Litaf cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Litaf
Entrez Gene ID	56722
Full Name	LPS-induced TN factor
Synonyms	3222402J11Rik,C85531,N4WBP3,TBX1
General protein information	Preferred Names LPS-induced TN factor Names lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog LITAF-like protein LPS-induced TNF-alpha factor homolog Nedd4 WW domain-binding protein 3 estrogen-enhanced transcript protein mEET
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 A1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006522427.1	XP_006522490.1	lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1
XM_030249222.1	XP_030105082.1	lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1
NM_019980.2	NP_064364.1	lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

Pathways from BioSystems

Homologies

Homo sapiens (human)	LITAF	NP_004853.2
	LITAF	XP_002802449.1
Mus musculus (house mouse)	Litaf	NP_064364.1
Danio rerio (zebrafish)	litaf	NP_001002184.1
Canis lupus familiaris (dog)	LITAF	XP_547124.2
Bos taurus (cattle)	LITAF	NP_001039717.1
Xenopus tropicalis (tropical clawed frog)	litaf	NP_988970.1
Gallus gallus (chicken)	LITAF	NP_989598.1
Pan troglodytes (chimpanzee)	LITAF	XP_001142641.1
Rattus norvegicus (Norway rat)	Litaf	NP_001099205.1

Gene Ontology
Bibliography

Related articles in PubMed

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Kennedy AJ, Rahn EJ, Paulukaitis BS, Savell KE, Kordasiewicz HB, Wang J, Lewis JW, Posey J, Strange SK, Guzman-Karlsson MC, Phillips SE, Decker K, Motley ST, Swayze EE, Ecker DJ, Michael TP, Day JJ, Sweatt JD
Cell reports16(10)2666-2685(2016 09)

LPS-induced TNF-? factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease.
Ceccarelli S, Panera N, Mina M, Gnani D, De Stefanis C, Crudele A, Rychlicki C, Petrini S, Bruscalupi G, Agostinelli L, Stronati L, Cucchiara S, Musso G, Furlanello C, Svegliati-Baroni G, Nobili V, Alisi A
Oncotarget6(39)41434-52(2015 Dec)

Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.
Li W, Zhu H, Zhao X, Brancho D, Liang Y, Zou Y, Bennett C, Chow CW
Molecular and cellular biology35(14)2464-78(2015 Jul)

Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes.
Zhu H, Guariglia S, Yu RY, Li W, Brancho D, Peinado H, Lyden D, Salzer J, Bennett C, Chow CW
Molecular biology of the cell24(11)1619-37, S1-3(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suggest LITAF as regulatory of pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease.
Title: LPS-induced TNF-? factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease.

Data suggest that atypical inflammatory signaling kinetics may account for the gain of function elicited by the Litaf protein SIMPLE mutation in Charcot-Marie-Tooth Type 1C (CMT1C) patients.
Title: Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.

Mutation of SIMPLE (Litaf) in Charcot-Marie-Tooth 1C alters production of exosomes.
Title: Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes.

This study demonistrated that loss of Litaf function is unlikely to be a major contributor to Charcot-Marie-Tooth disease, but modulating effects of macrophages need to be considered in the etiology of the disease.
Title: LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease.

Whole-body deletion of LPS-induced TNF-alpha factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis.
Title: Whole-body deletion of LPS-induced TNF-? factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis.

The following Litaf gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Litaf cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu11854	NM_019980.2 Latest version!	Mus musculus LPS-induced TN factor (Litaf), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu11854	XM_006522427.1 Latest version!	Mus musculus LPS-induced TN factor (Litaf), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu11854	XM_030249222.1 Latest version!	Mus musculus LPS-induced TN factor (Litaf), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Litaf ( NM_019980.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064364.1 Mus musculus LPS-induced TN factor (Litaf), mRNA.

Price & Availability↑

CloneID	OMu11854
Clone ID Related Accession (Same CDS sequence)	XM_006522427.1 , XM_030249222.1 , NM_019980.2
Accession Version	NM_019980.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Mus musculus(house mouse)
Product	lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK076162.1 and BX637242.1. On Apr 14, 2009 this sequence version replaced NM_019980.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK078708.1, AK076162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGGCTC CAGGACCTTA CCAAGCAGCT GCAGGCCCTT CAGTAGTGCC CACCGCACCC 
CCAACCTATG AAGAAACAGT GGGTGTCAAC AGTTACTACC CAACGCCCCC AGCACCTATG 
CCGGGACCAG CCACAGGGCT CATTACAGGC CCAGATGGGA AGGGAATGAA TCCACCTTCG 
TACTACACCC AGCCTGTGCC TGTCCCCAAC GCCAACGCAA TTGCCGTGCA GACCGTTTAT 
GTGCAGCAGC CTGTCTCCTT CTATGACCGC CCCGTCCAGA TGTGCTGTCC TTCCTGCAGC 
AAGATGATCG TGACCCAGCT GTCCTACAAT GCGGGAGCCC TCACCTGGCT CTCCTGTGGC 
AGTCTGTGTC TGCTGGGATG CGTTGCTGGC TGCTGCTTCA TCCCGTTCTG CGTAGACGCC 
CTACAGGATG TGGACCACTA CTGCCCCAAC TGCAAAGCGC TCCTGGGCAC CTACAAGCGC 
TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064364.1
CDS	82..567
Translation	MSAPGPYQAAAGPSVVPTAPPTYEETVGVNSYYPTPPAPMPGPATGLITGPDGKGMNPPSYYTQPVPVPNANAIAVQTVYVQQPVSFYDRPVQMCCPSCSKMIVTQLSYNAGALTWLSCGSLCLLGCVAGCCFIPFCVDALQDVDHYCPNCKALLGTYKRL

