Map3k3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map3k3
Entrez Gene ID	26406
Full Name	mitogen-activated protein kinase kinase kinase 3
Synonyms	AW548911,MAPKKK3,Mekk3,mKIAA4031
General protein information	Preferred Names mitogen-activated protein kinase kinase kinase 3 Names mitogen-activated protein kinase kinase kinase 3 MAPK/ERK kinase kinase 3 MEK kinase 3 MEKK 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_011947.4	NP_036077.1	mitogen-activated protein kinase kinase kinase 3
NM_011947.3	NP_036077.1	mitogen-activated protein kinase kinase kinase 3
XM_011249037.3	XP_011247339.1	mitogen-activated protein kinase kinase kinase 3 isoform X1
XM_011249037.2	XP_011247339.1	mitogen-activated protein kinase kinase kinase 3 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MAP3K3	XP_537600.2
Rattus norvegicus (Norway rat)	Map3k3	NP_001100528.1
Homo sapiens (human)	MAP3K3	NP_976226.1
Mus musculus (house mouse)	Map3k3	NP_036077.1
Pan troglodytes (chimpanzee)	MAP3K3	XP_003315723.1
Bos taurus (cattle)	MAP3K3	XP_005221038.1
Gallus gallus (chicken)	MAP3K3	XP_418076.3
Xenopus tropicalis (tropical clawed frog)	map3k3	XP_002935600.2
	MAP3K3	XP_001116209.1
Danio rerio (zebrafish)	map3k3	XP_688694.2

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease.
Yao L, Ye Y, Mao H, Lu F, He X, Lu G, Zhang S
Journal of neuroinflammation15(1)13(2018 Jan)

miR-188 promotes senescence of lineage-negative bone marrow cells by targeting MAP3K3 expression.
Zheng Y, Liu H, Kong Y
FEBS letters591(15)2290-2298(2017 Aug)

TAK1 knockdown enhances lipopolysaccharide-induced secretion of proinflammatory cytokines in myeloid cells via unleashing MEKK3 activity.
Li K, Wang M, Hu Y, Xu N, Yu Q, Wang Q
Cellular immunology310193-198(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MiR-188 regulated MAP3K3 expression in bone marrow cells.MAP3K3 is involved in miR-188-induced promotion of bone marrow cells senescence.
Title: miR-188 promotes senescence of lineage-negative bone marrow cells by targeting MAP3K3 expression.

this study shows that TAK1 negatively regulates lipopolysaccharide-induced cytokine secretion in myeloid cells by inhibiting MEKK3 activities
Title: TAK1 knockdown enhances lipopolysaccharide-induced secretion of proinflammatory cytokines in myeloid cells via unleashing MEKK3 activity.

endothelial-specific loss of Mekk3, Klf2 or Klf4 markedly prevents cerebral cavernous malformation lesion formation, reverses the increase in Rho activity, and rescues lethality
Title: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

CCM2:MEKK3-mediated regulation of Rho-ROCK signalling is required for maintenance of neurovascular integrity, a mechanism by which CCM2 loss leads to disease.
Title: Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.

reveal a molecular mechanism by which CCM signaling controls endothelial gene expression during cardiovascular development
Title: The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.

The following Map3k3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map3k3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu09198	NM_011947.4 Latest version!	Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu69203	XM_011249037.3 Latest version!	Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu09198	NM_011947.3	Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu69203	XM_011249037.2	Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map3k3 ( NM_011947.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036077.1 Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), mRNA.

