Peli3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Peli3
Entrez Gene ID	240518
Full Name	pellino 3
Synonyms	6030441F14Rik,A930011L17,BC028931
General protein information	Preferred Names pellino 3 Names E3 ubiquitin-protein ligase pellino homolog 3 RING-type E3 ubiquitin transferase pellino homolog 3 protein pellino homolog 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 A

mRNA and Protein(s)

mRNA	Protein	Name
XM_006531746.1	XP_006531809.1	E3 ubiquitin-protein ligase pellino homolog 3 isoform X2
NM_001347422.1	NP_001334351.1	E3 ubiquitin-protein ligase pellino homolog 3 isoform 2
XM_006531745.1	XP_006531808.1	E3 ubiquitin-protein ligase pellino homolog 3 isoform X1
NM_172835.3	NP_766423.3	E3 ubiquitin-protein ligase pellino homolog 3 isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PELI3	NP_001178415.1
Danio rerio (zebrafish)	LOC100331601	XP_002662845.2
	PELI3	XP_001110166.1
Rattus norvegicus (Norway rat)	Peli3	NP_001121014.1
Canis lupus familiaris (dog)	PELI3	XP_865840.1
Homo sapiens (human)	PELI3	NP_659502.2
Pan troglodytes (chimpanzee)	PELI3	XP_001172024.1
Mus musculus (house mouse)	Peli3	NP_766423.3

Gene Ontology
Bibliography

Related articles in PubMed

Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.
Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE
Journal of leukocyte biology98(6)963-74(2015 Dec)

The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.
Yang S, Wang B, Humphries F, Hogan AE, O'Shea D, Moynagh PN
Immunity41(6)973-87(2014 Dec)

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression.
Giegerich AK, Kuchler L, Sha LK, Knape T, Heide H, Wittig I, Behrends C, Br?ne B, von Knethen A
Autophagy10(11)1937-52(2014)

Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-?.
Yang S, Wang B, Tang LS, Siednienko J, Callanan JJ, Moynagh PN
Nature communications42583(2013)

WIP regulates persistence of cell migration and ruffle formation in both mesenchymal and amoeboid modes of motility.
Banon-Rodriguez I, Saez de Guinoa J, Bernardini A, Ragazzini C, Fernandez E, Carrasco YR, Jones GE, Wandosell F, Anton IM
PloS one8(8)e70364(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling.
Title: Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.

autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis by inhibiting proinflammatory IL1B expression
Title: Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression.

Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation.
Title: Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.

Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-alpha.
Title: Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-?.

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons.
Title: Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons.

