Noto cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Noto
Entrez Gene ID	384452
Full Name	notochord homeobox
Synonyms	Flh,MmNot,Not,tc
General protein information	Preferred Names notochord homeobox Names homeobox protein notochord Not homeodomain protein floating head homolog notochord homolog truncate
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 C3\|6 37.44 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006506356.3	XP_006506419.1	homeobox protein notochord isoform X1
XM_006506356.4	XP_006506419.1	homeobox protein notochord isoform X1
NM_001007472.2	NP_001007473.1	homeobox protein notochord

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NOTO	XP_525785.3
	NOTO	XP_001103636.2
Mus musculus (house mouse)	Noto	NP_001007473.1
Homo sapiens (human)	NOTO	NP_001127934.1
Bos taurus (cattle)	NOTO	XP_002691260.2
	LOC706983	XP_001095400.1
Rattus norvegicus (Norway rat)	Noto	NP_001178943.1

Gene Ontology
Bibliography

Related articles in PubMed

1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the mouse but not essential for motile ciliogenesis.
Stauber M, Boldt K, Wrede C, Weidemann M, Kellner M, Schuster-Gossler K, K?hnel MP, Hegermann J, Ueffing M, Gossler A
Developmental biology429(1)186-199(2017 09)

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.
Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K
Scientific reports7(1)9322(2017 Aug)

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, Nishimura H, McMahon AP, Willert K, Okada Y, Sasaki H, Shi D, Fujimori T, Ohtsuka T, Igarashi Y, Yamaguchi TP, Shimono A, Shiratori H, Hamada H
Developmental cell40(5)439-452.e4(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

noto and foxj1 have roles in node formation, nodal ciliogenesis and cilia positioning
Title: Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.

A novel mammal-specific three partite enhancer element regulates node and notochord-specific Noto expression.
Title: A novel mammal-specific three partite enhancer element regulates node and notochord-specific Noto expression.

findings suggest that Noto is involved in both rearrangement and morphogenesis of the tail bud during notochord formation.
Title: The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis.

Noto ss an essential regulator of node morphogenesis and ciliogenesis in the posterior notochord.
Title: The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.

Lack of Noto correlates with misplacing and wrong directed differentiation of the tissue in the tail bud region
Title: Morphological features of tail bud development in truncate mouse mutants.

The following Noto gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Noto cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13287	NM_001007472.2 Latest version!	Mus musculus notochord homeobox (Noto), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu37426	XM_006506356.4 Latest version!	Mus musculus notochord homeobox (Noto), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu37426	XM_006506356.3	Mus musculus notochord homeobox (Noto), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Noto ( NM_001007472.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001007473.1 Mus musculus notochord homeobox (Noto), mRNA.

Price & Availability↑

CloneID	OMu13287
Clone ID Related Accession (Same CDS sequence)	NM_001007472.2
Accession Version	NM_001007472.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Mus musculus(house mouse)
Product	homeobox protein notochord
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK135886.1. On Dec 17, 2009 this sequence version replaced NM_001007472.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK135886.1, AJ862873.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849384 [ECO:0000350] ##Evidence-Data-END##

ATGTCCAGCC CTGCTCCCTC AGGCACTCAG GTCCAGCCCG GGAGCCTGCG CCCCTGTCCG 
GGAGCTGTTT CCCCAGTTGT CCCGCGCCGA CTAGCTCGGG GACGCCTGGA GTCATCCTTC 
TCTGTCGAGG CCATCCTGGC GAGACCCAAG ACCCGAGAGC TGGCGGCCAC CTCTCTGCCG 
CTCTCTACCT GCACCAGTCT GAACCTCCTC GGTGCGGTGT CGCAGTACGG GGTCCTGCCC 
TGGGTGTGCT CCACAGGGTC TTGGCTGCCT GCCTACCTGA GCGTGGGCGT CTACCCGCTG 
TGCTCCATGT CCTGCGTGCC CGGACTGAAT GTCACTCACC ACCAGCAGGG CCTCAGGCTC 
ACAGGATCAG AGCTACCTTA CTGTCTAGGC CCTCTGAAAT GGGCACCCAC CGTGGACCTT 
CGGGACCACG GGACCGAGAG ACACACAAAG AGGGTTCGCA CAACGTTTAA CTTGCAGCAG 
CTGCAAGAGT TGGAGAAGGT GTTTGCAAAG CAGCACAACC TGGTGGGGAA GGAGAGAGCC 
CAGCTGGCTG CCAGGCTGCA CCTGACGGAG AATCAGGTGA GGATCTGGTT CCAAAATCGC 
AGGGTGAAGT ATCAGAAGCA GCAAAAACTG AAATTGCCTT CCTCCTCTGT CATGGAGGAG 
CCCTCCAGCA GCTCAGATGG CAACATCCAG AGTGAAGATG CTGAGTTGGG AATTGGCAGT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007473.1
CDS	106..828
Translation	MSSPAPSGTQVQPGSLRPCPGAVSPVVPRRLARGRLESSFSVEAILARPKTRELAATSLPLSTCTSLNLLGAVSQYGVLPWVCSTGSWLPAYLSVGVYPLCSMSCVPGLNVTHHQQGLRLTGSELPYCLGPLKWAPTVDLRDHGTERHTKRVRTTFNLQQLQELEKVFAKQHNLVGKERAQLAARLHLTENQVRIWFQNRRVKYQKQQKLKLPSSSVMEEPSSSSDGNIQSEDAELGIGS

