Sgcg cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sgcg
Entrez Gene ID	24053
Full Name	sarcoglycan, gamma (dystrophin-associated glycoprotein)
Synonyms	35kDa,5430420E18Rik,AI642964,gamma-SG
General protein information	Preferred Names sarcoglycan, gamma (dystrophin-associated glycoprotein) Names gamma-sarcoglycan 35 kDa dystrophin-associated glycoprotein 35DAG sarcoglycan, gamma (35kD dystrophin-associated glycoprotein)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_011892.3	NP_036022.1	gamma-sarcoglycan
XM_006519012.3	XP_006519075.1	gamma-sarcoglycan isoform X1
XM_006519012.2	XP_006519075.1	gamma-sarcoglycan isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sgcg	NP_001006994.1
Mus musculus (house mouse)	Sgcg	NP_036022.1
Xenopus tropicalis (tropical clawed frog)	sgcg	NP_001072908.1
Homo sapiens (human)	SGCG	NP_000222.1
Canis lupus familiaris (dog)	SGCG	NP_001014298.1
Pan troglodytes (chimpanzee)	SGCG	XP_001151216.1
Bos taurus (cattle)	SGCG	NP_001068712.1
Gallus gallus (chicken)	SGCG	XP_417139.2
Danio rerio (zebrafish)	LOC100538014	XP_003200060.1
	LOC721411	XP_001117551.2
Danio rerio (zebrafish)	sgcg	NP_001003748.1

Gene Ontology
Bibliography

Related articles in PubMed

Intermittent Glucocorticoid Dosing Improves Muscle Repair and Function in Mice with Limb-Girdle Muscular Dystrophy.
Quattrocelli M, Salamone IM, Page PG, Warner JL, Demonbreun AR, McNally EM
The American journal of pathology187(11)2520-2535(2017 Nov)

Cleavage of ?-dystroglycan occurs in sarcoglycan-deficient skeletal muscle without MMP-2 and MMP-9.
Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu SI, Hagiwara H, Noda M, Sasaoka T, Murakami T, Sunada Y
Biochemical and biophysical research communications492(2)199-205(2017 10)

HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.
Juo LY, Liao WC, Shih YL, Yang BY, Liu AB, Yan YT
Journal of cell science129(8)1661-70(2016 Apr)

Reengineering a transmembrane protein to treat muscular dystrophy using exon skipping.
Gao QQ, Wyatt E, Goldstein JA, LoPresti P, Castillo LM, Gazda A, Petrossian N, Earley JU, Hadhazy M, Barefield DY, Demonbreun AR, B?nnemann C, Wolf M, McNally EM
The Journal of clinical investigation125(11)4186-95(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cleavage of beta-DG still occurred when both MMP-2 and MMP-9 were knocked out in gamma - sarcoglycan-deficient mice. The study found that up-regulation of MMP-14 is capable of cleaving beta-DG, and it may be involved in the pathogenesis of sarcoglycanopathy.
Title: Cleavage of ?-dystroglycan occurs in sarcoglycan-deficient skeletal muscle without MMP-2 and MMP-9.

These results position archvillin as a mechanically sensitive component of the dystrophin complex and demonstrate that signaling defects caused by loss of gamma-SG occur both at the sarcolemma and in the nucleus.
Title: Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle.

for MD research. The Sgcg(-/-) mice have a more severe phenotype than the mdx mice. Muscle function was assessed by plethysmography and echocardiography. Histologically the Sgcg(-/-) mice displayed increased fibrosis and variable fiber size.
Title: Biochemical and Functional Comparisons of mdx and Sgcg(-/-) Muscular Dystrophy Mouse Models.

This study supports a model where dystrophin, but not the sarcoglycans, protects the cardiac myocyte against mechanical damage.
Title: Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex.

localization of gamma-SG does not require Tyr(6), but localization alone is insufficient for restoration of normal signal transduction patterns after mechanical perturbation
Title: Restoration of gamma-sarcoglycan localization and mechanical signal transduction are independent in murine skeletal muscle.

The following Sgcg gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sgcg cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu09100	NM_011892.3 Latest version!	Mus musculus sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu09100	XM_006519012.3 Latest version!	Mus musculus sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu09100	XM_006519012.2	Mus musculus sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sgcg ( NM_011892.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_036022.1 Mus musculus sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg), mRNA.