The following Peli3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Peli3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19610	NM_172835.3 Latest version!	Mus musculus pellino 3 (Peli3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu55066	NM_001347422.1 Latest version!	Mus musculus pellino 3 (Peli3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu19610	XM_006531745.1 Latest version!	Mus musculus pellino 3 (Peli3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu55066	XM_006531746.1 Latest version!	Mus musculus pellino 3 (Peli3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Peli3 ( NM_172835.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766423.3 Mus musculus pellino 3 (Peli3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19610
Clone ID Related Accession (Same CDS sequence)	XM_006531745.1 , NM_172835.3
Accession Version	NM_172835.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase pellino homolog 3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY128359.1, AK044418.1 and BY452323.1. On Jun 21, 2008 this sequence version replaced NM_172835.2. ##Evidence-Data-START## Transcript exon combination :: BC028931.1, AK044418.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGTGCTGG AAGGAAACCC TGACGTGGGA TCCCCCCGGA CCTCAGACCT CCAGCACCCG 
GGGAGCCAGG GCTCTTGCAT CCTGTCTTGT CCTGGTGAAG AAGCACTGGC AGGCGAGGAG 
CCCATCAAGT ATGGTGAACT CATCGTTCTG GGCTACAATG GGTGTCTGGC AAGTGGAGAC 
AAGGGCCGCC GCCGAAGCCG CCTGGCACTG AGCCGCCGGC CACATGCCAA CGGAGTGAAG 
CCAGATGTCA TGCACCACAT CTCCACACCA CTCGTCTCCA AGGCCCTGAG TAACCGAGGC 
CAGCACAGCA TCTCATTCAC ACTGTCCCGG AGTCACTCAG TCATAGTGGA GTACACACAT 
GACAGCGACA AAGACATGTT CCAGATTGGC CGCTCTACTG AAAACATGAT TGACTTTGTG 
GTAACAGACA CATCTCCTGG TGGAGGGGCT ACAGAGGGCC CTTCTGCCCA AAGTACCATC 
TCCCGCTATG CCTGCAGAAT TCTCTGTGAC CGCCGGCCAC CCTATACTGC CCGAATCTAC 
GCTGCTGGCT TTGATGCCTC TAGCAACATC TTTCTTGGAG AGCGGGCAGC CAAATGGAGG 
ACTCCGGATG GTCTGATGGA CGGCTTGACA ACCAATGGGG TTCTGGTGAT GCACCCAGCA 
GGTGGCTTCT CCGAGGACTC TGCCCCAGGT GTCTGGAGGG AGATTTCTGT CTGCGGGAAT 
GTGTACACGC TGCGGGATAG CCGATCAGCT CAGCAGCGGG GGAAGCTGGT GGAAAACGAA 
TCCAACGTCC TGCAAGACGG TTCGCTCATC GACCTGTGTG GGGCCACACT GTTGTGGCGC 
ACTCCGGCTG GGTTGCTGAG GGCACCCACA CTGAAACAAC TAGAGGCCCA GCGACAGGAG 
GCCAACGCAG CACGGCCCCA GTGCCCCGTG GGCCTTAGCA CCTTGGCCTT CCCCAGCCCA 
GCCCGTGGCC GCACAGCACC CGACAAACAG CAACCCTGGG TCTACGTCCG TTGTGGTCAT 
GTCCATGGCT ATCACGGCTG GGGCTGCCGG AGGGAACAAG GCCCCCAGGA GCGAGAGTGT 
CCTCTCTGCC GCCTTGTGGG ACCCTATGTG CCCCTGTGGC TCGGTCAGGA GGCCGGTCTC 
TGCCTGGACC CTGGGCCACC CAGCCACGCT TTTGCACCCT GTGGCCACGT CTGTTCTGAG 
AAGACTGCCC GCTACTGGGC TCAGACACCG CTGCCGCACG GCACCCATGC TTTCCACGCT 
GCCTGCCCCT TCTGTGGAGC TTGGCTCACC GGTGAGCTTG GCTGTGTCCG CCTCATTTTC 
CAGGGGCCAC TGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766423.3
CDS	157..1494
Translation	MVLEGNPDVGSPRTSDLQHPGSQGSCILSCPGEEALAGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKALSNRGQHSISFTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVVTDTSPGGGATEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRREQGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD

Target ORF information:

RefSeq Version	NM_172835.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus pellino 3 (Peli3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172835.3

ORF Insert Sequence:

ATGGTGCTGG AAGGAAACCC TGACGTGGGA TCCCCCCGGA CCTCAGACCT CCAGCACCCG 
GGGAGCCAGG GCTCTTGCAT CCTGTCTTGT CCTGGTGAAG AAGCACTGGC AGGCGAGGAG 
CCCATCAAGT ATGGTGAACT CATCGTTCTG GGCTACAATG GGTGTCTGGC AAGTGGAGAC 
AAGGGCCGCC GCCGAAGCCG CCTGGCACTG AGCCGCCGGC CACATGCCAA CGGAGTGAAG 
CCAGATGTCA TGCACCACAT CTCCACACCA CTCGTCTCCA AGGCCCTGAG TAACCGAGGC 
CAGCACAGCA TCTCATTCAC ACTGTCCCGG AGTCACTCAG TCATAGTGGA GTACACACAT 
GACAGCGACA AAGACATGTT CCAGATTGGC CGCTCTACTG AAAACATGAT TGACTTTGTG 
GTAACAGACA CATCTCCTGG TGGAGGGGCT ACAGAGGGCC CTTCTGCCCA AAGTACCATC 
TCCCGCTATG CCTGCAGAAT TCTCTGTGAC CGCCGGCCAC CCTATACTGC CCGAATCTAC 
GCTGCTGGCT TTGATGCCTC TAGCAACATC TTTCTTGGAG AGCGGGCAGC CAAATGGAGG 
ACTCCGGATG GTCTGATGGA CGGCTTGACA ACCAATGGGG TTCTGGTGAT GCACCCAGCA 
GGTGGCTTCT CCGAGGACTC TGCCCCAGGT GTCTGGAGGG AGATTTCTGT CTGCGGGAAT 
GTGTACACGC TGCGGGATAG CCGATCAGCT CAGCAGCGGG GGAAGCTGGT GGAAAACGAA 
TCCAACGTCC TGCAAGACGG TTCGCTCATC GACCTGTGTG GGGCCACACT GTTGTGGCGC 
ACTCCGGCTG GGTTGCTGAG GGCACCCACA CTGAAACAAC TAGAGGCCCA GCGACAGGAG 
GCCAACGCAG CACGGCCCCA GTGCCCCGTG GGCCTTAGCA CCTTGGCCTT CCCCAGCCCA 
GCCCGTGGCC GCACAGCACC CGACAAACAG CAACCCTGGG TCTACGTCCG TTGTGGTCAT 
GTCCATGGCT ATCACGGCTG GGGCTGCCGG AGGGAACAAG GCCCCCAGGA GCGAGAGTGT 
CCTCTCTGCC GCCTTGTGGG ACCCTATGTG CCCCTGTGGC TCGGTCAGGA GGCCGGTCTC 
TGCCTGGACC CTGGGCCACC CAGCCACGCT TTTGCACCCT GTGGCCACGT CTGTTCTGAG 
AAGACTGCCC GCTACTGGGC TCAGACACCG CTGCCGCACG GCACCCATGC TTTCCACGCT 
GCCTGCCCCT TCTGTGGAGC TTGGCTCACC GGTGAGCTTG GCTGTGTCCG CCTCATTTTC 
CAGGGGCCAC TGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Peli3 ( NM_001347422.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001334351.1 Mus musculus pellino 3 (Peli3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu55066
Clone ID Related Accession (Same CDS sequence)	XM_006531746.1 , NM_001347422.1
Accession Version	NM_001347422.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-16
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase pellino homolog 3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124502.4 and BC022735.1. On Nov 26, 2016 this sequence version replaced XM_006531747.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK135575.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCTGG AAGGAAACCC TGACGTGGGA TCCCCCCGGA CCTCAGACCT CCAGCACCCG 
GGGAGCCAGG GCTCTTGCAT CCTGTCTTGT CCTGGTGAAG AAGCACTGGC AGGCGAGGAG 
CCCATCAAGT ATGGTGAACT CATCGTTCTG GGCTACAATG GGTGTCTGGC AAGTGGAGAC 
AAGGGCCGCC GCCGAAGCCG CCTGGCACTG AGCCGCCGGC CACATGCCAA CGGAGTGAAG 
CCAGATGTCA TGCACCACAT CTCCACACCA CTCGTCTCCA AGATTGGCCG CTCTACTGAA 
AACATGATTG ACTTTGTGGT AACAGACACA TCTCCTGGTG GAGGGGCTAC AGAGGGCCCT 
TCTGCCCAAA GTACCATCTC CCGCTATGCC TGCAGAATTC TCTGTGACCG CCGGCCACCC 
TATACTGCCC GAATCTACGC TGCTGGCTTT GATGCCTCTA GCAACATCTT TCTTGGAGAG 
CGGGCAGCCA AATGGAGGAC TCCGGATGGT CTGATGGACG GCTTGACAAC CAATGGGGTT 
CTGGTGATGC ACCCAGCAGG TGGCTTCTCC GAGGACTCTG CCCCAGGTGT CTGGAGGGAG 
ATTTCTGTCT GCGGGAATGT GTACACGCTG CGGGATAGCC GATCAGCTCA GCAGCGGGGG 
AAGCTGGTGG AAAACGAATC CAACGTCCTG CAAGACGGTT CGCTCATCGA CCTGTGTGGG 
GCCACACTGT TGTGGCGCAC TCCGGCTGGG TTGCTGAGGG CACCCACACT GAAACAACTA 
GAGGCCCAGC GACAGGAGGC CAACGCAGCA CGGCCCCAGT GCCCCGTGGG CCTTAGCACC 
TTGGCCTTCC CCAGCCCAGC CCGTGGCCGC ACAGCACCCG ACAAACAGCA ACCCTGGGTC 
TACGTCCGTT GTGGTCATGT CCATGGCTAT CACGGCTGGG GCTGCCGGAG GGAACAAGGC 
CCCCAGGAGC GAGAGTGTCC TCTCTGCCGC CTTGTGGGAC CCTATGTGCC CCTGTGGCTC 
GGTCAGGAGG CCGGTCTCTG CCTGGACCCT GGGCCACCCA GCCACGCTTT TGCACCCTGT 
GGCCACGTCT GTTCTGAGAA GACTGCCCGC TACTGGGCTC AGACACCGCT GCCGCACGGC 
ACCCATGCTT TCCACGCTGC CTGCCCCTTC TGTGGAGCTT GGCTCACCGG TGAGCTTGGC 
TGTGTCCGCC TCATTTTCCA GGGGCCACTG GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334351.1
CDS	141..1376
Translation	MVLEGNPDVGSPRTSDLQHPGSQGSCILSCPGEEALAGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKIGRSTENMIDFVVTDTSPGGGATEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRREQGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD

Target ORF information:

RefSeq Version	NM_001347422.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus pellino 3 (Peli3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347422.1

ORF Insert Sequence:

ATGGTGCTGG AAGGAAACCC TGACGTGGGA TCCCCCCGGA CCTCAGACCT CCAGCACCCG 
GGGAGCCAGG GCTCTTGCAT CCTGTCTTGT CCTGGTGAAG AAGCACTGGC AGGCGAGGAG 
CCCATCAAGT ATGGTGAACT CATCGTTCTG GGCTACAATG GGTGTCTGGC AAGTGGAGAC 
AAGGGCCGCC GCCGAAGCCG CCTGGCACTG AGCCGCCGGC CACATGCCAA CGGAGTGAAG 
CCAGATGTCA TGCACCACAT CTCCACACCA CTCGTCTCCA AGATTGGCCG CTCTACTGAA 
AACATGATTG ACTTTGTGGT AACAGACACA TCTCCTGGTG GAGGGGCTAC AGAGGGCCCT 
TCTGCCCAAA GTACCATCTC CCGCTATGCC TGCAGAATTC TCTGTGACCG CCGGCCACCC 
TATACTGCCC GAATCTACGC TGCTGGCTTT GATGCCTCTA GCAACATCTT TCTTGGAGAG 
CGGGCAGCCA AATGGAGGAC TCCGGATGGT CTGATGGACG GCTTGACAAC CAATGGGGTT 
CTGGTGATGC ACCCAGCAGG TGGCTTCTCC GAGGACTCTG CCCCAGGTGT CTGGAGGGAG 
ATTTCTGTCT GCGGGAATGT GTACACGCTG CGGGATAGCC GATCAGCTCA GCAGCGGGGG 
AAGCTGGTGG AAAACGAATC CAACGTCCTG CAAGACGGTT CGCTCATCGA CCTGTGTGGG 
GCCACACTGT TGTGGCGCAC TCCGGCTGGG TTGCTGAGGG CACCCACACT GAAACAACTA 
GAGGCCCAGC GACAGGAGGC CAACGCAGCA CGGCCCCAGT GCCCCGTGGG CCTTAGCACC 
TTGGCCTTCC CCAGCCCAGC CCGTGGCCGC ACAGCACCCG ACAAACAGCA ACCCTGGGTC 
TACGTCCGTT GTGGTCATGT CCATGGCTAT CACGGCTGGG GCTGCCGGAG GGAACAAGGC 
CCCCAGGAGC GAGAGTGTCC TCTCTGCCGC CTTGTGGGAC CCTATGTGCC CCTGTGGCTC 
GGTCAGGAGG CCGGTCTCTG CCTGGACCCT GGGCCACCCA GCCACGCTTT TGCACCCTGT 
GGCCACGTCT GTTCTGAGAA GACTGCCCGC TACTGGGCTC AGACACCGCT GCCGCACGGC 
ACCCATGCTT TCCACGCTGC CTGCCCCTTC TGTGGAGCTT GGCTCACCGG TGAGCTTGGC 
TGTGTCCGCC TCATTTTCCA GGGGCCACTG GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Peli3 ( XM_006531745.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006531808.1 Mus musculus pellino 3 (Peli3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19610
Clone ID Related Accession (Same CDS sequence)	XM_006531745.1 , NM_172835.3
