Psca cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psca
Entrez Gene ID	72373
Full Name	prostate stem cell antigen
Synonyms	2210408B04Rik
General protein information	Preferred Names prostate stem cell antigen Names prostate stem cell antigen
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_028216.2	NP_082492.1	prostate stem cell antigen precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PSCA	XP_539189.2
	LOC703505	XP_001091808.1
Pan troglodytes (chimpanzee)	PSCA	XP_003951398.1
Mus musculus (house mouse)	Psca	NP_082492.1
Bos taurus (cattle)	PSCA	XP_003586924.2
Rattus norvegicus (Norway rat)	Psca	NP_001165577.1
Homo sapiens (human)	PSCA	NP_005663.2
Gallus gallus (chicken)	PSCA	XP_418414.2

Gene Ontology
Bibliography

Related articles in PubMed

Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17?-estradiol in C57BL mice.
Fujimoto N, Kanno J
The Journal of steroid biochemistry and molecular biology15856-62(2016 Apr)

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S, Swamynathan SK
Human genomics1010(2016 Apr)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation.
Moore ML, Teitell MA, Kim Y, Watabe T, Reiter RE, Witte ON, Dubey P
The Prostate68(2)139-51(2008 Feb)

The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis.
Xin L, Lawson DA, Witte ON
Proceedings of the National Academy of Sciences of the United States of America102(19)6942-7(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17beta-estradiol in C57BL mice
Title: Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17?-estradiol in C57BL mice.

PSCA may play a role in limiting prostate tumor progression in certain contexts, and deletion of PSCA may promote tumor migration and metastasis.
Title: Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation.

Sca-1-enriched prostate-regenerating cells possess multiple stem/progenitor cell properties
Title: The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis.

This transgenic system helps define the range of cellular changes associated with altered expression of PSCA, shows that transcriptional control is a major component regulating PSCA levels.
Title: Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter.

The following Psca gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psca cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05339	NM_028216.2 Latest version!	Mus musculus prostate stem cell antigen (Psca), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psca ( NM_028216.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082492.1 Mus musculus prostate stem cell antigen (Psca), mRNA.

Price & Availability↑

CloneID	OMu05339
Clone ID Related Accession (Same CDS sequence)	NM_028216.2
Accession Version	NM_028216.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	prostate stem cell antigen precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK008851.1, EH109693.1 and AF319173.1. On Oct 31, 2009 this sequence version replaced NM_028216.1. ##Evidence-Data-START## Transcript exon combination :: AF319173.1, BQ218635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAGACCG TCTTCTTTCT CCTGCTGGCC ACCTACTTAG CCCTGCATCC AGGTGCTGCT 
CTGCAGTGCT ATTCATGCAC AGCACAGATG AACAACAGAG ACTGTCTGAA TGTACAGAAC 
TGCAGCCTGG ACCAGCACAG TTGCTTTACA TCGCGCATCC GGGCCATTGG ACTCGTGACA 
GTTATCAGTA AGGGCTGCAG CTCACAGTGT GAGGATGACT CGGAGAACTA CTATTTGGGC 
AAGAAGAACA TCACGTGCTG CTACTCTGAC CTGTGCAATG TCAACGGGGC CCACACCCTG 
AAGCCACCCA CCACCCTGGG GCTGCTGACC GTGCTCTGCA GCCTGTTGCT GTGGGGCTCC 
AGCCGTCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082492.1
CDS	17..388
Translation	MKTVFFLLLATYLALHPGAALQCYSCTAQMNNRDCLNVQNCSLDQHSCFTSRIRAIGLVTVISKGCSSQCEDDSENYYLGKKNITCCYSDLCNVNGAHTLKPPTTLGLLTVLCSLLLWGSSRL

Target ORF information:

RefSeq Version	NM_028216.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus prostate stem cell antigen (Psca), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028216.2

ORF Insert Sequence:

ATGAAGACCG TCTTCTTTCT CCTGCTGGCC ACCTACTTAG CCCTGCATCC AGGTGCTGCT 
CTGCAGTGCT ATTCATGCAC AGCACAGATG AACAACAGAG ACTGTCTGAA TGTACAGAAC 
TGCAGCCTGG ACCAGCACAG TTGCTTTACA TCGCGCATCC GGGCCATTGG ACTCGTGACA 
GTTATCAGTA AGGGCTGCAG CTCACAGTGT GAGGATGACT CGGAGAACTA CTATTTGGGC 
AAGAAGAACA TCACGTGCTG CTACTCTGAC CTGTGCAATG TCAACGGGGC CCACACCCTG 
AAGCCACCCA CCACCCTGGG GCTGCTGACC GTGCTCTGCA GCCTGTTGCT GTGGGGCTCC 
AGCCGTCTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increase in prostate stem cell antigen expression in prostatic hyperplasia induced by testosterone and 17?-estradiol in C57BL mice.
The Journal of steroid biochemistry and molecular biology15856-62(2016 Apr)
Fujimoto N,Kanno J

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Human genomics1010(2016 Apr)
Loughner CL,Bruford EA,McAndrews MS,Delp EE,Swamynathan S,Swamynathan SK

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation.
The Prostate68(2)139-51(2008 Feb)
Moore ML,Teitell MA,Kim Y,Watabe T,Reiter RE,Witte ON,Dubey P

The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America102(19)6942-7(2005 May)
Xin L,Lawson DA,Witte ON

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Psca cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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