Price & Availability↑

CloneID	OMu09198
Clone ID Related Accession (Same CDS sequence)	NM_011947.4 , NM_011947.3
Accession Version	NM_011947.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-22
Organism	Mus musculus(house mouse)
Product	mitogen-activated protein kinase kinase kinase 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL596331.15. On Apr 28, 2007 this sequence version replaced NM_011947.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023781.1, AK137127.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGATGAAC AAGAGGCATT AGACTCGATC ATGAAGGACC TGGTGGCCCT CCAGATGAGC 
CGACGAACCC GGTTGTCTGG ATATGAGACC ATGAAGAATA AGGACACAGG TCACCCAAAC 
AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA CACAATGGGG AGAGACGAAT TATAGCATTC 
AGCCGGCCTG TGAGATACGA AGATGTGGAG CACAAGGTGA CAACAGTCTT TGGGCAGCCT 
CTTGATTTGC ATTATATGAA TAATGAGCTC TCCATCCTGT TGAAAAACCA AGATGATCTC 
GATAAAGCCA TTGACATTTT GGATAGAAGC TCAAGTATGA AAAGCCTTAG GATACTACTG 
TTATCCCAAG ACAGAAACCA TACTAGTTCC TCTCCCCACT CTGGAGTGTC CAGGCAGGTT 
CGGATCAAGC CTTCCCAGTC TGCAGGGGAT ATAAATACCA TCTACCAAGC TCCTGAGCCC 
AGAAGCAGGC ACCTGTCTGT CAGCTCCCAG AACCCTGGCC GAAGCTCTCC TCCCCCGGGA 
TATGTACCTG AGCGACAACA GCACATTGCC CGGCAAGGAT CCTATACGAG CATCAACAGC 
GAAGGTGAAT TCATCCCAGA GACCAGCGAA CAGTGTATGC TAGATCCCCT CAGCAGTGCC 
GAAAATTCCT TGTCAGGAAG CTGCCAATCC TTGGACAGGT CAGCAGACAG CCCATCCTTC 
AGGAAATCAC AAATGTCCCG AGCCCGGAGC TTCCCAGACA ACAGAAAGGA ATGCTCAGAT 
CGGGAGACCC AGCTCTATGA TAAAGGTGTC AAAGGTGGAA CCTATCCCAG GCGCTACCAT 
GTGTCTGTGC ATCACAAAGA CTACAATGAT GGCAGAAGAA CATTTCCCCG AATACGACGG 
CATCAAGGCA ACCTATTCAC TCTGGTGCCC TCAAGTCGCT CCTTGAGCAC AAATGGCGAG 
AACATGGGTG TAGCTGTGCA ATACCTGGAC CCCCGTGGGC GCCTACGGAG TGCAGACAGT 
GAGAATGCCC TCACTGTGCA GGAAAGGAAT GTGCCAACCA AATCTCCTAG TGCTCCCATC 
AATTGGCGTC GGGGGAAGCT CCTGGGTCAA GGTGCCTTCG GCAGGGTCTA CTTGTGCTAT 
GATGTGGACA CAGGACGTGA ACTTGCTTCT AAGCAGGTCC AGTTTGACCC AGATAGTCCT 
GAGACAAGCA AGGAGGTGAG TGCTCTGGAG TGTGAGATCC AGTTGCTGAA GAACCTGCAG 
CATGAGCGCA TTGTGCAGTA CTACGGCTGC CTGCGGGACC GTGCTGAGAA GATCCTCACC 
ATCTTTATGG AGTATATGCC AGGGGGCTCT GTAAAAGACC AGTTGAAGGC CTACGGAGCT 
CTGACAGAGA GTGTGACCCG CAAGTACACC CGGCAGATTC TGGAGGGCAT GTCATACCTG 
CACAGCAACA TGATTGTGCA TCGGGACATC AAGGGAGCCA ATATCCTCCG AGACTCAGCT 
GGGAATGTGA AGCTTGGGGA TTTTGGGGCC AGCAAACGCC TACAGACCAT CTGCATGTCA 
GGGACAGGCA TTCGCTCTGT CACTGGCACA CCCTACTGGA TGAGTCCTGA AGTCATCAGT 
GGCGAGGGCT ATGGAAGAAA GGCAGACGTG TGGAGCCTGG GCTGTACTGT GGTGGAAATG 
CTGACAGAGA AACCACCTTG GGCAGAGTAT GAAGCTATGG CTGCCATTTT CAAGATTGCC 
ACCCAGCCTA CCAATCCTCA GCTGCCCTCT CACATCTCAG AACACGGCAG GGACTTCCTG 
AGGCGCATAT TTGTGGAAGC TCGTCAGAGA CCCTCAGCTG AGGAGCTGCT CACACACCAC 
TTTGCACAGC TAGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036077.1
CDS	29..1909
Translation	MDEQEALDSIMKDLVALQMSRRTRLSGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGVAVQYLDPRGRLRSADSENALTVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY

Target ORF information:

RefSeq Version	NM_011947.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011947.3

ORF Insert Sequence:

ATGGATGAAC AAGAGGCATT AGACTCGATC ATGAAGGACC TGGTGGCCCT CCAGATGAGC 
CGACGAACCC GGTTGTCTGG ATATGAGACC ATGAAGAATA AGGACACAGG TCACCCAAAC 
AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA CACAATGGGG AGAGACGAAT TATAGCATTC 
AGCCGGCCTG TGAGATACGA AGATGTGGAG CACAAGGTGA CAACAGTCTT TGGGCAGCCT 
CTTGATTTGC ATTATATGAA TAATGAGCTC TCCATCCTGT TGAAAAACCA AGATGATCTC 
GATAAAGCCA TTGACATTTT GGATAGAAGC TCAAGTATGA AAAGCCTTAG GATACTACTG 
TTATCCCAAG ACAGAAACCA TACTAGTTCC TCTCCCCACT CTGGAGTGTC CAGGCAGGTT 
CGGATCAAGC CTTCCCAGTC TGCAGGGGAT ATAAATACCA TCTACCAAGC TCCTGAGCCC 
AGAAGCAGGC ACCTGTCTGT CAGCTCCCAG AACCCTGGCC GAAGCTCTCC TCCCCCGGGA 
TATGTACCTG AGCGACAACA GCACATTGCC CGGCAAGGAT CCTATACGAG CATCAACAGC 
GAAGGTGAAT TCATCCCAGA GACCAGCGAA CAGTGTATGC TAGATCCCCT CAGCAGTGCC 
GAAAATTCCT TGTCAGGAAG CTGCCAATCC TTGGACAGGT CAGCAGACAG CCCATCCTTC 
AGGAAATCAC AAATGTCCCG AGCCCGGAGC TTCCCAGACA ACAGAAAGGA ATGCTCAGAT 
CGGGAGACCC AGCTCTATGA TAAAGGTGTC AAAGGTGGAA CCTATCCCAG GCGCTACCAT 
GTGTCTGTGC ATCACAAAGA CTACAATGAT GGCAGAAGAA CATTTCCCCG AATACGACGG 
CATCAAGGCA ACCTATTCAC TCTGGTGCCC TCAAGTCGCT CCTTGAGCAC AAATGGCGAG 
AACATGGGTG TAGCTGTGCA ATACCTGGAC CCCCGTGGGC GCCTACGGAG TGCAGACAGT 
GAGAATGCCC TCACTGTGCA GGAAAGGAAT GTGCCAACCA AATCTCCTAG TGCTCCCATC 
AATTGGCGTC GGGGGAAGCT CCTGGGTCAA GGTGCCTTCG GCAGGGTCTA CTTGTGCTAT 
GATGTGGACA CAGGACGTGA ACTTGCTTCT AAGCAGGTCC AGTTTGACCC AGATAGTCCT 
GAGACAAGCA AGGAGGTGAG TGCTCTGGAG TGTGAGATCC AGTTGCTGAA GAACCTGCAG 
CATGAGCGCA TTGTGCAGTA CTACGGCTGC CTGCGGGACC GTGCTGAGAA GATCCTCACC 
ATCTTTATGG AGTATATGCC AGGGGGCTCT GTAAAAGACC AGTTGAAGGC CTACGGAGCT 
CTGACAGAGA GTGTGACCCG CAAGTACACC CGGCAGATTC TGGAGGGCAT GTCATACCTG 
CACAGCAACA TGATTGTGCA TCGGGACATC AAGGGAGCCA ATATCCTCCG AGACTCAGCT 
GGGAATGTGA AGCTTGGGGA TTTTGGGGCC AGCAAACGCC TACAGACCAT CTGCATGTCA 
GGGACAGGCA TTCGCTCTGT CACTGGCACA CCCTACTGGA TGAGTCCTGA AGTCATCAGT 
GGCGAGGGCT ATGGAAGAAA GGCAGACGTG TGGAGCCTGG GCTGTACTGT GGTGGAAATG 
CTGACAGAGA AACCACCTTG GGCAGAGTAT GAAGCTATGG CTGCCATTTT CAAGATTGCC 
ACCCAGCCTA CCAATCCTCA GCTGCCCTCT CACATCTCAG AACACGGCAG GGACTTCCTG 
AGGCGCATAT TTGTGGAAGC TCGTCAGAGA CCCTCAGCTG AGGAGCTGCT CACACACCAC 
TTTGCACAGC TAGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map3k3 ( XM_011249037.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011247339.1 Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu69203
Clone ID Related Accession (Same CDS sequence)	XM_011249037.3 , XM_011249037.2
Accession Version	XM_011249037.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1851bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	mitogen-activated protein kinase kinase kinase 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011249037.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGACC TGGTGGCCCT CCAGATGAGC CGACGAACCC GGTTGTCTGG ATATGAGACC 
ATGAAGAATA AGGACACAGG TCACCCAAAC AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA 
CACAATGGGG AGAGACGAAT TATAGCATTC AGCCGGCCTG TGAGATACGA AGATGTGGAG 
CACAAGGTGA CAACAGTCTT TGGGCAGCCT CTTGATTTGC ATTATATGAA TAATGAGCTC 
TCCATCCTGT TGAAAAACCA AGATGATCTC GATAAAGCCA TTGACATTTT GGATAGAAGC 
TCAAGTATGA AAAGCCTTAG GATACTACTG TTATCCCAAG ACAGAAACCA TACTAGTTCC 
TCTCCCCACT CTGGAGTGTC CAGGCAGGTT CGGATCAAGC CTTCCCAGTC TGCAGGGGAT 
ATAAATACCA TCTACCAAGC TCCTGAGCCC AGAAGCAGGC ACCTGTCTGT CAGCTCCCAG 
AACCCTGGCC GAAGCTCTCC TCCCCCGGGA TATGTACCTG AGCGACAACA GCACATTGCC 
CGGCAAGGAT CCTATACGAG CATCAACAGC GAAGGTGAAT TCATCCCAGA GACCAGCGAA 
CAGTGTATGC TAGATCCCCT CAGCAGTGCC GAAAATTCCT TGTCAGGAAG CTGCCAATCC 
TTGGACAGGT CAGCAGACAG CCCATCCTTC AGGAAATCAC AAATGTCCCG AGCCCGGAGC 
TTCCCAGACA ACAGAAAGGA ATGCTCAGAT CGGGAGACCC AGCTCTATGA TAAAGGTGTC 
AAAGGTGGAA CCTATCCCAG GCGCTACCAT GTGTCTGTGC ATCACAAAGA CTACAATGAT 
GGCAGAAGAA CATTTCCCCG AATACGACGG CATCAAGGCA ACCTATTCAC TCTGGTGCCC 
TCAAGTCGCT CCTTGAGCAC AAATGGCGAG AACATGGGTG TAGCTGTGCA ATACCTGGAC 
CCCCGTGGGC GCCTACGGAG TGCAGACAGT GAGAATGCCC TCACTGTGCA GGAAAGGAAT 
GTGCCAACCA AATCTCCTAG TGCTCCCATC AATTGGCGTC GGGGGAAGCT CCTGGGTCAA 
GGTGCCTTCG GCAGGGTCTA CTTGTGCTAT GATGTGGACA CAGGACGTGA ACTTGCTTCT 
AAGCAGGTCC AGTTTGACCC AGATAGTCCT GAGACAAGCA AGGAGGTGAG TGCTCTGGAG 
TGTGAGATCC AGTTGCTGAA GAACCTGCAG CATGAGCGCA TTGTGCAGTA CTACGGCTGC 
CTGCGGGACC GTGCTGAGAA GATCCTCACC ATCTTTATGG AGTATATGCC AGGGGGCTCT 
GTAAAAGACC AGTTGAAGGC CTACGGAGCT CTGACAGAGA GTGTGACCCG CAAGTACACC 
CGGCAGATTC TGGAGGGCAT GTCATACCTG CACAGCAACA TGATTGTGCA TCGGGACATC 
AAGGGAGCCA ATATCCTCCG AGACTCAGCT GGGAATGTGA AGCTTGGGGA TTTTGGGGCC 
AGCAAACGCC TACAGACCAT CTGCATGTCA GGGACAGGCA TTCGCTCTGT CACTGGCACA 
CCCTACTGGA TGAGTCCTGA AGTCATCAGT GGCGAGGGCT ATGGAAGAAA GGCAGACGTG 
TGGAGCCTGG GCTGTACTGT GGTGGAAATG CTGACAGAGA AACCACCTTG GGCAGAGTAT 
GAAGCTATGG CTGCCATTTT CAAGATTGCC ACCCAGCCTA CCAATCCTCA GCTGCCCTCT 
CACATCTCAG AACACGGCAG GGACTTCCTG AGGCGCATAT TTGTGGAAGC TCGTCAGAGA 
CCCTCAGCTG AGGAGCTGCT CACACACCAC TTTGCACAGC TAGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011247339.1
CDS	885..2735
Translation	MKDLVALQMSRRTRLSGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGVAVQYLDPRGRLRSADSENALTVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY

Target ORF information:

RefSeq Version	XM_011249037.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011249037.2

ORF Insert Sequence:

ATGAAGGACC TGGTGGCCCT CCAGATGAGC CGACGAACCC GGTTGTCTGG ATATGAGACC 
ATGAAGAATA AGGACACAGG TCACCCAAAC AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA 
CACAATGGGG AGAGACGAAT TATAGCATTC AGCCGGCCTG TGAGATACGA AGATGTGGAG 
CACAAGGTGA CAACAGTCTT TGGGCAGCCT CTTGATTTGC ATTATATGAA TAATGAGCTC 
TCCATCCTGT TGAAAAACCA AGATGATCTC GATAAAGCCA TTGACATTTT GGATAGAAGC 
TCAAGTATGA AAAGCCTTAG GATACTACTG TTATCCCAAG ACAGAAACCA TACTAGTTCC 
TCTCCCCACT CTGGAGTGTC CAGGCAGGTT CGGATCAAGC CTTCCCAGTC TGCAGGGGAT 
ATAAATACCA TCTACCAAGC TCCTGAGCCC AGAAGCAGGC ACCTGTCTGT CAGCTCCCAG 
AACCCTGGCC GAAGCTCTCC TCCCCCGGGA TATGTACCTG AGCGACAACA GCACATTGCC 
CGGCAAGGAT CCTATACGAG CATCAACAGC GAAGGTGAAT TCATCCCAGA GACCAGCGAA 
CAGTGTATGC TAGATCCCCT CAGCAGTGCC GAAAATTCCT TGTCAGGAAG CTGCCAATCC 
TTGGACAGGT CAGCAGACAG CCCATCCTTC AGGAAATCAC AAATGTCCCG AGCCCGGAGC 
TTCCCAGACA ACAGAAAGGA ATGCTCAGAT CGGGAGACCC AGCTCTATGA TAAAGGTGTC 
AAAGGTGGAA CCTATCCCAG GCGCTACCAT GTGTCTGTGC ATCACAAAGA CTACAATGAT 
GGCAGAAGAA CATTTCCCCG AATACGACGG CATCAAGGCA ACCTATTCAC TCTGGTGCCC 
TCAAGTCGCT CCTTGAGCAC AAATGGCGAG AACATGGGTG TAGCTGTGCA ATACCTGGAC 
CCCCGTGGGC GCCTACGGAG TGCAGACAGT GAGAATGCCC TCACTGTGCA GGAAAGGAAT 
GTGCCAACCA AATCTCCTAG TGCTCCCATC AATTGGCGTC GGGGGAAGCT CCTGGGTCAA 
GGTGCCTTCG GCAGGGTCTA CTTGTGCTAT GATGTGGACA CAGGACGTGA ACTTGCTTCT 
AAGCAGGTCC AGTTTGACCC AGATAGTCCT GAGACAAGCA AGGAGGTGAG TGCTCTGGAG 
TGTGAGATCC AGTTGCTGAA GAACCTGCAG CATGAGCGCA TTGTGCAGTA CTACGGCTGC 
CTGCGGGACC GTGCTGAGAA GATCCTCACC ATCTTTATGG AGTATATGCC AGGGGGCTCT 
GTAAAAGACC AGTTGAAGGC CTACGGAGCT CTGACAGAGA GTGTGACCCG CAAGTACACC 
CGGCAGATTC TGGAGGGCAT GTCATACCTG CACAGCAACA TGATTGTGCA TCGGGACATC 
AAGGGAGCCA ATATCCTCCG AGACTCAGCT GGGAATGTGA AGCTTGGGGA TTTTGGGGCC 
AGCAAACGCC TACAGACCAT CTGCATGTCA GGGACAGGCA TTCGCTCTGT CACTGGCACA 
CCCTACTGGA TGAGTCCTGA AGTCATCAGT GGCGAGGGCT ATGGAAGAAA GGCAGACGTG 
TGGAGCCTGG GCTGTACTGT GGTGGAAATG CTGACAGAGA AACCACCTTG GGCAGAGTAT 
GAAGCTATGG CTGCCATTTT CAAGATTGCC ACCCAGCCTA CCAATCCTCA GCTGCCCTCT 
CACATCTCAG AACACGGCAG GGACTTCCTG AGGCGCATAT TTGTGGAAGC TCGTCAGAGA 
CCCTCAGCTG AGGAGCTGCT CACACACCAC TTTGCACAGC TAGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map3k3 ( NM_011947.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036077.1 Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), mRNA.

