ARPC3 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARPC3
Entrez Gene ID	56378
Full Name	actin related protein 2/3 complex, subunit 3
Synonyms	1110006A04Rik,p21-ARC,p21-Ar,p21Arc
General protein information	Preferred Names actin related protein 2/3 complex, subunit 3 Names actin-related protein 2/3 complex subunit 3 Arp2/3 complex subunit p21-Arc arp2/3 complex 21 kDa subunit
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 5 Map Location: 5\|5 F

mRNA and Protein(s)

mRNA	Protein	Name
NM_019824.4	NP_062798.1	actin-related protein 2/3 complex subunit 3
NM_019824.3	NP_062798.1	actin-related protein 2/3 complex subunit 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	ARPC3	NP_001265485.1
Canis lupus familiaris (dog)	ARPC3	XP_003639957.1
Mus musculus (house mouse)	Arpc3	NP_062798.1
Eremothecium gossypii	AGOS_AFR584C	NP_986131.1
Arabidopsis thaliana (thale cress)	ARPC3	NP_001077743.1
Gallus gallus (chicken)	ARPC3	NP_001264415.1
Saccharomyces cerevisiae (baker's yeast)	ARC18	NP_013474.3
Schizosaccharomyces pombe (fission yeast)	arc3	NP_596291.1
	ARPC3	XP_001098559.2
Drosophila melanogaster (fruit fly)	Arpc3A	NP_650498.3
Kluyveromyces lactis	KLLA0B07821g	XP_451878.1
Neurospora crassa	NCU09572	XP_959683.1
Oryza sativa (rice)	Os02g0235000	NP_001046384.2
Pan troglodytes (chimpanzee)	ARPC3	NP_001238842.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001712	XP_321377.4
Caenorhabditis elegans (roundworm)	arx-5	NP_499667.1
Magnaporthe oryzae (rice blast fungus)	MGG_00307	XP_003718783.1
Xenopus tropicalis (tropical clawed frog)	arpc3	NP_001107138.1
Bos taurus (cattle)	ARPC3	NP_001029443.1
Rattus norvegicus (Norway rat)	Arpc3	NP_001099403.1
Danio rerio (zebrafish)	arpc3	NP_001002114.1

Gene Ontology
Bibliography

Related articles in PubMed

The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing.
Spence EF, Kanak DJ, Carlson BR, Soderling SH
The Journal of neuroscience : the official journal of the Society for Neuroscience36(37)9696-709(2016 Sep)

Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.
Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK
Cell165(2)434-448(2016 Apr)

CNS myelin wrapping is driven by actin disassembly.
Zuchero JB, Fu MM, Sloan SA, Ibrahim A, Olson A, Zaremba A, Dugas JC, Wienbar S, Caprariello AV, Kantor C, Leonoudakis D, Leonoudakus D, Lariosa-Willingham K, Kronenberg G, Gertz K, Soderling SH, Miller RH, Barres BA
Developmental cell34(2)152-67(2015 Jul)

Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.
Kim IH, Rossi MA, Aryal DK, Racz B, Kim N, Uezu A, Wang F, Wetsel WC, Weinberg RJ, Yin H, Soderling SH
Nature neuroscience18(6)883-91(2015 Jun)

The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine.
Zhou K, Sumigray KD, Lechler T
Molecular biology of the cell26(11)1995-2004(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study provided the first evidence that the Arp2/3 complex, a key actin nucleator, is involved in distinct stages of spine formation and is required for synapse unsilencing.
Title: The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing.

In the absence of ArpC3, enterocytes had defects in the organization of the endolysosomal system: transcytosis of IgG was disrupted, lipid absorption was perturbed, and neonatal mice died within days of birth.
Title: The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine.

GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch.
Title: GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism.

Together with the observation that Gadkin-mediated inhibition of cell spreading requires its binding to ARP2/3, these data indicate that Gadkin is a negative regulator of ARP2/3 function present on intracellular membranes
Title: Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex.

results demonstrate a critical role for the Arp2/3 complex in the assembly of lamellipodia-based leading edges and directional cell motility
Title: The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration.

