Setbp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Setbp1
Entrez Gene ID	240427
Full Name	SET binding protein 1
Synonyms	C130092E12,Seb,mKIAA0437
General protein information	Preferred Names SET binding protein 1 Names SET-binding protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_053099.2	NP_444329.2	SET-binding protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	SETBP1	NP_056374.2
	SETBP1	XP_002808207.1
Canis lupus familiaris (dog)	SETBP1	XP_547594.2
Bos taurus (cattle)	SETBP1	XP_003587826.1
Gallus gallus (chicken)	SETBP1	XP_001233854.3
Pan troglodytes (chimpanzee)	SETBP1	XP_512106.2
Mus musculus (house mouse)	Setbp1	NP_444329.2
Rattus norvegicus (Norway rat)	Setbp1	XP_006255044.1
Danio rerio (zebrafish)	setbp1	XP_005165732.1

Gene Ontology
Bibliography

Related articles in PubMed

Function of Nup98 subtypes and their fusion proteins, Nup98-TopII? and Nup98-SETBP1 in nuclear-cytoplasmic transport.
Saito S, Yokokawa T, Iizuka G, Cigdem S, Okuwaki M, Nagata K
Biochemical and biophysical research communications487(1)96-102(2017 05)

Myb expression is critical for myeloid leukemia development induced by Setbp1 activation.
Nguyen N, Vishwakarma BA, Oakley K, Han Y, Przychodzen B, Maciejewski JP, Du Y
Oncotarget7(52)86300-86312(2016 Dec)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development.
Vishwakarma BA, Nguyen N, Makishima H, Hosono N, Gudmundsson KO, Negi V, Oakley K, Han Y, Przychodzen B, Maciejewski JP, Du Y
Leukemia30(1)200-8(2016 Jan)

Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.
Oakley K, Han Y, Vishwakarma BA, Chu S, Bhatia R, Gudmundsson KO, Keller J, Chen X, Vasko V, Jenkins NA, Copeland NG, Du Y
Blood119(25)6099-108(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We demonstrated that Nup98-TopIIbeta and Nup98-SETBP1 negatively regulate the XPO1-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis.
Title: Function of Nup98 subtypes and their fusion proteins, Nup98-TopII? and Nup98-SETBP1 in nuclear-cytoplasmic transport.

Setbp1 overexpression also causes transcriptional repression of critical hematopoiesis regulator gene Runx1
Title: Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development.

Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.
Title: Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.

The following Setbp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Setbp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15473	NM_053099.2 Latest version!	Mus musculus SET binding protein 1 (Setbp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$811.30 $1159.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Setbp1 ( NM_053099.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444329.2 Mus musculus SET binding protein 1 (Setbp1), mRNA.