Price & Availability↑

CloneID	OMu09198
Clone ID Related Accession (Same CDS sequence)	NM_011947.4 , NM_011947.3
Accession Version	NM_011947.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1881bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Mus musculus(house mouse)
Product	mitogen-activated protein kinase kinase kinase 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL596331.15. On Dec 6, 2019 this sequence version replaced NM_011947.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK137127.1, BC023781.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGATGAAC AAGAGGCATT AGACTCGATC ATGAAGGACC TGGTGGCCCT CCAGATGAGC 
CGACGAACCC GGTTGTCTGG ATATGAGACC ATGAAGAATA AGGACACAGG TCACCCAAAC 
AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA CACAATGGGG AGAGACGAAT TATAGCATTC 
AGCCGGCCTG TGAGATACGA AGATGTGGAG CACAAGGTGA CAACAGTCTT TGGGCAGCCT 
CTTGATTTGC ATTATATGAA TAATGAGCTC TCCATCCTGT TGAAAAACCA AGATGATCTC 
GATAAAGCCA TTGACATTTT GGATAGAAGC TCAAGTATGA AAAGCCTTAG GATACTACTG 
TTATCCCAAG ACAGAAACCA TACTAGTTCC TCTCCCCACT CTGGAGTGTC CAGGCAGGTT 
CGGATCAAGC CTTCCCAGTC TGCAGGGGAT ATAAATACCA TCTACCAAGC TCCTGAGCCC 
AGAAGCAGGC ACCTGTCTGT CAGCTCCCAG AACCCTGGCC GAAGCTCTCC TCCCCCGGGA 
TATGTACCTG AGCGACAACA GCACATTGCC CGGCAAGGAT CCTATACGAG CATCAACAGC 
GAAGGTGAAT TCATCCCAGA GACCAGCGAA CAGTGTATGC TAGATCCCCT CAGCAGTGCC 
GAAAATTCCT TGTCAGGAAG CTGCCAATCC TTGGACAGGT CAGCAGACAG CCCATCCTTC 
AGGAAATCAC AAATGTCCCG AGCCCGGAGC TTCCCAGACA ACAGAAAGGA ATGCTCAGAT 
CGGGAGACCC AGCTCTATGA TAAAGGTGTC AAAGGTGGAA CCTATCCCAG GCGCTACCAT 
GTGTCTGTGC ATCACAAAGA CTACAATGAT GGCAGAAGAA CATTTCCCCG AATACGACGG 
CATCAAGGCA ACCTATTCAC TCTGGTGCCC TCAAGTCGCT CCTTGAGCAC AAATGGCGAG 
AACATGGGTG TAGCTGTGCA ATACCTGGAC CCCCGTGGGC GCCTACGGAG TGCAGACAGT 
GAGAATGCCC TCACTGTGCA GGAAAGGAAT GTGCCAACCA AATCTCCTAG TGCTCCCATC 
AATTGGCGTC GGGGGAAGCT CCTGGGTCAA GGTGCCTTCG GCAGGGTCTA CTTGTGCTAT 
GATGTGGACA CAGGACGTGA ACTTGCTTCT AAGCAGGTCC AGTTTGACCC AGATAGTCCT 
GAGACAAGCA AGGAGGTGAG TGCTCTGGAG TGTGAGATCC AGTTGCTGAA GAACCTGCAG 
CATGAGCGCA TTGTGCAGTA CTACGGCTGC CTGCGGGACC GTGCTGAGAA GATCCTCACC 
ATCTTTATGG AGTATATGCC AGGGGGCTCT GTAAAAGACC AGTTGAAGGC CTACGGAGCT 
CTGACAGAGA GTGTGACCCG CAAGTACACC CGGCAGATTC TGGAGGGCAT GTCATACCTG 
CACAGCAACA TGATTGTGCA TCGGGACATC AAGGGAGCCA ATATCCTCCG AGACTCAGCT 
GGGAATGTGA AGCTTGGGGA TTTTGGGGCC AGCAAACGCC TACAGACCAT CTGCATGTCA 
GGGACAGGCA TTCGCTCTGT CACTGGCACA CCCTACTGGA TGAGTCCTGA AGTCATCAGT 
GGCGAGGGCT ATGGAAGAAA GGCAGACGTG TGGAGCCTGG GCTGTACTGT GGTGGAAATG 
CTGACAGAGA AACCACCTTG GGCAGAGTAT GAAGCTATGG CTGCCATTTT CAAGATTGCC 
ACCCAGCCTA CCAATCCTCA GCTGCCCTCT CACATCTCAG AACACGGCAG GGACTTCCTG 
AGGCGCATAT TTGTGGAAGC TCGTCAGAGA CCCTCAGCTG AGGAGCTGCT CACACACCAC 
TTTGCACAGC TAGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036077.1
CDS	344..2224
Translation	MDEQEALDSIMKDLVALQMSRRTRLSGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGVAVQYLDPRGRLRSADSENALTVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY

Target ORF information:

RefSeq Version	NM_011947.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011947.4

ORF Insert Sequence:

ATGGATGAAC AAGAGGCATT AGACTCGATC ATGAAGGACC TGGTGGCCCT CCAGATGAGC 
CGACGAACCC GGTTGTCTGG ATATGAGACC ATGAAGAATA AGGACACAGG TCACCCAAAC 
AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA CACAATGGGG AGAGACGAAT TATAGCATTC 
AGCCGGCCTG TGAGATACGA AGATGTGGAG CACAAGGTGA CAACAGTCTT TGGGCAGCCT 
CTTGATTTGC ATTATATGAA TAATGAGCTC TCCATCCTGT TGAAAAACCA AGATGATCTC 
GATAAAGCCA TTGACATTTT GGATAGAAGC TCAAGTATGA AAAGCCTTAG GATACTACTG 
TTATCCCAAG ACAGAAACCA TACTAGTTCC TCTCCCCACT CTGGAGTGTC CAGGCAGGTT 
CGGATCAAGC CTTCCCAGTC TGCAGGGGAT ATAAATACCA TCTACCAAGC TCCTGAGCCC 
AGAAGCAGGC ACCTGTCTGT CAGCTCCCAG AACCCTGGCC GAAGCTCTCC TCCCCCGGGA 
TATGTACCTG AGCGACAACA GCACATTGCC CGGCAAGGAT CCTATACGAG CATCAACAGC 
GAAGGTGAAT TCATCCCAGA GACCAGCGAA CAGTGTATGC TAGATCCCCT CAGCAGTGCC 
GAAAATTCCT TGTCAGGAAG CTGCCAATCC TTGGACAGGT CAGCAGACAG CCCATCCTTC 
AGGAAATCAC AAATGTCCCG AGCCCGGAGC TTCCCAGACA ACAGAAAGGA ATGCTCAGAT 
CGGGAGACCC AGCTCTATGA TAAAGGTGTC AAAGGTGGAA CCTATCCCAG GCGCTACCAT 
GTGTCTGTGC ATCACAAAGA CTACAATGAT GGCAGAAGAA CATTTCCCCG AATACGACGG 
CATCAAGGCA ACCTATTCAC TCTGGTGCCC TCAAGTCGCT CCTTGAGCAC AAATGGCGAG 
AACATGGGTG TAGCTGTGCA ATACCTGGAC CCCCGTGGGC GCCTACGGAG TGCAGACAGT 
GAGAATGCCC TCACTGTGCA GGAAAGGAAT GTGCCAACCA AATCTCCTAG TGCTCCCATC 
AATTGGCGTC GGGGGAAGCT CCTGGGTCAA GGTGCCTTCG GCAGGGTCTA CTTGTGCTAT 
GATGTGGACA CAGGACGTGA ACTTGCTTCT AAGCAGGTCC AGTTTGACCC AGATAGTCCT 
GAGACAAGCA AGGAGGTGAG TGCTCTGGAG TGTGAGATCC AGTTGCTGAA GAACCTGCAG 
CATGAGCGCA TTGTGCAGTA CTACGGCTGC CTGCGGGACC GTGCTGAGAA GATCCTCACC 
ATCTTTATGG AGTATATGCC AGGGGGCTCT GTAAAAGACC AGTTGAAGGC CTACGGAGCT 
CTGACAGAGA GTGTGACCCG CAAGTACACC CGGCAGATTC TGGAGGGCAT GTCATACCTG 
CACAGCAACA TGATTGTGCA TCGGGACATC AAGGGAGCCA ATATCCTCCG AGACTCAGCT 
GGGAATGTGA AGCTTGGGGA TTTTGGGGCC AGCAAACGCC TACAGACCAT CTGCATGTCA 
GGGACAGGCA TTCGCTCTGT CACTGGCACA CCCTACTGGA TGAGTCCTGA AGTCATCAGT 
GGCGAGGGCT ATGGAAGAAA GGCAGACGTG TGGAGCCTGG GCTGTACTGT GGTGGAAATG 
CTGACAGAGA AACCACCTTG GGCAGAGTAT GAAGCTATGG CTGCCATTTT CAAGATTGCC 
ACCCAGCCTA CCAATCCTCA GCTGCCCTCT CACATCTCAG AACACGGCAG GGACTTCCTG 
AGGCGCATAT TTGTGGAAGC TCGTCAGAGA CCCTCAGCTG AGGAGCTGCT CACACACCAC 
TTTGCACAGC TAGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map3k3 ( XM_011249037.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011247339.1 Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), transcript variant X2, mRNA.