The following ARPC3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARPC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu83495	NM_019824.4 Latest version!	Mus musculus actin related protein 2/3 complex, subunit 3 (Arpc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu18049	NM_019824.3 Latest version!	Mus musculus actin related protein 2/3 complex, subunit 3 (Arpc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARPC3 ( NM_019824.4 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_062798.1 Mus musculus actin related protein 2/3 complex, subunit 3 (Arpc3), mRNA.

Price & Availability↑

CloneID	OMu83495
Clone ID Related Accession (Same CDS sequence)	NM_019824.4
Accession Version	NM_019824.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	actin-related protein 2/3 complex subunit 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY790451.1, AK003485.1 and CJ220494.1. On Nov 26, 2015 this sequence version replaced NM_019824.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB194870.1, CA977907.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGCAT ACCACTCTTC TCTCATGGAC CCGGACACCA AGCTCATCGG TAACATGGCC 
CTGTTGCCCC TCCGAAGCCA GTTCAAAGGA CCCGCCCCTC GCGAGACCAA AGACACGGAC 
ATTGTGGATG AAGCCATCTA CTACTTCAAG GCCAATGTCT TCTTCAAGAA CTATGAAATT 
AAGAATGAAG CGGACAGGAC ATTGATCTAC ATCACACTCT ACATTTCTGA GTGTCTAAAG 
AAACTCCAAA AGTGCAACTC CAAGAGCCAA GGCGAGAAGG AAATGTACAC GCTAGGAATC 
ACCAACTTCC CTATCCCCGG AGAGCCTGGC TTTCCTCTCA ACGCCATTTA TGCCAAGCCT 
GCGAGCAAAC AGGAGGACGA GATGATGCGG GCGTACCTCC AGCAGCTGAG GCAAGAGACC 
GGACTGAGGC TGTGTGAGAA GGTTTTTGAC CCTCAGAGTG ATAAACCCAG CAAGTGGTGG 
ACTTGCTTTG TGAAGAGACA GTTCATGAAC AAGAGTCTTT CGGGGCCTGG GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062798.1
CDS	115..651
Translation	MPAYHSSLMDPDTKLIGNMALLPLRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPASKQEDEMMRAYLQQLRQETGLRLCEKVFDPQSDKPSKWWTCFVKRQFMNKSLSGPGQ

Target ORF information:

RefSeq Version	NM_019824.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus actin related protein 2/3 complex, subunit 3 (Arpc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019824.4

ORF Insert Sequence:

ATGCCGGCAT ACCACTCTTC TCTCATGGAC CCGGACACCA AGCTCATCGG TAACATGGCC 
CTGTTGCCCC TCCGAAGCCA GTTCAAAGGA CCCGCCCCTC GCGAGACCAA AGACACGGAC 
ATTGTGGATG AAGCCATCTA CTACTTCAAG GCCAATGTCT TCTTCAAGAA CTATGAAATT 
AAGAATGAAG CGGACAGGAC ATTGATCTAC ATCACACTCT ACATTTCTGA GTGTCTAAAG 
AAACTCCAAA AGTGCAACTC CAAGAGCCAA GGCGAGAAGG AAATGTACAC GCTAGGAATC 
ACCAACTTCC CTATCCCCGG AGAGCCTGGC TTTCCTCTCA ACGCCATTTA TGCCAAGCCT 
GCGAGCAAAC AGGAGGACGA GATGATGCGG GCGTACCTCC AGCAGCTGAG GCAAGAGACC 
GGACTGAGGC TGTGTGAGAA GGTTTTTGAC CCTCAGAGTG ATAAACCCAG CAAGTGGTGG 
ACTTGCTTTG TGAAGAGACA GTTCATGAAC AAGAGTCTTT CGGGGCCTGG GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARPC3 ( NM_019824.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_062798.1 Mus musculus actin related protein 2/3 complex, subunit 3 (Arpc3), mRNA.

