Cul7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cul7
Entrez Gene ID	66515
Full Name	cullin 7
Synonyms	2510004L20Rik,AA409809,C230011P08Rik,p185,p193
General protein information	Preferred Names cullin 7 Names cullin-7 CUL-7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_025611.5	NP_079887.3	cullin-7

Pathways from BioSystems

Homologies

Homo sapiens (human)	CUL7	NP_001161842.1
Canis lupus familiaris (dog)	CUL7	XP_538928.3
Rattus norvegicus (Norway rat)	LOC680835	XP_006244636.1
Pan troglodytes (chimpanzee)	CUL7	XP_003311343.1
Bos taurus (cattle)	CUL7	XP_005223608.1
	CUL7	XP_002803791.1
Mus musculus (house mouse)	Cul7	NP_079887.3

Gene Ontology
Bibliography

Related articles in PubMed

CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.
Li Z, Pei XH, Yan J, Yan F, Cappell KM, Whitehurst AW, Xiong Y
Molecular cell54(5)805-19(2014 Jun)

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.
Scheufele F, Wolf B, Kruse M, Hartmann T, Lempart J, M?hlich S, Pfeiffer AFH, Field LJ, Charron MJ, Pan ZQ, Engelhardt S, Sarikas A
Cellular signalling26(2)233-239(2014 Feb)

An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.
Litterman N, Ikeuchi Y, Gallardo G, O'Connell BC, Sowa ME, Gygi SP, Harper JW, Bonni A
PLoS biology9(5)e1001060(2011 May)

Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction.
Hassink RJ, Nakajima H, Nakajima HO, Doevendans PA, Field LJ
Heart (British Cardiac Society)95(14)1159-64(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cul7-/- mouse embryonic fibroblasts displayed an increase in the activation of AKT and Erk phosphorylation upon insulin stimulation.
Title: Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.

Expression of the dominant interfering p193 transgene results in a decrease in infarct scar expansion and preservation of myocardial function at 4 weeks after Myocardial Infarction.
Title: Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction.

Results demonstrate a key role for the CUL7 E3 in targeting IRS-1 for degradation, a process that may contribute to the regulation of cellular senescence.
Title: The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.

suggested a role for p193/CUL7 in the regulation of apoptosis independently of p53 and Parc activity
Title: Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding.

Cul7 forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8.
Title: Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.

The following Cul7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cul7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00764	NM_025611.5 Latest version!	Mus musculus cullin 7 (Cul7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$1245.30 $1779.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cul7 ( NM_025611.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079887.3 Mus musculus cullin 7 (Cul7), mRNA.