Accession Version	XM_006531745.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase pellino homolog 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGCTGG AAGGAAACCC TGACGTGGGA TCCCCCCGGA CCTCAGACCT CCAGCACCCG 
GGGAGCCAGG GCTCTTGCAT CCTGTCTTGT CCTGGTGAAG AAGCACTGGC AGGCGAGGAG 
CCCATCAAGT ATGGTGAACT CATCGTTCTG GGCTACAATG GGTGTCTGGC AAGTGGAGAC 
AAGGGCCGCC GCCGAAGCCG CCTGGCACTG AGCCGCCGGC CACATGCCAA CGGAGTGAAG 
CCAGATGTCA TGCACCACAT CTCCACACCA CTCGTCTCCA AGGCCCTGAG TAACCGAGGC 
CAGCACAGCA TCTCATTCAC ACTGTCCCGG AGTCACTCAG TCATAGTGGA GTACACACAT 
GACAGCGACA AAGACATGTT CCAGATTGGC CGCTCTACTG AAAACATGAT TGACTTTGTG 
GTAACAGACA CATCTCCTGG TGGAGGGGCT ACAGAGGGCC CTTCTGCCCA AAGTACCATC 
TCCCGCTATG CCTGCAGAAT TCTCTGTGAC CGCCGGCCAC CCTATACTGC CCGAATCTAC 
GCTGCTGGCT TTGATGCCTC TAGCAACATC TTTCTTGGAG AGCGGGCAGC CAAATGGAGG 
ACTCCGGATG GTCTGATGGA CGGCTTGACA ACCAATGGGG TTCTGGTGAT GCACCCAGCA 
GGTGGCTTCT CCGAGGACTC TGCCCCAGGT GTCTGGAGGG AGATTTCTGT CTGCGGGAAT 
GTGTACACGC TGCGGGATAG CCGATCAGCT CAGCAGCGGG GGAAGCTGGT GGAAAACGAA 
TCCAACGTCC TGCAAGACGG TTCGCTCATC GACCTGTGTG GGGCCACACT GTTGTGGCGC 
ACTCCGGCTG GGTTGCTGAG GGCACCCACA CTGAAACAAC TAGAGGCCCA GCGACAGGAG 
GCCAACGCAG CACGGCCCCA GTGCCCCGTG GGCCTTAGCA CCTTGGCCTT CCCCAGCCCA 
GCCCGTGGCC GCACAGCACC CGACAAACAG CAACCCTGGG TCTACGTCCG TTGTGGTCAT 
GTCCATGGCT ATCACGGCTG GGGCTGCCGG AGGGAACAAG GCCCCCAGGA GCGAGAGTGT 
CCTCTCTGCC GCCTTGTGGG ACCCTATGTG CCCCTGTGGC TCGGTCAGGA GGCCGGTCTC 
TGCCTGGACC CTGGGCCACC CAGCCACGCT TTTGCACCCT GTGGCCACGT CTGTTCTGAG 
AAGACTGCCC GCTACTGGGC TCAGACACCG CTGCCGCACG GCACCCATGC TTTCCACGCT 
GCCTGCCCCT TCTGTGGAGC TTGGCTCACC GGTGAGCTTG GCTGTGTCCG CCTCATTTTC 
CAGGGGCCAC TGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006531808.1
CDS	126..1463
Translation	MVLEGNPDVGSPRTSDLQHPGSQGSCILSCPGEEALAGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKALSNRGQHSISFTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVVTDTSPGGGATEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRREQGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD

Target ORF information:

RefSeq Version	XM_006531745.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus pellino 3 (Peli3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006531745.1

ORF Insert Sequence:

ATGGTGCTGG AAGGAAACCC TGACGTGGGA TCCCCCCGGA CCTCAGACCT CCAGCACCCG 
GGGAGCCAGG GCTCTTGCAT CCTGTCTTGT CCTGGTGAAG AAGCACTGGC AGGCGAGGAG 
CCCATCAAGT ATGGTGAACT CATCGTTCTG GGCTACAATG GGTGTCTGGC AAGTGGAGAC 
AAGGGCCGCC GCCGAAGCCG CCTGGCACTG AGCCGCCGGC CACATGCCAA CGGAGTGAAG 
CCAGATGTCA TGCACCACAT CTCCACACCA CTCGTCTCCA AGGCCCTGAG TAACCGAGGC 
CAGCACAGCA TCTCATTCAC ACTGTCCCGG AGTCACTCAG TCATAGTGGA GTACACACAT 
GACAGCGACA AAGACATGTT CCAGATTGGC CGCTCTACTG AAAACATGAT TGACTTTGTG 
GTAACAGACA CATCTCCTGG TGGAGGGGCT ACAGAGGGCC CTTCTGCCCA AAGTACCATC 
TCCCGCTATG CCTGCAGAAT TCTCTGTGAC CGCCGGCCAC CCTATACTGC CCGAATCTAC 
GCTGCTGGCT TTGATGCCTC TAGCAACATC TTTCTTGGAG AGCGGGCAGC CAAATGGAGG 
ACTCCGGATG GTCTGATGGA CGGCTTGACA ACCAATGGGG TTCTGGTGAT GCACCCAGCA 
GGTGGCTTCT CCGAGGACTC TGCCCCAGGT GTCTGGAGGG AGATTTCTGT CTGCGGGAAT 
GTGTACACGC TGCGGGATAG CCGATCAGCT CAGCAGCGGG GGAAGCTGGT GGAAAACGAA 
TCCAACGTCC TGCAAGACGG TTCGCTCATC GACCTGTGTG GGGCCACACT GTTGTGGCGC 
ACTCCGGCTG GGTTGCTGAG GGCACCCACA CTGAAACAAC TAGAGGCCCA GCGACAGGAG 
GCCAACGCAG CACGGCCCCA GTGCCCCGTG GGCCTTAGCA CCTTGGCCTT CCCCAGCCCA 
GCCCGTGGCC GCACAGCACC CGACAAACAG CAACCCTGGG TCTACGTCCG TTGTGGTCAT 
GTCCATGGCT ATCACGGCTG GGGCTGCCGG AGGGAACAAG GCCCCCAGGA GCGAGAGTGT 
CCTCTCTGCC GCCTTGTGGG ACCCTATGTG CCCCTGTGGC TCGGTCAGGA GGCCGGTCTC 
TGCCTGGACC CTGGGCCACC CAGCCACGCT TTTGCACCCT GTGGCCACGT CTGTTCTGAG 
AAGACTGCCC GCTACTGGGC TCAGACACCG CTGCCGCACG GCACCCATGC TTTCCACGCT 
GCCTGCCCCT TCTGTGGAGC TTGGCTCACC GGTGAGCTTG GCTGTGTCCG CCTCATTTTC 
CAGGGGCCAC TGGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Peli3 ( XM_006531746.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006531809.1 Mus musculus pellino 3 (Peli3), transcript variant X2, mRNA.

