PSCA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSCA
Entrez Gene ID	8000
Full Name	prostate stem cell antigen
Synonyms	PRO232
General protein information	Preferred Names prostate stem cell antigen Names prostate stem cell antigen
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.3
Summary	This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
Disorder MIM:	602470

mRNA and Protein(s)

mRNA	Protein	Name
NM_005672.4	NP_005663.2	prostate stem cell antigen preproprotein
NM_005672.5	NP_005663.2	prostate stem cell antigen preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PSCA	XP_539189.2
	LOC703505	XP_001091808.1
Pan troglodytes (chimpanzee)	PSCA	XP_003951398.1
Mus musculus (house mouse)	Psca	NP_082492.1
Bos taurus (cattle)	PSCA	XP_003586924.2
Rattus norvegicus (Norway rat)	Psca	NP_001165577.1
Homo sapiens (human)	PSCA	NP_005663.2
Gallus gallus (chicken)	PSCA	XP_418414.2

Gene Ontology
Bibliography

Related articles in PubMed

PSCA promotes prostate cancer proliferation and cell-cycle progression by up-regulating c-Myc.
Li E, Liu L, Li F, Luo L, Zhao S, Wang J, Kang R, Luo J, Zhao Z
The Prostate77(16)1563-1572(2017 Dec)

PSCA regulates IL-6 expression through p38/NF-?B signaling in prostate cancer.
Liu L, Li E, Luo L, Zhao S, Li F, Wang J, Luo J, Zhao Z
The Prostate77(14)1389-1400(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PSCA is a novel cell cycle regulator with a key role in prostate cancer cell proliferation.
Title: PSCA promotes prostate cancer proliferation and cell-cycle progression by up-regulating c-Myc.

PSCA regulates IL-6 expression through p38/NF-kappaB signaling in Prostate cancer.
Title: PSCA regulates IL-6 expression through p38/NF-?B signaling in prostate cancer.

Among Chinese Han women, the PSCA rs2294008, rs2978974, and rs2976392 minor alleles are associated with increased breast cancer risk especially in progesterone receptor positive breast cancer patients, with breast cancer risk in postmenopausal women, and with high lymph node metastasis risk, respectively.
Title: Single-nucleotide polymorphisms in PSCA and the risk of breast cancer in a Chinese population.

the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for gastric cancer in this study population.
Title: PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.

suggest that PSCA is a useful tissue marker for predicting biochemical recurrence in patients with high risk PC receiving NHT and radical prostatectomy
Title: Prostate Stem Cell Antigen Expression in Radical Prostatectomy Specimens Predicts Early Biochemical Recurrence in Patients with High Risk Prostate Cancer Receiving Neoadjuvant Hormonal Therapy.

The following PSCA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSCA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18790	NM_005672.5 Latest version!	Homo sapiens prostate stem cell antigen (PSCA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18790	NM_005672.4	Homo sapiens prostate stem cell antigen (PSCA), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSCA ( NM_005672.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005663.2 Homo sapiens prostate stem cell antigen (PSCA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18790
Clone ID Related Accession (Same CDS sequence)	NM_005672.4 , NM_005672.5
Accession Version	NM_005672.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-11
Organism	Homo sapiens(human)
Product	prostate stem cell antigen preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB993163.1, BC048808.1 and AI685668.1. This sequence is a reference standard in the RefSeqGene project. On Feb 24, 2010 this sequence version replaced NM_005672.3. Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279849.9654.1, BC023582.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGGCT TGGCCCTGCA GCCAGGCACT GCCCTGCTGT GCTACTCCTG CAAAGCCCAG 
GTGAGCAACG AGGACTGCCT GCAGGTGGAG AACTGCACCC AGCTGGGGGA GCAGTGCTGG 
ACCGCGCGCA TCCGCGCAGT TGGCCTCCTG ACCGTCATCA GCAAAGGCTG CAGCTTGAAC 
TGCGTGGATG ACTCACAGGA CTACTACGTG GGCAAGAAGA ACATCACGTG CTGTGACACC 
GACTTGTGCA ACGCCAGCGG GGCCCATGCC CTGCAGCCGG CTGCTGCCAT CCTTGCGCTG 
CTCCCTGCAC TCGGCCTGCT GCTCTGGGGA CCCGGCCAGC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005663.2
CDS	84..428
Translation	MAGLALQPGTALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLPALGLLLWGPGQL

Target ORF information:

RefSeq Version	NM_005672.4
Organism	Homo sapiens(human)
Definition	Homo sapiens prostate stem cell antigen (PSCA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005672.4

ORF Insert Sequence:

ATGGCAGGCT TGGCCCTGCA GCCAGGCACT GCCCTGCTGT GCTACTCCTG CAAAGCCCAG 
GTGAGCAACG AGGACTGCCT GCAGGTGGAG AACTGCACCC AGCTGGGGGA GCAGTGCTGG 
ACCGCGCGCA TCCGCGCAGT TGGCCTCCTG ACCGTCATCA GCAAAGGCTG CAGCTTGAAC 
TGCGTGGATG ACTCACAGGA CTACTACGTG GGCAAGAAGA ACATCACGTG CTGTGACACC 
GACTTGTGCA ACGCCAGCGG GGCCCATGCC CTGCAGCCGG CTGCTGCCAT CCTTGCGCTG 
CTCCCTGCAC TCGGCCTGCT GCTCTGGGGA CCCGGCCAGC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSCA ( NM_005672.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005663.2 Homo sapiens prostate stem cell antigen (PSCA), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18790
Clone ID Related Accession (Same CDS sequence)	NM_005672.4 , NM_005672.5
Accession Version	NM_005672.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Homo sapiens(human)
Product	prostate stem cell antigen preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB993163.1, BC048808.1 and AI685668.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_005672.4. Transcript Variant: This variant (1) represents the shorter transcript but encodes the functional protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023582.2, SRR5189658.194276.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301258.5/ ENSP00000301258.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGGCT TGGCCCTGCA GCCAGGCACT GCCCTGCTGT GCTACTCCTG CAAAGCCCAG 
GTGAGCAACG AGGACTGCCT GCAGGTGGAG AACTGCACCC AGCTGGGGGA GCAGTGCTGG 
ACCGCGCGCA TCCGCGCAGT TGGCCTCCTG ACCGTCATCA GCAAAGGCTG CAGCTTGAAC 
TGCGTGGATG ACTCACAGGA CTACTACGTG GGCAAGAAGA ACATCACGTG CTGTGACACC 
GACTTGTGCA ACGCCAGCGG GGCCCATGCC CTGCAGCCGG CTGCTGCCAT CCTTGCGCTG 
CTCCCTGCAC TCGGCCTGCT GCTCTGGGGA CCCGGCCAGC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005663.2
CDS	45..389
Translation	MAGLALQPGTALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLPALGLLLWGPGQL

Target ORF information:

RefSeq Version	NM_005672.5
Organism	Homo sapiens(human)
Definition	Homo sapiens prostate stem cell antigen (PSCA), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005672.5

ORF Insert Sequence:

ATGGCAGGCT TGGCCCTGCA GCCAGGCACT GCCCTGCTGT GCTACTCCTG CAAAGCCCAG 
GTGAGCAACG AGGACTGCCT GCAGGTGGAG AACTGCACCC AGCTGGGGGA GCAGTGCTGG 
ACCGCGCGCA TCCGCGCAGT TGGCCTCCTG ACCGTCATCA GCAAAGGCTG CAGCTTGAAC 
TGCGTGGATG ACTCACAGGA CTACTACGTG GGCAAGAAGA ACATCACGTG CTGTGACACC 
GACTTGTGCA ACGCCAGCGG GGCCCATGCC CTGCAGCCGG CTGCTGCCAT CCTTGCGCTG 
CTCCCTGCAC TCGGCCTGCT GCTCTGGGGA CCCGGCCAGC TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PSCA promotes prostate cancer proliferation and cell-cycle progression by up-regulating c-Myc.
The Prostate77(16)1563-1572(2017 Dec)
Li E,Liu L,Li F,Luo L,Zhao S,Wang J,Kang R,Luo J,Zhao Z

PSCA regulates IL-6 expression through p38/NF-?B signaling in prostate cancer.
The Prostate77(14)1389-1400(2017 Oct)
Liu L,Li E,Luo L,Zhao S,Li F,Wang J,Luo J,Zhao Z

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PSCA cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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