Gipc1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gipc1
Entrez Gene ID	67903
Full Name	GIPC PDZ domain containing family, member 1
Synonyms	GIPC,Glut1CIP,Rgs19ip1,Semcap1,TIP-2,TaxIP2
General protein information	Preferred Names GIPC PDZ domain containing family, member 1 Names PDZ domain-containing protein GIPC1 GAIP C-terminus-interacting protein RGS-GAIP interacting protein GIPC RGS-GAIP-interacting protein RGS19-interacting protein 1 SEMCAP-1 Tax interacting protein, clone 2 neurophilin1-IP regulator of G-protein signaling 19 interacting protein 1 semaF cytoplasmic domain associated protein semaF cytoplasmic domain-associated protein 1 synectin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 C2

mRNA and Protein(s)

mRNA	Protein	Name
XM_030243739.1	XP_030099599.1	PDZ domain-containing protein GIPC1 isoform X1
NM_018771.3	NP_061241.1	PDZ domain-containing protein GIPC1

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	gipc-1	NP_498017.1
Homo sapiens (human)	GIPC1	NP_974199.1
Rattus norvegicus (Norway rat)	Gipc1	NP_445793.1
Pan troglodytes (chimpanzee)	GIPC1	XP_001157869.2
Bos taurus (cattle)	GIPC1	NP_001179947.1
Mus musculus (house mouse)	Gipc1	NP_061241.1
Danio rerio (zebrafish)	gipc1	NP_001004018.1
Canis lupus familiaris (dog)	GIPC1	XP_005632843.1
Caenorhabditis elegans (roundworm)	gipc-2	NP_501810.2
Xenopus tropicalis (tropical clawed frog)	gipc2	NP_001120269.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.
Shang G, Brautigam CA, Chen R, Lu D, Torres-V?zquez J, Zhang X
eLife6(2017 May)

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.
Fantin A, Lampropoulou A, Senatore V, Brash JT, Prahst C, Lange CA, Liyanage SE, Raimondi C, Bainbridge JW, Augustin HG, Ruhrberg C
The Journal of experimental medicine214(4)1049-1064(2017 Apr)

Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits.
Burk K, Mire E, Bellon A, Hocine M, Guillot J, Moraes F, Yoshida Y, Simons M, Chauvet S, Mann F
Nature communications814508(2017 Feb)

Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse.
Hegan PS, Lanahan AA, Simons M, Mooseker MS
Cytoskeleton (Hoboken, N.J.)72(8)373-87(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Down-regulation of endogenous GIPC1 is sufficient to inhibit the development of eye field cells from embryonic stem cells.
Title: The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells.

Higher ratios of PSD-95/GluN2B and GAIP-interacting protein C-terminus (GIPC)/GluN2B were associated with poorer learning index scores across all ages.
Title: An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging.

findings identify Gipc1 as a new interactor for Vangl2; show that a myosin VI-Gipc1 protein complex can regulate Vangl2 traffic in heterologous cells; results indicate a broad role for Gipc1 in the development of both stereociliary bundles and cell polarization
Title: Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear.

TGFbetaR3 interaction with GIPC1 is critical for regulating invasion and growth factor responsiveness in epicardial cells, and dysregulation of epicardial cell proliferation and invasion contributes to failed coronary vessel development in Tgfbr3(-/-) mice
Title: The cytoplasmic domain of TGF?R3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior.

GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion.
Title: GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion.

The following Gipc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gipc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11026	NM_018771.3 Latest version!	Mus musculus GIPC PDZ domain containing family, member 1 (Gipc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu11026	XM_030243739.1 Latest version!	Mus musculus GIPC PDZ domain containing family, member 1 (Gipc1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gipc1 ( NM_018771.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061241.1 Mus musculus GIPC PDZ domain containing family, member 1 (Gipc1), mRNA.