Price & Availability↑

CloneID	OMu09100
Clone ID Related Accession (Same CDS sequence)	NM_011892.3 , XM_006519012.3 , XM_006519012.2
Accession Version	NM_011892.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	gamma-sarcoglycan
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC138718.3 and AK132610.1. On Feb 9, 2007 this sequence version replaced NM_011892.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF282901.1, AK132610.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTTCGAG AACAGTACAC CACGGTCACC GAGGGCACTC ACATAGAGAG GCCCGAGAAC 
CAGCACATCT ACAAGATTGG CATTTACGGA TGGAGGAAGC GCTGCCTATA CCTATTCGTT 
CTTCTCCTGC TCGCCATCCT CGTTGTGAAT CTCGCTCTCA CTATCTGGAT TCTGAAAGTG 
ATGTGGTTTT CTCCAATAGG AATGGGTCAC TTGCATGTTA CAGCAGATGG ACTTCGCCTG 
GAAGGAGAGT CGGAATTTTT ATTTCCGCTG TATGCCAAAG AAATACGCTC CAGAGTGGAC 
TCATCTCTGC TTCTGCAGTC AACCCAGAAC GTGACAGTCA GTGCTCGCAA CTCAGAAGGG 
GAGGTCACAG GCCGGGTGAA AGTGGGTGCC CAGATGGTAG AAGTCCAGAG CCAGCACTTT 
CAGATCAATT CTGAAGATGG CAAGCCACTG TTCTCTGCGG AGGAGCAGGA CGTTGTGGTT 
GGCACAGGCA GACTGCGCGT AACAGGGCCA GAAGGAGCTC TTTTTGAACA CTCAGTGGAG 
ACACCCCTTG TCAGAGCTGA CCCATTTCAA GACCTTAGGT TAGAATCCCC AACTCGGAGT 
CTAAGCATGG ATGCCCCAAG GGGGGTTCAT GTTAAAGCTA ACGCTGGGAA ATTGGAGGCC 
CTCTCTCAGA TGGACATCAT CTTGCAGAGT AGTGAAGGAG TGCTGGTGCT GGATGCTGAA 
ACTGTGGGTT TGACCAAGTT GAAGCAGGGG ACACAGGGTC CCGCTGGCAG CTCTAATGGA 
TTCTATGAGA TCTGTGCGTG TCCTGATGGG AAGCTGTACC TGTCTATGGC TGGTGAAGTC 
ACCACCTGCG AGGAACACAG CCACGTCTGT CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036022.1
CDS	152..1027
Translation	MVREQYTTVTEGTHIERPENQHIYKIGIYGWRKRCLYLFVLLLLAILVVNLALTIWILKVMWFSPIGMGHLHVTADGLRLEGESEFLFPLYAKEIRSRVDSSLLLQSTQNVTVSARNSEGEVTGRVKVGAQMVEVQSQHFQINSEDGKPLFSAEEQDVVVGTGRLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVHVKANAGKLEALSQMDIILQSSEGVLVLDAETVGLTKLKQGTQGPAGSSNGFYEICACPDGKLYLSMAGEVTTCEEHSHVCL

Target ORF information:

RefSeq Version	NM_011892.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011892.3

ORF Insert Sequence:

