Mad2l1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mad2l1
Entrez Gene ID	56150
Full Name	MAD2 mitotic arrest deficient-like 1
Synonyms	AA673185,MAD2
General protein information	Preferred Names MAD2 mitotic arrest deficient-like 1 Names mitotic spindle assembly checkpoint protein MAD2A MAD2 (mitotic arrest deficient, homolog)-like 1 MAD2-like protein 1 mitotic arrest deficient 2-like protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 C1\|6 30.56 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_019499.4	NP_062372.2	mitotic spindle assembly checkpoint protein MAD2A
NM_019499.5	NP_062372.2	mitotic spindle assembly checkpoint protein MAD2A
XM_006506406.2	XP_006506469.1	mitotic spindle assembly checkpoint protein MAD2A isoform X1
XM_006506406.3	XP_006506469.1	mitotic spindle assembly checkpoint protein MAD2A isoform X1
NM_001355624.1	NP_001342553.1	mitotic spindle assembly checkpoint protein MAD2A

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mad2l1	NP_001017739.1
Kluyveromyces lactis	KLLA0D09438g	XP_453482.1
Pan troglodytes (chimpanzee)	MAD2L1	XP_003310508.1
	MAD2L1	XP_001097054.2
Saccharomyces cerevisiae (baker's yeast)	MAD2	NP_012504.3
Eremothecium gossypii	AGOS_ACR043W	NP_983446.1
Gallus gallus (chicken)	MAD2L1	NP_001264678.1
Magnaporthe oryzae (rice blast fungus)	MGG_08269	XP_003715816.1
Arabidopsis thaliana (thale cress)	MAD2	NP_189227.1
Homo sapiens (human)	MAD2L1	NP_002349.1
Bos taurus (cattle)	MAD2L1	NP_001178442.1
Mus musculus (house mouse)	Mad2l1	NP_062372.2
Drosophila melanogaster (fruit fly)	mad2	NP_647991.1
Schizosaccharomyces pombe (fission yeast)	mad2	NP_596370.1
Oryza sativa (rice)	Os04g0486500	NP_001053138.1
Canis lupus familiaris (dog)	LOC476070	XP_533278.2
Rattus norvegicus (Norway rat)	Mad2l1	NP_001100064.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000751	XP_311286.5
Caenorhabditis elegans (roundworm)	mdf-2	NP_001023563.1
Neurospora crassa	NCU05781	XP_960041.2
Xenopus tropicalis (tropical clawed frog)	mad2l1	NP_001096528.1

Gene Ontology
Bibliography

Related articles in PubMed

Reduced MAD2 levels dampen the apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidy.
Faisal I, Kauppi L
Development (Cambridge, England)144(11)1988-1996(2017 06)

SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.
Hwang G, Sun F, O'Brien M, Eppig JJ, Handel MA, Jordan PW
Development (Cambridge, England)144(9)1648-1660(2017 05)

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

Deletion of the
Foijer F, Albacker LA, Bakker B, Spierings DC, Yue Y, Xie SZ, Davis S, Lutum-Jehle A, Takemoto D, Hare B, Furey B, Bronson RT, Lansdorp PM, Bradley A, Sorger PK
eLife6(2017 Mar)

Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint.
Wu Q, Li Z, Huang Y, Qian D, Chen M, Xiao W, Wang B
Oxidative medicine and cellular longevity20172103190(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

reduced MAD2 levels attenuate the apoptotic response to mis-segregating sex chromosomes and allow the formation of aneuploid sperm.
Title: Reduced MAD2 levels dampen the apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidy.

Mad2-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.
Title: Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.

p31comet-induced cell death is mediated by interactions with Mad2
Title: p31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2.

study shows that Mad2 is a novel substrate for CCP6 in megakaryocytes; Mad2 polyglutamylation plays a crucial role in the regulation of megakaryopoiesis
Title: Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation.

Exacerbating chromosome missegregation in CENP-E+/- mice by reducing levels of another mitotic checkpoint component, Mad2, results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
Title: Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.

The following Mad2l1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mad2l1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19701	NM_019499.5 Latest version!	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu19701	NM_001355624.1 Latest version!	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu19701	XM_006506406.3 Latest version!	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
View Old Accession Versions >>
OMu19701	NM_019499.4	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu19701	XM_006506406.2	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mad2l1 ( NM_019499.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062372.2 Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), mRNA.

Price & Availability↑

CloneID	OMu19701
Clone ID Related Accession (Same CDS sequence)	NM_019499.4 , NM_019499.5 , XM_006506406.2 , XM_006506406.3 , NM_001355624.1
Accession Version	NM_019499.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	mitotic spindle assembly checkpoint protein MAD2A
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC122874.2. On Apr 28, 2007 this sequence version replaced NM_019499.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK082934.1, BC089012.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062372.2
CDS	60..677
Translation	MAQQLAREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLTTTDPELIKYLNNVVEQLKEWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKEEGVRREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNCEEVRLRSFTTTIHKVNSMVAYKTPVND

Target ORF information:

RefSeq Version	NM_019499.4
Organism	Mus musculus(House mouse)
Definition	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019499.4

ORF Insert Sequence:

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mad2l1 ( NM_019499.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062372.2 Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19701
Clone ID Related Accession (Same CDS sequence)	NM_019499.4 , NM_019499.5 , XM_006506406.2 , XM_006506406.3 , NM_001355624.1
Accession Version	NM_019499.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	mitotic spindle assembly checkpoint protein MAD2A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC122874.2. On Sep 21, 2017 this sequence version replaced NM_019499.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089012.1, AK082934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062372.2
CDS	307..924
Translation	MAQQLAREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLTTTDPELIKYLNNVVEQLKEWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKEEGVRREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNCEEVRLRSFTTTIHKVNSMVAYKTPVND

Target ORF information:

RefSeq Version	NM_019499.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019499.5

ORF Insert Sequence:

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mad2l1 ( NM_001355624.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001342553.1 Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19701
Clone ID Related Accession (Same CDS sequence)	NM_019499.4 , NM_019499.5 , XM_006506406.2 , XM_006506406.3 , NM_001355624.1
Accession Version	NM_001355624.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	mitotic spindle assembly checkpoint protein MAD2A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC122874.2. On Sep 21, 2017 this sequence version replaced XM_006506406.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK160286.1, AK010401.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001342553.1
CDS	307..924
Translation	MAQQLAREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLTTTDPELIKYLNNVVEQLKEWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKEEGVRREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNCEEVRLRSFTTTIHKVNSMVAYKTPVND

Target ORF information:

RefSeq Version	NM_001355624.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001355624.1

ORF Insert Sequence:

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mad2l1 ( XM_006506406.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006506469.1 Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19701
Clone ID Related Accession (Same CDS sequence)	NM_019499.4 , NM_019499.5 , XM_006506406.2 , XM_006506406.3 , NM_001355624.1
Accession Version	XM_006506406.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	mitotic spindle assembly checkpoint protein MAD2A isoform X1
Comment

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006506469.1
Translation	MAQQLAREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLTTTDPELIKYLNNVVEQLKEWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKEEGVRREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNCEEVRLRSFTTTIHKVNSMVAYKTPVND

Target ORF information:

RefSeq Version	XM_006506406.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006506406.2

ORF Insert Sequence:

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mad2l1 ( XM_006506406.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006506469.1 Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19701
Clone ID Related Accession (Same CDS sequence)	NM_019499.4 , NM_019499.5 , XM_006506406.2 , XM_006506406.3 , NM_001355624.1
Accession Version	XM_006506406.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(House mouse)
Product	mitotic spindle assembly checkpoint protein MAD2A isoform X1
Comment	MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006506406.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006506469.1
CDS	302..919
Translation	MAQQLAREQGITLRGSAEIVAEFFSFGINSILYQRGIYPSETFTRVQKYGLTLLTTTDPELIKYLNNVVEQLKEWLYKCSVQKLVVVISNIESGEVLERWQFDIECDKTAKEEGVRREKSQKAIQDEIRSVIRQITATVTFLPLLEVSCSFDLLIYTDKDLVVPEKWEESGPQFITNCEEVRLRSFTTTIHKVNSMVAYKTPVND

Target ORF information:

RefSeq Version	XM_006506406.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus MAD2 mitotic arrest deficient-like 1 (Mad2l1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006506406.3

ORF Insert Sequence:

ATGGCACAGC AGCTCGCCCG AGAGCAAGGC ATCACCCTGC GTGGGAGCGC AGAAATCGTG 
GCCGAGTTTT TCTCATTTGG CATCAACAGC ATTTTGTATC AGCGTGGCAT TTATCCGTCG 
GAAACCTTTA CTAGAGTGCA GAAATATGGA CTCACCTTGC TTACAACTAC TGACCCCGAG 
CTCATAAAGT ATCTCAATAA TGTGGTGGAA CAGCTAAAAG AGTGGCTGTA CAAGTGCTCA 
GTTCAGAAAC TGGTGGTGGT CATCTCAAAT ATTGAAAGTG GTGAAGTCCT TGAAAGATGG 
CAGTTTGATA TTGAGTGTGA CAAAACTGCA AAAGAGGAAG GTGTTCGTAG AGAAAAGTCC 
CAGAAAGCCA TACAGGATGA AATTCGCTCA GTGATTAGAC AGATTACAGC TACTGTGACA 
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCC TTTGATCTGC TGATTTACAC TGACAAAGAC 
TTGGTGGTAC CTGAAAAGTG GGAAGAATCG GGACCGCAAT TTATTACCAA TTGTGAAGAA 
GTCCGTCTAC GCTCATTTAC AACCACAATC CATAAAGTGA ATAGTATGGT GGCCTACAAA 
ACCCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reduced MAD2 levels dampen the apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidy.
Development (Cambridge, England)144(11)1988-1996(2017 06)
Faisal I,Kauppi L

SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.
Development (Cambridge, England)144(9)1648-1660(2017 05)
Hwang G,Sun F,O'Brien M,Eppig JJ,Handel MA,Jordan PW

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A

Deletion of the
eLife6(2017 Mar)
Foijer F,Albacker LA,Bakker B,Spierings DC,Yue Y,Xie SZ,Davis S,Lutum-Jehle A,Takemoto D,Hare B,Furey B,Bronson RT,Lansdorp PM,Bradley A,Sorger PK

Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint.
Oxidative medicine and cellular longevity20172103190(2017)
Wu Q,Li Z,Huang Y,Qian D,Chen M,Xiao W,Wang B

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Mad2l1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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