Price & Availability↑

CloneID	OMu00764
Clone ID Related Accession (Same CDS sequence)	NM_025611.5
Accession Version	NM_025611.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5070bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	cullin-7
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY749504.1, BC065096.1 and BC059865.1. On or before Jun 7, 2008 this sequence version replaced NM_177189.3, NM_025611.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC138998.1, AK170808.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGTAGGGG AGCTACGATA CAGGGAATTC AGGGTGCCCC TGGGGCCTGG CTTGCACGCG 
TATCCGGATG AATTGATCCG CCAACGGGTT GGCCATAATG GGCACCCCGA GTATCAGATC 
CGCTGGCTCA TCCTCAGGCG CGGGGATGAT GGGGACCGGG ACTCTACAGT GGACTGCAAG 
GCTGAGCATA TCCTGTTATG GATGTCTGAC GATGAGATCT ATGCCAACTG CCACAAGATG 
CTGGGCGAGA ATGGCCAAGT CATCGCACCT TCCCGGGAGT CCACTGAGGC AGGGGCCCTC 
GACAAGTCTG TGCTGGGGGA GATGGAAACA GATGTGAAGT CCTTGATTCA GAGGGCCCTT 
CGGCAGCTGG AGGAGTGCGT GGGCACCGTG CCTCCTGCCC CTCTCCTTCA CACGGTCCAT 
GTACTCAGTG CCTATGCCAG CATCGAGCCC CTCACTGGCA TCTTCAAAGA CCGCAGGGTT 
GTGAACTTGC TCATGCACAT GTTGAGCAGT CCTGATTATC AGATCCGCTG GAGCGCAGGC 
CGGATGATCC AAGCTCTGTC CTCCCACGAT GCTGGGACCC GGACCCAGAT CCTTCTGTCA 
TTGAGCCAAC AAGAGGCCAT TGAAAAGCAC CTGGATTTTG ATAGCCGCTG CGCTCTGCTT 
GCACTGTTCG CCCAGGCTAC TCTCACGGAA CACCCGATGT CTTTCGAGGG CGTTCAGCTG 
CCACAGGTCC CAGGACGGCT GCTCTTCTCC CTGGTAAAAC GCTACCTGCA CGTCACCTTC 
CTCCTGGATC GGCTGAACGG CGATGCAGGG GATCAAGGAG CCCAGAACAA CTTTATTCCT 
GAGGAGTTGA ATGTAGGGAG GGGCCGGCTG GAACTGGAAT TCAGTATGGC CATGGGCACT 
CTGATCTCTG AGCTGGTGCA GGCCATGCGC TGGGACGGGG CCTCAAGCAG ACCAGAGAGT 
TCTTCCTCCT CCACCTTCCA GCCTCGGCCA GCACAGTTCC GCCCCTACAC CCAGCGTTTC 
AGGAGGTCGA GGCGGTTTCG CCCCCGTGCC TCGTTTGCCA GTTTTAATAC CTATGCCTTG 
TATGTGCGGG ACACGCTGCG GCCCGGGATG CGGGTACGGA TGCTGGAGAA TTACGAGGAG 
ATCGCTGCTG GGGATGAGGG CCAGTTCCGA CAGAGCAATG ATGGCGTTCC CCCAGCGCAG 
GTGTTGTGGG ATTCAACAGG CCATACCTAC TGGGTGCACT GGCACATGCT GGAGATCTTG 
GGCTTTGAGG AAGACATCGA GGATGTGATT GATATTGAAG AGTTACAGGA GCTAGGGGCC 
