Ctrc cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ctrc
Entrez Gene ID	76701
Full Name	chymotrypsin C (caldecrin)
Synonyms	1810044E12Rik
General protein information	Preferred Names chymotrypsin C (caldecrin) Names chymotrypsin-C
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033875.2	NP_001029047.1	chymotrypsin-C precursor

Pathways from BioSystems

Homologies

	CTRC	XP_001089102.1
	LOC700270	XP_001088654.2
Xenopus tropicalis (tropical clawed frog)	ctrc	NP_001008077.1
Canis lupus familiaris (dog)	CTRC	XP_852179.1
Homo sapiens (human)	CTRC	NP_009203.2
Pan troglodytes (chimpanzee)	CTRC	XP_001149762.1
Bos taurus (cattle)	CTRC	NP_001092435.1
Mus musculus (house mouse)	Ctrc	NP_001029047.1
Gallus gallus (chicken)	CTRC	NP_001264846.1
Rattus norvegicus (Norway rat)	Ctrc	NP_001071117.1

Gene Ontology
Bibliography

Related articles in PubMed

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.
Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ
Development (Cambridge, England)141(16)3123-33(2014 Aug)

Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.
N?meth BC, Wartmann T, Halangk W, Sahin-T?th M
The Journal of biological chemistry288(33)24049-62(2013 Aug)

Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice.
Tomomura M, Fujii T, Sakagami H, Tomomura A
In vivo (Athens, Greece)25(2)157-63(2011 Mar-Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

autoactivation of mouse trypsinogens is under the control of mouse Ctrc.
Title: Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.

Data show that ectopic expression of the caldecrin gene in the muscle of dy/dy mice reduced the level of blood urea nitrogen and improved the dystrophic progression similarly to that of caldecrin-injected mice.
Title: Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice.

The following Ctrc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ctrc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12754	NM_001033875.2 Latest version!	Mus musculus chymotrypsin C (caldecrin) (Ctrc), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ctrc ( NM_001033875.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001029047.1 Mus musculus chymotrypsin C (caldecrin) (Ctrc), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu12754
Clone ID Related Accession (Same CDS sequence)	NM_001033875.2
Accession Version	NM_001033875.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 807bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	chymotrypsin-C precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC115516.1 and BC103715.1. On Mar 24, 2007 this sequence version replaced NM_001033875.1. Transcript Variant: This variant (1) represents the functional non-reference strain allele and encodes the full-length protein. Sequence Note: This RefSeq record was created from transcript data from a non-reference strain to represent the functional allele. ##Evidence-Data-START## Transcript exon combination :: BC103715.1, CF581326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: based on alignments, homology ##RefSeq-Attributes-END##

