TPH2 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	TPH2
Entrez Gene ID	664730
Full Name	tryptophan hydroxylase 2
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039946.1	NP_001035035.1	tryptophan 5-hydroxylase 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Tph2	NP_776211.1
Caenorhabditis elegans (roundworm)	tph-1	NP_495584.4
Homo sapiens (human)	TPH2	NP_775489.2
Canis lupus familiaris (dog)	TPH2	NP_001184049.1
Gallus gallus (chicken)	TPH2	NP_001001301.1
Mus musculus (house mouse)	Tph2	NP_775567.2
Xenopus tropicalis (tropical clawed frog)	tph2	XP_004913008.1
Pan troglodytes (chimpanzee)	TPH2	XP_522470.2
	TPH2	NP_001035035.1
Danio rerio (zebrafish)	tph2	NP_999960.1

Gene Ontology
Bibliography

Related articles in PubMed

TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys.
Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM
Genes, brain, and behavior9(3)335-47(2010 Apr)

The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis.
Chen GL, Novak MA, Meyer JS, Kelly BJ, Vallender EJ, Miller GM
Hormones and behavior57(2)184-91(2010 Feb)

Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability.
Chen GL, Miller GM
Neuroscience155(2)485-91(2008 Aug)

Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression.
Chen GL, Novak MA, Hakim S, Xie Z, Miller GM
Molecular psychiatry11(10)914-28(2006 Oct)

A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques.
Sanchez RL, Reddy AP, Centeno ML, Henderson JA, Bethea CL
Brain research. Molecular brain research135(1-2)194-203(2005 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with hypothalamo-pituitary-adrenal axis function and self-injurious behavior in rhesus monkeys
Title: TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys.

The present study supports the hypothesis that rearing experience and rhTPH2 A2051C interact to influence central 5-HT metabolism, HPA axis function, and aggressive behaviors
Title: The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis.

functional significance of two nonsynonymous single nucleotide polymorphisms (SNPs) (C74A and G223A) in rhesus monkey TPH2
Title: Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability.

Study identified 17 single nucleotide polymorphisms; 3'-UTR polymorphisms were significantly associated with HPA axis activity, especially 2051A>C, which was strikingly correlated with plasma cortisol level in the morning only.
Title: Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression.

The following TPH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TPH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb01132	NM_001039946.1 Latest version!	Macaca mulatta tryptophan hydroxylase 2 (TPH2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TPH2 ( NM_001039946.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001035035.1 Macaca mulatta tryptophan hydroxylase 2 (TPH2), mRNA.

Price & Availability↑

CloneID	OMb01132
Clone ID Related Accession (Same CDS sequence)	NM_001039946.1
Accession Version	NM_001039946.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-27
Organism	Macaca mulatta(Rhesus monkey)
Product	tryptophan 5-hydroxylase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ360113.1. ##Evidence-Data-START## Transcript exon combination :: DQ360113.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA4688315, SAMEA4688316 [ECO:0000350] ##Evidence-Data-END##

ATGCAGCCAG CAATGATGAT GTTTTCCAGT AAATACTGGG CAAGGAGAGG GTTTTCCCTG 
GATTCAGCAG TGCCCGAAGA GCATCAGCTA CTCGGCAACT TAACACTAAA TAAAGCTAAC 
TCTGGCAAAA ATGACGACAA AGGCAACAAG GGAAGCAGCA AAAATGAAAC TGCTACCGAA 
AGTGGCAAGA CAGCAGTTGT TTTCTCCTTG AAAAATGAAG TCGGTGGATT GGTGAAAGCA 
CTGAGGCTCT TTCAGGAAAA ACGCGTCCAC ATGGTTCATA TTGAATCCAG GAAATCTCGG 
CGAAGGAGCT CTGAGGTTGA AATCTTTGTG GACTGTGAGT GTGGGAAAAC AGAATTCAAT 
GAGCTCATTC AGTTGCTGAA ATTTCAAACC ACTATTGTGA CGCTGAATCC TCCAGAGAAT 
ATTTGGACAG AGGAAGAAGA GCTAGAGGAT GTGCCCTGGT TCCCTCGGAA GATCTCTGAG 
TTAGACAAAT GCTCTCACAG AGTTCTCATG TATGGTTCTG AGCTTGATGC CGACCACCCA 
GGATTTAAGG ACAATGTCTA TCGACAGAGA AGAAAGTATT TTGTGGATGT GGCCATGGGT 
TATAAATATG GTCAGCCCAT TCCCAGGGTG GAGTATACTG AAGAAGAAAC TAAAACTTGG 
GGCGTTGTAT TCCGGGAGCT CTCCAAACTC TATCCCACTC ATGCTTGCCG AGAGTATTTG 
AAAAACTTCC CTCTGCTGAC TAAATACTGT GGCTACAGAG AGGACAATGT GCCTCAACTC 
GAAGATGTCT CCATGTTTCT GAAAGAAAGG TCTGGCTTCA CCGTGAGGCC GGTGGCTGGA 
TACCTGAGCC CACGAGACTT TCTGGCAGGA CTGGCCTACA GAGTGTTCCA CTGTACCCAG 
TACATCCGGC ATGGCTCAGA TCCCCTCTAC ACCCCGGAAC CAGACACATG CCATGAACTC 
TTGGGACATG TTCCACTACT TGCGGATCCT AAGTTTGCTC AGTTTTCACA AGAAATAGGT 
CTGGCGTCTC TGGGAGCATC AGATGAAGAT GTTCAGAAAC TAGCCACGTG CTATTTCTTC 
ACAATCGAGT TTGGTCTTTG CAAGCAAGAA GGGCAACTGC GGGCATATGG AGCAGGACTC 
CTTTCCTCCA TTGGAGAATT AAAGCATGCC CTTTCTGACA AGGCATGTGT GAAAGCCTTT 
GACCCAAAGA CAACTTGCTT ACAGGAATGC CTTATCACCA CCTTCCAGGA AGCCTACTTT 
GTTTCAGAAA GTTTTGAAGA AGCCAAAGAA AAGATGAGGG ACTTTGCAAA GTCAATTACC 
CGTCCCTTCT CAGTATACTT CAATCCCTAC ACGCAGAGTA TTGAAATTCT GAAAGACACC 
AGAAGTATTG AAAATGTGGT GCAGGACCTT CGCAGCGACT TGAACACAGT GTGTGATGCC 
TTAAACAAAA TGAACCAATA TCTGGGGATT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035035.1
CDS	1..1473
Translation	MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGNLTLNKANSGKNDDKGNKGSSKNETATESGKTAVVFSLKNEVGGLVKALRLFQEKRVHMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI

Target ORF information:

RefSeq Version	NM_001039946.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta tryptophan hydroxylase 2 (TPH2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039946.1

ORF Insert Sequence:

ATGCAGCCAG CAATGATGAT GTTTTCCAGT AAATACTGGG CAAGGAGAGG GTTTTCCCTG 
GATTCAGCAG TGCCCGAAGA GCATCAGCTA CTCGGCAACT TAACACTAAA TAAAGCTAAC 
TCTGGCAAAA ATGACGACAA AGGCAACAAG GGAAGCAGCA AAAATGAAAC TGCTACCGAA 
AGTGGCAAGA CAGCAGTTGT TTTCTCCTTG AAAAATGAAG TCGGTGGATT GGTGAAAGCA 
CTGAGGCTCT TTCAGGAAAA ACGCGTCCAC ATGGTTCATA TTGAATCCAG GAAATCTCGG 
CGAAGGAGCT CTGAGGTTGA AATCTTTGTG GACTGTGAGT GTGGGAAAAC AGAATTCAAT 
GAGCTCATTC AGTTGCTGAA ATTTCAAACC ACTATTGTGA CGCTGAATCC TCCAGAGAAT 
ATTTGGACAG AGGAAGAAGA GCTAGAGGAT GTGCCCTGGT TCCCTCGGAA GATCTCTGAG 
TTAGACAAAT GCTCTCACAG AGTTCTCATG TATGGTTCTG AGCTTGATGC CGACCACCCA 
GGATTTAAGG ACAATGTCTA TCGACAGAGA AGAAAGTATT TTGTGGATGT GGCCATGGGT 
TATAAATATG GTCAGCCCAT TCCCAGGGTG GAGTATACTG AAGAAGAAAC TAAAACTTGG 
GGCGTTGTAT TCCGGGAGCT CTCCAAACTC TATCCCACTC ATGCTTGCCG AGAGTATTTG 
AAAAACTTCC CTCTGCTGAC TAAATACTGT GGCTACAGAG AGGACAATGT GCCTCAACTC 
GAAGATGTCT CCATGTTTCT GAAAGAAAGG TCTGGCTTCA CCGTGAGGCC GGTGGCTGGA 
TACCTGAGCC CACGAGACTT TCTGGCAGGA CTGGCCTACA GAGTGTTCCA CTGTACCCAG 
TACATCCGGC ATGGCTCAGA TCCCCTCTAC ACCCCGGAAC CAGACACATG CCATGAACTC 
TTGGGACATG TTCCACTACT TGCGGATCCT AAGTTTGCTC AGTTTTCACA AGAAATAGGT 
CTGGCGTCTC TGGGAGCATC AGATGAAGAT GTTCAGAAAC TAGCCACGTG CTATTTCTTC 
ACAATCGAGT TTGGTCTTTG CAAGCAAGAA GGGCAACTGC GGGCATATGG AGCAGGACTC 
CTTTCCTCCA TTGGAGAATT AAAGCATGCC CTTTCTGACA AGGCATGTGT GAAAGCCTTT 
GACCCAAAGA CAACTTGCTT ACAGGAATGC CTTATCACCA CCTTCCAGGA AGCCTACTTT 
GTTTCAGAAA GTTTTGAAGA AGCCAAAGAA AAGATGAGGG ACTTTGCAAA GTCAATTACC 
CGTCCCTTCT CAGTATACTT CAATCCCTAC ACGCAGAGTA TTGAAATTCT GAAAGACACC 
AGAAGTATTG AAAATGTGGT GCAGGACCTT CGCAGCGACT TGAACACAGT GTGTGATGCC 
TTAAACAAAA TGAACCAATA TCTGGGGATT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys.
Genes, brain, and behavior9(3)335-47(2010 Apr)
Chen GL,Novak MA,Meyer JS,Kelly BJ,Vallender EJ,Miller GM

The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis.
Hormones and behavior57(2)184-91(2010 Feb)
Chen GL,Novak MA,Meyer JS,Kelly BJ,Vallender EJ,Miller GM

Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability.
Neuroscience155(2)485-91(2008 Aug)
Chen GL,Miller GM

Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression.
Molecular psychiatry11(10)914-28(2006 Oct)
Chen GL,Novak MA,Hakim S,Xie Z,Miller GM

A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques.
Brain research. Molecular brain research135(1-2)194-203(2005 Apr)
Sanchez RL,Reddy AP,Centeno ML,Henderson JA,Bethea CL

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TPH2 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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