Pdxp cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdxp
Entrez Gene ID	57028
Full Name	pyridoxal (pyridoxine, vitamin B6) phosphatase
Synonyms	1600027H05Rik,AB041662,PLPP
General protein information	Preferred Names pyridoxal (pyridoxine, vitamin B6) phosphatase Names pyridoxal phosphate phosphatase PLP phosphatase PLP-phosophatase chronophilin chronophin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_020271.3	NP_064667.2	pyridoxal phosphate phosphatase

Pathways from BioSystems

Homologies

Homo sapiens (human)	PDXP	NP_064711.1
Canis lupus familiaris (dog)	PDXP	XP_003431551.1
Bos taurus (cattle)	PDXP	NP_001030207.1
Mus musculus (house mouse)	Pdxp	NP_064667.2
Gallus gallus (chicken)	LOC771207	XP_003640432.1
Arabidopsis thaliana (thale cress)	AT5G36790	NP_001190428.1
Arabidopsis thaliana (thale cress)	PGLP1	NP_001190427.1
Rattus norvegicus (Norway rat)	Pdxp	NP_001129291.1
Danio rerio (zebrafish)	zgc:194409	NP_001122177.1
Oryza sativa (rice)	Os04g0490800	NP_001053167.1
Pan troglodytes (chimpanzee)	PDXP	XP_003317269.1

Gene Ontology
Bibliography

Related articles in PubMed

PLPP/CIN regulates bidirectional synaptic plasticity via GluN2A interaction with postsynaptic proteins.
Kim JE, Kim YJ, Lee DS, Kim JY, Ko AR, Hyun HW, Kim MJ, Kang TC
Scientific reports626576(2016 May)

Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
Seifried A, Knobloch G, Duraphe PS, Segerer G, Manhard J, Schindelin H, Schultz J, Gohla A
The Journal of biological chemistry289(6)3416-31(2014 Feb)

Chronophin dimerization is required for proper positioning of its substrate specificity loop.
Kestler C, Knobloch G, Tessmer I, Jeanclos E, Schindelin H, Gohla A
The Journal of biological chemistry289(5)3094-103(2014 Jan)

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio E, Imbert J, Nijman IJ, Suchanek M, Saito T, W?lfing C, Malissen B, Malissen M
Nature immunology14(8)858-66(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
Title: Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.

Dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP coordination.
Title: Chronophin dimerization is required for proper positioning of its substrate specificity loop.

analysis of pyridoxal phosphatase cloning, expression and tissue distribution
Title: Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution.

The following Pdxp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdxp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17746	NM_020271.3 Latest version!	Mus musculus pyridoxal (pyridoxine, vitamin B6) phosphatase (Pdxp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdxp ( NM_020271.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064667.2 Mus musculus pyridoxal (pyridoxine, vitamin B6) phosphatase (Pdxp), mRNA.

Price & Availability↑

CloneID	OMu17746
Clone ID Related Accession (Same CDS sequence)	NM_020271.3
Accession Version	NM_020271.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Mus musculus(house mouse)
Product	pyridoxal phosphate phosphatase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX236940.1, BC069982.1 and AI845716.1. On Jan 27, 2006 this sequence version replaced NM_020271.2. ##Evidence-Data-START## Transcript exon combination :: BC049107.1, BC046955.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCGCT GCGAGCGGCT GCGCGGCGCG GCCCTGCGCG ACGTGCTGGG CCAGGCGCAG 
GGAGTCCTGT TCGACTGCGA CGGAGTGCTG TGGAACGGCG AACGCATCGT GCCGGGCGCC 
CCTGAGCTGC TGCAGCGGCT GGCGCGGGCC GGCAAGAACA CGCTGTTCGT GAGCAACAAC 
AGCCGGCGCG CGCGGCCCGA GCTGGCGCTG CGCTTCGCCC GCCTGGGCTT CGCGGGGCTG 
CGCGCCGAGC AGCTCTTCAG CTCCGCGCTG TGTGCCGCGC GCCTCCTGCG CCAGCGGCTG 
TCCGGGCCGC CCGACGCATC GGGCGCAGTG TTCGTGCTGG GAGGCGAGGG GCTGCGCGCT 
GAGCTGCGCG CCGCGGGGCT GCGCCTGGCG GGGGACCCCG GCGAGGACCC GCGCGTGCGC 
GCCGTGCTCG TAGGCTACGA CGAGCAGTTT TCCTTCTCCA GGTTGACCGA GGCGTGCGCG 
CACCTGCGCG ACCCCGACTG CCTGCTCGTG GCCACCGATC GCGACCCTTG GCACCCGCTC 
AGCGACGGAA GCCGGACCCC CGGTACTGGA AGCCTGGCTG CCGCGGTGGA GACAGCCTCG 
GGACGCCAGG CCCTGGTGGT GGGCAAGCCC AGCCCTTACA TGTTCCAGTG CATCACAGAA 
GACTTCAGCG TGGACCCCGC CCGCACGCTG ATGGTGGGGG ACCGCCTGGA GACCGACATA 
CTCTTTGGCC ACCGCTGCGG CATGACCACC GTGCTCACGC TCACGGGCGT CTCCAGCCTC 
GAAGAAGCCC AGGCCTACCT GACGGCTGGC CAGCGTGACC TTGTGCCTCA CTACTATGTG 
GAGAGCATTG CGGACTTGAT GGAGGGGCTG GAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064667.2
CDS	52..930
Translation	MARCERLRGAALRDVLGQAQGVLFDCDGVLWNGERIVPGAPELLQRLARAGKNTLFVSNNSRRARPELALRFARLGFAGLRAEQLFSSALCAARLLRQRLSGPPDASGAVFVLGGEGLRAELRAAGLRLAGDPGEDPRVRAVLVGYDEQFSFSRLTEACAHLRDPDCLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFQCITEDFSVDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSSLEEAQAYLTAGQRDLVPHYYVESIADLMEGLED

