Cks1b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cks1b
Entrez Gene ID	54124
Full Name	CDC28 protein kinase 1b
Synonyms	2410005G18Rik,2610005D03Rik,AA407784,Cks1,sid1334
General protein information	Preferred Names CDC28 protein kinase 1b Names cyclin-dependent kinases regulatory subunit 1 CKS-1 cyclin-dependent kinase regulatory subunit 1 sid 1334
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F1

mRNA and Protein(s)

mRNA	Protein	Name
NM_016904.1	NP_058600.1	cyclin-dependent kinases regulatory subunit 1

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Cks85A	NP_649817.1
Caenorhabditis elegans (roundworm)	cks-1	NP_501457.1
Xenopus tropicalis (tropical clawed frog)	cks1b	NP_001093685.1
Pan troglodytes (chimpanzee)	CKS1B	NP_001239475.1
Bos taurus (cattle)	CKS1B	NP_001106782.1
Homo sapiens (human)	CKS1B	NP_001817.1
Rattus norvegicus (Norway rat)	Cks1b	NP_001129221.1
Gallus gallus (chicken)	CKS1B	NP_001106277.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003796	XP_310353.5
	CKS1B	XP_001114905.1
Mus musculus (house mouse)	Cks1b	NP_058600.1
Canis lupus familiaris (dog)	CKS1B	XP_855067.1
Danio rerio (zebrafish)	cks1b	NP_001003593.1

Gene Ontology
Bibliography

Related articles in PubMed

EBV latent membrane protein 2A orchestrates p27
Fish K, Sora RP, Schaller SJ, Longnecker R, Ikeda M
Blood130(23)2516-2526(2017 12)

Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.
Kukalev A, Ng YM, Ju L, Saidi A, Lane S, Mondragon A, Dormann D, Walker SE, Grey W, Ho PW, Stephens DN, Carr AM, Lamsa K, Tse E, Yu VP
Cerebral cortex (New York, N.Y. : 1991)27(1)11-23(2017 Jan)

Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors.
Tomiatti V, Istv?nffy R, Pietschmann E, Kratzat S, Hoellein A, Quintanilla-Fend L, von Bubnoff N, Peschel C, Oostendorp RA, Keller U
Oncogene34(33)4347-57(2015 Aug)

The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment.
Frontini M, Kukalev A, Leo E, Ng YM, Cervantes M, Cheng CW, Holic R, Dormann D, Tse E, Pommier Y, Yu V
Developmental cell23(2)356-70(2012 Aug)

Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies.
Kratzat S, Nikolova V, Miething C, Hoellein A, Schoeffmann S, Gorka O, Pietschmann E, Illert AL, Ruland J, Peschel C, Nilsson J, Duyster J, Keller U
PloS one7(5)e37433(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results revealed that CKS1 is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.
Title: Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.

Cks1 is critical for Bcr-Abl-induced cytokine-independent clonogenic activity.
Title: Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors.

show that CKS2 counteracts CKS1 and stabilizes p27
Title: The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment.

establish p27(Kip1)-independent functions of Cks1 in regulating the G(1)-S transition
Title: Cks1 promotion of S phase entry and proliferation is independent of p27Kip1 suppression.

Cks1 is overexpressed in various B cell malignancies, is required for tumor cell proliferation but is not sufficient to induce hematopoietic malignancies.
Title: Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies.

The following Cks1b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cks1b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10762	NM_016904.1 Latest version!	Mus musculus CDC28 protein kinase 1b (Cks1b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cks1b ( NM_016904.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058600.1 Mus musculus CDC28 protein kinase 1b (Cks1b), mRNA.

Price & Availability↑

CloneID	OMu10762
Clone ID Related Accession (Same CDS sequence)	NM_016904.1
Accession Version	NM_016904.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 240bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	cyclin-dependent kinases regulatory subunit 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB025409.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB025409.1, DV063560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGTCCCACA AACAAATCTA CTATTCGGAC AAATACGACG ACGAGGAGTT CGAATACCGG 
CATGTCATGT TGCCCAAGGA CATAGCCAAG CTGGTCCCGA AAACCCATCT GATGTCTGAA 
TCTGAATGGA GGAACCTCGG CGTTCAGCAG AGTCAGGGAT GGGTCCACTA TATGATCCAT 
GAACCAGAAC CTCACATCTT ACTGTTCCGA CGGCCACTGC CCAAGAAGCC AAAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058600.1
CDS	79..318
Translation	MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIHEPEPHILLFRRPLPKKPKK

Target ORF information:

RefSeq Version	NM_016904.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus CDC28 protein kinase 1b (Cks1b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016904.1

ORF Insert Sequence:

ATGTCCCACA AACAAATCTA CTATTCGGAC AAATACGACG ACGAGGAGTT CGAATACCGG 
CATGTCATGT TGCCCAAGGA CATAGCCAAG CTGGTCCCGA AAACCCATCT GATGTCTGAA 
TCTGAATGGA GGAACCTCGG CGTTCAGCAG AGTCAGGGAT GGGTCCACTA TATGATCCAT 
GAACCAGAAC CTCACATCTT ACTGTTCCGA CGGCCACTGC CCAAGAAGCC AAAGAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

EBV latent membrane protein 2A orchestrates p27
Blood130(23)2516-2526(2017 12)
Fish K,Sora RP,Schaller SJ,Longnecker R,Ikeda M

Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.
Cerebral cortex (New York, N.Y. : 1991)27(1)11-23(2017 Jan)
Kukalev A,Ng YM,Ju L,Saidi A,Lane S,Mondragon A,Dormann D,Walker SE,Grey W,Ho PW,Stephens DN,Carr AM,Lamsa K,Tse E,Yu VP

Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors.
Oncogene34(33)4347-57(2015 Aug)
Tomiatti V,Istv?nffy R,Pietschmann E,Kratzat S,Hoellein A,Quintanilla-Fend L,von Bubnoff N,Peschel C,Oostendorp RA,Keller U

The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment.
Developmental cell23(2)356-70(2012 Aug)
Frontini M,Kukalev A,Leo E,Ng YM,Cervantes M,Cheng CW,Holic R,Dormann D,Tse E,Pommier Y,Yu V

Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies.
PloS one7(5)e37433(2012)
Kratzat S,Nikolova V,Miething C,Hoellein A,Schoeffmann S,Gorka O,Pietschmann E,Illert AL,Ruland J,Peschel C,Nilsson J,Duyster J,Keller U

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Cks1b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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