Xrcc2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xrcc2
Entrez Gene ID	57434
Full Name	X-ray repair complementing defective repair in Chinese hamster cells 2
Synonyms	4921524O04Rik,8030409M04Rik,RAD51,RecA
General protein information	Preferred Names X-ray repair complementing defective repair in Chinese hamster cells 2 Names DNA repair protein XRCC2 X-ray repair cross-complementing protein 2 recA/RAD51 family protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_020570.2	NP_065595.2	DNA repair protein XRCC2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	XRCC2	XP_532771.3
Xenopus tropicalis (tropical clawed frog)	xrcc2	XP_002932541.2
Homo sapiens (human)	XRCC2	NP_005422.1
Rattus norvegicus (Norway rat)	Xrcc2	NP_001102685.1
	XRCC2	XP_001108141.1
Danio rerio (zebrafish)	LOC553395	XP_685091.2
Pan troglodytes (chimpanzee)	XRCC2	XP_001140134.1
Bos taurus (cattle)	XRCC2	NP_001095824.1
Mus musculus (house mouse)	Xrcc2	NP_065595.2
Gallus gallus (chicken)	XRCC2	XP_418543.3

Gene Ontology
Bibliography

Related articles in PubMed

ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4.
Pieraccioli M, Nicolai S, Antonov A, Somers J, Malewicz M, Melino G, Raschell? G
Oncogene35(20)2592-601(2016 05)

Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.
Lee Y, Brown EJ, Chang S, McKinnon PJ
The Journal of neuroscience : the official journal of the Society for Neuroscience34(23)7836-44(2014 Jun)

Identification of early replicating fragile sites that contribute to genome instability.
Barlow JH, Faryabi RB, Call?n E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A
Cell152(3)620-32(2013 Jan)

Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.
Cappelli E, Townsend S, Griffin C, Thacker J
Experimental cell research317(8)1203-13(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
Title: ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4.

Data show that XRCC2 and other homologous recombination proteins, including the key recombinase RAD51, co-localize with the centrosome, potentially to coordinate the deployment of a DNA damage response at vulnerable phases of the cell cycle.
Title: Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.

These findings indicate that Xrcc2 haploinsufficiency reduces spontaneous tumor incidence on an Apc(min/+) background but increases the tumorigenic response to radiation.
Title: Xrcc2 modulates spontaneous and radiation-induced tumorigenesis in Apcmin/+ mice.

An important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage.
Title: The importance of XRCC2 in RAD51-related DNA damage repair.

DNA replication licensing factor MCM2 and DNA mismatch repair (MMR) protein MSH2 were confirmed to be present in co-precipitations with MmXRCC2.
Title: The interaction profile of homologous recombination repair proteins RAD51C, RAD51D and XRCC2 as determined by proteomic analysis.

The following Xrcc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xrcc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12101	NM_020570.2 Latest version!	Mus musculus X-ray repair complementing defective repair in Chinese hamster cells 2 (Xrcc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xrcc2 ( NM_020570.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_065595.2 Mus musculus X-ray repair complementing defective repair in Chinese hamster cells 2 (Xrcc2), mRNA.