ATGGTTCGAG AACAGTACAC CACGGTCACC GAGGGCACTC ACATAGAGAG GCCCGAGAAC 
CAGCACATCT ACAAGATTGG CATTTACGGA TGGAGGAAGC GCTGCCTATA CCTATTCGTT 
CTTCTCCTGC TCGCCATCCT CGTTGTGAAT CTCGCTCTCA CTATCTGGAT TCTGAAAGTG 
ATGTGGTTTT CTCCAATAGG AATGGGTCAC TTGCATGTTA CAGCAGATGG ACTTCGCCTG 
GAAGGAGAGT CGGAATTTTT ATTTCCGCTG TATGCCAAAG AAATACGCTC CAGAGTGGAC 
TCATCTCTGC TTCTGCAGTC AACCCAGAAC GTGACAGTCA GTGCTCGCAA CTCAGAAGGG 
GAGGTCACAG GCCGGGTGAA AGTGGGTGCC CAGATGGTAG AAGTCCAGAG CCAGCACTTT 
CAGATCAATT CTGAAGATGG CAAGCCACTG TTCTCTGCGG AGGAGCAGGA CGTTGTGGTT 
GGCACAGGCA GACTGCGCGT AACAGGGCCA GAAGGAGCTC TTTTTGAACA CTCAGTGGAG 
ACACCCCTTG TCAGAGCTGA CCCATTTCAA GACCTTAGGT TAGAATCCCC AACTCGGAGT 
CTAAGCATGG ATGCCCCAAG GGGGGTTCAT GTTAAAGCTA ACGCTGGGAA ATTGGAGGCC 
CTCTCTCAGA TGGACATCAT CTTGCAGAGT AGTGAAGGAG TGCTGGTGCT GGATGCTGAA 
ACTGTGGGTT TGACCAAGTT GAAGCAGGGG ACACAGGGTC CCGCTGGCAG CTCTAATGGA 
TTCTATGAGA TCTGTGCGTG TCCTGATGGG AAGCTGTACC TGTCTATGGC TGGTGAAGTC 
ACCACCTGCG AGGAACACAG CCACGTCTGT CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sgcg ( XM_006519012.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006519075.1 Mus musculus sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu09100
Clone ID Related Accession (Same CDS sequence)	NM_011892.3 , XM_006519012.3 , XM_006519012.2
Accession Version	XM_006519012.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	gamma-sarcoglycan isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006519012.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTTCGAG AACAGTACAC CACGGTCACC GAGGGCACTC ACATAGAGAG GCCCGAGAAC 
CAGCACATCT ACAAGATTGG CATTTACGGA TGGAGGAAGC GCTGCCTATA CCTATTCGTT 
CTTCTCCTGC TCGCCATCCT CGTTGTGAAT CTCGCTCTCA CTATCTGGAT TCTGAAAGTG 
ATGTGGTTTT CTCCAATAGG AATGGGTCAC TTGCATGTTA CAGCAGATGG ACTTCGCCTG 
GAAGGAGAGT CGGAATTTTT ATTTCCGCTG TATGCCAAAG AAATACGCTC CAGAGTGGAC 
TCATCTCTGC TTCTGCAGTC AACCCAGAAC GTGACAGTCA GTGCTCGCAA CTCAGAAGGG 
GAGGTCACAG GCCGGGTGAA AGTGGGTGCC CAGATGGTAG AAGTCCAGAG CCAGCACTTT 
CAGATCAATT CTGAAGATGG CAAGCCACTG TTCTCTGCGG AGGAGCAGGA CGTTGTGGTT 
GGCACAGGCA GACTGCGCGT AACAGGGCCA GAAGGAGCTC TTTTTGAACA CTCAGTGGAG 
ACACCCCTTG TCAGAGCTGA CCCATTTCAA GACCTTAGGT TAGAATCCCC AACTCGGAGT 
CTAAGCATGG ATGCCCCAAG GGGGGTTCAT GTTAAAGCTA ACGCTGGGAA ATTGGAGGCC 
CTCTCTCAGA TGGACATCAT CTTGCAGAGT AGTGAAGGAG TGCTGGTGCT GGATGCTGAA 
ACTGTGGGTT TGACCAAGTT GAAGCAGGGG ACACAGGGTC CCGCTGGCAG CTCTAATGGA 
TTCTATGAGA TCTGTGCGTG TCCTGATGGG AAGCTGTACC TGTCTATGGC TGGTGAAGTC 
ACCACCTGCG AGGAACACAG CCACGTCTGT CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006519075.1
CDS	260..1135
Translation	MVREQYTTVTEGTHIERPENQHIYKIGIYGWRKRCLYLFVLLLLAILVVNLALTIWILKVMWFSPIGMGHLHVTADGLRLEGESEFLFPLYAKEIRSRVDSSLLLQSTQNVTVSARNSEGEVTGRVKVGAQMVEVQSQHFQINSEDGKPLFSAEEQDVVVGTGRLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVHVKANAGKLEALSQMDIILQSSEGVLVLDAETVGLTKLKQGTQGPAGSSNGFYEICACPDGKLYLSMAGEVTTCEEHSHVCL

Target ORF information:

RefSeq Version	XM_006519012.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006519012.2

ORF Insert Sequence:

ATGGTTCGAG AACAGTACAC CACGGTCACC GAGGGCACTC ACATAGAGAG GCCCGAGAAC 
CAGCACATCT ACAAGATTGG CATTTACGGA TGGAGGAAGC GCTGCCTATA CCTATTCGTT 
CTTCTCCTGC TCGCCATCCT CGTTGTGAAT CTCGCTCTCA CTATCTGGAT TCTGAAAGTG 
ATGTGGTTTT CTCCAATAGG AATGGGTCAC TTGCATGTTA CAGCAGATGG ACTTCGCCTG 
GAAGGAGAGT CGGAATTTTT ATTTCCGCTG TATGCCAAAG AAATACGCTC CAGAGTGGAC 
TCATCTCTGC TTCTGCAGTC AACCCAGAAC GTGACAGTCA GTGCTCGCAA CTCAGAAGGG 
GAGGTCACAG GCCGGGTGAA AGTGGGTGCC CAGATGGTAG AAGTCCAGAG CCAGCACTTT 
CAGATCAATT CTGAAGATGG CAAGCCACTG TTCTCTGCGG AGGAGCAGGA CGTTGTGGTT 
GGCACAGGCA GACTGCGCGT AACAGGGCCA GAAGGAGCTC TTTTTGAACA CTCAGTGGAG 
ACACCCCTTG TCAGAGCTGA CCCATTTCAA GACCTTAGGT TAGAATCCCC AACTCGGAGT 
CTAAGCATGG ATGCCCCAAG GGGGGTTCAT GTTAAAGCTA ACGCTGGGAA ATTGGAGGCC 
CTCTCTCAGA TGGACATCAT CTTGCAGAGT AGTGAAGGAG TGCTGGTGCT GGATGCTGAA 
ACTGTGGGTT TGACCAAGTT GAAGCAGGGG ACACAGGGTC CCGCTGGCAG CTCTAATGGA 
TTCTATGAGA TCTGTGCGTG TCCTGATGGG AAGCTGTACC TGTCTATGGC TGGTGAAGTC 
ACCACCTGCG AGGAACACAG CCACGTCTGT CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sgcg ( XM_006519012.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006519075.1 Mus musculus sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu09100
Clone ID Related Accession (Same CDS sequence)	NM_011892.3 , XM_006519012.3 , XM_006519012.2
Accession Version	XM_006519012.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	gamma-sarcoglycan isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006519012.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTTCGAG AACAGTACAC CACGGTCACC GAGGGCACTC ACATAGAGAG GCCCGAGAAC 
CAGCACATCT ACAAGATTGG CATTTACGGA TGGAGGAAGC GCTGCCTATA CCTATTCGTT 
CTTCTCCTGC TCGCCATCCT CGTTGTGAAT CTCGCTCTCA CTATCTGGAT TCTGAAAGTG 
ATGTGGTTTT CTCCAATAGG AATGGGTCAC TTGCATGTTA CAGCAGATGG ACTTCGCCTG 
GAAGGAGAGT CGGAATTTTT ATTTCCGCTG TATGCCAAAG AAATACGCTC CAGAGTGGAC 
TCATCTCTGC TTCTGCAGTC AACCCAGAAC GTGACAGTCA GTGCTCGCAA CTCAGAAGGG 
GAGGTCACAG GCCGGGTGAA AGTGGGTGCC CAGATGGTAG AAGTCCAGAG CCAGCACTTT 
CAGATCAATT CTGAAGATGG CAAGCCACTG TTCTCTGCGG AGGAGCAGGA CGTTGTGGTT 
GGCACAGGCA GACTGCGCGT AACAGGGCCA GAAGGAGCTC TTTTTGAACA CTCAGTGGAG 
ACACCCCTTG TCAGAGCTGA CCCATTTCAA GACCTTAGGT TAGAATCCCC AACTCGGAGT 
CTAAGCATGG ATGCCCCAAG GGGGGTTCAT GTTAAAGCTA ACGCTGGGAA ATTGGAGGCC 
CTCTCTCAGA TGGACATCAT CTTGCAGAGT AGTGAAGGAG TGCTGGTGCT GGATGCTGAA 
ACTGTGGGTT TGACCAAGTT GAAGCAGGGG ACACAGGGTC CCGCTGGCAG CTCTAATGGA 
TTCTATGAGA TCTGTGCGTG TCCTGATGGG AAGCTGTACC TGTCTATGGC TGGTGAAGTC 
ACCACCTGCG AGGAACACAG CCACGTCTGT CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006519075.1
CDS	464..1339
Translation	MVREQYTTVTEGTHIERPENQHIYKIGIYGWRKRCLYLFVLLLLAILVVNLALTIWILKVMWFSPIGMGHLHVTADGLRLEGESEFLFPLYAKEIRSRVDSSLLLQSTQNVTVSARNSEGEVTGRVKVGAQMVEVQSQHFQINSEDGKPLFSAEEQDVVVGTGRLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVHVKANAGKLEALSQMDIILQSSEGVLVLDAETVGLTKLKQGTQGPAGSSNGFYEICACPDGKLYLSMAGEVTTCEEHSHVCL

