Gbx1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gbx1
Entrez Gene ID	231044
Full Name	gastrulation brain homeobox 1
Synonyms	Gbx-1
General protein information	Preferred Names gastrulation brain homeobox 1 Names homeobox protein GBX-1 gastrulation and brain-specific homeobox protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 A3\|5 11.93 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_015739.2	NP_056554.1	homeobox protein GBX-1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GBX1	XP_001138059.2
Rattus norvegicus (Norway rat)	Gbx1	NP_001258382.1
Homo sapiens (human)	GBX1	NP_001092304.1
Bos taurus (cattle)	GBX1	XP_002687021.2
Gallus gallus (chicken)	GBX1	XP_003640677.1
Danio rerio (zebrafish)	gbx1	NP_777286.1
	LOC714193	XP_001103813.1
Mus musculus (house mouse)	Gbx1	NP_056554.1

Gene Ontology
Bibliography

Related articles in PubMed

Developmental specification of forebrain cholinergic neurons.
Allaway KC, Machold R
Developmental biology421(1)1-7(2017 Jan)

Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.
Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein JLR
Neuron91(6)1260-1275(2016 Sep)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum.
Hoch RV, Lindtner S, Price JD, Rubenstein JL
Cell reports12(3)482-94(2015 Jul)

Comprehensive comparative homeobox gene annotation in human and mouse.
Wilming LG, Boychenko V, Harrow JL
Database : the journal of biological databases and curation2015(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate the role for Gbx1 in development of the spinal cord.
Title: Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development.

Data show that Gbx1 is regionally enriched in the Basal Nucleus of Meynert of mouse brain.
Title: Identification of a set of genes showing regionally enriched expression in the mouse brain.

expression of Gbx1 suggests that it controls development of a specific subset of GABAergic neurons in the dorsal horn of the spinal cord
Title: The homeodomain transcription factor Gbx1 identifies a subpopulation of late-born GABAergic interneurons in the developing dorsal spinal cord.

sequence and expression pattern of Gbx1 in mouse
Title: Isolation and expression of the homeobox gene Gbx1 during mouse development.

Combined expression of Lhx7 and Gbx1 plays a role in the development of the cholinergic system of the basal forebrain.
Title: The homeobox genes Lhx7 and Gbx1 are expressed in the basal forebrain cholinergic system.

The following Gbx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gbx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10200	NM_015739.2 Latest version!	Mus musculus gastrulation brain homeobox 1 (Gbx1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gbx1 ( NM_015739.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_056554.1 Mus musculus gastrulation brain homeobox 1 (Gbx1), mRNA.

Price & Availability↑

CloneID	OMu10200
Clone ID Related Accession (Same CDS sequence)	NM_015739.2
Accession Version	NM_015739.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	homeobox protein GBX-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC120353.9. On Nov 17, 2006 this sequence version replaced NM_015739.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF547996.1, AY319256.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGAGTCCGG AGGGCGACAC CCCCAACCCG CCCGCCCGCC CCCTCCCTCC TTATGAGCGA 
GAGAGCGCGG CGCCGGAGCC ACACTGCGCC GAGCCCGCGC CCCGCCGCCA CCTCGGCCCG 
CGCGCCCGCA GCGAGCCCTG CGTGTCCGCG CGGGGCGCAC GGCGGGGCCC GGGCAGCGCC 
ATGCAGAGAG CGGCAGGCGG CGGCGCCCCC GGGGGCAGCG GCGGGAGCAG CGGCGGCCCC 
GGCGCCGCCT TCTCCATCGA CTCGCTCATC GGGCCGCCGC CGCCGCGCTC GGGCCACCTG 
CTCTACACCG GCTACCCCAT GTTCATGCCC TACCGGCCGC TCGTGTTGCC GCAGGCGCTG 
GCCCCCGCGC CGCTGCCCGC CGGCCTGCCG CCGCTCGCCC CGCTCGCCTC GTTCGCCGGC 
CGCCTGAGCA ATACCTTCTG CGCGGGGCTG GGCCAGGCGG TGCCCTCGAT GGTGGCGCTG 
ACCACTGCGC TGCCCAGCTT CGCAGAGCCC CCGGACGCCT ACTACGGGCC CCCGGAGCTC 
GCCGCCGCCG CCGCCTCCAC CGCCTCGCGA AGCAACCCGG AGCCCGCGGC CCGGCGCACT 
GACGGAGCGC TGGACGCTGA GGAGCTGCTG CCCGCGCGCG AGAAAGTGAC TGAACCTCCG 
CCGCCCCCGC CTCCGCACTT CTCTGAGACT TTCCCGAGTC TACCGGCAGA GGGGAAGGTG 
TACAGCTCAG ATGAAGAGAA GCTAGAGCCC CCAGCAGGAG ACCCAGCAGG CAGCGAGCAG 
GAGGAAGAGG GCTCAGGCGG TGACAGCGAG GACAGCTTCC TGGACAGTTC TGCAGGGGGC 
CCAGGGGCTC TTCTGGGACC TAAACCGAAG CTAAAGGGAA GCCCGGGGAC TGGCGCTGAG 
GAGGGGACAC CAGTGGCCAC AGGGGTCACC ACGCCTGGGG GGAAAAGCCG AAGGCGGCGC 
ACAGCCTTCA CCAGCGAGCA GCTTTTGGAG CTGGAGAAGG AGTTTCACTG CAAGAAATAC 
CTGAGTCTGA CAGAGCGCTC CCAGATCGCC CACGCCCTCA AGCTCAGTGA GGTGCAGGTG 
AAGATCTGGT TTCAGAACCG CCGGGCCAAG TGGAAGCGCA TCAAGGCTGG CAATGTGAGC 
AGTCGTTCTG GGGAGCCGGT GAGAAACCCC AAGATTGTAG TGCCCATACC TGTGCACGTC 
AACAGGTTTG CTGTGCGCAG CCAGCACCAA CAGATGGAGC AAGGAGCCCG GCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_056554.1
CDS	33..1289
Translation	MSPEGDTPNPPARPLPPYERESAAPEPHCAEPAPRRHLGPRARSEPCVSARGARRGPGSAMQRAAGGGAPGGSGGSSGGPGAAFSIDSLIGPPPPRSGHLLYTGYPMFMPYRPLVLPQALAPAPLPAGLPPLAPLASFAGRLSNTFCAGLGQAVPSMVALTTALPSFAEPPDAYYGPPELAAAAASTASRSNPEPAARRTDGALDAEELLPAREKVTEPPPPPPPHFSETFPSLPAEGKVYSSDEEKLEPPAGDPAGSEQEEEGSGGDSEDSFLDSSAGGPGALLGPKPKLKGSPGTGAEEGTPVATGVTTPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVSSRSGEPVRNPKIVVPIPVHVNRFAVRSQHQQMEQGARP