AATGGAGCAC TGAGCATCGT CCCGCCGTCC CAGCGCTGGA AGCCCATAAC TCAGCTCTTT 
GCCGAGCCTT ACGTGGTACC CGAGGAGGAA GACAGGGAAG AGAGCGAGAA CTTGACCCAG 
GCTGAGTGGT GGGAGCTCCT CTTCTTCATC CGGCAGTTGA GTGAGGCAGA GCGCCTTCAC 
ATCGTGGATC TCCTGCAAGA CCACCTGGAA GAGGAGCGCG TTCTGGACTA CGATATGCTG 
CCTGAGCTGA CCGTGCCCGT TGACTTGGCC CAGGATCTGC TGTTGTCTCT GCCTCAGCAA 
CTTGAGGACA GTGCTCTGAG GGACCTGTTC AGCTGCAGTG TCTACAGGAA GTATGGGCCC 
GAAGTCCTGG TAGGGCATCT AAGCTACCCA TTTGTGCCAG GTGCCCAGCC AAATTTATTC 
GGAGCCAATG AAGAGTCTGA AGCCAAAGAT CCCCCACTTC AGAGTGCCAG CCCTGCCCTG 
CAGCGCCTGG TGGAGAGCTT GGGCCCCGAA GGGGAGGTCC TTGTGGAACT GGAACAAGCC 
CTCGGCTCCG AGGCTCCCCA GGAAACTGAG GTCAAGTCCT GCTTGTTGCA GCTCCAGGAG 
CAGCCCCAGC CCTTCCTCGC TCTGATGCGG AGCCTGGACA CTTCCGCCAG CAACAAGACC 
CTGCACCTCA CTGTGCTCAG AATCTTAATG CAGCTGGTGA ACTTCCCAGA GGCGCTGTTG 
CTACCCTGGC ACGAGGCCAT GGATGCCTGC GTGACCTGCC TTCGGTCCCC CAATACTGAC 
CGAGAGGTGC TCCAGGAACT AATCTTTTTC CTGCACCGCC TGACCACCAC AAGCCGGGAC 
TATGCGGTGA TACTAAACCA GCTAGGAGCC CGGGACGCCA TCTCCAAAGT CCTGGAAAAG 
CACCGAGGGA AACTGGAGTT GGCTCAGGAG CTGCGGGATA TGGTGTCCAA GTGTGAGAAG 
CATGCCCACC TCTACCGGAA ACTCACCACC AACATCCTGG GCGGTTGCAT CCAGATGGTC 
CTGGGTCAGA TTGAAGACCA CAGACGAACC CACCGGCCCA TCCAAATCCC ATTCTTTGAT 
GTGTTTCTCA GATATCTGTG CCAGGGCTCC AGTGAGGAAA TGAAGAAAAA CAGGTACTGG 
GAGAAGGTGG AGGTGTCCTC CAACCCACAG CGGGCCAGCA GGCTGACGGA CCGCAACCCC 
AAGACCTACT GGGAGTCCAG TGGCAGGGCC GGCTCCCACT TCATCACCTT ACACATGCGC 
CCAGGTGTCA TCATCAGGCA GCTGACTCTA CTGGTGGCTG GCGAGGACTC AAGCTACATG 
CCAGCCTGGG TGGTGGTATG CGGGGGCAAC AGCATCAAGT CCGTTAATAA AGAACTCAAC 
ACGGTAAACG TGATGCCCTC TGCCAGCCGG GTGACCCTCC TGGAGAACCT GACCCGCTTC 
TGGCCCATCA TCCAAATCAG AATAAAGCGC TGCCAGCAGG GTGGCATTAA CACGCGCATC 
CGGGGCCTAG AGGTGCTGGG CCCCAAGCCC ACCTTCTGGC CAGTGTTCCG AGAGCAACTG 
TGCCGGCACA CGCGCCTCTT CTACATGGTT CGGGCCCAGG CATGGAGTCA GGACATAGCA 
GAGGACCGCC GGAGCCTTCT GCACCTGAGT TCTAGGCTAA ATGGGGCTCT GCGCCATGAA 
CAGAATTTTG CAGAGCGCTT CCTTCCTGAT ATGGAGGCCG CCCAAGCACT GAGCAAGACC 
