Vdac2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vdac2
Entrez Gene ID	22334
Full Name	voltage-dependent anion channel 2
Synonyms	Vdac6,mVDAC2,mVDAC6
General protein information	Preferred Names voltage-dependent anion channel 2 Names voltage-dependent anion-selective channel protein 2 VDAC-2 VDAC-6 outer mitochondrial membrane protein porin 2 voltage-dependent anion-selective channel protein 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 A3\|14 11.91 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011695.2	NP_035825.1	voltage-dependent anion-selective channel protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	VDAC2	XP_851742.1
Danio rerio (zebrafish)	vdac2	NP_955879.1
Schizosaccharomyces pombe (fission yeast)	SPAC1635.01	NP_594661.1
Bos taurus (cattle)	VDAC2	NP_776911.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009833	XP_318947.2
Eremothecium gossypii	AGOS_ADL247C	NP_983849.2
Neurospora crassa	NCU04304	XP_960950.1
Pan troglodytes (chimpanzee)	VDAC2	XP_003312692.1
	VDAC2	XP_001096590.2
Kluyveromyces lactis	KLLA0F03553g	XP_455241.1
Magnaporthe oryzae (rice blast fungus)	MGG_00968	XP_003717982.1
Homo sapiens (human)	VDAC2	NP_003366.2
Mus musculus (house mouse)	Vdac2	NP_035825.1
Rattus norvegicus (Norway rat)	Vdac2	NP_112644.1
Gallus gallus (chicken)	VDAC2	NP_990072.1
Caenorhabditis elegans (roundworm)	R05G6.7	NP_501211.1
Saccharomyces cerevisiae (baker's yeast)	POR1	NP_014343.1
Drosophila melanogaster (fruit fly)	porin	NP_001033899.1
Xenopus tropicalis (tropical clawed frog)	vdac2	NP_001016193.1

Gene Ontology
Bibliography

Related articles in PubMed

Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.
Naghdi S, V?rnai P, Hajn?czky G
Proceedings of the National Academy of Sciences of the United States of America112(41)E5590-9(2015 Oct)

MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals.
Yuan J, Zhang Y, Sheng Y, Fu X, Cheng H, Zhou R
Autophagy11(7)1081-98(2015)

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function.
Ma SB, Nguyen TN, Tan I, Ninnis R, Iyer S, Stroud DA, Menard M, Kluck RM, Ryan MT, Dewson G
Cell death and differentiation21(12)1925-35(2014 Dec)

An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.
Huang H, Hu X, Eno CO, Zhao G, Li C, White C
The Journal of biological chemistry288(27)19870-81(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.
Title: Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.

an important MYBL2-VDAC2-BECN1-BCL2L1 pathway linking autophagy suppression in the developing ovary, is reported.
Title: MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals.

Bax localizes to the mitochondrial outer membrane via alternate mechanisms, either constitutively via an interaction with VDAC2 or after activation via interaction with Bcl-2 family proteins.
Title: Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function.

Bcl-xL interacts functionally with VDAC1 and -3 but not VDAC2.
Title: An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.

Abnormal regulation of VDACs negatively affected sperm function. Thus, VDACs may be key regulators of the fertilization ability of spermatozoa.
Title: Voltage-dependent anion channels are a key factor of male fertility.

The following Vdac2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vdac2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16317	NM_011695.2 Latest version!	Mus musculus voltage-dependent anion channel 2 (Vdac2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vdac2 ( NM_011695.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035825.1 Mus musculus voltage-dependent anion channel 2 (Vdac2), mRNA.