Target ORF information:

RefSeq Version	NM_015739.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus gastrulation brain homeobox 1 (Gbx1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015739.2

ORF Insert Sequence:

ATGAGTCCGG AGGGCGACAC CCCCAACCCG CCCGCCCGCC CCCTCCCTCC TTATGAGCGA 
GAGAGCGCGG CGCCGGAGCC ACACTGCGCC GAGCCCGCGC CCCGCCGCCA CCTCGGCCCG 
CGCGCCCGCA GCGAGCCCTG CGTGTCCGCG CGGGGCGCAC GGCGGGGCCC GGGCAGCGCC 
ATGCAGAGAG CGGCAGGCGG CGGCGCCCCC GGGGGCAGCG GCGGGAGCAG CGGCGGCCCC 
GGCGCCGCCT TCTCCATCGA CTCGCTCATC GGGCCGCCGC CGCCGCGCTC GGGCCACCTG 
CTCTACACCG GCTACCCCAT GTTCATGCCC TACCGGCCGC TCGTGTTGCC GCAGGCGCTG 
GCCCCCGCGC CGCTGCCCGC CGGCCTGCCG CCGCTCGCCC CGCTCGCCTC GTTCGCCGGC 
CGCCTGAGCA ATACCTTCTG CGCGGGGCTG GGCCAGGCGG TGCCCTCGAT GGTGGCGCTG 
ACCACTGCGC TGCCCAGCTT CGCAGAGCCC CCGGACGCCT ACTACGGGCC CCCGGAGCTC 
GCCGCCGCCG CCGCCTCCAC CGCCTCGCGA AGCAACCCGG AGCCCGCGGC CCGGCGCACT 
GACGGAGCGC TGGACGCTGA GGAGCTGCTG CCCGCGCGCG AGAAAGTGAC TGAACCTCCG 
CCGCCCCCGC CTCCGCACTT CTCTGAGACT TTCCCGAGTC TACCGGCAGA GGGGAAGGTG 
TACAGCTCAG ATGAAGAGAA GCTAGAGCCC CCAGCAGGAG ACCCAGCAGG CAGCGAGCAG 
GAGGAAGAGG GCTCAGGCGG TGACAGCGAG GACAGCTTCC TGGACAGTTC TGCAGGGGGC 
CCAGGGGCTC TTCTGGGACC TAAACCGAAG CTAAAGGGAA GCCCGGGGAC TGGCGCTGAG 
GAGGGGACAC CAGTGGCCAC AGGGGTCACC ACGCCTGGGG GGAAAAGCCG AAGGCGGCGC 
ACAGCCTTCA CCAGCGAGCA GCTTTTGGAG CTGGAGAAGG AGTTTCACTG CAAGAAATAC 
CTGAGTCTGA CAGAGCGCTC CCAGATCGCC CACGCCCTCA AGCTCAGTGA GGTGCAGGTG 
AAGATCTGGT TTCAGAACCG CCGGGCCAAG TGGAAGCGCA TCAAGGCTGG CAATGTGAGC 
AGTCGTTCTG GGGAGCCGGT GAGAAACCCC AAGATTGTAG TGCCCATACC TGTGCACGTC 
AACAGGTTTG CTGTGCGCAG CCAGCACCAA CAGATGGAGC AAGGAGCCCG GCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Developmental specification of forebrain cholinergic neurons.
Developmental biology421(1)1-7(2017 Jan)
Allaway KC,Machold R

Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.
Neuron91(6)1260-1275(2016 Sep)
Sandberg M,Flandin P,Silberberg S,Su-Feher L,Price JD,Hu JS,Kim C,Visel A,Nord AS,Rubenstein JLR

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum.
Cell reports12(3)482-94(2015 Jul)
Hoch RV,Lindtner S,Price JD,Rubenstein JL

Comprehensive comparative homeobox gene annotation in human and mouse.
Database : the journal of biological databases and curation2015(2015)
Wilming LG,Boychenko V,Harrow JL

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Gbx1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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