Il20 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il20
Entrez Gene ID	58181
Full Name	interleukin 20
Synonyms	Zcyto10
General protein information	Preferred Names interleukin 20 Names interleukin-20 IL-20 cytokine Zcyto10 four alpha helix cytokine ZCYTO10 four helix bundle cytokine 10
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 E4

mRNA and Protein(s)

mRNA	Protein	Name
NM_001311091.1	NP_001298020.1	interleukin-20 isoform 2
NM_021380.2	NP_067355.1	interleukin-20 isoform 1 precursor

Pathways from BioSystems

Homologies

	IL20	XP_001084726.2
Rattus norvegicus (Norway rat)	Il20	NP_001137353.1
Gallus gallus (chicken)	IL19	XP_425824.2
Canis lupus familiaris (dog)	IL20	XP_851510.1
Pan troglodytes (chimpanzee)	IL20	XP_001165196.2
Bos taurus (cattle)	IL20	XP_002693938.2
Homo sapiens (human)	IL20	NP_061194.2
Mus musculus (house mouse)	Il20	NP_067355.1
Danio rerio (zebrafish)	il34	NP_001076424.1

Gene Ontology
Bibliography

Related articles in PubMed

IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice.
Kolumam G, Wu X, Lee WP, Hackney JA, Zavala-Solorio J, Gandham V, Danilenko DM, Arora P, Wang X, Ouyang W
PloS one12(1)e0170639(2017)

Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis.
Hsu YH, Chiu YS, Chen WY, Huang KY, Jou IM, Wu PT, Wu CH, Chang MS
Scientific reports624339(2016 Apr)

AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin.
Garcin G, Guiraud I, Lacroix M, Genthon C, Rialle S, Joujoux JM, Meunier L, Lavabre-Bertrand T, Stoebner PE, Le Gallic L
The Journal of investigative dermatology135(11)2732-2741(2015 Nov)

Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without Affecting HbA1c in Type 2 Diabetic db/db Mice.
Mayer C, Bergholdt R, Cucak H, Rolin BC, Sams A, Rosendahl A
PloS one10(7)e0131306(2015)

Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models.
Hsu YH, Hsing CH, Li CF, Chan CH, Chang MC, Yan JJ, Chang MS
Journal of immunology (Baltimore, Md. : 1950)188(4)1981-91(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22, and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) .
Title: IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice.

The authors conclude that IL-20 affects bone formation and downregulates osteoblastogenesis by modulating sclerostin, osterix, RUNX2, and osteoprotegerin on osteoblasts.
Title: Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis.

IL-20 is primarily up regulated in psoriatic skin at the post-transcriptional level.
Title: AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin.

Data show that interleukin 20 (IL-20) is expressed in type 2 diabetic db/db islets and contributes to inflammation.
Title: Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without Affecting HbA1c in Type 2 Diabetic db/db Mice.

our results suggest that IL-20 plays pivotal roles in the tumor progression of breast cancer. IL-20 expression in breast cancer tissue is associated with a poor clinical outcome.
Title: Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models.

The following Il20 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il20 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58121	NM_021380.2 Latest version!	Mus musculus interleukin 20 (Il20), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu69768	NM_001311091.1 Latest version!	Mus musculus interleukin 20 (Il20), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il20 ( NM_021380.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067355.1 Mus musculus interleukin 20 (Il20), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu58121
Clone ID Related Accession (Same CDS sequence)	NM_021380.2
Accession Version	NM_021380.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	interleukin-20 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF224267.1 and BB064801.2. On Jul 24, 2015 this sequence version replaced NM_021380.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK078698.1, BC111821.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAAGGCT TTGGTCTTGC CTTTGGACTG TTCTCCGCTG TGGGTTTTCT TCTCTGGACT 
CCTTTAACTG GGCTCAAGAC CCTCCATTTG GGAAGCTGTG TGATTACTGC AAACCTACAG 
GCAATACAAA AGGAATTTTC TGAGATTCGG GATAGTGTGC AAGCTGAAGA TACAAATATT 
GACATCAGAA TTTTAAGGAC GACTGAGTCT TTGAAAGACA TAAAGTCTTT GGATAGGTGC 
TGCTTCCTTC GTCATCTAGT GAGATTCTAT CTGGACAGGG TATTCAAAGT CTACCAGACC 
CCTGACCACC ATACCCTGAG AAAGATCAGC AGCCTCGCCA ACTCCTTTCT TATCATCAAG 
AAGGACCTCT CAGTCTGTCA TTCTCACATG GCATGTCATT GTGGGGAAGA AGCAATGGAG 
AAATACAACC AAATTCTGAG TCACTTCATA GAGTTGGAAC TTCAGGCAGC GGTGGTAAAG 
GCTTTGGGAG AACTAGGCAT TCTTCTGAGA TGGATGGAGG AGATGCTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067355.1
CDS	71..601
Translation	MKGFGLAFGLFSAVGFLLWTPLTGLKTLHLGSCVITANLQAIQKEFSEIRDSVQAEDTNIDIRILRTTESLKDIKSLDRCCFLRHLVRFYLDRVFKVYQTPDHHTLRKISSLANSFLIIKKDLSVCHSHMACHCGEEAMEKYNQILSHFIELELQAAVVKALGELGILLRWMEEML

Target ORF information:

RefSeq Version	NM_021380.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 20 (Il20), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021380.2

ORF Insert Sequence:

ATGAAAGGCT TTGGTCTTGC CTTTGGACTG TTCTCCGCTG TGGGTTTTCT TCTCTGGACT 
CCTTTAACTG GGCTCAAGAC CCTCCATTTG GGAAGCTGTG TGATTACTGC AAACCTACAG 
GCAATACAAA AGGAATTTTC TGAGATTCGG GATAGTGTGC AAGCTGAAGA TACAAATATT 
GACATCAGAA TTTTAAGGAC GACTGAGTCT TTGAAAGACA TAAAGTCTTT GGATAGGTGC 
TGCTTCCTTC GTCATCTAGT GAGATTCTAT CTGGACAGGG TATTCAAAGT CTACCAGACC 
CCTGACCACC ATACCCTGAG AAAGATCAGC AGCCTCGCCA ACTCCTTTCT TATCATCAAG 
AAGGACCTCT CAGTCTGTCA TTCTCACATG GCATGTCATT GTGGGGAAGA AGCAATGGAG 
AAATACAACC AAATTCTGAG TCACTTCATA GAGTTGGAAC TTCAGGCAGC GGTGGTAAAG 
GCTTTGGGAG AACTAGGCAT TCTTCTGAGA TGGATGGAGG AGATGCTATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il20 ( NM_001311091.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001298020.1 Mus musculus interleukin 20 (Il20), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu69768
Clone ID Related Accession (Same CDS sequence)	NM_001311091.1
Accession Version	NM_001311091.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	interleukin-20 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF224267.1 and BB064801.2. On Jul 24, 2015 this sequence version replaced XM_006529765.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY876923.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAAGGCT TTGGTCTTGC CTTTGGACTG TTCTCCGCTG TGGGTTTTCT TCTCTGGACT 
CCTTTAACTG GGCTCAAGAC CCTCCATTTG GGAAGCTGTG TGATTACTGC AAACCTACAG 
GCAATACAAA AGGAATTTTC TGAGATTCGG GATAGTGTGT CTTTGGATAG GTGCTGCTTC 
CTTCGTCATC TAGTGAGATT CTATCTGGAC AGGGTATTCA AAGTCTACCA GACCCCTGAC 
CACCATACCC TGAGAAAGAT CAGCAGCCTC GCCAACTCCT TTCTTATCAT CAAGAAGGAC 
CTCTCAGTCT GTCATTCTCA CATGGCATGT CATTGTGGGG AAGAAGCAAT GGAGAAATAC 
AACCAAATTC TGAGTCACTT CATAGAGTTG GAACTTCAGG CAGCGGTGGT AAAGGCTTTG 
GGAGAACTAG GCATTCTTCT GAGATGGATG GAGGAGATGC TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298020.1
CDS	71..535
Translation	MKGFGLAFGLFSAVGFLLWTPLTGLKTLHLGSCVITANLQAIQKEFSEIRDSVSLDRCCFLRHLVRFYLDRVFKVYQTPDHHTLRKISSLANSFLIIKKDLSVCHSHMACHCGEEAMEKYNQILSHFIELELQAAVVKALGELGILLRWMEEML

Target ORF information:

RefSeq Version	NM_001311091.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 20 (Il20), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311091.1

ORF Insert Sequence:

ATGAAAGGCT TTGGTCTTGC CTTTGGACTG TTCTCCGCTG TGGGTTTTCT TCTCTGGACT 
CCTTTAACTG GGCTCAAGAC CCTCCATTTG GGAAGCTGTG TGATTACTGC AAACCTACAG 
GCAATACAAA AGGAATTTTC TGAGATTCGG GATAGTGTGT CTTTGGATAG GTGCTGCTTC 
CTTCGTCATC TAGTGAGATT CTATCTGGAC AGGGTATTCA AAGTCTACCA GACCCCTGAC 
CACCATACCC TGAGAAAGAT CAGCAGCCTC GCCAACTCCT TTCTTATCAT CAAGAAGGAC 
CTCTCAGTCT GTCATTCTCA CATGGCATGT CATTGTGGGG AAGAAGCAAT GGAGAAATAC 
AACCAAATTC TGAGTCACTT CATAGAGTTG GAACTTCAGG CAGCGGTGGT AAAGGCTTTG 
GGAGAACTAG GCATTCTTCT GAGATGGATG GAGGAGATGC TATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice.
PloS one12(1)e0170639(2017)
Kolumam G,Wu X,Lee WP,Hackney JA,Zavala-Solorio J,Gandham V,Danilenko DM,Arora P,Wang X,Ouyang W

Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis.
Scientific reports624339(2016 Apr)
Hsu YH,Chiu YS,Chen WY,Huang KY,Jou IM,Wu PT,Wu CH,Chang MS

AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin.
The Journal of investigative dermatology135(11)2732-2741(2015 Nov)
Garcin G,Guiraud I,Lacroix M,Genthon C,Rialle S,Joujoux JM,Meunier L,Lavabre-Bertrand T,Stoebner PE,Le Gallic L

Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without Affecting HbA1c in Type 2 Diabetic db/db Mice.
PloS one10(7)e0131306(2015)
Mayer C,Bergholdt R,Cucak H,Rolin BC,Sams A,Rosendahl A

Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models.
Journal of immunology (Baltimore, Md. : 1950)188(4)1981-91(2012 Feb)
Hsu YH,Hsing CH,Li CF,Chan CH,Chang MC,Yan JJ,Chang MS

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Il20 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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