Target ORF information:

RefSeq Version	NM_019980.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus LPS-induced TN factor (Litaf), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019980.2

ORF Insert Sequence:

ATGTCGGCTC CAGGACCTTA CCAAGCAGCT GCAGGCCCTT CAGTAGTGCC CACCGCACCC 
CCAACCTATG AAGAAACAGT GGGTGTCAAC AGTTACTACC CAACGCCCCC AGCACCTATG 
CCGGGACCAG CCACAGGGCT CATTACAGGC CCAGATGGGA AGGGAATGAA TCCACCTTCG 
TACTACACCC AGCCTGTGCC TGTCCCCAAC GCCAACGCAA TTGCCGTGCA GACCGTTTAT 
GTGCAGCAGC CTGTCTCCTT CTATGACCGC CCCGTCCAGA TGTGCTGTCC TTCCTGCAGC 
AAGATGATCG TGACCCAGCT GTCCTACAAT GCGGGAGCCC TCACCTGGCT CTCCTGTGGC 
AGTCTGTGTC TGCTGGGATG CGTTGCTGGC TGCTGCTTCA TCCCGTTCTG CGTAGACGCC 
CTACAGGATG TGGACCACTA CTGCCCCAAC TGCAAAGCGC TCCTGGGCAC CTACAAGCGC 
TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Litaf ( XM_006522427.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006522490.1 Mus musculus LPS-induced TN factor (Litaf), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu11854
Clone ID Related Accession (Same CDS sequence)	XM_006522427.1 , XM_030249222.1 , NM_019980.2
Accession Version	XM_006522427.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGCTC CAGGACCTTA CCAAGCAGCT GCAGGCCCTT CAGTAGTGCC CACCGCACCC 
CCAACCTATG AAGAAACAGT GGGTGTCAAC AGTTACTACC CAACGCCCCC AGCACCTATG 
CCGGGACCAG CCACAGGGCT CATTACAGGC CCAGATGGGA AGGGAATGAA TCCACCTTCG 
TACTACACCC AGCCTGTGCC TGTCCCCAAC GCCAACGCAA TTGCCGTGCA GACCGTTTAT 
GTGCAGCAGC CTGTCTCCTT CTATGACCGC CCCGTCCAGA TGTGCTGTCC TTCCTGCAGC 
AAGATGATCG TGACCCAGCT GTCCTACAAT GCGGGAGCCC TCACCTGGCT CTCCTGTGGC 
AGTCTGTGTC TGCTGGGATG CGTTGCTGGC TGCTGCTTCA TCCCGTTCTG CGTAGACGCC 
CTACAGGATG TGGACCACTA CTGCCCCAAC TGCAAAGCGC TCCTGGGCAC CTACAAGCGC 
TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006522490.1
CDS	185..670
Translation	MSAPGPYQAAAGPSVVPTAPPTYEETVGVNSYYPTPPAPMPGPATGLITGPDGKGMNPPSYYTQPVPVPNANAIAVQTVYVQQPVSFYDRPVQMCCPSCSKMIVTQLSYNAGALTWLSCGSLCLLGCVAGCCFIPFCVDALQDVDHYCPNCKALLGTYKRL

Target ORF information:

RefSeq Version	XM_006522427.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus LPS-induced TN factor (Litaf), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006522427.1

ORF Insert Sequence:

ATGTCGGCTC CAGGACCTTA CCAAGCAGCT GCAGGCCCTT CAGTAGTGCC CACCGCACCC 
CCAACCTATG AAGAAACAGT GGGTGTCAAC AGTTACTACC CAACGCCCCC AGCACCTATG 
CCGGGACCAG CCACAGGGCT CATTACAGGC CCAGATGGGA AGGGAATGAA TCCACCTTCG 
TACTACACCC AGCCTGTGCC TGTCCCCAAC GCCAACGCAA TTGCCGTGCA GACCGTTTAT 
GTGCAGCAGC CTGTCTCCTT CTATGACCGC CCCGTCCAGA TGTGCTGTCC TTCCTGCAGC 
AAGATGATCG TGACCCAGCT GTCCTACAAT GCGGGAGCCC TCACCTGGCT CTCCTGTGGC 
AGTCTGTGTC TGCTGGGATG CGTTGCTGGC TGCTGCTTCA TCCCGTTCTG CGTAGACGCC 
CTACAGGATG TGGACCACTA CTGCCCCAAC TGCAAAGCGC TCCTGGGCAC CTACAAGCGC 
TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Litaf ( XM_030249222.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030105082.1 Mus musculus LPS-induced TN factor (Litaf), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu11854
Clone ID Related Accession (Same CDS sequence)	XM_006522427.1 , XM_030249222.1 , NM_019980.2
Accession Version	XM_030249222.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGCTC CAGGACCTTA CCAAGCAGCT GCAGGCCCTT CAGTAGTGCC CACCGCACCC 
CCAACCTATG AAGAAACAGT GGGTGTCAAC AGTTACTACC CAACGCCCCC AGCACCTATG 
CCGGGACCAG CCACAGGGCT CATTACAGGC CCAGATGGGA AGGGAATGAA TCCACCTTCG 
TACTACACCC AGCCTGTGCC TGTCCCCAAC GCCAACGCAA TTGCCGTGCA GACCGTTTAT 
GTGCAGCAGC CTGTCTCCTT CTATGACCGC CCCGTCCAGA TGTGCTGTCC TTCCTGCAGC 
AAGATGATCG TGACCCAGCT GTCCTACAAT GCGGGAGCCC TCACCTGGCT CTCCTGTGGC 
AGTCTGTGTC TGCTGGGATG CGTTGCTGGC TGCTGCTTCA TCCCGTTCTG CGTAGACGCC 
CTACAGGATG TGGACCACTA CTGCCCCAAC TGCAAAGCGC TCCTGGGCAC CTACAAGCGC 
TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030105082.1
CDS	249..734
Translation	MSAPGPYQAAAGPSVVPTAPPTYEETVGVNSYYPTPPAPMPGPATGLITGPDGKGMNPPSYYTQPVPVPNANAIAVQTVYVQQPVSFYDRPVQMCCPSCSKMIVTQLSYNAGALTWLSCGSLCLLGCVAGCCFIPFCVDALQDVDHYCPNCKALLGTYKRL

Target ORF information:

RefSeq Version	XM_030249222.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus LPS-induced TN factor (Litaf), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030249222.1

ORF Insert Sequence:

ATGTCGGCTC CAGGACCTTA CCAAGCAGCT GCAGGCCCTT CAGTAGTGCC CACCGCACCC 
CCAACCTATG AAGAAACAGT GGGTGTCAAC AGTTACTACC CAACGCCCCC AGCACCTATG 
CCGGGACCAG CCACAGGGCT CATTACAGGC CCAGATGGGA AGGGAATGAA TCCACCTTCG 
TACTACACCC AGCCTGTGCC TGTCCCCAAC GCCAACGCAA TTGCCGTGCA GACCGTTTAT 
GTGCAGCAGC CTGTCTCCTT CTATGACCGC CCCGTCCAGA TGTGCTGTCC TTCCTGCAGC 
AAGATGATCG TGACCCAGCT GTCCTACAAT GCGGGAGCCC TCACCTGGCT CTCCTGTGGC 
AGTCTGTGTC TGCTGGGATG CGTTGCTGGC TGCTGCTTCA TCCCGTTCTG CGTAGACGCC 
CTACAGGATG TGGACCACTA CTGCCCCAAC TGCAAAGCGC TCCTGGGCAC CTACAAGCGC 
TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.
Cell reports16(10)2666-2685(2016 09)
Kennedy AJ,Rahn EJ,Paulukaitis BS,Savell KE,Kordasiewicz HB,Wang J,Lewis JW,Posey J,Strange SK,Guzman-Karlsson MC,Phillips SE,Decker K,Motley ST,Swayze EE,Ecker DJ,Michael TP,Day JJ,Sweatt JD

LPS-induced TNF-? factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease.
Oncotarget6(39)41434-52(2015 Dec)
Ceccarelli S,Panera N,Mina M,Gnani D,De Stefanis C,Crudele A,Rychlicki C,Petrini S,Bruscalupi G,Agostinelli L,Stronati L,Cucchiara S,Musso G,Furlanello C,Svegliati-Baroni G,Nobili V,Alisi A

Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.
Molecular and cellular biology35(14)2464-78(2015 Jul)
Li W,Zhu H,Zhao X,Brancho D,Liang Y,Zou Y,Bennett C,Chow CW

Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes.
Molecular biology of the cell24(11)1619-37, S1-3(2013 Jun)
Zhu H,Guariglia S,Yu RY,Li W,Brancho D,Peinado H,Lyden D,Salzer J,Bennett C,Chow CW

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Litaf cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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