Target ORF information:

RefSeq Version	XM_006519012.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus sarcoglycan, gamma (dystrophin-associated glycoprotein) (Sgcg), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006519012.3

ORF Insert Sequence:

ATGGTTCGAG AACAGTACAC CACGGTCACC GAGGGCACTC ACATAGAGAG GCCCGAGAAC 
CAGCACATCT ACAAGATTGG CATTTACGGA TGGAGGAAGC GCTGCCTATA CCTATTCGTT 
CTTCTCCTGC TCGCCATCCT CGTTGTGAAT CTCGCTCTCA CTATCTGGAT TCTGAAAGTG 
ATGTGGTTTT CTCCAATAGG AATGGGTCAC TTGCATGTTA CAGCAGATGG ACTTCGCCTG 
GAAGGAGAGT CGGAATTTTT ATTTCCGCTG TATGCCAAAG AAATACGCTC CAGAGTGGAC 
TCATCTCTGC TTCTGCAGTC AACCCAGAAC GTGACAGTCA GTGCTCGCAA CTCAGAAGGG 
GAGGTCACAG GCCGGGTGAA AGTGGGTGCC CAGATGGTAG AAGTCCAGAG CCAGCACTTT 
CAGATCAATT CTGAAGATGG CAAGCCACTG TTCTCTGCGG AGGAGCAGGA CGTTGTGGTT 
GGCACAGGCA GACTGCGCGT AACAGGGCCA GAAGGAGCTC TTTTTGAACA CTCAGTGGAG 
ACACCCCTTG TCAGAGCTGA CCCATTTCAA GACCTTAGGT TAGAATCCCC AACTCGGAGT 
CTAAGCATGG ATGCCCCAAG GGGGGTTCAT GTTAAAGCTA ACGCTGGGAA ATTGGAGGCC 
CTCTCTCAGA TGGACATCAT CTTGCAGAGT AGTGAAGGAG TGCTGGTGCT GGATGCTGAA 
ACTGTGGGTT TGACCAAGTT GAAGCAGGGG ACACAGGGTC CCGCTGGCAG CTCTAATGGA 
TTCTATGAGA TCTGTGCGTG TCCTGATGGG AAGCTGTACC TGTCTATGGC TGGTGAAGTC 
ACCACCTGCG AGGAACACAG CCACGTCTGT CTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Intermittent Glucocorticoid Dosing Improves Muscle Repair and Function in Mice with Limb-Girdle Muscular Dystrophy.
The American journal of pathology187(11)2520-2535(2017 Nov)
Quattrocelli M,Salamone IM,Page PG,Warner JL,Demonbreun AR,McNally EM

Cleavage of ?-dystroglycan occurs in sarcoglycan-deficient skeletal muscle without MMP-2 and MMP-9.
Biochemical and biophysical research communications492(2)199-205(2017 10)
Fukai Y,Ohsawa Y,Ohtsubo H,Nishimatsu SI,Hagiwara H,Noda M,Sasaoka T,Murakami T,Sunada Y

HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.
Journal of cell science129(8)1661-70(2016 Apr)
Juo LY,Liao WC,Shih YL,Yang BY,Liu AB,Yan YT

Reengineering a transmembrane protein to treat muscular dystrophy using exon skipping.
The Journal of clinical investigation125(11)4186-95(2015 Nov)
Gao QQ,Wyatt E,Goldstein JA,LoPresti P,Castillo LM,Gazda A,Petrossian N,Earley JU,Hadhazy M,Barefield DY,Demonbreun AR,B?nnemann C,Wolf M,McNally EM

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Sgcg cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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