Price & Availability↑

CloneID	OMu15473
Clone ID Related Accession (Same CDS sequence)	NM_053099.2
Accession Version	NM_053099.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	SET-binding protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC114924.5, BC080865.1, AC140455.2 and AI661659.1. On Sep 4, 2008 this sequence version replaced NM_053099.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCA GGGAAATGTT AAGCAGCTGC CGGCAAAGAG GGAGTGAGTC GGAATTCCTT 
CAGGGCTCCT CATCCAGATC CCCACCTGCT CCTGGCTGTT CAGGAGAGCC CTTGAAAGGC 
ATCTCTGTGG GTGGAGAACG CATGGAGCCA GAGGAGGAGG ATGAATTGGG CTCAGGACGA 
GATGTGGATT GCAATTCTAA TGCAGACAGT GAGAAATGGG TGGCTGGAGA TGGCTTGGAG 
GAGCAGGAGT TCTCCATCAA GGAGGCCAAC TTCACTGAGG GGAGCTTAAA GCTGAAGATT 
CAGACCACAA AGCGGGCTAA GAAACCCCCC AAAAACCTGG AGAACTATAT CTGCCCACCT 
GAGATCAAGA TCACCATAAA GCAGTCTGGG GACCAGAAGG TGTCCCGTAC TGGGAAAAAT 
AGCAAAGCGA CTAAGGAAGA TGAAAGAAAC CACTCCAAAA AGAAGCTCCT CACAGCCGGT 
GACCCTACAG CCAGCGACCT CAAAGCATTT CAGACACAGG CATACGAGAG GCCCCAGAAA 
CACTCAACAC TTCAGTATGA CCCAGGTCAC TCCCAGGGCT TCACCAGTGA CACCTTAAAA 
CCAAAGCACC AGCAAAAAAG CAGCAGTCAG AGCCACATGG AATGGTCCTC CAACTCTGAC 
AGTGGACCAG CTACTCAGAA TTGCTTCATC AGTCCAGAGG CTGGCCGAGA CACTGCAAGC 
ACCAGCAAGG TCCCAGCTCT TGAACCCGTG GCTTCCTTTG CAAAGGCCCA GAGTAAAAAA 
GGCAGTACAG GAGGGGCCTG GAGTCAGTTG TCCAGCAGTA GCAAAGACCT GCTCTTGGGA 
AGTGTGGTAC CATCCCCCAG CAGCCACAAC TCCCCAGCGA CCCCTAGCAG CTCGGCTGAG 
TGCAATGGAC TCCAGCCATT GGGAGATCAA GATGGAGGAA GTACAAAGGA CCTCCCAGAG 
CCACCCACTC TCAGTAGCAA GAAGAAGTCC AGTAAAAAAG ATATGATAAG CCAAACCCTA 
CCGAACTCAG ATCTGGATTG GGTCAAGAGT GCCCAGAAAG CATTTGAAAC CACAGAAGGG 
AAACGGGAGG CCTACTCTGC AGACAGTGCT CAAGAGGCAT CGCCAGCCCG GCAGAGCATC 
AGTTCCGTCA GTAATCCGGA AAATGATTCC AGTCATGTCC GGATTACTAT CCCCATAAAG 
ACACCTTCTC TGGATCCAAG CAACCATAAG AGGAAAAAGA GGCAGTCTAT TAAAGCTGTG 
GTGGAGAAAA TCGTTCCGGA GAAAGCACTG GCTTCAGGGA TTTCCATGAG CAGCGAGGTT 
GTTAATAGAA TACTTTCCAA CTCAGAGGGA AGTAAGAAAG ACCCTCGAGT CCCGAAGTTG 
GGTAAGATGA TAGAGAACGA AACCCCCTCA GTTGGCCTTG AAACAGGTGG GAACGCTGAA 
AAGATTGTCC CCGGAGGTGC GTCCAAGCAG AGGAAACCGC CCATGGTCAT GACGTCACCC 
ACACGCACAG AGCACGCTCC ATCAGGAAAG CTGTCTGAGA TCCAGCACCC CAAGTTTGCT 
GCAAAAAGGA GGTGTAGCAA GGCCAAACCT CCGGCTATGC TTCGAGAGGC AGTCTTAGCT 
ACCGCCGAAA AACTGATGGT GGAGCCACCG TCTGCTTACC CCATTACCCC ATCCAGCCCT 
CTGTACACCA ACACGGACAG TCTTACTGTG ATCACACCGG TCAAAAAGAA GCGGGGACGA 
CCAAAGAAGC AACCTCTGCT CACTGTGGAG ACGATTCACG AAGGCACTTC CACTAGCCCC 
GTCAGCCCAA TCAGCAGAGA GTTTCCTGGC ACCAAGAAAA GGAAGAGACG GCGCAATCTG 