TGCTGGGAGG CGCTGGTCAG CCCCCTGGTG CAGAACATTA CATCTCCCGA TGAGGACAGC 
ACCAGCTCCT TGGGCTGGCT GCTGGATCAG TACTTGGGAT GCAGGGAGGC TGCCTACAAT 
CCCCAGAGCA GGGCTGCTGC TTTCTCCTCC CGGGTTCGCC GCCTTACCCA CCTCCTGGTC 
CATGTGGAGC CCCGTGAGGC AGCACCTCCG GTGGTGGCCA TCCCTCGATC CAAGGGCAGG 
AACAGAATCC ATGACTGGAG CTACTTGATC ACCCGGGGCC TTCCAAGTAG CATCATGAAG 
AACCTGACCC GCTGTTGGCG GTCTGTGGTG GAGGAGCAGA TGAACAAGTT TCTGACTGCG 
TCCTGGAAAG ACGATGATTT CGTACCCCGC TATTGCGAGC GCTATTACGT CCTGCAGAAG 
TCCAGCTCAG AGCTGTTTGG GCCACGAGCT GCCTTCTTGC TGGCAATGCG GAATGGCTGT 
GCTGATGCTG TGCTGAGGCT CCCTTTCCTC AGGGCCGCCC ATGTGAGCGA GCAGTTTGCT 
CGGCACATTG ACCAGAGGAT CCAAGGCAGT AGGATGGGTG GAGCCCGGGG AATGGAGATG 
CTGGCACAGT TGCAGCGATG CCTGGAGTCT GTCCTGATTT TCTCTCCCCT GGAGATAGCC 
ACCACCTTTG AGCATTACTA CCAGCACTAC ATGGCTGACC GTCTCCTGAG CGTAGGCTCC 
AGCTGGCTGG AGGGGGCCGT ACTGGAGCAG ATCGGTCCCT GCTTCCCCAG CCGTCTTCCC 
CAGCAGATGC TACAGAGCCT GAACGTCTCA GAGGAGTTGC AGCGTCAGTT CCACGTTTAC 
CAGCTGCAGC AGCTTGATCA GGAGCTCCTG AAGCTGGAAG ACACGGAAAA GAAGATACAG 
GTGGCCCATG AGGACAGTGG CAGAGAGGAC AAGAGCAAGA AGGAAGAAGC CATTGGAGAA 
GCCGCGGCTG TGGCTATGGC AGAGGAGGAG GATCAAGGGA AGAAGGAGGA GGGAGAGGAG 
GAAGGGGAGG GAGAGGATGA GGAGGAAGAG CGCTATTATA AAGGAACAAT GCCAGAAGTG 
TGTGTACTTG TCGTGACGCC ACGCTTCTGG CCTGTCGCCT CCGTCTGCCA AATGCTCAAC 
CCGGCAACGT GCCTGCCCGC ATACCTGCGG GGGACCATAA ACCACTACAC CAACTTTTAC 
AGCAAGAGTC AGAGCCGCTC CAGCTTAGAG AAAGAGCCAC AGAGGCGGCT GCAGTGGACC 
TGGCAGGGCC GGGCAGAAGT GCAGTTCGGG GGTCAGATTC TGCATGTGTC CACAGTACAG 
ATGTGGCTGC TGCTGCATCT CAACAACCAA AAGGAGGTGT CTGTCGAGAG CCTGCAGGCT 
ATCTCGGAGC TCCCTCCAGA TGTGCTTCAC AGGGCCATCG GGCCTCTCAC CTCATCAAGA 
GGTCCCTTGG ACCTGCAGGA GCAGAAGAAC GTACCAGGAG GGGTGCTCAA GATTCGAGAT 
GACAGTGAGG AACCCAGGCC GAGGAGGGGC AACGTGTGGC TGATCCCACC TCAGACATAC 
CTACAAGCTG AGGCCGAAGA GGGCCGGAAC ATGGAGAAGA GAAGGAATCT TCTGAATTGC 
CTTGTTGTCC GAATCCTCAA GGCTCACGGG GATGAAGGCT TGCATGTTGA CCGGCTCGTC 
TATCTGGTGC TAGAAGCGTG GGAGAAAGGC CCGTGTCCTG CTAGGGGTCT GGTCAGCAGC 
CTCGGCAGGG GAGCAACCTG CAGGAGCTCT GATGTCCTCT CCTGCATCCT GCACCTCCTG 
