Icosl cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Icosl
Entrez Gene ID	50723
Full Name	icos ligand
Synonyms	AU044799,B7-H2,B7RP-1,B7h,BG071784,GI50,GL50,GL50-B,ICOS-L,Icoslg,LICOS,Ly115l,mKIAA0653
General protein information	Preferred Names icos ligand Names ICOS ligand B7 homolog 2 B7-like protein Gl50 B7-related protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_015790.3	NP_056605.1	ICOS ligand precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ICOSLG	XP_003319157.1
	LOC722191	XP_002803158.1
Homo sapiens (human)	ICOSLG	NP_056074.1
Homo sapiens (human)	LOC102723996	XP_006723963.1
Bos taurus (cattle)	ICOSLG	XP_005202100.1
Gallus gallus (chicken)	ICOSLG	NP_990415.1
Canis lupus familiaris (dog)	ICOSLG	XP_005639015.1
Mus musculus (house mouse)	Icosl	NP_056605.1
Rattus norvegicus (Norway rat)	Icoslg	XP_006256322.1

Gene Ontology
Bibliography

Related articles in PubMed

Generation of ROR?t
Kim BS, Lu H, Ichiyama K, Chen X, Zhang YB, Mistry NA, Tanaka K, Lee YH, Nurieva R, Zhang L, Yang X, Chung Y, Jin W, Chang SH, Dong C
Cell reports21(1)195-207(2017 Oct)

ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
Lownik JC, Luker AJ, Damle SR, Cooley LF, El Sayed R, Hutloff A, Pitzalis C, Martin RK, El Shikh MEM, Conrad DH
Journal of immunology (Baltimore, Md. : 1950)199(7)2305-2315(2017 Oct)

The Spontaneous Autoimmune Neuromyopathy in ICOSL
Briet C, Bourdenet G, Rogner UC, Becourt C, Tardivel I, Drouot L, Arnoult C, do Rego JC, Prevot N, Massaad C, Boyer O, Boitard C
Frontiers in immunology8287(2017)

Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.
Kunishige T, Taniguchi H, Terada M, Akiba H, Yagita H, Abe R, Hori J
Investigative ophthalmology & visual science57(15)6815-6823(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study confirms the importance of ICOSL shedding in ICOS/ICOSL function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL levels
Title: ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.

The expression of ICOSL in the cornea and the ICOS-mediated induction of Foxp3+ CD4+ regulatory T cells may contribute to successful corneal allograft survival.
Title: Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.

results showed that monocyte-derived osteoclast (OC)-like cells (MDOCs) express B7h during their differentiation, and that B7h triggering reversibly inhibits OC differentiation and function both in vitro and in vivo
Title: ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo.

this study shows that sICOSL in the serum of healthy donors increases in an age-dependent manner and that the matrix metalloproteinase inhibitor (MMPI) could suppress sICOSL production
Title: Development of a novel monoclonal antibody to human inducible co-stimulator ligand (ICOSL): Biological characteristics and application for enzyme-linked immunosorbent assay.

study concludse that lymphopenia-driven autoimmunity and the development of Tfh17 cells in Rasgrp1-deficient mice occur independently of CD275(B7-H2)
Title: CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice.

The following Icosl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Icosl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15860	NM_015790.3 Latest version!	Mus musculus icos ligand (Icosl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Icosl ( NM_015790.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_056605.1 Mus musculus icos ligand (Icosl), mRNA.

Price & Availability↑

CloneID	OMu15860
Clone ID Related Accession (Same CDS sequence)	NM_015790.3
Accession Version	NM_015790.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	ICOS ligand precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC153507.11. On Nov 17, 2006 this sequence version replaced NM_015790.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029227.1, AF216747.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCTAA AGTGTCCCTG TTTTGTGTCC TTGGGAACCA GGCAGCCTGT TTGGAAGAAG 
CTCCATGTTT CTAGCGGGTT CTTTTCTGGT CTTGGTCTGT TCTTGCTGCT GTTGAGCAGC 
CTCTGTGCTG CCTCTGCAGA GACTGAAGTC GGTGCAATGG TGGGCAGCAA TGTGGTGCTC 
AGCTGCATTG ACCCCCACAG ACGCCATTTC AACTTGAGTG GTCTGTATGT CTATTGGCAA 
ATCGAAAACC CAGAAGTTTC GGTGACTTAC TACCTGCCTT ACAAGTCTCC AGGGATCAAT 
GTGGACAGTT CCTACAAGAA CAGGGGCCAT CTGTCCCTGG ACTCCATGAA GCAGGGTAAC 
TTCTCTCTGT ACCTGAAGAA TGTCACCCCT CAGGATACCC AGGAGTTCAC ATGCCGGGTA 
TTTATGAATA CAGCCACAGA GTTAGTCAAG ATCTTGGAAG AGGTGGTCAG GCTGCGTGTG 
GCAGCAAACT TCAGTACACC TGTCATCAGC ACCTCTGATA GCTCCAACCC GGGCCAGGAA 
CGTACCTACA CCTGCATGTC CAAGAATGGC TACCCAGAGC CCAACCTGTA TTGGATCAAC 
ACAACGGACA ATAGCCTAAT AGACACGGCT CTGCAGAATA ACACTGTCTA CTTGAACAAG 
TTGGGCCTGT ATGATGTAAT CAGCACATTA AGGCTCCCTT GGACATCTCG TGGGGATGTT 
CTGTGCTGCG TAGAGAATGT GGCTCTCCAC CAGAACATCA CTAGCATTAG CCAGGCAGAA 
AGTTTCACTG GAAATAACAC AAAGAACCCA CAGGAAACCC ACAATAATGA GTTAAAAGTC 
CTTGTCCCCG TCCTTGCTGT ACTGGCGGCA GCGGCATTCG TTTCCTTCAT CATATACAGA 
CGCACGCGTC CCCACCGAAG CTATACAGGA CCCAAGACTG TACAGCTTGA ACTTACAGAC 
CACGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056605.1
CDS	158..1126
Translation	MQLKCPCFVSLGTRQPVWKKLHVSSGFFSGLGLFLLLLSSLCAASAETEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVFMNTATELVKILEEVVRLRVAANFSTPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWINTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLPWTSRGDVLCCVENVALHQNITSISQAESFTGNNTKNPQETHNNELKVLVPVLAVLAAAAFVSFIIYRRTRPHRSYTGPKTVQLELTDHA

