Serpinb3b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpinb3b
Entrez Gene ID	383548
Full Name	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B
Synonyms	Scca2-rs,Scca2-rs1
General protein information	Preferred Names serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B Names serine (or cysteine) proteinase inhibitor, clade b, member 3b serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3B squamous cell carcinoma antigen 2 related protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 E2.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_198680.2	NP_941373.1	serine (or cysteine) proteinase inhibitor, clade b, member 3b

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Serpinb3c	NP_958751.2
Mus musculus (house mouse)	Serpinb3b	NP_941373.1

Gene Ontology
Bibliography

Related articles in PubMed

Serpinb3 is overexpressed in the liver in presence of iron overload.
Turato C, Kent P, Sebastiani G, Cannito S, Morello E, Terrin L, Biasiolo A, Simonato D, Parola M, Pantopoulos K, Pontisso P
Journal of investigative medicine : the official publication of the American Federation for Clinical Research66(1)32-38(2018 Jan)

SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.
Sivaprasad U, Kinker KG, Ericksen MB, Lindsey M, Gibson AM, Bass SA, Hershey NS, Deng J, Medvedovic M, Khurana Hershey GK
The Journal of investigative dermatology135(1)160-169(2015 Jan)

Update of the human and mouse SERPIN gene superfamily.
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V
Human genomics722(2013 Oct)

Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure.
Villano G, Lunardi F, Turato C, Schiff S, Tono N, Campagna F, Gatta A, Amodio P, Calabrese F, Pontisso P
Experimental biology and medicine (Maywood, N.J.)237(12)1474-82(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Serpinb3a deficiency attenuates barrier dysfunction and the early inflammatory response following cutaneous allergen exposure.
Title: SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.

in acute liver failure SERPINB3 determines an enhanced inflammatory background, mainly mediated by higher levels of Th1 proinflammatory cytokines.
Title: Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure.

Data suggest that SCCA1 inhibits cell death induced by lysosomal injury while, on the other hand, it sensitizes cells to ER stress by activating caspase-8 independently of the death receptor apoptotic pathway.
Title: Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.

Characerization of the functional properties of Serpinb3b.
Title: Characterization of novel squamous cell carcinoma antigen-related molecules in mice.

The following Serpinb3b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpinb3b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09168	NM_198680.2 Latest version!	Mus musculus serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B (Serpinb3b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpinb3b ( NM_198680.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_941373.1 Mus musculus serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B (Serpinb3b), mRNA.

Price & Availability↑

CloneID	OMu09168
Clone ID Related Accession (Same CDS sequence)	NM_198680.2
Accession Version	NM_198680.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1164bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Mus musculus(house mouse)
Product	serine (or cysteine) proteinase inhibitor, clade b, member 3b
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK003220.1. On Apr 6, 2007 this sequence version replaced NM_198680.1. ##Evidence-Data-START## Transcript exon combination :: AK003220.1, BC099584.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164137 [ECO:0000348] ##Evidence-Data-END##

ATGATTCGTT TTCATGCAGC TGATGTTAAA TTCGCAGTTG AAATGTACAG GCAGCTCAGA 
GAATCAGACA AGAACATTTT CTATTCCCCG ATCAGCATGA TGACAGCATT AGCAATGCTC 
CAGCTTGGAG CCAAAGGAAA CACTGAAATA CAAATTGAGA AGGTTCTTCA ATTCATTGAA 
ACCACCAAGA AGACAACAGA AAAATCTGAA CACTGCGATG ATGAAGAAAA TGTCCATGAA 
CAATTTCAAA AGCTTATAAC TCAGTTAAAC AAATCCAATG ATGATTATGA CCTGAAGGCT 
GCCAACAGTA TCTATGGAGC AAAGGGTTTC CCATTTCTCC AGACATTTTT GGAAGACATT 
AAGGAATATT ATCAAGCTAA GGTGGAATCA CTGGATTTCG AACATGCAAC AGAAGAGAGC 
GAAAAGAAGA TTAATTCCTG GGTGGAAAGC AAAACAAATG GAAAAATCAA AGACTTATTT 
CCTAGTGGGA GCCTAAGCAG TAGCACTATA CTGGTTCTGG TGAATGCAGT GTATTTCAAA 
GGGCAATGGA ATCGCAAATT TAATGAAAAC CATACAAGAG AAGAAAAGTT TTGGCTGAAC 
AAGAACACAA GTAAACCTGT CCAGATGATG AAACAACGAA ACAAATTTAA CTTCAGCTTT 
CTGGGGGATG TGCACGCCCA GATTGTGGAA ATACCATACA AAGGCAAAGA TCTAAGTATG 
TTTGTCCTGC TGCCAATGGA AATTGATGGT CTGAAGCAGC TTGAAGAACA ACTCACTACT 
GACAAATTAC TAGAGTGGAT AAAAGCAGAA AACATGCATT TGACTGAGTT GTATTTATCT 
TTGCCTCGGT TCAAAGTGGA AGAGAAGTAT GACCTCCAAG TTCCATTGGA ACACATGGGG 
ATGGTCGACG CCTTTGATCC ACAGAAGGCT GACTTCTCTG GCATGAGCAG CATTCCAGGT 
CTTGTGGTGT CTAAAGTTTT ACACAAGTCC TTTGTGGAGG TGAATGAAGA GGGAACAGAA 
GCTGCTGCTG CCACAGGAGT GGAAGTCAGT GTAAGATCAG CACAGATAGC AGAAGATTTC 
TGTTGTGATC ATCCATTCCT ATTCTTCATC ATTCACAGAA TGACCAACAG CATCCTCTTC 
TTTGGCAGAA TCTGCTCCCC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_941373.1
CDS	61..1224
Translation	MIRFHAADVKFAVEMYRQLRESDKNIFYSPISMMTALAMLQLGAKGNTEIQIEKVLQFIETTKKTTEKSEHCDDEENVHEQFQKLITQLNKSNDDYDLKAANSIYGAKGFPFLQTFLEDIKEYYQAKVESLDFEHATEESEKKINSWVESKTNGKIKDLFPSGSLSSSTILVLVNAVYFKGQWNRKFNENHTREEKFWLNKNTSKPVQMMKQRNKFNFSFLGDVHAQIVEIPYKGKDLSMFVLLPMEIDGLKQLEEQLTTDKLLEWIKAENMHLTELYLSLPRFKVEEKYDLQVPLEHMGMVDAFDPQKADFSGMSSIPGLVVSKVLHKSFVEVNEEGTEAAAATGVEVSVRSAQIAEDFCCDHPFLFFIIHRMTNSILFFGRICSP

