Kank2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kank2
Entrez Gene ID	235041
Full Name	KN motif and ankyrin repeat domains 2
Synonyms	AI504612,Ankrd25,BC010245
General protein information	Preferred Names KN motif and ankyrin repeat domains 2 Names KN motif and ankyrin repeat domain-containing protein 2 ankyrin repeat domain 25 ankyrin repeat domain-containing protein 25
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_145611.4	NP_663586.3	KN motif and ankyrin repeat domain-containing protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KANK2	XP_003432823.1
Rattus norvegicus (Norway rat)	Kank2	NP_001257342.1
Pan troglodytes (chimpanzee)	KANK2	XP_003316135.1
Bos taurus (cattle)	KANK2	NP_001069999.1
Mus musculus (house mouse)	Kank2	NP_663586.3
Homo sapiens (human)	KANK2	NP_001129663.1
Danio rerio (zebrafish)	LOC571549	XP_005164397.1
Xenopus tropicalis (tropical clawed frog)	kank2	XP_002942889.2

Gene Ontology
Bibliography

Related articles in PubMed

Kank2 activates talin, reduces force transduction across integrins and induces central adhesion?formation.
Sun Z, Tseng HY, Tan S, Senger F, Kurzawa L, Dedden D, Mizuno N, Wasik AA, Thery M, Dunn AR, F?ssler R
Nature cell biology18(9)941-53(2016 09)

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.
Gee HY, Zhang F, Ashraf S, Kohl S, Sadowski CE, Vega-Warner V, Zhou W, Lovric S, Fang H, Nettleton M, Zhu JY, Hoefele J, Weber LT, Podracka L, Boor A, Fehrenbach H, Innis JW, Washburn J, Levy S, Lifton RP, Otto EA, Han Z, Hildebrandt F
The Journal of clinical investigation125(6)2375-84(2015 Jun)

KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.
Garg A, O'Rourke J, Long C, Doering J, Ravenscroft G, Bezprozvannaya S, Nelson BR, Beetz N, Li L, Chen S, Laing NG, Grange RW, Bassel-Duby R, Olson EN
The Journal of clinical investigation124(8)3529-39(2014 Aug)

Expression of novel podocyte-associated proteins sult1b1 and ankrd25.
Xu X, Patrakka J, Sistani L, Uhlen M, Jalanko H, Betsholtz C, Tryggvason K
Nephron. Experimental nephrology117(2)e39-46(2011)

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Developmental cell17(6)836-48(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identify Kank proteins as talin activators that decrease the grip between the integrin-talin complex and actomyosin to regulate cell migration velocity
Title: Kank2 activates talin, reduces force transduction across integrins and induces central adhesion?formation.

sult1b1 may be involved in the sulfonylation of podocyte protein podocalyxin, whereas ankrd25 may contribute to controlling actin dynamics in podocyte foot processes.
Title: Expression of novel podocyte-associated proteins sult1b1 and ankrd25.

The following Kank2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kank2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11886	NM_145611.4 Latest version!	Mus musculus KN motif and ankyrin repeat domains 2 (Kank2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$496.30 $709.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kank2 ( NM_145611.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663586.3 Mus musculus KN motif and ankyrin repeat domains 2 (Kank2), mRNA.

