Plagl2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plagl2
Entrez Gene ID	54711
Full Name	pleiomorphic adenoma gene-like 2
Synonyms	AU018672,AW552839,mKIAA0198
General protein information	Preferred Names pleiomorphic adenoma gene-like 2 Names zinc finger protein PLAGL2 pleomorphic adenoma gene like 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 H1

mRNA and Protein(s)

mRNA	Protein	Name
NM_018807.5	NP_061277.2	zinc finger protein PLAGL2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PLAGL2	XP_003316959.1
Gallus gallus (chicken)	LOC100859766	XP_003642539.1
Canis lupus familiaris (dog)	PLAGL2	XP_542953.2
Bos taurus (cattle)	PLAGL2	XP_002692333.2
Mus musculus (house mouse)	Plagl2	NP_061277.2
Homo sapiens (human)	PLAGL2	NP_002648.1
Danio rerio (zebrafish)	plagl2	NP_705938.1

Gene Ontology
Bibliography

Related articles in PubMed

Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
Chen AC, Donovan A, Ned-Sykes R, Andrews NC
Proceedings of the National Academy of Sciences of the United States of America112(37)11714-9(2015 Sep)

Pleiomorphic adenoma gene-like 2 expression is associated with the development of lung adenocarcinoma and emphysema.
Yang YS, Yang MC, Weissler JC
Lung cancer (Amsterdam, Netherlands)74(1)12-24(2011 Oct)

The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells.
Landrette SF, Madera D, He F, Castilla LH
Leukemia25(4)655-62(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

expression is associated with the development of lung adenocarcinoma and emphysema
Title: Pleiomorphic adenoma gene-like 2 expression is associated with the development of lung adenocarcinoma and emphysema.

Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling
Title: PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas.

Increased cell injury and/or death could be caused directly by the upregulation of bNip3, a preapoptotic molecule that dimerizes with Bcl-2, or indirectly by the aberrant expression of SP-C-induced endoplasmic reticulum stress in epithelial cells.
Title: PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity.

PlagL2 regulates important aspects of dietary lipid absorption, and the PlagL2(-/-) animal model has implications for the amelioration of obesity and the metabolic syndrome.
Title: Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.

induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis.
Title: A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis.

The following Plagl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plagl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11020	NM_018807.5 Latest version!	Mus musculus pleiomorphic adenoma gene-like 2 (Plagl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plagl2 ( NM_018807.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061277.2 Mus musculus pleiomorphic adenoma gene-like 2 (Plagl2), mRNA.