Target ORF information:

RefSeq Version	NM_001007472.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus notochord homeobox (Noto), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007472.2

ORF Insert Sequence:

ATGTCCAGCC CTGCTCCCTC AGGCACTCAG GTCCAGCCCG GGAGCCTGCG CCCCTGTCCG 
GGAGCTGTTT CCCCAGTTGT CCCGCGCCGA CTAGCTCGGG GACGCCTGGA GTCATCCTTC 
TCTGTCGAGG CCATCCTGGC GAGACCCAAG ACCCGAGAGC TGGCGGCCAC CTCTCTGCCG 
CTCTCTACCT GCACCAGTCT GAACCTCCTC GGTGCGGTGT CGCAGTACGG GGTCCTGCCC 
TGGGTGTGCT CCACAGGGTC TTGGCTGCCT GCCTACCTGA GCGTGGGCGT CTACCCGCTG 
TGCTCCATGT CCTGCGTGCC CGGACTGAAT GTCACTCACC ACCAGCAGGG CCTCAGGCTC 
ACAGGATCAG AGCTACCTTA CTGTCTAGGC CCTCTGAAAT GGGCACCCAC CGTGGACCTT 
CGGGACCACG GGACCGAGAG ACACACAAAG AGGGTTCGCA CAACGTTTAA CTTGCAGCAG 
CTGCAAGAGT TGGAGAAGGT GTTTGCAAAG CAGCACAACC TGGTGGGGAA GGAGAGAGCC 
CAGCTGGCTG CCAGGCTGCA CCTGACGGAG AATCAGGTGA GGATCTGGTT CCAAAATCGC 
AGGGTGAAGT ATCAGAAGCA GCAAAAACTG AAATTGCCTT CCTCCTCTGT CATGGAGGAG 
CCCTCCAGCA GCTCAGATGG CAACATCCAG AGTGAAGATG CTGAGTTGGG AATTGGCAGT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Noto ( XM_006506356.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006506419.1 Mus musculus notochord homeobox (Noto), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu37426
Clone ID Related Accession (Same CDS sequence)	XM_006506356.3 , XM_006506356.4
Accession Version	XM_006506356.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	homeobox protein notochord isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006506356.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGCC CTGCTCCCTC AGGCACTCAG GTCCAGCCCG GGAGCCTGCG CCCCTGTCCG 
GGAGCTGTTT CCCCAGTTGT CCCGCGCCGA CTAGCTCGGG GACGCCTGGA GTCATCCTTC 
TCTGTCGAGG CCATCCTGGC GAGACCCAAG ACCCGAGAGC TGGCGGCCAC CTCTCTGCCG 
CTCTCTACCT GCACCAGTCT GAACCTCCTC GGTGCGGTGT CGCAGTACGG GGTCCTGCCC 
TGGGTGTGCT CCACAGGGTC TTGGCTGCCT GCCTACCTGA GCGTGGGCGT CTACCCGCTG 
TGCTCCATGT CCTGCGTGCC CGGACTGAAT GTCACTCACC ACCAGCAGGG CCTCAGGCTC 
ACAGGTGAGG ATCTGGTTCC AAAATCGCAG GGTGAAGTAT CAGAAGCAGC AAAAACTGAA 
ATTGCCTTCC TCCTCTGTCA TGGAGGAGCC CTCCAGCAGC TCAGATGGCA ACATCCAGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006506419.1
CDS	93..575
Translation	MSSPAPSGTQVQPGSLRPCPGAVSPVVPRRLARGRLESSFSVEAILARPKTRELAATSLPLSTCTSLNLLGAVSQYGVLPWVCSTGSWLPAYLSVGVYPLCSMSCVPGLNVTHHQQGLRLTGEDLVPKSQGEVSEAAKTEIAFLLCHGGALQQLRWQHPE

Target ORF information:

RefSeq Version	XM_006506356.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus notochord homeobox (Noto), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006506356.3

ORF Insert Sequence:

ATGTCCAGCC CTGCTCCCTC AGGCACTCAG GTCCAGCCCG GGAGCCTGCG CCCCTGTCCG 
GGAGCTGTTT CCCCAGTTGT CCCGCGCCGA CTAGCTCGGG GACGCCTGGA GTCATCCTTC 
TCTGTCGAGG CCATCCTGGC GAGACCCAAG ACCCGAGAGC TGGCGGCCAC CTCTCTGCCG 
CTCTCTACCT GCACCAGTCT GAACCTCCTC GGTGCGGTGT CGCAGTACGG GGTCCTGCCC 
TGGGTGTGCT CCACAGGGTC TTGGCTGCCT GCCTACCTGA GCGTGGGCGT CTACCCGCTG 
TGCTCCATGT CCTGCGTGCC CGGACTGAAT GTCACTCACC ACCAGCAGGG CCTCAGGCTC 
ACAGGTGAGG ATCTGGTTCC AAAATCGCAG GGTGAAGTAT CAGAAGCAGC AAAAACTGAA 
ATTGCCTTCC TCCTCTGTCA TGGAGGAGCC CTCCAGCAGC TCAGATGGCA ACATCCAGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Noto ( XM_006506356.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006506419.1 Mus musculus notochord homeobox (Noto), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu37426
Clone ID Related Accession (Same CDS sequence)	XM_006506356.3 , XM_006506356.4
Accession Version	XM_006506356.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	homeobox protein notochord isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006506356.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCAGCC CTGCTCCCTC AGGCACTCAG GTCCAGCCCG GGAGCCTGCG CCCCTGTCCG 
GGAGCTGTTT CCCCAGTTGT CCCGCGCCGA CTAGCTCGGG GACGCCTGGA GTCATCCTTC 
TCTGTCGAGG CCATCCTGGC GAGACCCAAG ACCCGAGAGC TGGCGGCCAC CTCTCTGCCG 
CTCTCTACCT GCACCAGTCT GAACCTCCTC GGTGCGGTGT CGCAGTACGG GGTCCTGCCC 
TGGGTGTGCT CCACAGGGTC TTGGCTGCCT GCCTACCTGA GCGTGGGCGT CTACCCGCTG 
TGCTCCATGT CCTGCGTGCC CGGACTGAAT GTCACTCACC ACCAGCAGGG CCTCAGGCTC 
ACAGGTGAGG ATCTGGTTCC AAAATCGCAG GGTGAAGTAT CAGAAGCAGC AAAAACTGAA 
ATTGCCTTCC TCCTCTGTCA TGGAGGAGCC CTCCAGCAGC TCAGATGGCA ACATCCAGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006506419.1
CDS	93..575
Translation	MSSPAPSGTQVQPGSLRPCPGAVSPVVPRRLARGRLESSFSVEAILARPKTRELAATSLPLSTCTSLNLLGAVSQYGVLPWVCSTGSWLPAYLSVGVYPLCSMSCVPGLNVTHHQQGLRLTGEDLVPKSQGEVSEAAKTEIAFLLCHGGALQQLRWQHPE

Target ORF information:

RefSeq Version	XM_006506356.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus notochord homeobox (Noto), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006506356.4

ORF Insert Sequence:

ATGTCCAGCC CTGCTCCCTC AGGCACTCAG GTCCAGCCCG GGAGCCTGCG CCCCTGTCCG 
GGAGCTGTTT CCCCAGTTGT CCCGCGCCGA CTAGCTCGGG GACGCCTGGA GTCATCCTTC 
TCTGTCGAGG CCATCCTGGC GAGACCCAAG ACCCGAGAGC TGGCGGCCAC CTCTCTGCCG 
CTCTCTACCT GCACCAGTCT GAACCTCCTC GGTGCGGTGT CGCAGTACGG GGTCCTGCCC 
TGGGTGTGCT CCACAGGGTC TTGGCTGCCT GCCTACCTGA GCGTGGGCGT CTACCCGCTG 
TGCTCCATGT CCTGCGTGCC CGGACTGAAT GTCACTCACC ACCAGCAGGG CCTCAGGCTC 
ACAGGTGAGG ATCTGGTTCC AAAATCGCAG GGTGAAGTAT CAGAAGCAGC AAAAACTGAA 
ATTGCCTTCC TCCTCTGTCA TGGAGGAGCC CTCCAGCAGC TCAGATGGCA ACATCCAGAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

1700012B09Rik, a FOXJ1 effector gene active in ciliated tissues of the mouse but not essential for motile ciliogenesis.
Developmental biology429(1)186-199(2017 09)
Stauber M,Boldt K,Wrede C,Weidemann M,Kellner M,Schuster-Gossler K,K?hnel MP,Hegermann J,Ueffing M,Gossler A

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.
Scientific reports7(1)9322(2017 Aug)
Bhargava S,Cox B,Polydorou C,Gresakova V,Korinek V,Strnad H,Sedlacek R,Epp TA,Chawengsaksophak K

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
Developmental cell40(5)439-452.e4(2017 03)
Minegishi K,Hashimoto M,Ajima R,Takaoka K,Shinohara K,Ikawa Y,Nishimura H,McMahon AP,Willert K,Okada Y,Sasaki H,Shi D,Fujimori T,Ohtsuka T,Igarashi Y,Yamaguchi TP,Shimono A,Shiratori H,Hamada H

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Noto cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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