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CloneID	OMu69203
Clone ID Related Accession (Same CDS sequence)	XM_011249037.3 , XM_011249037.2
Accession Version	XM_011249037.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1851bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	mitogen-activated protein kinase kinase kinase 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011249037.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGACC TGGTGGCCCT CCAGATGAGC CGACGAACCC GGTTGTCTGG ATATGAGACC 
ATGAAGAATA AGGACACAGG TCACCCAAAC AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA 
CACAATGGGG AGAGACGAAT TATAGCATTC AGCCGGCCTG TGAGATACGA AGATGTGGAG 
CACAAGGTGA CAACAGTCTT TGGGCAGCCT CTTGATTTGC ATTATATGAA TAATGAGCTC 
TCCATCCTGT TGAAAAACCA AGATGATCTC GATAAAGCCA TTGACATTTT GGATAGAAGC 
TCAAGTATGA AAAGCCTTAG GATACTACTG TTATCCCAAG ACAGAAACCA TACTAGTTCC 
TCTCCCCACT CTGGAGTGTC CAGGCAGGTT CGGATCAAGC CTTCCCAGTC TGCAGGGGAT 
ATAAATACCA TCTACCAAGC TCCTGAGCCC AGAAGCAGGC ACCTGTCTGT CAGCTCCCAG 
AACCCTGGCC GAAGCTCTCC TCCCCCGGGA TATGTACCTG AGCGACAACA GCACATTGCC 
CGGCAAGGAT CCTATACGAG CATCAACAGC GAAGGTGAAT TCATCCCAGA GACCAGCGAA 
CAGTGTATGC TAGATCCCCT CAGCAGTGCC GAAAATTCCT TGTCAGGAAG CTGCCAATCC 
TTGGACAGGT CAGCAGACAG CCCATCCTTC AGGAAATCAC AAATGTCCCG AGCCCGGAGC 
TTCCCAGACA ACAGAAAGGA ATGCTCAGAT CGGGAGACCC AGCTCTATGA TAAAGGTGTC 
AAAGGTGGAA CCTATCCCAG GCGCTACCAT GTGTCTGTGC ATCACAAAGA CTACAATGAT 
GGCAGAAGAA CATTTCCCCG AATACGACGG CATCAAGGCA ACCTATTCAC TCTGGTGCCC 
TCAAGTCGCT CCTTGAGCAC AAATGGCGAG AACATGGGTG TAGCTGTGCA ATACCTGGAC 
CCCCGTGGGC GCCTACGGAG TGCAGACAGT GAGAATGCCC TCACTGTGCA GGAAAGGAAT 
GTGCCAACCA AATCTCCTAG TGCTCCCATC AATTGGCGTC GGGGGAAGCT CCTGGGTCAA 
GGTGCCTTCG GCAGGGTCTA CTTGTGCTAT GATGTGGACA CAGGACGTGA ACTTGCTTCT 
AAGCAGGTCC AGTTTGACCC AGATAGTCCT GAGACAAGCA AGGAGGTGAG TGCTCTGGAG 
TGTGAGATCC AGTTGCTGAA GAACCTGCAG CATGAGCGCA TTGTGCAGTA CTACGGCTGC 
CTGCGGGACC GTGCTGAGAA GATCCTCACC ATCTTTATGG AGTATATGCC AGGGGGCTCT 
GTAAAAGACC AGTTGAAGGC CTACGGAGCT CTGACAGAGA GTGTGACCCG CAAGTACACC 
CGGCAGATTC TGGAGGGCAT GTCATACCTG CACAGCAACA TGATTGTGCA TCGGGACATC 
AAGGGAGCCA ATATCCTCCG AGACTCAGCT GGGAATGTGA AGCTTGGGGA TTTTGGGGCC 
AGCAAACGCC TACAGACCAT CTGCATGTCA GGGACAGGCA TTCGCTCTGT CACTGGCACA 
CCCTACTGGA TGAGTCCTGA AGTCATCAGT GGCGAGGGCT ATGGAAGAAA GGCAGACGTG 
TGGAGCCTGG GCTGTACTGT GGTGGAAATG CTGACAGAGA AACCACCTTG GGCAGAGTAT 
GAAGCTATGG CTGCCATTTT CAAGATTGCC ACCCAGCCTA CCAATCCTCA GCTGCCCTCT 
CACATCTCAG AACACGGCAG GGACTTCCTG AGGCGCATAT TTGTGGAAGC TCGTCAGAGA 
CCCTCAGCTG AGGAGCTGCT CACACACCAC TTTGCACAGC TAGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011247339.1
CDS	1804..3654
Translation	MKDLVALQMSRRTRLSGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGVAVQYLDPRGRLRSADSENALTVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFVEARQRPSAEELLTHHFAQLVY

Target ORF information:

RefSeq Version	XM_011249037.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011249037.3

ORF Insert Sequence:

ATGAAGGACC TGGTGGCCCT CCAGATGAGC CGACGAACCC GGTTGTCTGG ATATGAGACC 
ATGAAGAATA AGGACACAGG TCACCCAAAC AGGCAGAGTG ACGTCAGAAT CAAGTTTGAA 
CACAATGGGG AGAGACGAAT TATAGCATTC AGCCGGCCTG TGAGATACGA AGATGTGGAG 
CACAAGGTGA CAACAGTCTT TGGGCAGCCT CTTGATTTGC ATTATATGAA TAATGAGCTC 
TCCATCCTGT TGAAAAACCA AGATGATCTC GATAAAGCCA TTGACATTTT GGATAGAAGC 
TCAAGTATGA AAAGCCTTAG GATACTACTG TTATCCCAAG ACAGAAACCA TACTAGTTCC 
TCTCCCCACT CTGGAGTGTC CAGGCAGGTT CGGATCAAGC CTTCCCAGTC TGCAGGGGAT 
ATAAATACCA TCTACCAAGC TCCTGAGCCC AGAAGCAGGC ACCTGTCTGT CAGCTCCCAG 
AACCCTGGCC GAAGCTCTCC TCCCCCGGGA TATGTACCTG AGCGACAACA GCACATTGCC 
CGGCAAGGAT CCTATACGAG CATCAACAGC GAAGGTGAAT TCATCCCAGA GACCAGCGAA 
CAGTGTATGC TAGATCCCCT CAGCAGTGCC GAAAATTCCT TGTCAGGAAG CTGCCAATCC 
TTGGACAGGT CAGCAGACAG CCCATCCTTC AGGAAATCAC AAATGTCCCG AGCCCGGAGC 
TTCCCAGACA ACAGAAAGGA ATGCTCAGAT CGGGAGACCC AGCTCTATGA TAAAGGTGTC 
AAAGGTGGAA CCTATCCCAG GCGCTACCAT GTGTCTGTGC ATCACAAAGA CTACAATGAT 
GGCAGAAGAA CATTTCCCCG AATACGACGG CATCAAGGCA ACCTATTCAC TCTGGTGCCC 
TCAAGTCGCT CCTTGAGCAC AAATGGCGAG AACATGGGTG TAGCTGTGCA ATACCTGGAC 
CCCCGTGGGC GCCTACGGAG TGCAGACAGT GAGAATGCCC TCACTGTGCA GGAAAGGAAT 
GTGCCAACCA AATCTCCTAG TGCTCCCATC AATTGGCGTC GGGGGAAGCT CCTGGGTCAA 
GGTGCCTTCG GCAGGGTCTA CTTGTGCTAT GATGTGGACA CAGGACGTGA ACTTGCTTCT 
AAGCAGGTCC AGTTTGACCC AGATAGTCCT GAGACAAGCA AGGAGGTGAG TGCTCTGGAG 
TGTGAGATCC AGTTGCTGAA GAACCTGCAG CATGAGCGCA TTGTGCAGTA CTACGGCTGC 
CTGCGGGACC GTGCTGAGAA GATCCTCACC ATCTTTATGG AGTATATGCC AGGGGGCTCT 
GTAAAAGACC AGTTGAAGGC CTACGGAGCT CTGACAGAGA GTGTGACCCG CAAGTACACC 
CGGCAGATTC TGGAGGGCAT GTCATACCTG CACAGCAACA TGATTGTGCA TCGGGACATC 
AAGGGAGCCA ATATCCTCCG AGACTCAGCT GGGAATGTGA AGCTTGGGGA TTTTGGGGCC 
AGCAAACGCC TACAGACCAT CTGCATGTCA GGGACAGGCA TTCGCTCTGT CACTGGCACA 
CCCTACTGGA TGAGTCCTGA AGTCATCAGT GGCGAGGGCT ATGGAAGAAA GGCAGACGTG 
TGGAGCCTGG GCTGTACTGT GGTGGAAATG CTGACAGAGA AACCACCTTG GGCAGAGTAT 
GAAGCTATGG CTGCCATTTT CAAGATTGCC ACCCAGCCTA CCAATCCTCA GCTGCCCTCT 
CACATCTCAG AACACGGCAG GGACTTCCTG AGGCGCATAT TTGTGGAAGC TCGTCAGAGA 
CCCTCAGCTG AGGAGCTGCT CACACACCAC TTTGCACAGC TAGTGTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease.
Journal of neuroinflammation15(1)13(2018 Jan)
Yao L,Ye Y,Mao H,Lu F,He X,Lu G,Zhang S

miR-188 promotes senescence of lineage-negative bone marrow cells by targeting MAP3K3 expression.
FEBS letters591(15)2290-2298(2017 Aug)
Zheng Y,Liu H,Kong Y

TAK1 knockdown enhances lipopolysaccharide-induced secretion of proinflammatory cytokines in myeloid cells via unleashing MEKK3 activity.
Cellular immunology310193-198(2016 Dec)
Li K,Wang M,Hu Y,Xu N,Yu Q,Wang Q

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Map3k3 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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