Price & Availability↑

CloneID	OMu18049
Clone ID Related Accession (Same CDS sequence)	NM_019824.3
Accession Version	NM_019824.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	actin-related protein 2/3 complex subunit 3
Comment

ATGCCGGCAT ACCACTCTTC TCTCATGGAC CCGGACACCA AGCTCATCGG TAACATGGCC 
CTGTTGCCCC TCCGAAGCCA GTTCAAAGGA CCCGCCCCTC GCGAGACCAA AGACACGGAC 
ATTGTGGATG AAGCCATCTA CTACTTCAAG GCCAATGTCT TCTTCAAGAA CTATGAAATT 
AAGAATGAAG CGGACAGGAC ATTGATCTAC ATCACACTCT ACATTTCTGA GTGTCTAAAG 
AAACTCCAAA AGTGCAACTC CAAGAGCCAA GGCGAGAAGG AAATGTACAC GCTAGGAATC 
ACCAACTTCC CCATCCCCGG AGAGCCTGGC TTTCCTCTCA ACGCCATTTA TGCCAAGCCT 
GCGAGCAAAC AGGAGGACGA GATGATGCGT GCGTACCTCC AGCAGCTGAG GCAAGAGACC 
GGACTGAGGC TGTGTGAGAA GGTTTTTGAC CCTCAGAGTG ATAAACCCAG CAAGTGGTGG 
ACTTGCTTTG TGAAGAGACA GTTCATGAAC AAGAGTCTTT CGGGGCCTGG GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062798.1
Translation	MPAYHSSLMDPDTKLIGNMALLPLRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPASKQEDEMMRAYLQQLRQETGLRLCEKVFDPQSDKPSKWWTCFVKRQFMNKSLSGPGQ

Target ORF information:

RefSeq Version	NM_019824.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus actin related protein 2/3 complex, subunit 3 (Arpc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019824.3

ORF Insert Sequence:

ATGCCGGCAT ACCACTCTTC TCTCATGGAC CCGGACACCA AGCTCATCGG TAACATGGCC 
CTGTTGCCCC TCCGAAGCCA GTTCAAAGGA CCCGCCCCTC GCGAGACCAA AGACACGGAC 
ATTGTGGATG AAGCCATCTA CTACTTCAAG GCCAATGTCT TCTTCAAGAA CTATGAAATT 
AAGAATGAAG CGGACAGGAC ATTGATCTAC ATCACACTCT ACATTTCTGA GTGTCTAAAG 
AAACTCCAAA AGTGCAACTC CAAGAGCCAA GGCGAGAAGG AAATGTACAC GCTAGGAATC 
ACCAACTTCC CCATCCCCGG AGAGCCTGGC TTTCCTCTCA ACGCCATTTA TGCCAAGCCT 
GCGAGCAAAC AGGAGGACGA GATGATGCGT GCGTACCTCC AGCAGCTGAG GCAAGAGACC 
GGACTGAGGC TGTGTGAGAA GGTTTTTGAC CCTCAGAGTG ATAAACCCAG CAAGTGGTGG 
ACTTGCTTTG TGAAGAGACA GTTCATGAAC AAGAGTCTTT CGGGGCCTGG GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(37)9696-709(2016 Sep)
Spence EF,Kanak DJ,Carlson BR,Soderling SH

Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.
Cell165(2)434-448(2016 Apr)
Zhang Y,Zhang XF,Fleming MR,Amiri A,El-Hassar L,Surguchev AA,Hyland C,Jenkins DP,Desai R,Brown MR,Gazula VR,Waters MF,Large CH,Horvath TL,Navaratnam D,Vaccarino FM,Forscher P,Kaczmarek LK

CNS myelin wrapping is driven by actin disassembly.
Developmental cell34(2)152-67(2015 Jul)
Zuchero JB,Fu MM,Sloan SA,Ibrahim A,Olson A,Zaremba A,Dugas JC,Wienbar S,Caprariello AV,Kantor C,Leonoudakis D,Leonoudakus D,Lariosa-Willingham K,Kronenberg G,Gertz K,Soderling SH,Miller RH,Barres BA

Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.
Nature neuroscience18(6)883-91(2015 Jun)
Kim IH,Rossi MA,Aryal DK,Racz B,Kim N,Uezu A,Wang F,Wetsel WC,Weinberg RJ,Yin H,Soderling SH

The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine.
Molecular biology of the cell26(11)1995-2004(2015 Jun)
Zhou K,Sumigray KD,Lechler T

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ARPC3 cDNA ORF clone, Mus musculus(House mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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