GCTAAATTGG CCCAGTTAGT GCCCGGAGAG GACAAACCCA TGAGCGAAAT GAAGTTTCAC 
AAAAAGGTTG GCAAGCTTGG TGTGCTGGAT AAGAAGACCA TCAAAACGAT CAACAAGATG 
AAGACACTCA AGAGAAAAAA TATCTTAAAT CAGATCTTGT CCTGTTCCAG CAGCGTGGCC 
CTAAAGGCCA AAGCTCCCCC AGAGACTAGT CCTGGGGCAG CATCTATCGA AAGTAAACTG 
GGAAAGCAGA TTAATGTCAG CAAGAGAGGA ACCATCTACA TAGGCAAGAA GAGGGGCAGG 
AAGCCAAGGA CAGAGCTTCC ACCCCCATCC GAGGAACCCA AAACAGCCAT CAAGCACCCC 
AGGCCTGTGT CTAGCCAGCC GGACGTTCCA GCCGTGCCTT CCAGCTTCCA GTCACCCGTG 
GCTTCTTCAC CAGCAGCTAT GCACCCACTC TCAACACAGT TAGGTGGGTC CAATGGCAAC 
CTGAGCCCCG CCAGCACTGA AACCAATTTT TCAGAGTTAA AAACTATGCC GAACCTCCAG 
CCCATCAGTG CTCTTCCAAC CAAAACCCAG AAGGGAATCC ACGGTGGGAC CTGGAAGCTG 
TCCCCACCCC GGCTGATGGC CAACTCCCCA TCACACCTTT GCGAGATTGG CTCACTGAAG 
GAGATAACGT TGTCCCCTGT GAGTGAGTCC CACAGCGAGG AGACTATCCC GAGCGACAGT 
GGCATCGGGA CAGACAACAA CAGCACCTCC GACCAAGCAG AGAAGAGTTC AGAATCCCGG 
CGGAGGTACT CTTTCGACTT CTGTTCCCTT GACAACCCAG AGGCCATTCC ATCCGACACC 
AGCACAAAGA ACCGGCACGG CCACCGGCAG AAGCATCTCA TTGTGGACAC TTTTCTGGCC 
CACGAAAGCC TCAAGAAGCC AAAGCACAAG AGGAAACGGA AGAGCCTGCA AAACCGCGAT 
GATCTCCAGT TTCTGGCAGA GCTGGAAGAA CTCATCACCA AGTTTCAAGT GTTCAGGATC 
TCCCACCGGG GCTACACTTT CTACCATGAG AATCCGTATC CCAGCATCTT TAGGATTAAC 
TTTGATCAGT ATTACCCGGT GCCATATATC CAGTACGACC CATTGCTCTA TCTTCGTAGG 
ACTTCAGACC TGAAGTCAAA GAAGAAGCGT GGTAGGCCTG CAAAAACCAA TGACACCATG 
ACAAAGGTGC CTTTTTTACA GGGGTTCAGC TACCCTATCC CCAGTGGAAG TTACTATGCA 
CCCTATGGAA TGCCTTACAC ATCAATGCCT ATGATGAACC TTGGTTACTA TGGTCAGTAC 
CCGGCTCCTC TGTACCTGTC ACACACACTC GGAGCAGCAT CCCCTTTCAT GAGGCCGACA 
GTGCCACCAC CCCAGTTCCA CGCAAGTTCT CATGTAAAGA TATCCGGGGC AACGAAACAT 
AAAGCCAAGC ATGGCGTCCA CTTGCAGGGA ACCGTAGGCA TGGGCCTTGG TGACATACAG 
CCATCCCTGA ACCCTCCCAA GGTGGGCGGG GCCACTCTGT CCAGCAGTAG GCTCCACAAG 
AGGAAACACA AACATAAGCG TAAGCACAAG GAAGACCGAA TCCTAGGGAC CCATGACAAC 
CTGAGTGGTC TCTTTGCAGG CAAAGCCACA GGCTTCTCCA GCCACCTCCT GAGTGAACGG 
CTCAGCGGTT CCGACAAAGA GCTGCCGCTG GTGAGCGAGA AGAGCAAACA CAAGGAGAGA 
CAGAAGCACC AGCACGGGGA GGCCAGCCAC AAGGTTTCCA AGAACAACTT TGAGGTGGAC 
ACCCTGTCTA CGCTGTCACT TTCTGACGCC CAGCACTGGA CACAGGCTAA GGACAAAGGT 
GACTTGAGCA GTGAGCCTGT GGAGTCCTGT GCTAAAAGGT ACTCTGGCAG CGGTGGAGAC 
AGCACAAGAT CGGAGGGTCT GGATGTGTTC AGTGAAATGA ATCCTTCCAG CGACAAGTGG 
GACAGTGACA TGGGTGGGAG TAAGAGGAGG AGCTTTGAAG GCTTTGGGAC GTACAGGGAG 
AAGGACATCC AAGCCTTCAA GATGAATCGC AAGGAGAGAG GTTCTTATGA GTCCTCCATG 
TCTCCAGGGA TGCCAAGTCC CCACTTAAAA GTGGACCAGA CAGCAGCACA CAGTAAGAGC 
GAGGGCTCAA TATCTGCCAT GATGGCCAGG AAGAAGCCAA CTGCAGTGGA CAGTGTTGCG 