Price & Availability↑

CloneID	OMu11026
Clone ID Related Accession (Same CDS sequence)	XM_030243739.1 , NM_018771.3
Accession Version	NM_018771.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	PDZ domain-containing protein GIPC1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC003490.1. On Nov 2, 2002 this sequence version replaced NM_018771.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003490.1, AK086506.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCACTGG GACTGGGGCG AAGGAAGAAA GCACCGCCTC TGGTGGAAAA TGAGGAGGCG 
GAGCCAAGCC GGAGTGGGCT GGGTGTTGGG GAGCCTGGGC CCCTGGGTGG GAGCGCAGCA 
GGAGAATCCC AGATGGGCTT GCCCCCACCT CCTGCTGCCC TCCGGCCTCG CCTCGTGTTC 
CATACCCAGC TGGCCCACGG CAGCCCCACA GGCCGCATCG AGGGCTTCAC TAATGTCAAG 
GAGCTGTACG GCAAGATCGC TGAGGCCTTC CGACTACCAG CTGCTGAGGT GATGTTCTGC 
ACCCTCAACA CCCACAAAGT GGACATGGAC AAACTCCTGG GGGGCCAGAT CGGCCTGGAA 
GACTTCATCT TTGCCCATGT GAAGGGGCAG CGCAAAGAGG TGGAAGTGTT CAAGTCGGAG 
GAGGCTCTGG GGCTCACCAT CACCGACAAC GGGGCCGGCT ACGCCTTCAT TAAGCGCATC 
AAGGAAGGCA GTGTGATTGA CCACATTCAG CTCATCAGCG TGGGGGACAT GATTGAAGCC 
ATCAACGGGC AGAGCCTGCT GGGCTGTCGG CATTACGAGG TTGCCAGGCT CCTCAAGGAG 
CTGCCCCGAG GCCGCACCTT CACCCTCAAA CTCACAGAAC CTCGAAAGGC CTTTGATATG 
ATCAGCCAGC GTTCAGCCGG TGGCCACCCT GGTTCAGGCC CACAACTGGG CACTGGCCGA 
GGGACCCTCC GTCTCCGATC CCGGGGCCCT GCCACCGTGG AGGATCTGCC GTCGGCCTTT 
GAGGAGAAGG CCATTGAGAA GGTGGATGAC TTGCTAGAGA GCTACATGGG GATCAGAGAC 
ACGGAGCTGG CTGCCACCAT GGTGGAGCTG GGAAAGGACA AAAGGAACCC GGACGAGCTG 
GCAGAAGCCC TGGATGAGCG GCTCGGTGAC TTCGCATTCC CAGATGAATT TGTCTTTGAT 
GTCTGGGGAG CTATCGGGGA TGCCAAGGTT GGCCGCTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061241.1
CDS	95..1096
Translation	MPLGLGRRKKAPPLVENEEAEPSRSGLGVGEPGPLGGSAAGESQMGLPPPPAALRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPAAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEEALGLTITDNGAGYAFIKRIKEGSVIDHIQLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGHPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY

Target ORF information:

RefSeq Version	NM_018771.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus GIPC PDZ domain containing family, member 1 (Gipc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018771.3

ORF Insert Sequence:

ATGCCACTGG GACTGGGGCG AAGGAAGAAA GCACCGCCTC TGGTGGAAAA TGAGGAGGCG 
GAGCCAAGCC GGAGTGGGCT GGGTGTTGGG GAGCCTGGGC CCCTGGGTGG GAGCGCAGCA 
GGAGAATCCC AGATGGGCTT GCCCCCACCT CCTGCTGCCC TCCGGCCTCG CCTCGTGTTC 
CATACCCAGC TGGCCCACGG CAGCCCCACA GGCCGCATCG AGGGCTTCAC TAATGTCAAG 
GAGCTGTACG GCAAGATCGC TGAGGCCTTC CGACTACCAG CTGCTGAGGT GATGTTCTGC 
ACCCTCAACA CCCACAAAGT GGACATGGAC AAACTCCTGG GGGGCCAGAT CGGCCTGGAA 
GACTTCATCT TTGCCCATGT GAAGGGGCAG CGCAAAGAGG TGGAAGTGTT CAAGTCGGAG 
GAGGCTCTGG GGCTCACCAT CACCGACAAC GGGGCCGGCT ACGCCTTCAT TAAGCGCATC 
AAGGAAGGCA GTGTGATTGA CCACATTCAG CTCATCAGCG TGGGGGACAT GATTGAAGCC 
ATCAACGGGC AGAGCCTGCT GGGCTGTCGG CATTACGAGG TTGCCAGGCT CCTCAAGGAG 
CTGCCCCGAG GCCGCACCTT CACCCTCAAA CTCACAGAAC CTCGAAAGGC CTTTGATATG 
ATCAGCCAGC GTTCAGCCGG TGGCCACCCT GGTTCAGGCC CACAACTGGG CACTGGCCGA 
GGGACCCTCC GTCTCCGATC CCGGGGCCCT GCCACCGTGG AGGATCTGCC GTCGGCCTTT 
GAGGAGAAGG CCATTGAGAA GGTGGATGAC TTGCTAGAGA GCTACATGGG GATCAGAGAC 
ACGGAGCTGG CTGCCACCAT GGTGGAGCTG GGAAAGGACA AAAGGAACCC GGACGAGCTG 
GCAGAAGCCC TGGATGAGCG GCTCGGTGAC TTCGCATTCC CAGATGAATT TGTCTTTGAT 
GTCTGGGGAG CTATCGGGGA TGCCAAGGTT GGCCGCTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gipc1 ( XM_030243739.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030099599.1 Mus musculus GIPC PDZ domain containing family, member 1 (Gipc1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu11026
Clone ID Related Accession (Same CDS sequence)	XM_030243739.1 , NM_018771.3
Accession Version	XM_030243739.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	PDZ domain-containing protein GIPC1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCACTGG GACTGGGGCG AAGGAAGAAA GCACCGCCTC TGGTGGAAAA TGAGGAGGCG 
GAGCCAAGCC GGAGTGGGCT GGGTGTTGGG GAGCCTGGGC CCCTGGGTGG GAGCGCAGCA 
GGAGAATCCC AGATGGGCTT GCCCCCACCT CCTGCTGCCC TCCGGCCTCG CCTCGTGTTC 
CATACCCAGC TGGCCCACGG CAGCCCCACA GGCCGCATCG AGGGCTTCAC TAATGTCAAG 
GAGCTGTACG GCAAGATCGC TGAGGCCTTC CGACTACCAG CTGCTGAGGT GATGTTCTGC 
ACCCTCAACA CCCACAAAGT GGACATGGAC AAACTCCTGG GGGGCCAGAT CGGCCTGGAA 
GACTTCATCT TTGCCCATGT GAAGGGGCAG CGCAAAGAGG TGGAAGTGTT CAAGTCGGAG 
GAGGCTCTGG GGCTCACCAT CACCGACAAC GGGGCCGGCT ACGCCTTCAT TAAGCGCATC 
AAGGAAGGCA GTGTGATTGA CCACATTCAG CTCATCAGCG TGGGGGACAT GATTGAAGCC 
ATCAACGGGC AGAGCCTGCT GGGCTGTCGG CATTACGAGG TTGCCAGGCT CCTCAAGGAG 
CTGCCCCGAG GCCGCACCTT CACCCTCAAA CTCACAGAAC CTCGAAAGGC CTTTGATATG 
ATCAGCCAGC GTTCAGCCGG TGGCCACCCT GGTTCAGGCC CACAACTGGG CACTGGCCGA 
GGGACCCTCC GTCTCCGATC CCGGGGCCCT GCCACCGTGG AGGATCTGCC GTCGGCCTTT 
GAGGAGAAGG CCATTGAGAA GGTGGATGAC TTGCTAGAGA GCTACATGGG GATCAGAGAC 
ACGGAGCTGG CTGCCACCAT GGTGGAGCTG GGAAAGGACA AAAGGAACCC GGACGAGCTG 
GCAGAAGCCC TGGATGAGCG GCTCGGTGAC TTCGCATTCC CAGATGAATT TGTCTTTGAT 
GTCTGGGGAG CTATCGGGGA TGCCAAGGTT GGCCGCTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030099599.1
CDS	882..1883
Translation	MPLGLGRRKKAPPLVENEEAEPSRSGLGVGEPGPLGGSAAGESQMGLPPPPAALRPRLVFHTQLAHGSPTGRIEGFTNVKELYGKIAEAFRLPAAEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHVKGQRKEVEVFKSEEALGLTITDNGAGYAFIKRIKEGSVIDHIQLISVGDMIEAINGQSLLGCRHYEVARLLKELPRGRTFTLKLTEPRKAFDMISQRSAGGHPGSGPQLGTGRGTLRLRSRGPATVEDLPSAFEEKAIEKVDDLLESYMGIRDTELAATMVELGKDKRNPDELAEALDERLGDFAFPDEFVFDVWGAIGDAKVGRY