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CloneID	OMu55066
Clone ID Related Accession (Same CDS sequence)	XM_006531746.1 , NM_001347422.1
Accession Version	XM_006531746.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase pellino homolog 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGCTGG AAGGAAACCC TGACGTGGGA TCCCCCCGGA CCTCAGACCT CCAGCACCCG 
GGGAGCCAGG GCTCTTGCAT CCTGTCTTGT CCTGGTGAAG AAGCACTGGC AGGCGAGGAG 
CCCATCAAGT ATGGTGAACT CATCGTTCTG GGCTACAATG GGTGTCTGGC AAGTGGAGAC 
AAGGGCCGCC GCCGAAGCCG CCTGGCACTG AGCCGCCGGC CACATGCCAA CGGAGTGAAG 
CCAGATGTCA TGCACCACAT CTCCACACCA CTCGTCTCCA AGATTGGCCG CTCTACTGAA 
AACATGATTG ACTTTGTGGT AACAGACACA TCTCCTGGTG GAGGGGCTAC AGAGGGCCCT 
TCTGCCCAAA GTACCATCTC CCGCTATGCC TGCAGAATTC TCTGTGACCG CCGGCCACCC 
TATACTGCCC GAATCTACGC TGCTGGCTTT GATGCCTCTA GCAACATCTT TCTTGGAGAG 
CGGGCAGCCA AATGGAGGAC TCCGGATGGT CTGATGGACG GCTTGACAAC CAATGGGGTT 
CTGGTGATGC ACCCAGCAGG TGGCTTCTCC GAGGACTCTG CCCCAGGTGT CTGGAGGGAG 
ATTTCTGTCT GCGGGAATGT GTACACGCTG CGGGATAGCC GATCAGCTCA GCAGCGGGGG 
AAGCTGGTGG AAAACGAATC CAACGTCCTG CAAGACGGTT CGCTCATCGA CCTGTGTGGG 
GCCACACTGT TGTGGCGCAC TCCGGCTGGG TTGCTGAGGG CACCCACACT GAAACAACTA 
GAGGCCCAGC GACAGGAGGC CAACGCAGCA CGGCCCCAGT GCCCCGTGGG CCTTAGCACC 
TTGGCCTTCC CCAGCCCAGC CCGTGGCCGC ACAGCACCCG ACAAACAGCA ACCCTGGGTC 
TACGTCCGTT GTGGTCATGT CCATGGCTAT CACGGCTGGG GCTGCCGGAG GGAACAAGGC 
CCCCAGGAGC GAGAGTGTCC TCTCTGCCGC CTTGTGGGAC CCTATGTGCC CCTGTGGCTC 
GGTCAGGAGG CCGGTCTCTG CCTGGACCCT GGGCCACCCA GCCACGCTTT TGCACCCTGT 
GGCCACGTCT GTTCTGAGAA GACTGCCCGC TACTGGGCTC AGACACCGCT GCCGCACGGC 
ACCCATGCTT TCCACGCTGC CTGCCCCTTC TGTGGAGCTT GGCTCACCGG TGAGCTTGGC 
TGTGTCCGCC TCATTTTCCA GGGGCCACTG GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006531809.1
CDS	192..1427
Translation	MVLEGNPDVGSPRTSDLQHPGSQGSCILSCPGEEALAGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKIGRSTENMIDFVVTDTSPGGGATEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRREQGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD

Target ORF information:

RefSeq Version	XM_006531746.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus pellino 3 (Peli3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006531746.1

ORF Insert Sequence:

ATGGTGCTGG AAGGAAACCC TGACGTGGGA TCCCCCCGGA CCTCAGACCT CCAGCACCCG 
GGGAGCCAGG GCTCTTGCAT CCTGTCTTGT CCTGGTGAAG AAGCACTGGC AGGCGAGGAG 
CCCATCAAGT ATGGTGAACT CATCGTTCTG GGCTACAATG GGTGTCTGGC AAGTGGAGAC 
AAGGGCCGCC GCCGAAGCCG CCTGGCACTG AGCCGCCGGC CACATGCCAA CGGAGTGAAG 
CCAGATGTCA TGCACCACAT CTCCACACCA CTCGTCTCCA AGATTGGCCG CTCTACTGAA 
AACATGATTG ACTTTGTGGT AACAGACACA TCTCCTGGTG GAGGGGCTAC AGAGGGCCCT 
TCTGCCCAAA GTACCATCTC CCGCTATGCC TGCAGAATTC TCTGTGACCG CCGGCCACCC 
TATACTGCCC GAATCTACGC TGCTGGCTTT GATGCCTCTA GCAACATCTT TCTTGGAGAG 
CGGGCAGCCA AATGGAGGAC TCCGGATGGT CTGATGGACG GCTTGACAAC CAATGGGGTT 
CTGGTGATGC ACCCAGCAGG TGGCTTCTCC GAGGACTCTG CCCCAGGTGT CTGGAGGGAG 
ATTTCTGTCT GCGGGAATGT GTACACGCTG CGGGATAGCC GATCAGCTCA GCAGCGGGGG 
AAGCTGGTGG AAAACGAATC CAACGTCCTG CAAGACGGTT CGCTCATCGA CCTGTGTGGG 
GCCACACTGT TGTGGCGCAC TCCGGCTGGG TTGCTGAGGG CACCCACACT GAAACAACTA 
GAGGCCCAGC GACAGGAGGC CAACGCAGCA CGGCCCCAGT GCCCCGTGGG CCTTAGCACC 
TTGGCCTTCC CCAGCCCAGC CCGTGGCCGC ACAGCACCCG ACAAACAGCA ACCCTGGGTC 
TACGTCCGTT GTGGTCATGT CCATGGCTAT CACGGCTGGG GCTGCCGGAG GGAACAAGGC 
CCCCAGGAGC GAGAGTGTCC TCTCTGCCGC CTTGTGGGAC CCTATGTGCC CCTGTGGCTC 
GGTCAGGAGG CCGGTCTCTG CCTGGACCCT GGGCCACCCA GCCACGCTTT TGCACCCTGT 
GGCCACGTCT GTTCTGAGAA GACTGCCCGC TACTGGGCTC AGACACCGCT GCCGCACGGC 
ACCCATGCTT TCCACGCTGC CTGCCCCTTC TGTGGAGCTT GGCTCACCGG TGAGCTTGGC 
TGTGTCCGCC TCATTTTCCA GGGGCCACTG GACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.
Journal of leukocyte biology98(6)963-74(2015 Dec)
Murphy MB,Xiong Y,Pattabiraman G,Manavalan TT,Qiu F,Medvedev AE

The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.
Immunity41(6)973-87(2014 Dec)
Yang S,Wang B,Humphries F,Hogan AE,O'Shea D,Moynagh PN

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression.
Autophagy10(11)1937-52(2014)
Giegerich AK,Kuchler L,Sha LK,Knape T,Heide H,Wittig I,Behrends C,Br?ne B,von Knethen A

Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-?.
Nature communications42583(2013)
Yang S,Wang B,Tang LS,Siednienko J,Callanan JJ,Moynagh PN

WIP regulates persistence of cell migration and ruffle formation in both mesenchymal and amoeboid modes of motility.
PloS one8(8)e70364(2013)
Banon-Rodriguez I,Saez de Guinoa J,Bernardini A,Ragazzini C,Fernandez E,Carrasco YR,Jones GE,Wandosell F,Anton IM

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Peli3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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