ATTCCCTCAG CACCCGTGTT ATCTCTCCTT GCTGCATCTG CAGCAACATC GGATGCAGCC 
AGCTCCTCCC TGAAGAAGAG ATTCAAGAGA CGGGAGATCG AAGCCATCCA ATGCGAAGTG 
CGGAAGATGT GCCATTACAC CAAGCTTCTG TCCACCAAGA AGAACCTGGA CCACGTGAAC 
AAAATCCTGA AGGCCAAGCG GCTGCAGAGA CAATCAAAGA CGGGCAACAA CTTTGTCAAG 
AAGAGGCGAG GCCGGCCTAG GAAGCAGCCC TCACAGTTCG ATGAGGACTC CAGAGACCAA 
ATGCCAGTGC TGGAAAAGTG CATTGACCTA CCCAGCAAGA GAGGCCAGAA GCCCAGCCTG 
AGTCCCCTAG CGCTGGAACC GGCCTCGGGC CAGGATGCAG TGATGGCCAC CATCGAGGCT 
GTCATCCACA TGGCTCGGGA GGCGCCGCCG CTGCCCCCGC CGCCGCCCCC ACCACTGCCA 
CCGCCCCCGC CTCCACCACC GCCGCCCCCG CCGCTGCCCA AGACGGCTCG GGGCGGGAAG 
AGGAAACACA GACCGCAGCC CCCAGCGCAG CCCGCGCAGC CCACGCCGCA GCCCCTTCCC 
CAGGAAGAGG AGGTGAAGGC CAAAAGGCCA CGGAAGTCCC GAGCCAGCGA GAGTGATGTC 
CTTCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444329.2
CDS	370..5118
Translation	MEPREMLSSCRQRGSESEFLQGSSSRSPPAPGCSGEPLKGISVGGERMEPEEEDELGSGRDVDCNSNADSEKWVAGDGLEEQEFSIKEANFTEGSLKLKIQTTKRAKKPPKNLENYICPPEIKITIKQSGDQKVSRTGKNSKATKEDERNHSKKKLLTAGDPTASDLKAFQTQAYERPQKHSTLQYDPGHSQGFTSDTLKPKHQQKSSSQSHMEWSSNSDSGPATQNCFISPEAGRDTASTSKVPALEPVASFAKAQSKKGSTGGAWSQLSSSSKDLLLGSVVPSPSSHNSPATPSSSAECNGLQPLGDQDGGSTKDLPEPPTLSSKKKSSKKDMISQTLPNSDLDWVKSAQKAFETTEGKREAYSADSAQEASPARQSISSVSNPENDSSHVRITIPIKTPSLDPSNHKRKKRQSIKAVVEKIVPEKALASGISMSSEVVNRILSNSEGSKKDPRVPKLGKMIENETPSVGLETGGNAEKIVPGGASKQRKPPMVMTSPTRTEHAPSGKLSEIQHPKFAAKRRCSKAKPPAMLREAVLATAEKLMVEPPSAYPITPSSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISREFPGTKKRKRRRNLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQILSCSSSVALKAKAPPETSPGAASIESKLGKQINVSKRGTIYIGKKRGRKPRTELPPPSEEPKTAIKHPRPVSSQPDVPAVPSSFQSPVASSPAAMHPLSTQLGGSNGNLSPASTETNFSELKTMPNLQPISALPTKTQKGIHGGTWKLSPPRLMANSPSHLCEIGSLKEITLSPVSESHSEETIPSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPSDTSTKNRHGHRQKHLIVDTFLAHESLKKPKHKRKRKSLQNRDDLQFLAELEELITKFQVFRISHRGYTFYHENPYPSIFRINFDQYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMTKVPFLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYGQYPAPLYLSHTLGAASPFMRPTVPPPQFHASSHVKISGATKHKAKHGVHLQGTVGMGLGDIQPSLNPPKVGGATLSSSRLHKRKHKHKRKHKEDRILGTHDNLSGLFAGKATGFSSHLLSERLSGSDKELPLVSEKSKHKERQKHQHGEASHKVSKNNFEVDTLSTLSLSDAQHWTQAKDKGDLSSEPVESCAKRYSGSGGDSTRSEGLDVFSEMNPSSDKWDSDMGGSKRRSFEGFGTYREKDIQAFKMNRKERGSYESSMSPGMPSPHLKVDQTAAHSKSEGSISAMMARKKPTAVDSVAIPSAPVLSLLAASAATSDAASSSLKKRFKRREIEAIQCEVRKMCHYTKLLSTKKNLDHVNKILKAKRLQRQSKTGNNFVKKRRGRPRKQPSQFDEDSRDQMPVLEKCIDLPSKRGQKPSLSPLALEPASGQDAVMATIEAVIHMAREAPPLPPPPPPPLPPPPPPPPPPPPLPKTARGGKRKHRPQPPAQPAQPTPQPLPQEEEVKAKRPRKSRASESDVLP

