Aard cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aard
Entrez Gene ID	239435
Full Name	alanine and arginine rich domain containing protein
Synonyms	A5D3,AV328152
General protein information	Preferred Names alanine and arginine rich domain containing protein Names alanine and arginine-rich domain-containing protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_175503.3	NP_780712.2	alanine and arginine-rich domain-containing protein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Aard	NP_780712.2
Rattus norvegicus (Norway rat)	Aard	NP_659561.1
Pan troglodytes (chimpanzee)	AARD	XP_519917.2
Bos taurus (cattle)	AARD	XP_002692809.1
Homo sapiens (human)	AARD	NP_001020528.1

Gene Ontology
Bibliography

Related articles in PubMed

Alanine and arginine rich domain containing protein, Aard, is directly regulated by androgen receptor in mouse Sertoli cells.
Geng Q, Ni LW, Ouyang B, Hu YH, Zhao Y, Guo J
Molecular medicine reports15(1)352-358(2017 Jan)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC
PLoS genetics12(2)e1005691(2016 Feb)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, ?estan N, Gage FH, Lein ES
Development (Cambridge, England)140(22)4633-44(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of the present study indicate that Aard is a target of AR action in mouse Sertoli cells and suggest a novel finding by which the loss of AR function in Sertoli cells blocks spermatogenesis and results in male infertility.
Title: Alanine and arginine rich domain containing protein, Aard, is directly regulated by androgen receptor in mouse Sertoli cells.

Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation.
Title: Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation.

The following Aard gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aard cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05483	NM_175503.3 Latest version!	Mus musculus alanine and arginine rich domain containing protein (Aard), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aard ( NM_175503.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780712.2 Mus musculus alanine and arginine rich domain containing protein (Aard), mRNA.

Price & Availability↑

CloneID	OMu05483
Clone ID Related Accession (Same CDS sequence)	NM_175503.3
Accession Version	NM_175503.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Mus musculus(house mouse)
Product	alanine and arginine-rich domain-containing protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK046414.1 and AY134665.1. On Nov 19, 2006 this sequence version replaced NM_175503.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY134665.1, AK046414.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGGGCTTGG GTGACTACAG CCACTGCAGA CAGAGGATGT CCCGGGGACT CTACGGAGTC 
TCTGGAAGGG CTGCGCTATG GTCCCCAGTC TTCCACCCGG TGCACCGCAT GCCTTGCGGC 
ACCTGGCGCA TCGGCATCGA AGTGCCAGAG CACGTCCGGG CGTCCAGCCC GGTGCTGGAG 
CACCTCCGCA GGCAGCTGGA GCGCGCCTTT CAGCGGGCGG CGGCACGCGG GCGCGCCAGA 
CGCGCGCGGG AGGCGGTGGC GGCGGTGGCG GCGGCCGCAG CGGCAGCACG GGAGGAAAGG 
AGCCGGACGC GCATGGAGTG CGCCCTGGCC CGGCTGCGCG CGGAGCTGCT GGAACTGCGT 
TTCCAGAACC ACCAGCTGGC CCGAACTTTA CTGGATTTAA ACATGAAAAT GCAGCAGCTG 
AAGAAGAGGC AGGACCAGGA GCTAGCTTCC AAACCCCAGA GCCCGCAGGA TAAGGAGATG 
AATTCCGAGT GTGGAAGCGC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780712.2
CDS	77..580
Translation	MGLGDYSHCRQRMSRGLYGVSGRAALWSPVFHPVHRMPCGTWRIGIEVPEHVRASSPVLEHLRRQLERAFQRAAARGRARRAREAVAAVAAAAAAAREERSRTRMECALARLRAELLELRFQNHQLARTLLDLNMKMQQLKKRQDQELASKPQSPQDKEMNSECGSA

Target ORF information:

RefSeq Version	NM_175503.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus alanine and arginine rich domain containing protein (Aard), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175503.3

ORF Insert Sequence:

ATGGGCTTGG GTGACTACAG CCACTGCAGA CAGAGGATGT CCCGGGGACT CTACGGAGTC 
TCTGGAAGGG CTGCGCTATG GTCCCCAGTC TTCCACCCGG TGCACCGCAT GCCTTGCGGC 
ACCTGGCGCA TCGGCATCGA AGTGCCAGAG CACGTCCGGG CGTCCAGCCC GGTGCTGGAG 
CACCTCCGCA GGCAGCTGGA GCGCGCCTTT CAGCGGGCGG CGGCACGCGG GCGCGCCAGA 
CGCGCGCGGG AGGCGGTGGC GGCGGTGGCG GCGGCCGCAG CGGCAGCACG GGAGGAAAGG 
AGCCGGACGC GCATGGAGTG CGCCCTGGCC CGGCTGCGCG CGGAGCTGCT GGAACTGCGT 
TTCCAGAACC ACCAGCTGGC CCGAACTTTA CTGGATTTAA ACATGAAAAT GCAGCAGCTG 
AAGAAGAGGC AGGACCAGGA GCTAGCTTCC AAACCCCAGA GCCCGCAGGA TAAGGAGATG 
AATTCCGAGT GTGGAAGCGC ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alanine and arginine rich domain containing protein, Aard, is directly regulated by androgen receptor in mouse Sertoli cells.
Molecular medicine reports15(1)352-358(2017 Jan)
Geng Q,Ni LW,Ouyang B,Hu YH,Zhao Y,Guo J

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
PLoS genetics12(2)e1005691(2016 Feb)
West DB,Engelhard EK,Adkisson M,Nava AJ,Kirov JV,Cipollone A,Willis B,Rapp J,de Jong PJ,Lloyd KC

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Development (Cambridge, England)140(22)4633-44(2013 Nov)
Miller JA,Nathanson J,Franjic D,Shim S,Dalley RA,Shapouri S,Smith KA,Sunkin SM,Bernard A,Bennett JL,Lee CK,Hawrylycz MJ,Jones AR,Amaral DG,?estan N,Gage FH,Lein ES

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Aard cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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