Bhmt2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bhmt2
Entrez Gene ID	64918
Full Name	betaine-homocysteine methyltransferase 2
Synonyms	C81077,D13Ucla2
General protein information	Preferred Names betaine-homocysteine methyltransferase 2 Names S-methylmethionine--homocysteine S-methyltransferase BHMT2 SMM-hcy methyltransferase betaine--homocysteine S-methyltransferase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 C3\|13 47.88 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_022884.2	NP_075022.2	S-methylmethionine--homocysteine S-methyltransferase BHMT2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	BHMT2	XP_527207.2
Rattus norvegicus (Norway rat)	Bhmt2	NP_001014278.2
Homo sapiens (human)	BHMT2	NP_060084.2
Bos taurus (cattle)	BHMT2	XP_003586562.2
	BHMT2	XP_001103987.1
Canis lupus familiaris (dog)	BHMT2	XP_546051.2
Mus musculus (house mouse)	Bhmt2	NP_075022.2

Gene Ontology
Bibliography

Related articles in PubMed

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Tamplin OJ, Cox BJ, Rossant J
Developmental biology360(2)415-25(2011 Dec)

Yeast, plants, worms, and flies use a methyltransferase to metabolize age-damaged (R,S)-AdoMet, but what do mammals do?
Vinci CR, Clarke SG
Rejuvenation research13(2-3)362-4(2010 Apr-Jun)

An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity.
Liu HH, Lu P, Guo Y, Farrell E, Zhang X, Zheng M, Bosano B, Zhang Z, Allard J, Liao G, Fu S, Chen J, Dolim K, Kuroda A, Usuka J, Cheng J, Tao W, Welch K, Liu Y, Pease J, de Keczer SA, Masjedizadeh M, Hu JS, Weller P, Garrow T, Peltz G
Genome research20(1)28-35(2010 Jan)

Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes.
Chadwick LH, McCandless SE, Silverman GL, Schwartz S, Westaway D, Nadeau JH
Genomics70(1)66-73(2000 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the mouse liver extracts, containing the BHMT-2 homocysteine methyltransferase candidate for a similar activity, recognizes (S,S)-AdoMet but not (R,S)-AdoMet.
Title: Yeast, plants, worms, and flies use a methyltransferase to metabolize age-damaged (R,S)-AdoMet, but what do mammals do?

Betaine-homocysteine methyltransferase 2 (Bhmt2) was identified as a diet-dependent genetic factor that affected susceptibility to acetaminophen-induced liver toxicity in mice.
Title: An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity.

The following Bhmt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bhmt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12649	NM_022884.2 Latest version!	Mus musculus betaine-homocysteine methyltransferase 2 (Bhmt2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bhmt2 ( NM_022884.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_075022.2 Mus musculus betaine-homocysteine methyltransferase 2 (Bhmt2), mRNA.

Price & Availability↑

CloneID	OMu12649
Clone ID Related Accession (Same CDS sequence)	NM_022884.2
Accession Version	NM_022884.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1092bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	S-methylmethionine--homocysteine S-methyltransferase BHMT2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK145901.1 and AA014354.1. On Apr 20, 2007 this sequence version replaced NM_022884.1. ##Evidence-Data-START## Transcript exon combination :: BC013515.1, AK145901.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGGCACCAG CTGGAAGCAC TCGAGCCAAG AAGGGCATCT TGGAGCGTCT GGACAGCGGG 
GAGGTGGTGG TTGGGGACAG CGGCTTTCTC TTCACTCTGG AAAAGAGAGG CTTCGTGAAG 
GCGGGGCTTT GGACTCCAGA AGCAGTGGTA GAACATCCAA GTGCAGTTCG TCAACTTCAC 
ACAGAATTCT TGAGAGCGGG AGCTGATGTC TTGCAGACAT TCACCTTTTC TGCTACTGAA 
GACAATATGG CCAGCAAGTG GGAAGCTGTG AATGCAGCTG CCTGTGACCT GGCCCAGGAG 
GTGGCTGGTG GAGGGGGTGC TTTGGTGGCA GGGGGCATCT GCCAGACATC ACTCTACAAG 
TACCACAAGG ATGAAACTAG AATTAAAAAC ATTTTTCGAC TACAGCTAGA AGTTTTTGCC 
AGGAAAAATG TGGACTTCTT GATTGCAGAG TATTTTGAGC ATGTGGAAGA AGCTGTATGG 
GCTGTCGAAG TCTTGAGAGA GGTGGGGGCA CCTGTGGCTG TGACCATGTG CATCGGCCCA 
GAGGGGGACA TGCACGACGT GACACCTGGA GAGTGTGCGG TGAAGCTGGC GCGTGCAGGG 
GCGGACATCA TTGGGGTCAA CTGCCGGTTT GGGCCCTGGA CTAGCTTGCA GACCATGAAG 
CTCATGAAAG AGGGCCTCAG AGATGCCAGC CTGCAGGCTC ACCTTATGGT CCAGTGCTTG 
GGCTTCCACA CACCGGACTG TGGCAAGGGA GGGTTTGTGG ACCTCCCAGA GTATCCCTTT 
GGCCTGGAGC CAAGAGTTGC CACCAGATGG GATATTCAAA AATACGCCAG AGAGGCCTAC 
AACCTGGGGA TCAGGTACAT TGGCGGCTGC TGCGGATTTG AGCCCTACCA CATCAGGGCG 
ATTGCAGAGG AACTGGCCCC AGAAAGGGGA TTTTTGCCAC CGGCTTCAGA GAAACATGGC 
AGCTGGGGAA GTGGTCTGAA CATGCACACC AAACCCTGGA TCAGAGCAAG GGCTAGACGA 
GAATACTGGG AGAATCTGCT GCCAGCCTCA GGAAGACCTT TCTGTCCTTC CCTATCAAAG 
CCAGATGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075022.2
CDS	33..1124
Translation	MAPAGSTRAKKGILERLDSGEVVVGDSGFLFTLEKRGFVKAGLWTPEAVVEHPSAVRQLHTEFLRAGADVLQTFTFSATEDNMASKWEAVNAAACDLAQEVAGGGGALVAGGICQTSLYKYHKDETRIKNIFRLQLEVFARKNVDFLIAEYFEHVEEAVWAVEVLREVGAPVAVTMCIGPEGDMHDVTPGECAVKLARAGADIIGVNCRFGPWTSLQTMKLMKEGLRDASLQAHLMVQCLGFHTPDCGKGGFVDLPEYPFGLEPRVATRWDIQKYAREAYNLGIRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLNMHTKPWIRARARREYWENLLPASGRPFCPSLSKPDA