Target ORF information:

RefSeq Version	NM_053099.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET binding protein 1 (Setbp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053099.2

ORF Insert Sequence:

ATGGAGCCCA GGGAAATGTT AAGCAGCTGC CGGCAAAGAG GGAGTGAGTC GGAATTCCTT 
CAGGGCTCCT CATCCAGATC CCCACCTGCT CCTGGCTGTT CAGGAGAGCC CTTGAAAGGC 
ATCTCTGTGG GTGGAGAACG CATGGAGCCA GAGGAGGAGG ATGAATTGGG CTCAGGACGA 
GATGTGGATT GCAATTCTAA TGCAGACAGT GAGAAATGGG TGGCTGGAGA TGGCTTGGAG 
GAGCAGGAGT TCTCCATCAA GGAGGCCAAC TTCACTGAGG GGAGCTTAAA GCTGAAGATT 
CAGACCACAA AGCGGGCTAA GAAACCCCCC AAAAACCTGG AGAACTATAT CTGCCCACCT 
GAGATCAAGA TCACCATAAA GCAGTCTGGG GACCAGAAGG TGTCCCGTAC TGGGAAAAAT 
AGCAAAGCGA CTAAGGAAGA TGAAAGAAAC CACTCCAAAA AGAAGCTCCT CACAGCCGGT 
GACCCTACAG CCAGCGACCT CAAAGCATTT CAGACACAGG CATACGAGAG GCCCCAGAAA 
CACTCAACAC TTCAGTATGA CCCAGGTCAC TCCCAGGGCT TCACCAGTGA CACCTTAAAA 
CCAAAGCACC AGCAAAAAAG CAGCAGTCAG AGCCACATGG AATGGTCCTC CAACTCTGAC 
AGTGGACCAG CTACTCAGAA TTGCTTCATC AGTCCAGAGG CTGGCCGAGA CACTGCAAGC 
ACCAGCAAGG TCCCAGCTCT TGAACCCGTG GCTTCCTTTG CAAAGGCCCA GAGTAAAAAA 
GGCAGTACAG GAGGGGCCTG GAGTCAGTTG TCCAGCAGTA GCAAAGACCT GCTCTTGGGA 
AGTGTGGTAC CATCCCCCAG CAGCCACAAC TCCCCAGCGA CCCCTAGCAG CTCGGCTGAG 
TGCAATGGAC TCCAGCCATT GGGAGATCAA GATGGAGGAA GTACAAAGGA CCTCCCAGAG 
CCACCCACTC TCAGTAGCAA GAAGAAGTCC AGTAAAAAAG ATATGATAAG CCAAACCCTA 
CCGAACTCAG ATCTGGATTG GGTCAAGAGT GCCCAGAAAG CATTTGAAAC CACAGAAGGG 
AAACGGGAGG CCTACTCTGC AGACAGTGCT CAAGAGGCAT CGCCAGCCCG GCAGAGCATC 
AGTTCCGTCA GTAATCCGGA AAATGATTCC AGTCATGTCC GGATTACTAT CCCCATAAAG 
ACACCTTCTC TGGATCCAAG CAACCATAAG AGGAAAAAGA GGCAGTCTAT TAAAGCTGTG 
GTGGAGAAAA TCGTTCCGGA GAAAGCACTG GCTTCAGGGA TTTCCATGAG CAGCGAGGTT 
GTTAATAGAA TACTTTCCAA CTCAGAGGGA AGTAAGAAAG ACCCTCGAGT CCCGAAGTTG 
GGTAAGATGA TAGAGAACGA AACCCCCTCA GTTGGCCTTG AAACAGGTGG GAACGCTGAA 
AAGATTGTCC CCGGAGGTGC GTCCAAGCAG AGGAAACCGC CCATGGTCAT GACGTCACCC 
ACACGCACAG AGCACGCTCC ATCAGGAAAG CTGTCTGAGA TCCAGCACCC CAAGTTTGCT 
GCAAAAAGGA GGTGTAGCAA GGCCAAACCT CCGGCTATGC TTCGAGAGGC AGTCTTAGCT 
ACCGCCGAAA AACTGATGGT GGAGCCACCG TCTGCTTACC CCATTACCCC ATCCAGCCCT 
CTGTACACCA ACACGGACAG TCTTACTGTG ATCACACCGG TCAAAAAGAA GCGGGGACGA 