Target ORF information:

RefSeq Version	XM_030243739.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus GIPC PDZ domain containing family, member 1 (Gipc1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030243739.1

ORF Insert Sequence:

ATGCCACTGG GACTGGGGCG AAGGAAGAAA GCACCGCCTC TGGTGGAAAA TGAGGAGGCG 
GAGCCAAGCC GGAGTGGGCT GGGTGTTGGG GAGCCTGGGC CCCTGGGTGG GAGCGCAGCA 
GGAGAATCCC AGATGGGCTT GCCCCCACCT CCTGCTGCCC TCCGGCCTCG CCTCGTGTTC 
CATACCCAGC TGGCCCACGG CAGCCCCACA GGCCGCATCG AGGGCTTCAC TAATGTCAAG 
GAGCTGTACG GCAAGATCGC TGAGGCCTTC CGACTACCAG CTGCTGAGGT GATGTTCTGC 
ACCCTCAACA CCCACAAAGT GGACATGGAC AAACTCCTGG GGGGCCAGAT CGGCCTGGAA 
GACTTCATCT TTGCCCATGT GAAGGGGCAG CGCAAAGAGG TGGAAGTGTT CAAGTCGGAG 
GAGGCTCTGG GGCTCACCAT CACCGACAAC GGGGCCGGCT ACGCCTTCAT TAAGCGCATC 
AAGGAAGGCA GTGTGATTGA CCACATTCAG CTCATCAGCG TGGGGGACAT GATTGAAGCC 
ATCAACGGGC AGAGCCTGCT GGGCTGTCGG CATTACGAGG TTGCCAGGCT CCTCAAGGAG 
CTGCCCCGAG GCCGCACCTT CACCCTCAAA CTCACAGAAC CTCGAAAGGC CTTTGATATG 
ATCAGCCAGC GTTCAGCCGG TGGCCACCCT GGTTCAGGCC CACAACTGGG CACTGGCCGA 
GGGACCCTCC GTCTCCGATC CCGGGGCCCT GCCACCGTGG AGGATCTGCC GTCGGCCTTT 
GAGGAGAAGG CCATTGAGAA GGTGGATGAC TTGCTAGAGA GCTACATGGG GATCAGAGAC 
ACGGAGCTGG CTGCCACCAT GGTGGAGCTG GGAAAGGACA AAAGGAACCC GGACGAGCTG 
GCAGAAGCCC TGGATGAGCG GCTCGGTGAC TTCGCATTCC CAGATGAATT TGTCTTTGAT 
GTCTGGGGAG CTATCGGGGA TGCCAAGGTT GGCCGCTACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.
eLife6(2017 May)
Shang G,Brautigam CA,Chen R,Lu D,Torres-V?zquez J,Zhang X

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.
The Journal of experimental medicine214(4)1049-1064(2017 Apr)
Fantin A,Lampropoulou A,Senatore V,Brash JT,Prahst C,Lange CA,Liyanage SE,Raimondi C,Bainbridge JW,Augustin HG,Ruhrberg C

Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits.
Nature communications814508(2017 Feb)
Burk K,Mire E,Bellon A,Hocine M,Guillot J,Moraes F,Yoshida Y,Simons M,Chauvet S,Mann F

Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse.
Cytoskeleton (Hoboken, N.J.)72(8)373-87(2015 Aug)
Hegan PS,Lanahan AA,Simons M,Mooseker MS

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Gipc1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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