Price & Availability↑

CloneID	OMu11886
Clone ID Related Accession (Same CDS sequence)	NM_145611.4
Accession Version	NM_145611.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2532bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	KN motif and ankyrin repeat domain-containing protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK049288.1, AC161371.4 and BB517655.1. On Nov 15, 2007 this sequence version replaced NM_145611.3. ##Evidence-Data-START## Transcript exon combination :: AK031324.1, AK045492.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN01164142 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCAGG TCCTGCATGT GCCCGCCCCA TTCCCAGGAA CCCCTGGTCA GGCCTCCCCA 
GCGGCCTTCC CCAGCAAGGA GCCAGACCCA CCGTACTCAG TGGAAACGCC CTATGGCTAC 
CGCCTGGACC TGGATTTTCT TAAGTACGTG GATGACATTG AGAAGGGCCA CACACTGCGC 
AGGGTGGCGG TACAGCGCCG GCCGCGCCTG GGTTCCCTGC CACGGGGCCC GGGCTCCTGG 
TGGACGTCCA CAGAGTCTCT GTGCTCTGAT GCCAGTGGGG ACAGCCGGCA CTCGGCCTAC 
TCCTACTGTG GCCGCGGCTT CTACCCACAG TACGGAGCCT TGGAGACCCG AATCGGCTCC 
AACCCTCGTG TGGAGCGCAC GCTGCTGGAT GCGCGGCGCC GGCTGGAGGA CCAGGCGGCT 
GCCCCATCGT CCGGTGGCCT GGGCTCCCTC ACACCCAGCG CCGCGGGCTC CACCAGCTCC 
CTGGCAGGCG TGGGCCTGCT GCCCCCCACG CCTCGCAGCT CCGGCCTGTC CACCCCGGTG 
GCACCCAGCG CTGGTCACCT AGCCCACGTG CGCGAGCAGA TGGCTGGAGC CCTGCGCAAG 
CTGCGCCAGC TGGAGGAGCA GGTCAAGCTG ATCCCCGTTC TCCAAGTCAA GCTGTCAGTG 
CTCCAGGAGG AAAAGAGACA GCTCACCGTG CAGCTCAAGA GCCAGAAGTT TCTAGGTCAC 
CCCTCAGGGA CACGGAGCCG GAGTGAGCTC TGCCTGGACC TTCCCGAGGC CCCTGACGAC 
CCTGCTGCAC TAGAGACCCG CTCGGTGGGC ACCTGGGTTA GAGAACGGGA CTTGGGCATT 
CCAGATGGTG AAGCTGCCCT GGTAGCTAAA GTGGCCGTGT TGGAGACCCA GCTCAAAAAA 
GCGCTACAGG AGCTGCGGGC GGCTCAGACC CAGCAGGTCG ACCTCCAGCC CCAGGCCTGG 
CCACCACCAG ACACCCAGGT CCGCGTGGAC ACCGTGCGAG TAGTGGAGGG TCCCCGGGAA 
GTGGAGGTGG CAGCCAGCAC GGCAGCCGGG GCCCTTGCAC AGCGAGCTCA GAGTCTGGAA 
CCCTACGGAA CAGGGCTGAA GGCCCTGACC ACATCTGGGG GACCAGAGAA CACCCTCGTG 
TTCCGCAGTC ATGAAGTGGT GGAGACCATG TGCCCACTGC CCACAGCTAC CACTGGCAAT 
GTGCACACAG CCAAGAAGAT CAGCATTACA GAACGGAGTT GCACCGGTGC ACCCAGGATG 
ACAGAGCCTT CCTCCGTTAA TCCACGCCCT GCTGCAGCCT CTGTGGTACA GCCTGAGAAC 
CCTGTCCCGG CTGCCCAGGA CACCACTGAC AAGAAGCCCA CCAGGCCAGC AGCAGCATCG 
CAGGACTCAC AAGCGGCTGA CGGAGCAGGC AGAGCCTCTT TGGCCACGAA GAGGAAAGAG 
GACCCCGCAG ACCCTGAAGT CAACCAGAGG AACCTCCAGT TTGTGGGAGT CAATGGCGGG 
TATGAGTCCC CCTCGGAGGA CTCCAGCACA GCAGAAAACT CCGAACACGA GAGCACAGAG 
AACGAGGGCC CGGAGCCACC AGCAAGGGTT CTGAGCCCAG CTGAATGTCC TCAGCTCAGG 
CCTCCAGGGG CTGCAGTGGC CACGACCAGT CTGGAGGGGC CCCAGCTCTC CCAGGAATCC 
CAGCGTGTGC CTGCACCTGA GGTGGCGTCA GGACCCGATC CTGAGGAGGA AATTCGGATG 
GATCTGAGCC CTGACCTCAT ATCAGCCTGC TTGGCCCTGG AGAAATACCT GGAGAACCCC 
AATGCCCTCA CAGAGCGAGA ACTGAAAGTG GCCTATACCA CAGTGCTTCA GGAGTGGCTG 
CGCCTGGCCT GCCGCAGTGA CGCACACCCT GAGCTTGTGC GGCGACATCT AGTCACCTTC 
AGGGCCATGT CTGCCCGGCT GCTGGACTAC GTGGTCAACA TCGCCGACAG CAATGGTAAC 
ACTGCCCTGC ACTACTCAGT GTCACACGCC AACTTCCCTG TGGTGCGGCA GTTGCTGGAC 
AGCGGGGTCT GTCATGTGGA CAAGCTGAAC CGTGCCGGCT ACAGCCCTAT TATGCTCACT 
GCCCTGGCCA CGTTGAAGAC CCAGGACGAC ATTGAGACCA TCCTTCAGCT CTTCCGGCTT 
GGGAATGTCA ATGCCAAAGC CAGCCAGGCA GGACAGACGG CCCTGATGCT GGCCGTCAGC 
CACGGGCGGG TGGACGTGGT GAGAGCATTG CTGGCCTGTG AGGCGGACGT CAACATTCAG 
GATGAGGACG GCTCCACGGC CCTGATGTGT GCATGTGAGC ACGGACACAA GGAGATCACC 
GGGCTCCTGC TGGCTGTGCC TAGCTGTGAC ATCTCACTCA CTGACCGCGA CGGGAGCACA 
GCACTGATGG TGGCCCTGGA CGCTGGGCAG AGCGAGATCG CATCTATGCT GTACTCACGC 
ATGAACATCA AGTGCTCGTT CGCTCCCATG TCAGACTACG AGAGTCCGGC TTCGTCTTCA 
GCCGAGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663586.3
CDS	144..2675
Translation	MAQVLHVPAPFPGTPGQASPAAFPSKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRIGSNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAALETRSVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRVVEGPREVEVAASTAAGALAQRAQSLEPYGTGLKALTTSGGPENTLVFRSHEVVETMCPLPTATTGNVHTAKKISITERSCTGAPRMTEPSSVNPRPAAASVVQPENPVPAAQDTTDKKPTRPAAASQDSQAADGAGRASLATKRKEDPADPEVNQRNLQFVGVNGGYESPSEDSSTAENSEHESTENEGPEPPARVLSPAECPQLRPPGAAVATTSLEGPQLSQESQRVPAPEVASGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCHVDKLNRAGYSPIMLTALATLKTQDDIETILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVRALLACEADVNIQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE

Target ORF information:

RefSeq Version	NM_145611.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus KN motif and ankyrin repeat domains 2 (Kank2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145611.4

ORF Insert Sequence:

ATGGCCCAGG TCCTGCATGT GCCCGCCCCA TTCCCAGGAA CCCCTGGTCA GGCCTCCCCA 
GCGGCCTTCC CCAGCAAGGA GCCAGACCCA CCGTACTCAG TGGAAACGCC CTATGGCTAC 
CGCCTGGACC TGGATTTTCT TAAGTACGTG GATGACATTG AGAAGGGCCA CACACTGCGC 
AGGGTGGCGG TACAGCGCCG GCCGCGCCTG GGTTCCCTGC CACGGGGCCC GGGCTCCTGG 
TGGACGTCCA CAGAGTCTCT GTGCTCTGAT GCCAGTGGGG ACAGCCGGCA CTCGGCCTAC 
TCCTACTGTG GCCGCGGCTT CTACCCACAG TACGGAGCCT TGGAGACCCG AATCGGCTCC 
AACCCTCGTG TGGAGCGCAC GCTGCTGGAT GCGCGGCGCC GGCTGGAGGA CCAGGCGGCT 
GCCCCATCGT CCGGTGGCCT GGGCTCCCTC ACACCCAGCG CCGCGGGCTC CACCAGCTCC 
CTGGCAGGCG TGGGCCTGCT GCCCCCCACG CCTCGCAGCT CCGGCCTGTC CACCCCGGTG 
GCACCCAGCG CTGGTCACCT AGCCCACGTG CGCGAGCAGA TGGCTGGAGC CCTGCGCAAG 
CTGCGCCAGC TGGAGGAGCA GGTCAAGCTG ATCCCCGTTC TCCAAGTCAA GCTGTCAGTG 
CTCCAGGAGG AAAAGAGACA GCTCACCGTG CAGCTCAAGA GCCAGAAGTT TCTAGGTCAC 
CCCTCAGGGA CACGGAGCCG GAGTGAGCTC TGCCTGGACC TTCCCGAGGC CCCTGACGAC 
CCTGCTGCAC TAGAGACCCG CTCGGTGGGC ACCTGGGTTA GAGAACGGGA CTTGGGCATT 
CCAGATGGTG AAGCTGCCCT GGTAGCTAAA GTGGCCGTGT TGGAGACCCA GCTCAAAAAA 
GCGCTACAGG AGCTGCGGGC GGCTCAGACC CAGCAGGTCG ACCTCCAGCC CCAGGCCTGG 
CCACCACCAG ACACCCAGGT CCGCGTGGAC ACCGTGCGAG TAGTGGAGGG TCCCCGGGAA 
GTGGAGGTGG CAGCCAGCAC GGCAGCCGGG GCCCTTGCAC AGCGAGCTCA GAGTCTGGAA 
CCCTACGGAA CAGGGCTGAA GGCCCTGACC ACATCTGGGG GACCAGAGAA CACCCTCGTG 
TTCCGCAGTC ATGAAGTGGT GGAGACCATG TGCCCACTGC CCACAGCTAC CACTGGCAAT 
GTGCACACAG CCAAGAAGAT CAGCATTACA GAACGGAGTT GCACCGGTGC ACCCAGGATG 
ACAGAGCCTT CCTCCGTTAA TCCACGCCCT GCTGCAGCCT CTGTGGTACA GCCTGAGAAC 
CCTGTCCCGG CTGCCCAGGA CACCACTGAC AAGAAGCCCA CCAGGCCAGC AGCAGCATCG 
CAGGACTCAC AAGCGGCTGA CGGAGCAGGC AGAGCCTCTT TGGCCACGAA GAGGAAAGAG 
GACCCCGCAG ACCCTGAAGT CAACCAGAGG AACCTCCAGT TTGTGGGAGT CAATGGCGGG 
TATGAGTCCC CCTCGGAGGA CTCCAGCACA GCAGAAAACT CCGAACACGA GAGCACAGAG 
AACGAGGGCC CGGAGCCACC AGCAAGGGTT CTGAGCCCAG CTGAATGTCC TCAGCTCAGG 
CCTCCAGGGG CTGCAGTGGC CACGACCAGT CTGGAGGGGC CCCAGCTCTC CCAGGAATCC 
CAGCGTGTGC CTGCACCTGA GGTGGCGTCA GGACCCGATC CTGAGGAGGA AATTCGGATG 
GATCTGAGCC CTGACCTCAT ATCAGCCTGC TTGGCCCTGG AGAAATACCT GGAGAACCCC 
AATGCCCTCA CAGAGCGAGA ACTGAAAGTG GCCTATACCA CAGTGCTTCA GGAGTGGCTG 
CGCCTGGCCT GCCGCAGTGA CGCACACCCT GAGCTTGTGC GGCGACATCT AGTCACCTTC 
AGGGCCATGT CTGCCCGGCT GCTGGACTAC GTGGTCAACA TCGCCGACAG CAATGGTAAC 
ACTGCCCTGC ACTACTCAGT GTCACACGCC AACTTCCCTG TGGTGCGGCA GTTGCTGGAC 
AGCGGGGTCT GTCATGTGGA CAAGCTGAAC CGTGCCGGCT ACAGCCCTAT TATGCTCACT 
GCCCTGGCCA CGTTGAAGAC CCAGGACGAC ATTGAGACCA TCCTTCAGCT CTTCCGGCTT 
GGGAATGTCA ATGCCAAAGC CAGCCAGGCA GGACAGACGG CCCTGATGCT GGCCGTCAGC 
CACGGGCGGG TGGACGTGGT GAGAGCATTG CTGGCCTGTG AGGCGGACGT CAACATTCAG 
GATGAGGACG GCTCCACGGC CCTGATGTGT GCATGTGAGC ACGGACACAA GGAGATCACC 
GGGCTCCTGC TGGCTGTGCC TAGCTGTGAC ATCTCACTCA CTGACCGCGA CGGGAGCACA 
GCACTGATGG TGGCCCTGGA CGCTGGGCAG AGCGAGATCG CATCTATGCT GTACTCACGC 
ATGAACATCA AGTGCTCGTT CGCTCCCATG TCAGACTACG AGAGTCCGGC TTCGTCTTCA 
GCCGAGGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Kank2 activates talin, reduces force transduction across integrins and induces central adhesion?formation.
Nature cell biology18(9)941-53(2016 09)
Sun Z,Tseng HY,Tan S,Senger F,Kurzawa L,Dedden D,Mizuno N,Wasik AA,Thery M,Dunn AR,F?ssler R