Target ORF information:

RefSeq Version	NM_015790.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus icos ligand (Icosl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015790.3

ORF Insert Sequence:

ATGCAGCTAA AGTGTCCCTG TTTTGTGTCC TTGGGAACCA GGCAGCCTGT TTGGAAGAAG 
CTCCATGTTT CTAGCGGGTT CTTTTCTGGT CTTGGTCTGT TCTTGCTGCT GTTGAGCAGC 
CTCTGTGCTG CCTCTGCAGA GACTGAAGTC GGTGCAATGG TGGGCAGCAA TGTGGTGCTC 
AGCTGCATTG ACCCCCACAG ACGCCATTTC AACTTGAGTG GTCTGTATGT CTATTGGCAA 
ATCGAAAACC CAGAAGTTTC GGTGACTTAC TACCTGCCTT ACAAGTCTCC AGGGATCAAT 
GTGGACAGTT CCTACAAGAA CAGGGGCCAT CTGTCCCTGG ACTCCATGAA GCAGGGTAAC 
TTCTCTCTGT ACCTGAAGAA TGTCACCCCT CAGGATACCC AGGAGTTCAC ATGCCGGGTA 
TTTATGAATA CAGCCACAGA GTTAGTCAAG ATCTTGGAAG AGGTGGTCAG GCTGCGTGTG 
GCAGCAAACT TCAGTACACC TGTCATCAGC ACCTCTGATA GCTCCAACCC GGGCCAGGAA 
CGTACCTACA CCTGCATGTC CAAGAATGGC TACCCAGAGC CCAACCTGTA TTGGATCAAC 
ACAACGGACA ATAGCCTAAT AGACACGGCT CTGCAGAATA ACACTGTCTA CTTGAACAAG 
TTGGGCCTGT ATGATGTAAT CAGCACATTA AGGCTCCCTT GGACATCTCG TGGGGATGTT 
CTGTGCTGCG TAGAGAATGT GGCTCTCCAC CAGAACATCA CTAGCATTAG CCAGGCAGAA 
AGTTTCACTG GAAATAACAC AAAGAACCCA CAGGAAACCC ACAATAATGA GTTAAAAGTC 
CTTGTCCCCG TCCTTGCTGT ACTGGCGGCA GCGGCATTCG TTTCCTTCAT CATATACAGA 
CGCACGCGTC CCCACCGAAG CTATACAGGA CCCAAGACTG TACAGCTTGA ACTTACAGAC 
CACGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Generation of ROR?t
Cell reports21(1)195-207(2017 Oct)
Kim BS,Lu H,Ichiyama K,Chen X,Zhang YB,Mistry NA,Tanaka K,Lee YH,Nurieva R,Zhang L,Yang X,Chung Y,Jin W,Chang SH,Dong C

ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
Journal of immunology (Baltimore, Md. : 1950)199(7)2305-2315(2017 Oct)
Lownik JC,Luker AJ,Damle SR,Cooley LF,El Sayed R,Hutloff A,Pitzalis C,Martin RK,El Shikh MEM,Conrad DH

The Spontaneous Autoimmune Neuromyopathy in ICOSL
Frontiers in immunology8287(2017)
Briet C,Bourdenet G,Rogner UC,Becourt C,Tardivel I,Drouot L,Arnoult C,do Rego JC,Prevot N,Massaad C,Boyer O,Boitard C

Protective Role of ICOS and ICOS Ligand in Corneal Transplantation and in Maintenance of Immune Privilege.
Investigative ophthalmology & visual science57(15)6815-6823(2016 12)
Kunishige T,Taniguchi H,Terada M,Akiba H,Yagita H,Abe R,Hori J

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Icosl cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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