GTCAAGGGCA CGCTGAGACG CCATGACGAC CGGCCGCAGG TGCTGTACTA TGCAGTTCCT 
GTAACTGTGA TGGAGCCCCA CATGGAGTCC CTGAACCCTG GCTCGGCAGG CCCCAATCCA 
CCCCTCACCT TCCACACCCT GCAGATTCGA TCCCGGGGTG TGCCTTACGC CTCCTGCACT 
GATAACCACA CCTTCTCCAC TTTCCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079887.3
CDS	387..5456
Translation	MVGELRYREFRVPLGPGLHAYPDELIRQRVGHNGHPEYQIRWLILRRGDDGDRDSTVDCKAEHILLWMSDDEIYANCHKMLGENGQVIAPSRESTEAGALDKSVLGEMETDVKSLIQRALRQLEECVGTVPPAPLLHTVHVLSAYASIEPLTGIFKDRRVVNLLMHMLSSPDYQIRWSAGRMIQALSSHDAGTRTQILLSLSQQEAIEKHLDFDSRCALLALFAQATLTEHPMSFEGVQLPQVPGRLLFSLVKRYLHVTFLLDRLNGDAGDQGAQNNFIPEELNVGRGRLELEFSMAMGTLISELVQAMRWDGASSRPESSSSSTFQPRPAQFRPYTQRFRRSRRFRPRASFASFNTYALYVRDTLRPGMRVRMLENYEEIAAGDEGQFRQSNDGVPPAQVLWDSTGHTYWVHWHMLEILGFEEDIEDVIDIEELQELGANGALSIVPPSQRWKPITQLFAEPYVVPEEEDREESENLTQAEWWELLFFIRQLSEAERLHIVDLLQDHLEEERVLDYDMLPELTVPVDLAQDLLLSLPQQLEDSALRDLFSCSVYRKYGPEVLVGHLSYPFVPGAQPNLFGANEESEAKDPPLQSASPALQRLVESLGPEGEVLVELEQALGSEAPQETEVKSCLLQLQEQPQPFLALMRSLDTSASNKTLHLTVLRILMQLVNFPEALLLPWHEAMDACVTCLRSPNTDREVLQELIFFLHRLTTTSRDYAVILNQLGARDAISKVLEKHRGKLELAQELRDMVSKCEKHAHLYRKLTTNILGGCIQMVLGQIEDHRRTHRPIQIPFFDVFLRYLCQGSSEEMKKNRYWEKVEVSSNPQRASRLTDRNPKTYWESSGRAGSHFITLHMRPGVIIRQLTLLVAGEDSSYMPAWVVVCGGNSIKSVNKELNTVNVMPSASRVTLLENLTRFWPIIQIRIKRCQQGGINTRIRGLEVLGPKPTFWPVFREQLCRHTRLFYMVRAQAWSQDIAEDRRSLLHLSSRLNGALRHEQNFAERFLPDMEAAQALSKTCWEALVSPLVQNITSPDEDSTSSLGWLLDQYLGCREAAYNPQSRAAAFSSRVRRLTHLLVHVEPREAAPPVVAIPRSKGRNRIHDWSYLITRGLPSSIMKNLTRCWRSVVEEQMNKFLTASWKDDDFVPRYCERYYVLQKSSSELFGPRAAFLLAMRNGCADAVLRLPFLRAAHVSEQFARHIDQRIQGSRMGGARGMEMLAQLQRCLESVLIFSPLEIATTFEHYYQHYMADRLLSVGSSWLEGAVLEQIGPCFPSRLPQQMLQSLNVSEELQRQFHVYQLQQLDQELLKLEDTEKKIQVAHEDSGREDKSKKEEAIGEAAAVAMAEEEDQGKKEEGEEEGEGEDEEEERYYKGTMPEVCVLVVTPRFWPVASVCQMLNPATCLPAYLRGTINHYTNFYSKSQSRSSLEKEPQRRLQWTWQGRAEVQFGGQILHVSTVQMWLLLHLNNQKEVSVESLQAISELPPDVLHRAIGPLTSSRGPLDLQEQKNVPGGVLKIRDDSEEPRPRRGNVWLIPPQTYLQAEAEEGRNMEKRRNLLNCLVVRILKAHGDEGLHVDRLVYLVLEAWEKGPCPARGLVSSLGRGATCRSSDVLSCILHLLVKGTLRRHDDRPQVLYYAVPVTVMEPHMESLNPGSAGPNPPLTFHTLQIRSRGVPYASCTDNHTFSTFR