Price & Availability↑

CloneID	OMu12101
Clone ID Related Accession (Same CDS sequence)	NM_020570.2
Accession Version	NM_020570.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	DNA repair protein XRCC2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC033417.1. On Jun 9, 2003 this sequence version replaced NM_020570.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033417.1, Y17040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849379, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTAGCG ACTTTCGCAG AGCGGAATCC GGGACAGAGC TCCTTGCCCG ACTTGAAGGC 
AGAAGCTCGT TGAAAGAACT AGAACCCAAC CTGTTTGCTG ATGAAGATTC ACCAGTGCAC 
GGTGATATTT TTGAATTTCA TGGTCCAGAA GGAACGGGGA AAACAGAAAT GCTTTATCAT 
TTAACAGCCC GATGTATACT TCCAAAATCA GAGGGTGGAC TGCAAATAGA AGTCTTATTT 
ATTGATACAG ATTACCACTT TGACATGCTA CGGCTCGTGA CAGTTCTTGA ACACAGACTC 
TCGCAAAGCT CCGAGGAAGC CATGAAGCTG TGCCTAGCCA GGTTGTTCCT GGCGTACTGC 
AGCAGCAGCA TGCAGTTACT GCTCACGCTG CACTCCCTGG AAGCCCTGCT CTGCAGTCGC 
CCCTCTCTCT GCCTTCTCAT TGTGGACAGC CTGTCGTCTT TTTACTGGAT AGACCGAGTC 
AGTGGAGGAG AGAGTGTGGC CCTGCAGGAG TCAACGCTGC AGAAGTGCTC TCAGCTCCTA 
GAGCGGCTTG TCACTGAGTA CCGCTTGCTG CTTTTTGCGA CAACGCAGAG TCTAATGCAG 
AAAGGCTCAG ACTCTGCAGA CGGGCCTTCT TCCTCCAAGC ACCCATGCGA TGGAGACATG 
GGCTACAGAG CCTATCTCTG CAAGGCCTGG CAGAGGGTCG TGAAGCACAG GGTCATCTTC 
TCCAGGGACG ACGAGGCCAA GAGCAGCCGG TTCTCATTAG TTTCACGTCA TTTAAAAAGT 
AACAGTTTAA AAAAACACAG TTTTATGGTC AGAGAAAGTG GGGTGGAGTT TTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065595.2
CDS	82..918
Translation	MCSDFRRAESGTELLARLEGRSSLKELEPNLFADEDSPVHGDIFEFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQSSEEAMKLCLARLFLAYCSSSMQLLLTLHSLEALLCSRPSLCLLIVDSLSSFYWIDRVSGGESVALQESTLQKCSQLLERLVTEYRLLLFATTQSLMQKGSDSADGPSSSKHPCDGDMGYRAYLCKAWQRVVKHRVIFSRDDEAKSSRFSLVSRHLKSNSLKKHSFMVRESGVEFC

Target ORF information:

RefSeq Version	NM_020570.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus X-ray repair complementing defective repair in Chinese hamster cells 2 (Xrcc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020570.2

ORF Insert Sequence:

ATGTGTAGCG ACTTTCGCAG AGCGGAATCC GGGACAGAGC TCCTTGCCCG ACTTGAAGGC 
AGAAGCTCGT TGAAAGAACT AGAACCCAAC CTGTTTGCTG ATGAAGATTC ACCAGTGCAC 
GGTGATATTT TTGAATTTCA TGGTCCAGAA GGAACGGGGA AAACAGAAAT GCTTTATCAT 
TTAACAGCCC GATGTATACT TCCAAAATCA GAGGGTGGAC TGCAAATAGA AGTCTTATTT 
ATTGATACAG ATTACCACTT TGACATGCTA CGGCTCGTGA CAGTTCTTGA ACACAGACTC 
TCGCAAAGCT CCGAGGAAGC CATGAAGCTG TGCCTAGCCA GGTTGTTCCT GGCGTACTGC 
AGCAGCAGCA TGCAGTTACT GCTCACGCTG CACTCCCTGG AAGCCCTGCT CTGCAGTCGC 
CCCTCTCTCT GCCTTCTCAT TGTGGACAGC CTGTCGTCTT TTTACTGGAT AGACCGAGTC 
AGTGGAGGAG AGAGTGTGGC CCTGCAGGAG TCAACGCTGC AGAAGTGCTC TCAGCTCCTA 
GAGCGGCTTG TCACTGAGTA CCGCTTGCTG CTTTTTGCGA CAACGCAGAG TCTAATGCAG 
AAAGGCTCAG ACTCTGCAGA CGGGCCTTCT TCCTCCAAGC ACCCATGCGA TGGAGACATG 
GGCTACAGAG CCTATCTCTG CAAGGCCTGG CAGAGGGTCG TGAAGCACAG GGTCATCTTC 
TCCAGGGACG ACGAGGCCAA GAGCAGCCGG TTCTCATTAG TTTCACGTCA TTTAAAAAGT 
AACAGTTTAA AAAAACACAG TTTTATGGTC AGAGAAAGTG GGGTGGAGTT TTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4.
Oncogene35(20)2592-601(2016 05)
Pieraccioli M,Nicolai S,Antonov A,Somers J,Malewicz M,Melino G,Raschell? G

Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(23)7836-44(2014 Jun)
Lee Y,Brown EJ,Chang S,McKinnon PJ

Identification of early replicating fragile sites that contribute to genome instability.
Cell152(3)620-32(2013 Jan)
Barlow JH,Faryabi RB,Call?n E,Wong N,Malhowski A,Chen HT,Gutierrez-Cruz G,Sun HW,McKinnon P,Wright G,Casellas R,Robbiani DF,Staudt L,Fernandez-Capetillo O,Nussenzweig A

Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.
Experimental cell research317(8)1203-13(2011 May)
Cappelli E,Townsend S,Griffin C,Thacker J

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Xrcc2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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