Ufm1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ufm1
Entrez Gene ID	67890
Full Name	ubiquitin-fold modifier 1
Synonyms	1810045K17Rik,AI132708,AI463323,Gm10726
General protein information	Preferred Names ubiquitin-fold modifier 1 Names ubiquitin-fold modifier 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_026435.5	NP_080711.1	ubiquitin-fold modifier 1 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	UFM1	XP_001149496.1
Rattus norvegicus (Norway rat)	Ufm1	NP_001119552.1
Bos taurus (cattle)	UFM1	NP_001039779.1
Anopheles gambiae (African malaria mosquito)	UFM1_ANOGA	XP_321781.3
Arabidopsis thaliana (thale cress)	AT1G77710	NP_177894.1
Xenopus tropicalis (tropical clawed frog)	ufm1	NP_001016988.1
	UFM1	XP_001086251.1
Canis lupus familiaris (dog)	UFM1	XP_534489.3
Homo sapiens (human)	UFM1	NP_057701.1
Gallus gallus (chicken)	UFM1	NP_001025998.1
Danio rerio (zebrafish)	ufm1	NP_997792.1
Caenorhabditis elegans (roundworm)	tag-277	NP_498705.1
Mus musculus (house mouse)	Ufm1	NP_080711.1
Drosophila melanogaster (fruit fly)	CG34191	NP_001097354.1
Oryza sativa (rice)	Os01g0962400	NP_001045478.1

Gene Ontology
Bibliography

Related articles in PubMed

Biallelic Variants in UBA5 Link Dysfunctional UFM1?Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
Muona M, Ishimura R, Laari A, Ichimura Y, Linnankivi T, Keski-Filppula R, Herva R, Rantala H, Paetau A, P?yh?nen M, Obata M, Uemura T, Karhu T, Bizen N, Takebayashi H, McKee S, Parker MJ, Akawi N, McRae J, Hurles ME, , Kuismin O, Kurki MI, Anttonen AK, Tanaka K, Palotie A, Waguri S, Lehesjoki AE, Komatsu M
American journal of human genetics99(3)683-694(2016 Sep)

UFM1 Protects Macrophages from oxLDL-Induced Foam Cell Formation Through a Liver X Receptor ? Dependent Pathway.
Pang Q, Xiong J, Hu XL, He JP, Liu HF, Zhang GY, Li YY, Chen FL
Journal of atherosclerosis and thrombosis22(11)1124-40(2015)

Ufmylation and FATylation pathways are downregulated in human alcoholic and nonalcoholic steatohepatitis, and mice fed DDC, where Mallory-Denk bodies (MDBs) form.
Liu H, Li J, Tillman B, French BA, French SW
Experimental and molecular pathology97(1)81-8(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CNS-specific knockout of Ufm1 in mice causes neonatal death accompanied by microcephaly and apoptosis in specific neurons, further suggesting that the UFM1 system is essential for CNS development and function
Title: Biallelic Variants in UBA5 Link Dysfunctional UFM1?Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.

High UFM1 expression is associated with Atherosclerosis.
Title: UFM1 Protects Macrophages from oxLDL-Induced Foam Cell Formation Through a Liver X Receptor ? Dependent Pathway.

transcription downregulation of the Ufm1 and FAT10 conjugation system in liver Mallory-Denk bodies formation
Title: Ufmylation and FATylation pathways are downregulated in human alcoholic and nonalcoholic steatohepatitis, and mice fed DDC, where Mallory-Denk bodies (MDBs) form.

These data suggest that UFM1-UFBP1 participate in preventing ER stress-induced apoptosis in protein secretory cells.
Title: Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.

A novel type of E3 ligase for the Ufm1 conjugation system.
Title: A novel type of E3 ligase for the Ufm1 conjugation system.

The following Ufm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ufm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02284	NM_026435.5 Latest version!	Mus musculus ubiquitin-fold modifier 1 (Ufm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ufm1 ( NM_026435.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080711.1 Mus musculus ubiquitin-fold modifier 1 (Ufm1), mRNA.

Price & Availability↑

CloneID	OMu02284
Clone ID Related Accession (Same CDS sequence)	NM_026435.5
Accession Version	NM_026435.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	ubiquitin-fold modifier 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ075089.1, AK167301.1, AC147262.4 and BP754244.1. On or before Dec 2, 2010 this sequence version replaced XM_003084556.1, XM_003086295.1, NM_026435.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY243074.1, AK148146.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGAAGG TGTCCTTTAA AATCACGTTG ACGTCGGACC CGCGGCTGCC GTACAAAGTT 
CTCAGTGTTC CTGAAAGTAC GCCGTTCACA GCAGTGCTAA AGTTTGCAGC AGAAGAATTT 
AAAGTTCCTG CAGCTACAAG TGCGATTATT ACTAATGATG GAATAGGAAT AAATCCTGCA 
CAGACTGCTG GGAATGTTTT CCTGAAGCAC GGCTCAGAAC TGAGAATCAT TCCTAGAGAC 
CGAGTTGGAA GCTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080711.1
CDS	58..315
Translation	MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPAQTAGNVFLKHGSELRIIPRDRVGSC

Target ORF information:

RefSeq Version	NM_026435.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquitin-fold modifier 1 (Ufm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026435.5

ORF Insert Sequence:

ATGTCGAAGG TGTCCTTTAA AATCACGTTG ACGTCGGACC CGCGGCTGCC GTACAAAGTT 
CTCAGTGTTC CTGAAAGTAC GCCGTTCACA GCAGTGCTAA AGTTTGCAGC AGAAGAATTT 
AAAGTTCCTG CAGCTACAAG TGCGATTATT ACTAATGATG GAATAGGAAT AAATCCTGCA 
CAGACTGCTG GGAATGTTTT CCTGAAGCAC GGCTCAGAAC TGAGAATCAT TCCTAGAGAC 
CGAGTTGGAA GCTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biallelic Variants in UBA5 Link Dysfunctional UFM1?Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
American journal of human genetics99(3)683-694(2016 Sep)
Muona M,Ishimura R,Laari A,Ichimura Y,Linnankivi T,Keski-Filppula R,Herva R,Rantala H,Paetau A,P?yh?nen M,Obata M,Uemura T,Karhu T,Bizen N,Takebayashi H,McKee S,Parker MJ,Akawi N,McRae J,Hurles ME,,Kuismin O,Kurki MI,Anttonen AK,Tanaka K,Palotie A,Waguri S,Lehesjoki AE,Komatsu M

UFM1 Protects Macrophages from oxLDL-Induced Foam Cell Formation Through a Liver X Receptor ? Dependent Pathway.
Journal of atherosclerosis and thrombosis22(11)1124-40(2015)
Pang Q,Xiong J,Hu XL,He JP,Liu HF,Zhang GY,Li YY,Chen FL

Ufmylation and FATylation pathways are downregulated in human alcoholic and nonalcoholic steatohepatitis, and mice fed DDC, where Mallory-Denk bodies (MDBs) form.
Experimental and molecular pathology97(1)81-8(2014 Aug)
Liu H,Li J,Tillman B,French BA,French SW

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Ufm1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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