Target ORF information:

RefSeq Version	NM_025611.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus cullin 7 (Cul7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025611.5

ORF Insert Sequence:

ATGGTAGGGG AGCTACGATA CAGGGAATTC AGGGTGCCCC TGGGGCCTGG CTTGCACGCG 
TATCCGGATG AATTGATCCG CCAACGGGTT GGCCATAATG GGCACCCCGA GTATCAGATC 
CGCTGGCTCA TCCTCAGGCG CGGGGATGAT GGGGACCGGG ACTCTACAGT GGACTGCAAG 
GCTGAGCATA TCCTGTTATG GATGTCTGAC GATGAGATCT ATGCCAACTG CCACAAGATG 
CTGGGCGAGA ATGGCCAAGT CATCGCACCT TCCCGGGAGT CCACTGAGGC AGGGGCCCTC 
GACAAGTCTG TGCTGGGGGA GATGGAAACA GATGTGAAGT CCTTGATTCA GAGGGCCCTT 
CGGCAGCTGG AGGAGTGCGT GGGCACCGTG CCTCCTGCCC CTCTCCTTCA CACGGTCCAT 
GTACTCAGTG CCTATGCCAG CATCGAGCCC CTCACTGGCA TCTTCAAAGA CCGCAGGGTT 
GTGAACTTGC TCATGCACAT GTTGAGCAGT CCTGATTATC AGATCCGCTG GAGCGCAGGC 
CGGATGATCC AAGCTCTGTC CTCCCACGAT GCTGGGACCC GGACCCAGAT CCTTCTGTCA 
TTGAGCCAAC AAGAGGCCAT TGAAAAGCAC CTGGATTTTG ATAGCCGCTG CGCTCTGCTT 
GCACTGTTCG CCCAGGCTAC TCTCACGGAA CACCCGATGT CTTTCGAGGG CGTTCAGCTG 
CCACAGGTCC CAGGACGGCT GCTCTTCTCC CTGGTAAAAC GCTACCTGCA CGTCACCTTC 
CTCCTGGATC GGCTGAACGG CGATGCAGGG GATCAAGGAG CCCAGAACAA CTTTATTCCT 
GAGGAGTTGA ATGTAGGGAG GGGCCGGCTG GAACTGGAAT TCAGTATGGC CATGGGCACT 
CTGATCTCTG AGCTGGTGCA GGCCATGCGC TGGGACGGGG CCTCAAGCAG ACCAGAGAGT 
TCTTCCTCCT CCACCTTCCA GCCTCGGCCA GCACAGTTCC GCCCCTACAC CCAGCGTTTC 
AGGAGGTCGA GGCGGTTTCG CCCCCGTGCC TCGTTTGCCA GTTTTAATAC CTATGCCTTG 
TATGTGCGGG ACACGCTGCG GCCCGGGATG CGGGTACGGA TGCTGGAGAA TTACGAGGAG 
ATCGCTGCTG GGGATGAGGG CCAGTTCCGA CAGAGCAATG ATGGCGTTCC CCCAGCGCAG 
GTGTTGTGGG ATTCAACAGG CCATACCTAC TGGGTGCACT GGCACATGCT GGAGATCTTG 
GGCTTTGAGG AAGACATCGA GGATGTGATT GATATTGAAG AGTTACAGGA GCTAGGGGCC 
AATGGAGCAC TGAGCATCGT CCCGCCGTCC CAGCGCTGGA AGCCCATAAC TCAGCTCTTT 
GCCGAGCCTT ACGTGGTACC CGAGGAGGAA GACAGGGAAG AGAGCGAGAA CTTGACCCAG 
GCTGAGTGGT GGGAGCTCCT CTTCTTCATC CGGCAGTTGA GTGAGGCAGA GCGCCTTCAC 
ATCGTGGATC TCCTGCAAGA CCACCTGGAA GAGGAGCGCG TTCTGGACTA CGATATGCTG 
CCTGAGCTGA CCGTGCCCGT TGACTTGGCC CAGGATCTGC TGTTGTCTCT GCCTCAGCAA 
CTTGAGGACA GTGCTCTGAG GGACCTGTTC AGCTGCAGTG TCTACAGGAA GTATGGGCCC 
GAAGTCCTGG TAGGGCATCT AAGCTACCCA TTTGTGCCAG GTGCCCAGCC AAATTTATTC 
GGAGCCAATG AAGAGTCTGA AGCCAAAGAT CCCCCACTTC AGAGTGCCAG CCCTGCCCTG 