Target ORF information:

RefSeq Version	NM_198680.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B (Serpinb3b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198680.2

ORF Insert Sequence:

ATGATTCGTT TTCATGCAGC TGATGTTAAA TTCGCAGTTG AAATGTACAG GCAGCTCAGA 
GAATCAGACA AGAACATTTT CTATTCCCCG ATCAGCATGA TGACAGCATT AGCAATGCTC 
CAGCTTGGAG CCAAAGGAAA CACTGAAATA CAAATTGAGA AGGTTCTTCA ATTCATTGAA 
ACCACCAAGA AGACAACAGA AAAATCTGAA CACTGCGATG ATGAAGAAAA TGTCCATGAA 
CAATTTCAAA AGCTTATAAC TCAGTTAAAC AAATCCAATG ATGATTATGA CCTGAAGGCT 
GCCAACAGTA TCTATGGAGC AAAGGGTTTC CCATTTCTCC AGACATTTTT GGAAGACATT 
AAGGAATATT ATCAAGCTAA GGTGGAATCA CTGGATTTCG AACATGCAAC AGAAGAGAGC 
GAAAAGAAGA TTAATTCCTG GGTGGAAAGC AAAACAAATG GAAAAATCAA AGACTTATTT 
CCTAGTGGGA GCCTAAGCAG TAGCACTATA CTGGTTCTGG TGAATGCAGT GTATTTCAAA 
GGGCAATGGA ATCGCAAATT TAATGAAAAC CATACAAGAG AAGAAAAGTT TTGGCTGAAC 
AAGAACACAA GTAAACCTGT CCAGATGATG AAACAACGAA ACAAATTTAA CTTCAGCTTT 
CTGGGGGATG TGCACGCCCA GATTGTGGAA ATACCATACA AAGGCAAAGA TCTAAGTATG 
TTTGTCCTGC TGCCAATGGA AATTGATGGT CTGAAGCAGC TTGAAGAACA ACTCACTACT 
GACAAATTAC TAGAGTGGAT AAAAGCAGAA AACATGCATT TGACTGAGTT GTATTTATCT 
TTGCCTCGGT TCAAAGTGGA AGAGAAGTAT GACCTCCAAG TTCCATTGGA ACACATGGGG 
ATGGTCGACG CCTTTGATCC ACAGAAGGCT GACTTCTCTG GCATGAGCAG CATTCCAGGT 
CTTGTGGTGT CTAAAGTTTT ACACAAGTCC TTTGTGGAGG TGAATGAAGA GGGAACAGAA 
GCTGCTGCTG CCACAGGAGT GGAAGTCAGT GTAAGATCAG CACAGATAGC AGAAGATTTC 
TGTTGTGATC ATCCATTCCT ATTCTTCATC ATTCACAGAA TGACCAACAG CATCCTCTTC 
TTTGGCAGAA TCTGCTCCCC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Serpinb3 is overexpressed in the liver in presence of iron overload.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research66(1)32-38(2018 Jan)
Turato C,Kent P,Sebastiani G,Cannito S,Morello E,Terrin L,Biasiolo A,Simonato D,Parola M,Pantopoulos K,Pontisso P

SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.
The Journal of investigative dermatology135(1)160-169(2015 Jan)
Sivaprasad U,Kinker KG,Ericksen MB,Lindsey M,Gibson AM,Bass SA,Hershey NS,Deng J,Medvedovic M,Khurana Hershey GK

Update of the human and mouse SERPIN gene superfamily.
Human genomics722(2013 Oct)
Heit C,Jackson BC,McAndrews M,Wright MW,Thompson DC,Silverman GA,Nebert DW,Vasiliou V

Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure.
Experimental biology and medicine (Maywood, N.J.)237(12)1474-82(2012 Dec)
Villano G,Lunardi F,Turato C,Schiff S,Tono N,Campagna F,Gatta A,Amodio P,Calabrese F,Pontisso P

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Serpinb3b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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