CCAAAGAAGC AACCTCTGCT CACTGTGGAG ACGATTCACG AAGGCACTTC CACTAGCCCC 
GTCAGCCCAA TCAGCAGAGA GTTTCCTGGC ACCAAGAAAA GGAAGAGACG GCGCAATCTG 
GCTAAATTGG CCCAGTTAGT GCCCGGAGAG GACAAACCCA TGAGCGAAAT GAAGTTTCAC 
AAAAAGGTTG GCAAGCTTGG TGTGCTGGAT AAGAAGACCA TCAAAACGAT CAACAAGATG 
AAGACACTCA AGAGAAAAAA TATCTTAAAT CAGATCTTGT CCTGTTCCAG CAGCGTGGCC 
CTAAAGGCCA AAGCTCCCCC AGAGACTAGT CCTGGGGCAG CATCTATCGA AAGTAAACTG 
GGAAAGCAGA TTAATGTCAG CAAGAGAGGA ACCATCTACA TAGGCAAGAA GAGGGGCAGG 
AAGCCAAGGA CAGAGCTTCC ACCCCCATCC GAGGAACCCA AAACAGCCAT CAAGCACCCC 
AGGCCTGTGT CTAGCCAGCC GGACGTTCCA GCCGTGCCTT CCAGCTTCCA GTCACCCGTG 
GCTTCTTCAC CAGCAGCTAT GCACCCACTC TCAACACAGT TAGGTGGGTC CAATGGCAAC 
CTGAGCCCCG CCAGCACTGA AACCAATTTT TCAGAGTTAA AAACTATGCC GAACCTCCAG 
CCCATCAGTG CTCTTCCAAC CAAAACCCAG AAGGGAATCC ACGGTGGGAC CTGGAAGCTG 
TCCCCACCCC GGCTGATGGC CAACTCCCCA TCACACCTTT GCGAGATTGG CTCACTGAAG 
GAGATAACGT TGTCCCCTGT GAGTGAGTCC CACAGCGAGG AGACTATCCC GAGCGACAGT 
GGCATCGGGA CAGACAACAA CAGCACCTCC GACCAAGCAG AGAAGAGTTC AGAATCCCGG 
CGGAGGTACT CTTTCGACTT CTGTTCCCTT GACAACCCAG AGGCCATTCC ATCCGACACC 
AGCACAAAGA ACCGGCACGG CCACCGGCAG AAGCATCTCA TTGTGGACAC TTTTCTGGCC 
CACGAAAGCC TCAAGAAGCC AAAGCACAAG AGGAAACGGA AGAGCCTGCA AAACCGCGAT 
GATCTCCAGT TTCTGGCAGA GCTGGAAGAA CTCATCACCA AGTTTCAAGT GTTCAGGATC 
TCCCACCGGG GCTACACTTT CTACCATGAG AATCCGTATC CCAGCATCTT TAGGATTAAC 
TTTGATCAGT ATTACCCGGT GCCATATATC CAGTACGACC CATTGCTCTA TCTTCGTAGG 
ACTTCAGACC TGAAGTCAAA GAAGAAGCGT GGTAGGCCTG CAAAAACCAA TGACACCATG 
ACAAAGGTGC CTTTTTTACA GGGGTTCAGC TACCCTATCC CCAGTGGAAG TTACTATGCA 
CCCTATGGAA TGCCTTACAC ATCAATGCCT ATGATGAACC TTGGTTACTA TGGTCAGTAC 
CCGGCTCCTC TGTACCTGTC ACACACACTC GGAGCAGCAT CCCCTTTCAT GAGGCCGACA 
GTGCCACCAC CCCAGTTCCA CGCAAGTTCT CATGTAAAGA TATCCGGGGC AACGAAACAT 
AAAGCCAAGC ATGGCGTCCA CTTGCAGGGA ACCGTAGGCA TGGGCCTTGG TGACATACAG 
CCATCCCTGA ACCCTCCCAA GGTGGGCGGG GCCACTCTGT CCAGCAGTAG GCTCCACAAG 
AGGAAACACA AACATAAGCG TAAGCACAAG GAAGACCGAA TCCTAGGGAC CCATGACAAC 
CTGAGTGGTC TCTTTGCAGG CAAAGCCACA GGCTTCTCCA GCCACCTCCT GAGTGAACGG 
CTCAGCGGTT CCGACAAAGA GCTGCCGCTG GTGAGCGAGA AGAGCAAACA CAAGGAGAGA 
CAGAAGCACC AGCACGGGGA GGCCAGCCAC AAGGTTTCCA AGAACAACTT TGAGGTGGAC 