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.
The Journal of clinical investigation125(6)2375-84(2015 Jun)
Gee HY,Zhang F,Ashraf S,Kohl S,Sadowski CE,Vega-Warner V,Zhou W,Lovric S,Fang H,Nettleton M,Zhu JY,Hoefele J,Weber LT,Podracka L,Boor A,Fehrenbach H,Innis JW,Washburn J,Levy S,Lifton RP,Otto EA,Han Z,Hildebrandt F

KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.
The Journal of clinical investigation124(8)3529-39(2014 Aug)
Garg A,O'Rourke J,Long C,Doering J,Ravenscroft G,Bezprozvannaya S,Nelson BR,Beetz N,Li L,Chen S,Laing NG,Grange RW,Bassel-Duby R,Olson EN

Expression of novel podocyte-associated proteins sult1b1 and ankrd25.
Nephron. Experimental nephrology117(2)e39-46(2011)
Xu X,Patrakka J,Sistani L,Uhlen M,Jalanko H,Betsholtz C,Tryggvason K

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Developmental cell17(6)836-48(2009 Dec)
Yokoyama S,Ito Y,Ueno-Kudoh H,Shimizu H,Uchibe K,Albini S,Mitsuoka K,Miyaki S,Kiso M,Nagai A,Hikata T,Osada T,Fukuda N,Yamashita S,Harada D,Mezzano V,Kasai M,Puri PL,Hayashizaki Y,Okado H,Hashimoto M,Asahara H

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Kank2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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