAAACGCTT CTGCAAATGC TGTTCCATTT TCCAGCAAGA GGCTCCCGAG 
CGAGCAAGTT CAGTTTACAC CCGATCCACT GGGGAGCAGG AAATATCTGT GGGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCR5 ( XM_015131082.2 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> XP_014986568.1 Macaca mulatta C-C motif chemokine receptor 5 (CCR5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMb28605
Clone ID Related Accession (Same CDS sequence)	XM_015131082.1 , XM_015131082.2
Accession Version	XM_015131082.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1140bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-25
Organism	Macaca mulatta(Rhesus monkey)
Product	C-C chemokine receptor type 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_041755.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 23, 2019 this sequence version replaced XM_015131082.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Macaca mulatta Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTGATT TGCACAACTC ATCTGCCAGA AGAGCTGAGA CATCCGTTCC CCTACAAGAA 
ACTCTCCCTG GGTGGAACAA GATGGACTAT CAAGTGTCAA GTCCAACCTA TGACATCGAT 
TATTATACAT CGGAACCCTG CCAAAAAATC AATGTGAAAC AAATCGCAGC CCGCCTCCTG 
CCTCCGCTCT ACTCACTGGT GTTCATCTTT GGTTTTGTGG GCAACATACT GGTCGTCCTC 
ATCCTGATAA ACTGCAAAAG GCTGAAAAGC ATGACTGACA TCTACCTGCT CAACCTGGCC 
ATCTCTGACC TGCTTTTCCT TCTTACTGTC CCCTTCTGGG CTCACTATGC TGCTGCCCAG 
TGGGACTTTG GAAATACAAT GTGTCAACTC TTGACAGGGC TCTATTTTAT AGGCTTCTTC 
TCTGGAATCT TCTTCATCAT CCTCCTGACA ATCGATAGGT ACCTGGCTAT CGTCCATGCT 
GTGTTTGCTT TAAAAGCCAG GACAGTCACC TTTGGGGTGG TGACAAGTGT GATCACTTGG 
GTGGTGGCTG TGTTTGCCTC TCTCCCAGGA ATCATCTTTA CCAGATCTCA GAGAGAAGGT 
CTTCATTACA CCTGCAGCTC TCATTTTCCA TACAGTCAGT ATCAATTCTG GAAGAATTTT 
CAGACATTAA AGATGGTCAT CTTGGGGCTG GTCCTGCCGC TGCTTGTCAT GGTCATCTGC 
TACTCGGGAA TCCTGAAAAC TCTGCTTCGG TGTCGAAACG AGAAGAAGAG GCACAGGGCT 
GTGAGGCTTA TCTTCACCAT CATGATTGTT TATTTTCTCT TCTGGGCTCC CTACAACATT 
GTCCTTCTCC TGAACACCTT CCAGGAGTTC TTTGGCCTGA ATAATTGCAG TAGCTCTAAC 
AGGTTGGACC AAGCCATGCA GGTGACAGAG ACTCTTGGGA TGACACACTG CTGCATCAAC 
CCCATCATCT ATGCCTTCGT CGGGGAGAAG TTCAGAAACT ACCTCTTAGT CTTCTTCCAA 
AAGCACATTG CCAAACGCTT CTGCAAATGC TGTTCCATTT TCCAGCAAGA GGCTCCCGAG 
CGAGCAAGTT CAGTTTACAC CCGATCCACT GGGGAGCAGG AAATATCTGT GGGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_014986568.1
CDS	176..1315
Translation	MIDLHNSSARRAETSVPLQETLPGWNKMDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKRLKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSSHFPYSQYQFWKNFQTLKMVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Target ORF information:

RefSeq Version	XM_015131082.2
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta C-C motif chemokine receptor 5 (CCR5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015131082.2

ORF Insert Sequence:

ATGATTGATT TGCACAACTC ATCTGCCAGA AGAGCTGAGA CATCCGTTCC CCTACAAGAA 
ACTCTCCCTG GGTGGAACAA GATGGACTAT CAAGTGTCAA GTCCAACCTA TGACATCGAT 
TATTATACAT CGGAACCCTG CCAAAAAATC AATGTGAAAC AAATCGCAGC CCGCCTCCTG 
CCTCCGCTCT ACTCACTGGT GTTCATCTTT GGTTTTGTGG GCAACATACT GGTCGTCCTC 
ATCCTGATAA ACTGCAAAAG GCTGAAAAGC ATGACTGACA TCTACCTGCT CAACCTGGCC 
ATCTCTGACC TGCTTTTCCT TCTTACTGTC CCCTTCTGGG CTCACTATGC TGCTGCCCAG 
TGGGACTTTG GAAATACAAT GTGTCAACTC TTGACAGGGC TCTATTTTAT AGGCTTCTTC 
TCTGGAATCT TCTTCATCAT CCTCCTGACA ATCGATAGGT ACCTGGCTAT CGTCCATGCT 
GTGTTTGCTT TAAAAGCCAG GACAGTCACC TTTGGGGTGG TGACAAGTGT GATCACTTGG 
GTGGTGGCTG TGTTTGCCTC TCTCCCAGGA ATCATCTTTA CCAGATCTCA GAGAGAAGGT 
CTTCATTACA CCTGCAGCTC TCATTTTCCA TACAGTCAGT ATCAATTCTG GAAGAATTTT 
CAGACATTAA AGATGGTCAT CTTGGGGCTG GTCCTGCCGC TGCTTGTCAT GGTCATCTGC 
TACTCGGGAA TCCTGAAAAC TCTGCTTCGG TGTCGAAACG AGAAGAAGAG GCACAGGGCT 
GTGAGGCTTA TCTTCACCAT CATGATTGTT TATTTTCTCT TCTGGGCTCC CTACAACATT 
GTCCTTCTCC TGAACACCTT CCAGGAGTTC TTTGGCCTGA ATAATTGCAG TAGCTCTAAC 
AGGTTGGACC AAGCCATGCA GGTGACAGAG ACTCTTGGGA TGACACACTG CTGCATCAAC 
CCCATCATCT ATGCCTTCGT CGGGGAGAAG TTCAGAAACT ACCTCTTAGT CTTCTTCCAA 
AAGCACATTG CCAAACGCTT CTGCAAATGC TGTTCCATTT TCCAGCAAGA GGCTCCCGAG 
CGAGCAAGTT CAGTTTACAC CCGATCCACT GGGGAGCAGG AAATATCTGT GGGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

CCR5 inhibition prevents cardiac dysfunction in the SIV/macaque model of HIV.
Journal of the American Heart Association3(2)e000874(2014 Apr)
Kelly KM,Tocchetti CG,Lyashkov A,Tarwater PM,Bedja D,Graham DR,Beck SE,Metcalf Pate KA,Queen SE,Adams RJ,Paolocci N,Mankowski JL

A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.
Journal of virology88(4)2011-24(2014 Feb)
Van Rompay KK,Hunter Z,Jayashankar K,Peabody J,Montefiori D,LaBranche CC,Keele BF,Jensen K,Abel K,Chackerian B

Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques.
Nature biotechnology29(11)1019-23(2011 Oct)
Yan G,Zhang G,Fang X,Zhang Y,Li C,Ling F,Cooper DN,Li Q,Li Y,van Gool AJ,Du H,Chen J,Chen R,Zhang P,Huang Z,Thompson JR,Meng Y,Bai Y,Wang J,Zhuo M,Wang T,Huang Y,Wei L,Li J,Wang Z,Hu H,Yang P,Le L,Stenson PD,Li B,Liu X,Ball EV,An N,Huang Q,Zhang Y,Fan W,Zhang X,Li Y,Wang W,Katze MG,Su B,Nielsen R,Yang H,Wang J,Wang X,Wang J

TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection.
Virology409(1)132-40(2011 Jan)
Minang JT,Trivett MT,Barsov EV,Del Prete GQ,Trubey CM,Thomas JA,Gorelick RJ,Piatak M Jr,Ott DE,Ohlen C

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CCR5 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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