ACCCTGTCTA CGCTGTCACT TTCTGACGCC CAGCACTGGA CACAGGCTAA GGACAAAGGT 
GACTTGAGCA GTGAGCCTGT GGAGTCCTGT GCTAAAAGGT ACTCTGGCAG CGGTGGAGAC 
AGCACAAGAT CGGAGGGTCT GGATGTGTTC AGTGAAATGA ATCCTTCCAG CGACAAGTGG 
GACAGTGACA TGGGTGGGAG TAAGAGGAGG AGCTTTGAAG GCTTTGGGAC GTACAGGGAG 
AAGGACATCC AAGCCTTCAA GATGAATCGC AAGGAGAGAG GTTCTTATGA GTCCTCCATG 
TCTCCAGGGA TGCCAAGTCC CCACTTAAAA GTGGACCAGA CAGCAGCACA CAGTAAGAGC 
GAGGGCTCAA TATCTGCCAT GATGGCCAGG AAGAAGCCAA CTGCAGTGGA CAGTGTTGCG 
ATTCCCTCAG CACCCGTGTT ATCTCTCCTT GCTGCATCTG CAGCAACATC GGATGCAGCC 
AGCTCCTCCC TGAAGAAGAG ATTCAAGAGA CGGGAGATCG AAGCCATCCA ATGCGAAGTG 
CGGAAGATGT GCCATTACAC CAAGCTTCTG TCCACCAAGA AGAACCTGGA CCACGTGAAC 
AAAATCCTGA AGGCCAAGCG GCTGCAGAGA CAATCAAAGA CGGGCAACAA CTTTGTCAAG 
AAGAGGCGAG GCCGGCCTAG GAAGCAGCCC TCACAGTTCG ATGAGGACTC CAGAGACCAA 
ATGCCAGTGC TGGAAAAGTG CATTGACCTA CCCAGCAAGA GAGGCCAGAA GCCCAGCCTG 
AGTCCCCTAG CGCTGGAACC GGCCTCGGGC CAGGATGCAG TGATGGCCAC CATCGAGGCT 
GTCATCCACA TGGCTCGGGA GGCGCCGCCG CTGCCCCCGC CGCCGCCCCC ACCACTGCCA 
CCGCCCCCGC CTCCACCACC GCCGCCCCCG CCGCTGCCCA AGACGGCTCG GGGCGGGAAG 
AGGAAACACA GACCGCAGCC CCCAGCGCAG CCCGCGCAGC CCACGCCGCA GCCCCTTCCC 
CAGGAAGAGG AGGTGAAGGC CAAAAGGCCA CGGAAGTCCC GAGCCAGCGA GAGTGATGTC 
CTTCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Function of Nup98 subtypes and their fusion proteins, Nup98-TopII? and Nup98-SETBP1 in nuclear-cytoplasmic transport.
Biochemical and biophysical research communications487(1)96-102(2017 05)
Saito S,Yokokawa T,Iizuka G,Cigdem S,Okuwaki M,Nagata K

Myb expression is critical for myeloid leukemia development induced by Setbp1 activation.
Oncotarget7(52)86300-86312(2016 Dec)
Nguyen N,Vishwakarma BA,Oakley K,Han Y,Przychodzen B,Maciejewski JP,Du Y

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development.
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Vishwakarma BA,Nguyen N,Makishima H,Hosono N,Gudmundsson KO,Negi V,Oakley K,Han Y,Przychodzen B,Maciejewski JP,Du Y

Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.
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Setbp1 cDNA ORF clone, Mus musculus(house mouse)

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