CAGCGCCTGG TGGAGAGCTT GGGCCCCGAA GGGGAGGTCC TTGTGGAACT GGAACAAGCC 
CTCGGCTCCG AGGCTCCCCA GGAAACTGAG GTCAAGTCCT GCTTGTTGCA GCTCCAGGAG 
CAGCCCCAGC CCTTCCTCGC TCTGATGCGG AGCCTGGACA CTTCCGCCAG CAACAAGACC 
CTGCACCTCA CTGTGCTCAG AATCTTAATG CAGCTGGTGA ACTTCCCAGA GGCGCTGTTG 
CTACCCTGGC ACGAGGCCAT GGATGCCTGC GTGACCTGCC TTCGGTCCCC CAATACTGAC 
CGAGAGGTGC TCCAGGAACT AATCTTTTTC CTGCACCGCC TGACCACCAC AAGCCGGGAC 
TATGCGGTGA TACTAAACCA GCTAGGAGCC CGGGACGCCA TCTCCAAAGT CCTGGAAAAG 
CACCGAGGGA AACTGGAGTT GGCTCAGGAG CTGCGGGATA TGGTGTCCAA GTGTGAGAAG 
CATGCCCACC TCTACCGGAA ACTCACCACC AACATCCTGG GCGGTTGCAT CCAGATGGTC 
CTGGGTCAGA TTGAAGACCA CAGACGAACC CACCGGCCCA TCCAAATCCC ATTCTTTGAT 
GTGTTTCTCA GATATCTGTG CCAGGGCTCC AGTGAGGAAA TGAAGAAAAA CAGGTACTGG 
GAGAAGGTGG AGGTGTCCTC CAACCCACAG CGGGCCAGCA GGCTGACGGA CCGCAACCCC 
AAGACCTACT GGGAGTCCAG TGGCAGGGCC GGCTCCCACT TCATCACCTT ACACATGCGC 
CCAGGTGTCA TCATCAGGCA GCTGACTCTA CTGGTGGCTG GCGAGGACTC AAGCTACATG 
CCAGCCTGGG TGGTGGTATG CGGGGGCAAC AGCATCAAGT CCGTTAATAA AGAACTCAAC 
ACGGTAAACG TGATGCCCTC TGCCAGCCGG GTGACCCTCC TGGAGAACCT GACCCGCTTC 
TGGCCCATCA TCCAAATCAG AATAAAGCGC TGCCAGCAGG GTGGCATTAA CACGCGCATC 
CGGGGCCTAG AGGTGCTGGG CCCCAAGCCC ACCTTCTGGC CAGTGTTCCG AGAGCAACTG 
TGCCGGCACA CGCGCCTCTT CTACATGGTT CGGGCCCAGG CATGGAGTCA GGACATAGCA 
GAGGACCGCC GGAGCCTTCT GCACCTGAGT TCTAGGCTAA ATGGGGCTCT GCGCCATGAA 
CAGAATTTTG CAGAGCGCTT CCTTCCTGAT ATGGAGGCCG CCCAAGCACT GAGCAAGACC 
TGCTGGGAGG CGCTGGTCAG CCCCCTGGTG CAGAACATTA CATCTCCCGA TGAGGACAGC 
ACCAGCTCCT TGGGCTGGCT GCTGGATCAG TACTTGGGAT GCAGGGAGGC TGCCTACAAT 
CCCCAGAGCA GGGCTGCTGC TTTCTCCTCC CGGGTTCGCC GCCTTACCCA CCTCCTGGTC 
CATGTGGAGC CCCGTGAGGC AGCACCTCCG GTGGTGGCCA TCCCTCGATC CAAGGGCAGG 
AACAGAATCC ATGACTGGAG CTACTTGATC ACCCGGGGCC TTCCAAGTAG CATCATGAAG 
AACCTGACCC GCTGTTGGCG GTCTGTGGTG GAGGAGCAGA TGAACAAGTT TCTGACTGCG 
TCCTGGAAAG ACGATGATTT CGTACCCCGC TATTGCGAGC GCTATTACGT CCTGCAGAAG 
TCCAGCTCAG AGCTGTTTGG GCCACGAGCT GCCTTCTTGC TGGCAATGCG GAATGGCTGT 
GCTGATGCTG TGCTGAGGCT CCCTTTCCTC AGGGCCGCCC ATGTGAGCGA GCAGTTTGCT 
CGGCACATTG ACCAGAGGAT CCAAGGCAGT AGGATGGGTG GAGCCCGGGG AATGGAGATG 
CTGGCACAGT TGCAGCGATG CCTGGAGTCT GTCCTGATTT TCTCTCCCCT GGAGATAGCC 
ACCACCTTTG AGCATTACTA CCAGCACTAC ATGGCTGACC GTCTCCTGAG CGTAGGCTCC 
AGCTGGCTGG AGGGGGCCGT ACTGGAGCAG ATCGGTCCCT GCTTCCCCAG CCGTCTTCCC 