Price & Availability↑

CloneID	OMu11020
Clone ID Related Accession (Same CDS sequence)	NM_018807.5
Accession Version	NM_018807.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Mus musculus(house mouse)
Product	zinc finger protein PLAGL2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL807380.6. On Nov 17, 2006 this sequence version replaced NM_018807.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC078453.1, AK133833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGACCACAT TTTTCACCAG CGTCCCTCCC TGGATTCAAG ATGCAAAGCA GGAGGAGGAA 
GTGGGCTGGA AACTAGTTCC CAGGCCTCGG GGCCGGGAGG CAGAGAGTCA AGTGAAGTGC 
CAATGTGAAA TCTCGGGGAC ACCATTTTCA AATGGGGAGA AGCTAAGGCC TCACAGCCTT 
CCCCATCCGG AGCAGAGACC ATATAGCTGT CCTCAGCTGC ACTGCGGCAA GGCTTTTGCC 
TCCAAGTACA AGCTGTATAG GCACATGGCC ACCCACTCGG CCCAGAAACC CCACCAGTGC 
ATGTACTGTG ACAAGATGTT TCACCGAAAG GACCATCTGC GGAACCACTT GCAGACCCAT 
GACCCCAACA AAGAGGCCCT CCACTGCTCT GAGTGTGGTA AGAATTATAA TACAAAGCTG 
GGATACCGTC GTCACCTGGC CATGCATGCT GCCAGCAGTG GTGATCTCAG CTGCAAGGTG 
TGCCTGCAGA CCTTTGAGAG TACCCAGGCC CTATTGGAGC ACCTGAAGGC TCACTCACGC 
CGGGTAGCAG GAGGTGCTAA GGAGAAGAAG CACCCCTGTG ACCATTGTGA CAGGCGGTTC 
TATACTCGGA AGGATGTCCG ACGGCACCTA GTGGTGCACA CAGGTCGTAA GGACTTCCTG 
TGTCAGTACT GTGCCCAGAG ATTTGGCCGC AAGGATCACC TGACACGCCA TGTCAAGAAG 
AGCCACTCAC AGGAACTGCT CAAGATCAAG ACAGAGCCAG TGGATATGTT AGGCTTGCTC 
AGCTGTAGCT CTACAGTCAG TGTAAAGGAA GAGCTGAGCC CTGTGCTTTG CATGGCCTCT 
CGGGACGTGA TGGGGGCTAA GGCCTTTCCT GGCATGTTGC CCATGGGTAT GTATGGTGCC 
CACATCCCTA CCATGCCCAG TGCGGGCATG CCACACTCCC TGGTGCACAA CACACTGCCC 
ATGGGTATGA GTTACCCTCT GGAATCTTCT CCTATCTCCT CCTCAGCTCA GCTCCCTCCA 
AAATACCAGC TTGGATCTAC CTCATACTTG CCCGACAAAC TGCCCAAAGT GGAGGTGGAT 
AGTTTTCTGG CAGAGCTTCC TGGAAGCCTG TCTCTCTCCT CGGCTGAACC TCAGCCCGCC 
TCACCTCAGC CGGCGGCAGC TGCAGCCCTC CTGGATGAAG CACTGCTCGC CAAGAGTCCC 
GCCAACCTCT CCGAGGCCCT CTGCGCTGCT AATGTGGACT TTTCCCACTT ACTGGGCTTT 
CTTCCGCTCA ACCTACCCCC ATGTAACCCA CCAGGGGCCA CAGGAGGCTT GGTTATGGGC 
TACTCCCAAG CTGAGGCACA GCCTTTGCTC ACCACTTTGC AGGCTCAGCC TCAAGATTCC 
GCTGGAGCTG GGGGACCCCT GAACTTTGGG CCTCTGCACT CCTTACCTCC TGTCTTCACC 
TCTGGCCTGA GTACCACCAC CCTGCCTCGT TTCCACCAAG CATTCCAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061277.2
CDS	197..1687
Translation	MTTFFTSVPPWIQDAKQEEEVGWKLVPRPRGREAESQVKCQCEISGTPFSNGEKLRPHSLPHPEQRPYSCPQLHCGKAFASKYKLYRHMATHSAQKPHQCMYCDKMFHRKDHLRNHLQTHDPNKEALHCSECGKNYNTKLGYRRHLAMHAASSGDLSCKVCLQTFESTQALLEHLKAHSRRVAGGAKEKKHPCDHCDRRFYTRKDVRRHLVVHTGRKDFLCQYCAQRFGRKDHLTRHVKKSHSQELLKIKTEPVDMLGLLSCSSTVSVKEELSPVLCMASRDVMGAKAFPGMLPMGMYGAHIPTMPSAGMPHSLVHNTLPMGMSYPLESSPISSSAQLPPKYQLGSTSYLPDKLPKVEVDSFLAELPGSLSLSSAEPQPASPQPAAAAALLDEALLAKSPANLSEALCAANVDFSHLLGFLPLNLPPCNPPGATGGLVMGYSQAEAQPLLTTLQAQPQDSAGAGGPLNFGPLHSLPPVFTSGLSTTTLPRFHQAFQ

Target ORF information:

RefSeq Version	NM_018807.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus pleiomorphic adenoma gene-like 2 (Plagl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018807.5

ORF Insert Sequence:

ATGACCACAT TTTTCACCAG CGTCCCTCCC TGGATTCAAG ATGCAAAGCA GGAGGAGGAA 
GTGGGCTGGA AACTAGTTCC CAGGCCTCGG GGCCGGGAGG CAGAGAGTCA AGTGAAGTGC 
CAATGTGAAA TCTCGGGGAC ACCATTTTCA AATGGGGAGA AGCTAAGGCC TCACAGCCTT 
CCCCATCCGG AGCAGAGACC ATATAGCTGT CCTCAGCTGC ACTGCGGCAA GGCTTTTGCC 
TCCAAGTACA AGCTGTATAG GCACATGGCC ACCCACTCGG CCCAGAAACC CCACCAGTGC 
ATGTACTGTG ACAAGATGTT TCACCGAAAG GACCATCTGC GGAACCACTT GCAGACCCAT 
GACCCCAACA AAGAGGCCCT CCACTGCTCT GAGTGTGGTA AGAATTATAA TACAAAGCTG 
GGATACCGTC GTCACCTGGC CATGCATGCT GCCAGCAGTG GTGATCTCAG CTGCAAGGTG 
TGCCTGCAGA CCTTTGAGAG TACCCAGGCC CTATTGGAGC ACCTGAAGGC TCACTCACGC 
CGGGTAGCAG GAGGTGCTAA GGAGAAGAAG CACCCCTGTG ACCATTGTGA CAGGCGGTTC 
TATACTCGGA AGGATGTCCG ACGGCACCTA GTGGTGCACA CAGGTCGTAA GGACTTCCTG 
TGTCAGTACT GTGCCCAGAG ATTTGGCCGC AAGGATCACC TGACACGCCA TGTCAAGAAG 
AGCCACTCAC AGGAACTGCT CAAGATCAAG ACAGAGCCAG TGGATATGTT AGGCTTGCTC 
AGCTGTAGCT CTACAGTCAG TGTAAAGGAA GAGCTGAGCC CTGTGCTTTG CATGGCCTCT 
CGGGACGTGA TGGGGGCTAA GGCCTTTCCT GGCATGTTGC CCATGGGTAT GTATGGTGCC 
CACATCCCTA CCATGCCCAG TGCGGGCATG CCACACTCCC TGGTGCACAA CACACTGCCC 
ATGGGTATGA GTTACCCTCT GGAATCTTCT CCTATCTCCT CCTCAGCTCA GCTCCCTCCA 
AAATACCAGC TTGGATCTAC CTCATACTTG CCCGACAAAC TGCCCAAAGT GGAGGTGGAT 
AGTTTTCTGG CAGAGCTTCC TGGAAGCCTG TCTCTCTCCT CGGCTGAACC TCAGCCCGCC 
TCACCTCAGC CGGCGGCAGC TGCAGCCCTC CTGGATGAAG CACTGCTCGC CAAGAGTCCC 
GCCAACCTCT CCGAGGCCCT CTGCGCTGCT AATGTGGACT TTTCCCACTT ACTGGGCTTT 
CTTCCGCTCA ACCTACCCCC ATGTAACCCA CCAGGGGCCA CAGGAGGCTT GGTTATGGGC 
TACTCCCAAG CTGAGGCACA GCCTTTGCTC ACCACTTTGC AGGCTCAGCC TCAAGATTCC 
GCTGGAGCTG GGGGACCCCT GAACTTTGGG CCTCTGCACT CCTTACCTCC TGTCTTCACC 
TCTGGCCTGA GTACCACCAC CCTGCCTCGT TTCCACCAAG CATTCCAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
Proceedings of the National Academy of Sciences of the United States of America112(37)11714-9(2015 Sep)
Chen AC,Donovan A,Ned-Sykes R,Andrews NC

Pleiomorphic adenoma gene-like 2 expression is associated with the development of lung adenocarcinoma and emphysema.
Lung cancer (Amsterdam, Netherlands)74(1)12-24(2011 Oct)
Yang YS,Yang MC,Weissler JC

The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells.
Leukemia25(4)655-62(2011 Apr)
Landrette SF,Madera D,He F,Castilla LH

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Plagl2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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