ATGTTGGGAA TTACAGTCCT CGCTGCCATC CTGGCCTGCG CCTCCAGCTG TGGGGACCCC 
ACCTTCCCAC CCAACCTGTC AGCCAGAGTG GTAGGAGGAG AGGATGCTGT CCCCAATAGC 
TGGCCTTGGC AGGTCTCTCT TCAGTACCTC AGGGATGACA CTTGGAGGCA CACCTGTGGG 
GGCAGTCTCA TCACCACCAG CCACGTCCTC ACTGCTGCCC ACTGCATCAA CACAAACTTG 
ACCTACCGCG TGGGCCTGGG GAAGTATAAC CTGACAGTGG AGGATGAGGA AGGCTCCGTG 
TACGCGGAGG TGGATACCAT CTACGTCCAT GAGAAGTGGA ACCGTCTTCT GCTGTGGAAC 
GACATCGCCA TCATCAAGTT GGCTGAGCCT GTGGAGCTGA GCGACACCAT CCAGGTGGCC 
TGTATCCCAG AGCAAGATTC CTTGCTGCCT GGGGACTATC CCTGCTATGT CACTGGCTGG 
GGTCGCCTCT GGACCAACGG TCCCATTGCT GAAGTGCTCC AGCAGGGTCT GCAGCCCATA 
GTGAACCACA CCACGTGCTC CAGGTTGGAC TGGTGGTTCA TCAAGGTCCG GGAGACGATG 
GTGTGCGCTG GTGGTGACGG TGTCATCTCT GCCTGTAACG GAGACTCTGG TGGCCCACTG 
AACTGCCCAG TGGAAGACGG CTTGTGGCAG GTGCATGGCA TCGTGAGCTT TGGTTCCAGT 
AGAGGCTGCA ACACATACAA GAAGCCCGTG GTCTTCACCC GTGTGTCTGC CTATATTGAC 
TGGATCAAGG AGAAAATACA ACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029047.1
CDS	92..898
Translation	MLGITVLAAILACASSCGDPTFPPNLSARVVGGEDAVPNSWPWQVSLQYLRDDTWRHTCGGSLITTSHVLTAAHCINTNLTYRVGLGKYNLTVEDEEGSVYAEVDTIYVHEKWNRLLLWNDIAIIKLAEPVELSDTIQVACIPEQDSLLPGDYPCYVTGWGRLWTNGPIAEVLQQGLQPIVNHTTCSRLDWWFIKVRETMVCAGGDGVISACNGDSGGPLNCPVEDGLWQVHGIVSFGSSRGCNTYKKPVVFTRVSAYIDWIKEKIQL

Target ORF information:

RefSeq Version	NM_001033875.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus chymotrypsin C (caldecrin) (Ctrc), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033875.2

ORF Insert Sequence:

ATGTTGGGAA TTACAGTCCT CGCTGCCATC CTGGCCTGCG CCTCCAGCTG TGGGGACCCC 
ACCTTCCCAC CCAACCTGTC AGCCAGAGTG GTAGGAGGAG AGGATGCTGT CCCCAATAGC 
TGGCCTTGGC AGGTCTCTCT TCAGTACCTC AGGGATGACA CTTGGAGGCA CACCTGTGGG 
GGCAGTCTCA TCACCACCAG CCACGTCCTC ACTGCTGCCC ACTGCATCAA CACAAACTTG 
ACCTACCGCG TGGGCCTGGG GAAGTATAAC CTGACAGTGG AGGATGAGGA AGGCTCCGTG 
TACGCGGAGG TGGATACCAT CTACGTCCAT GAGAAGTGGA ACCGTCTTCT GCTGTGGAAC 
GACATCGCCA TCATCAAGTT GGCTGAGCCT GTGGAGCTGA GCGACACCAT CCAGGTGGCC 
TGTATCCCAG AGCAAGATTC CTTGCTGCCT GGGGACTATC CCTGCTATGT CACTGGCTGG 
GGTCGCCTCT GGACCAACGG TCCCATTGCT GAAGTGCTCC AGCAGGGTCT GCAGCCCATA 
GTGAACCACA CCACGTGCTC CAGGTTGGAC TGGTGGTTCA TCAAGGTCCG GGAGACGATG 
GTGTGCGCTG GTGGTGACGG TGTCATCTCT GCCTGTAACG GAGACTCTGG TGGCCCACTG 
AACTGCCCAG TGGAAGACGG CTTGTGGCAG GTGCATGGCA TCGTGAGCTT TGGTTCCAGT 
AGAGGCTGCA ACACATACAA GAAGCCCGTG GTCTTCACCC GTGTGTCTGC CTATATTGAC 
TGGATCAAGG AGAAAATACA ACTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.
Development (Cambridge, England)141(16)3123-33(2014 Aug)
Hale MA,Swift GH,Hoang CQ,Deering TG,Masui T,Lee YK,Xue J,MacDonald RJ

Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.
The Journal of biological chemistry288(33)24049-62(2013 Aug)
N?meth BC,Wartmann T,Halangk W,Sahin-T?th M

Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice.
In vivo (Athens, Greece)25(2)157-63(2011 Mar-Apr)
Tomomura M,Fujii T,Sakagami H,Tomomura A