Target ORF information:

RefSeq Version	NM_022884.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus betaine-homocysteine methyltransferase 2 (Bhmt2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022884.2

ORF Insert Sequence:

ATGGCACCAG CTGGAAGCAC TCGAGCCAAG AAGGGCATCT TGGAGCGTCT GGACAGCGGG 
GAGGTGGTGG TTGGGGACAG CGGCTTTCTC TTCACTCTGG AAAAGAGAGG CTTCGTGAAG 
GCGGGGCTTT GGACTCCAGA AGCAGTGGTA GAACATCCAA GTGCAGTTCG TCAACTTCAC 
ACAGAATTCT TGAGAGCGGG AGCTGATGTC TTGCAGACAT TCACCTTTTC TGCTACTGAA 
GACAATATGG CCAGCAAGTG GGAAGCTGTG AATGCAGCTG CCTGTGACCT GGCCCAGGAG 
GTGGCTGGTG GAGGGGGTGC TTTGGTGGCA GGGGGCATCT GCCAGACATC ACTCTACAAG 
TACCACAAGG ATGAAACTAG AATTAAAAAC ATTTTTCGAC TACAGCTAGA AGTTTTTGCC 
AGGAAAAATG TGGACTTCTT GATTGCAGAG TATTTTGAGC ATGTGGAAGA AGCTGTATGG 
GCTGTCGAAG TCTTGAGAGA GGTGGGGGCA CCTGTGGCTG TGACCATGTG CATCGGCCCA 
GAGGGGGACA TGCACGACGT GACACCTGGA GAGTGTGCGG TGAAGCTGGC GCGTGCAGGG 
GCGGACATCA TTGGGGTCAA CTGCCGGTTT GGGCCCTGGA CTAGCTTGCA GACCATGAAG 
CTCATGAAAG AGGGCCTCAG AGATGCCAGC CTGCAGGCTC ACCTTATGGT CCAGTGCTTG 
GGCTTCCACA CACCGGACTG TGGCAAGGGA GGGTTTGTGG ACCTCCCAGA GTATCCCTTT 
GGCCTGGAGC CAAGAGTTGC CACCAGATGG GATATTCAAA AATACGCCAG AGAGGCCTAC 
AACCTGGGGA TCAGGTACAT TGGCGGCTGC TGCGGATTTG AGCCCTACCA CATCAGGGCG 
ATTGCAGAGG AACTGGCCCC AGAAAGGGGA TTTTTGCCAC CGGCTTCAGA GAAACATGGC 
AGCTGGGGAA GTGGTCTGAA CATGCACACC AAACCCTGGA TCAGAGCAAG GGCTAGACGA 
GAATACTGGG AGAATCTGCT GCCAGCCTCA GGAAGACCTT TCTGTCCTTC CCTATCAAAG 
CCAGATGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.
Developmental biology360(2)415-25(2011 Dec)
Tamplin OJ,Cox BJ,Rossant J

Yeast, plants, worms, and flies use a methyltransferase to metabolize age-damaged (R,S)-AdoMet, but what do mammals do?
Rejuvenation research13(2-3)362-4(2010 Apr-Jun)
Vinci CR,Clarke SG

An integrative genomic analysis identifies Bhmt2 as a diet-dependent genetic factor protecting against acetaminophen-induced liver toxicity.
Genome research20(1)28-35(2010 Jan)
Liu HH,Lu P,Guo Y,Farrell E,Zhang X,Zheng M,Bosano B,Zhang Z,Allard J,Liao G,Fu S,Chen J,Dolim K,Kuroda A,Usuka J,Cheng J,Tao W,Welch K,Liu Y,Pease J,de Keczer SA,Masjedizadeh M,Hu JS,Weller P,Garrow T,Peltz G

Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes.
Genomics70(1)66-73(2000 Nov)
Chadwick LH,McCandless SE,Silverman GL,Schwartz S,Westaway D,Nadeau JH

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Bhmt2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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