CAGCAGATGC TACAGAGCCT GAACGTCTCA GAGGAGTTGC AGCGTCAGTT CCACGTTTAC 
CAGCTGCAGC AGCTTGATCA GGAGCTCCTG AAGCTGGAAG ACACGGAAAA GAAGATACAG 
GTGGCCCATG AGGACAGTGG CAGAGAGGAC AAGAGCAAGA AGGAAGAAGC CATTGGAGAA 
GCCGCGGCTG TGGCTATGGC AGAGGAGGAG GATCAAGGGA AGAAGGAGGA GGGAGAGGAG 
GAAGGGGAGG GAGAGGATGA GGAGGAAGAG CGCTATTATA AAGGAACAAT GCCAGAAGTG 
TGTGTACTTG TCGTGACGCC ACGCTTCTGG CCTGTCGCCT CCGTCTGCCA AATGCTCAAC 
CCGGCAACGT GCCTGCCCGC ATACCTGCGG GGGACCATAA ACCACTACAC CAACTTTTAC 
AGCAAGAGTC AGAGCCGCTC CAGCTTAGAG AAAGAGCCAC AGAGGCGGCT GCAGTGGACC 
TGGCAGGGCC GGGCAGAAGT GCAGTTCGGG GGTCAGATTC TGCATGTGTC CACAGTACAG 
ATGTGGCTGC TGCTGCATCT CAACAACCAA AAGGAGGTGT CTGTCGAGAG CCTGCAGGCT 
ATCTCGGAGC TCCCTCCAGA TGTGCTTCAC AGGGCCATCG GGCCTCTCAC CTCATCAAGA 
GGTCCCTTGG ACCTGCAGGA GCAGAAGAAC GTACCAGGAG GGGTGCTCAA GATTCGAGAT 
GACAGTGAGG AACCCAGGCC GAGGAGGGGC AACGTGTGGC TGATCCCACC TCAGACATAC 
CTACAAGCTG AGGCCGAAGA GGGCCGGAAC ATGGAGAAGA GAAGGAATCT TCTGAATTGC 
CTTGTTGTCC GAATCCTCAA GGCTCACGGG GATGAAGGCT TGCATGTTGA CCGGCTCGTC 
TATCTGGTGC TAGAAGCGTG GGAGAAAGGC CCGTGTCCTG CTAGGGGTCT GGTCAGCAGC 
CTCGGCAGGG GAGCAACCTG CAGGAGCTCT GATGTCCTCT CCTGCATCCT GCACCTCCTG 
GTCAAGGGCA CGCTGAGACG CCATGACGAC CGGCCGCAGG TGCTGTACTA TGCAGTTCCT 
GTAACTGTGA TGGAGCCCCA CATGGAGTCC CTGAACCCTG GCTCGGCAGG CCCCAATCCA 
CCCCTCACCT TCCACACCCT GCAGATTCGA TCCCGGGGTG TGCCTTACGC CTCCTGCACT 
GATAACCACA CCTTCTCCAC TTTCCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.
Molecular cell54(5)805-19(2014 Jun)
Li Z,Pei XH,Yan J,Yan F,Cappell KM,Whitehurst AW,Xiong Y

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.
Cellular signalling26(2)233-239(2014 Feb)
Scheufele F,Wolf B,Kruse M,Hartmann T,Lempart J,M?hlich S,Pfeiffer AFH,Field LJ,Charron MJ,Pan ZQ,Engelhardt S,Sarikas A

An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.
PLoS biology9(5)e1001060(2011 May)
Litterman N,Ikeuchi Y,Gallardo G,O'Connell BC,Sowa ME,Gygi SP,Harper JW,Bonni A

Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction.
Heart (British Cardiac Society)95(14)1159-64(2009 Jul)
Hassink RJ,Nakajima H,Nakajima HO,Doevendans PA,Field LJ

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Cul7 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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