Target ORF information:

RefSeq Version	NM_020271.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus pyridoxal (pyridoxine, vitamin B6) phosphatase (Pdxp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020271.3

ORF Insert Sequence:

ATGGCGCGCT GCGAGCGGCT GCGCGGCGCG GCCCTGCGCG ACGTGCTGGG CCAGGCGCAG 
GGAGTCCTGT TCGACTGCGA CGGAGTGCTG TGGAACGGCG AACGCATCGT GCCGGGCGCC 
CCTGAGCTGC TGCAGCGGCT GGCGCGGGCC GGCAAGAACA CGCTGTTCGT GAGCAACAAC 
AGCCGGCGCG CGCGGCCCGA GCTGGCGCTG CGCTTCGCCC GCCTGGGCTT CGCGGGGCTG 
CGCGCCGAGC AGCTCTTCAG CTCCGCGCTG TGTGCCGCGC GCCTCCTGCG CCAGCGGCTG 
TCCGGGCCGC CCGACGCATC GGGCGCAGTG TTCGTGCTGG GAGGCGAGGG GCTGCGCGCT 
GAGCTGCGCG CCGCGGGGCT GCGCCTGGCG GGGGACCCCG GCGAGGACCC GCGCGTGCGC 
GCCGTGCTCG TAGGCTACGA CGAGCAGTTT TCCTTCTCCA GGTTGACCGA GGCGTGCGCG 
CACCTGCGCG ACCCCGACTG CCTGCTCGTG GCCACCGATC GCGACCCTTG GCACCCGCTC 
AGCGACGGAA GCCGGACCCC CGGTACTGGA AGCCTGGCTG CCGCGGTGGA GACAGCCTCG 
GGACGCCAGG CCCTGGTGGT GGGCAAGCCC AGCCCTTACA TGTTCCAGTG CATCACAGAA 
GACTTCAGCG TGGACCCCGC CCGCACGCTG ATGGTGGGGG ACCGCCTGGA GACCGACATA 
CTCTTTGGCC ACCGCTGCGG CATGACCACC GTGCTCACGC TCACGGGCGT CTCCAGCCTC 
GAAGAAGCCC AGGCCTACCT GACGGCTGGC CAGCGTGACC TTGTGCCTCA CTACTATGTG 
GAGAGCATTG CGGACTTGAT GGAGGGGCTG GAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PLPP/CIN regulates bidirectional synaptic plasticity via GluN2A interaction with postsynaptic proteins.
Scientific reports626576(2016 May)
Kim JE,Kim YJ,Lee DS,Kim JY,Ko AR,Hyun HW,Kim MJ,Kang TC

Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
The Journal of biological chemistry289(6)3416-31(2014 Feb)
Seifried A,Knobloch G,Duraphe PS,Segerer G,Manhard J,Schindelin H,Schultz J,Gohla A

Chronophin dimerization is required for proper positioning of its substrate specificity loop.
The Journal of biological chemistry289(5)3094-103(2014 Jan)
Kestler C,Knobloch G,Tessmer I,Jeanclos E,Schindelin H,Gohla A

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Nature immunology14(8)858-66(2013 Aug)
Liang Y,Cucchetti M,Roncagalli R,Yokosuka T,Malzac A,Bertosio E,Imbert J,Nijman IJ,Suchanek M,Saito T,W?lfing C,Malissen B,Malissen M

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Pdxp cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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