Price & Availability↑

CloneID	OMu16317
Clone ID Related Accession (Same CDS sequence)	NM_011695.2
Accession Version	NM_011695.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Mus musculus(house mouse)
Product	voltage-dependent anion-selective channel protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC151533.3 and AC132590.3. On Nov 17, 2006 this sequence version replaced NM_011695.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U30838.1, AK150940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCTGAGT GCTGTGTACC GGTATGCCCA CGGCCGATGT GTATCCCTCC ACCCTATGCT 
GACCTCGGCA AAGCTGCCAG AGACATTTTC AACAAAGGAT TTGGCTTTGG GCTGGTGAAG 
CTGGATGTGA AGACGAAGTC ATGCAGCGGT GTGGAATTTT CAACATCTGG CTCATCTAAT 
ACAGACACTG GTAAAGTTAG CGGGACCTTG GAGACCAAGT ACAAATGGTG TGAGTATGGT 
CTGACTTTCA CAGAGAAGTG GAACACCGAT AACACTCTGG GGACAGAGAT TGCAATTGAA 
GACCAGATTT GTCAAGGTTT GAAACTGACT TTTGACACCA CCTTTTCACC GAACACAGGA 
AAGAAAAGTG GTAAAATCAA GTCTGCTTAC AAGAGGGAGT GTATAAACCT CGGCTGTGAT 
GTTGACTTTG ATTTTGCTGG ACCTGCCATC CATGGGTCAG CTGTCTTTGG TTACGAGGGC 
TGGCTTGCTG GGTACCAAAT GACCTTTGAC AGTGCCAAGT CAAAGCTGAC AAGGAGTAAC 
TTTGCAGTCG GCTACAGGAC TGGGGACTTC CAGCTACACA CAAATGTAAA TAATGGGACA 
GAATTTGGAG GATCAATTTA TCAGAAAGTA TGTGAAGATT TTGACACTTC AGTAAACCTC 
GCTTGGACAT CAGGTACCAA CTGCACTCGT TTTGGCATTG CAGCTAAATA CCAGTTGGAT 
CCTACTGCTT CTATCTCTGC AAAGGTCAAC AACTCTAGTT TAATTGGAGT GGGCTATACT 
CAGACTCTGA GGCCTGGTGT GAAGCTTACA CTGTCTGCTC TGGTAGACGG GAAGAGCTTT 
AATGCTGGAG GCCACAAACT TGGGCTTGCC TTGGAATTGG AGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035825.1
CDS	133..1020
Translation	MAECCVPVCPRPMCIPPPYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNTDTGKVSGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGKKSGKIKSAYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRSNFAVGYRTGDFQLHTNVNNGTEFGGSIYQKVCEDFDTSVNLAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSFNAGGHKLGLALELEA

Target ORF information:

RefSeq Version	NM_011695.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus voltage-dependent anion channel 2 (Vdac2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011695.2

ORF Insert Sequence:

ATGGCTGAGT GCTGTGTACC GGTATGCCCA CGGCCGATGT GTATCCCTCC ACCCTATGCT 
GACCTCGGCA AAGCTGCCAG AGACATTTTC AACAAAGGAT TTGGCTTTGG GCTGGTGAAG 
CTGGATGTGA AGACGAAGTC ATGCAGCGGT GTGGAATTTT CAACATCTGG CTCATCTAAT 
ACAGACACTG GTAAAGTTAG CGGGACCTTG GAGACCAAGT ACAAATGGTG TGAGTATGGT 
CTGACTTTCA CAGAGAAGTG GAACACCGAT AACACTCTGG GGACAGAGAT TGCAATTGAA 
GACCAGATTT GTCAAGGTTT GAAACTGACT TTTGACACCA CCTTTTCACC GAACACAGGA 
AAGAAAAGTG GTAAAATCAA GTCTGCTTAC AAGAGGGAGT GTATAAACCT CGGCTGTGAT 
GTTGACTTTG ATTTTGCTGG ACCTGCCATC CATGGGTCAG CTGTCTTTGG TTACGAGGGC 
TGGCTTGCTG GGTACCAAAT GACCTTTGAC AGTGCCAAGT CAAAGCTGAC AAGGAGTAAC 
TTTGCAGTCG GCTACAGGAC TGGGGACTTC CAGCTACACA CAAATGTAAA TAATGGGACA 
GAATTTGGAG GATCAATTTA TCAGAAAGTA TGTGAAGATT TTGACACTTC AGTAAACCTC 
GCTTGGACAT CAGGTACCAA CTGCACTCGT TTTGGCATTG CAGCTAAATA CCAGTTGGAT 
CCTACTGCTT CTATCTCTGC AAAGGTCAAC AACTCTAGTT TAATTGGAGT GGGCTATACT 
CAGACTCTGA GGCCTGGTGT GAAGCTTACA CTGTCTGCTC TGGTAGACGG GAAGAGCTTT 
AATGCTGGAG GCCACAAACT TGGGCTTGCC TTGGAATTGG AGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America112(41)E5590-9(2015 Oct)
Naghdi S,V?rnai P,Hajn?czky G

MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals.
Autophagy11(7)1081-98(2015)
Yuan J,Zhang Y,Sheng Y,Fu X,Cheng H,Zhou R

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function.
Cell death and differentiation21(12)1925-35(2014 Dec)
Ma SB,Nguyen TN,Tan I,Ninnis R,Iyer S,Stroud DA,Menard M,Kluck RM,Ryan MT,Dewson G

An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.
The Journal of biological chemistry288(27)19870-81(2013 Jul)
Huang H,Hu X,Eno CO,Zhao G,Li C,White C

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Vdac2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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