Ccno cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccno
Entrez Gene ID	218630
Full Name	cyclin O
Synonyms	C86987,Ccnu,E130318K11,Ung2
General protein information	Preferred Names cyclin O Names cyclin-O UDG2 cyclin U cyclin-like uracil-DNA glycosylase uracil DNA glycosylase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 D2.2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001081062.1	NP_001074531.1	cyclin-O

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CCNO	XP_544336.2
Gallus gallus (chicken)	CCNO	XP_003643032.1
Xenopus tropicalis (tropical clawed frog)	ccno	NP_998837.1
Homo sapiens (human)	CCNO	NP_066970.3
Pan troglodytes (chimpanzee)	CCNO	XP_001147153.1
Mus musculus (house mouse)	Ccno	NP_001074531.1
Danio rerio (zebrafish)	LOC101883490	XP_005168712.1
Rattus norvegicus (Norway rat)	Ccno	NP_001102645.1
	CCNO	XP_001098228.1
Bos taurus (cattle)	CCNO	XP_002696375.1

Gene Ontology
Bibliography

Related articles in PubMed

Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility.
N?nez-Oll? M, Jung C, Terr? B, Balsiger NA, Plata C, Roset R, Pardo-Pastor C, Garrido M, Rojas S, Alameda F, Lloreta J, Mart?n-Caballero J, Flores JM, Stracker TH, Valverde MA, Mu?oz FJ, Gil-G?mez G
Oncotarget8(59)99261-99273(2017 Nov)

Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit.
Otto T, Candido SV, Pilarz MS, Sicinska E, Bronson RT, Bowden M, Lachowicz IA, Mulry K, Fassl A, Han RC, Jecrois ES, Sicinski P
Proceedings of the National Academy of Sciences of the United States of America114(40)10660-10665(2017 Oct)

The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis.
Villa M, Crotta S, Dingwell KS, Hirst EM, Gialitakis M, Ahlfors H, Smith JC, Stockinger B, Wack A
Nature communications712652(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ccno-deficient multiciliated cells fail to sufficiently generate deuterosomes, and only reduced numbers of fully functional centrioles that undergo maturation to ciliary basal bodies are formed.
Title: Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells.

We thus conclude that cyclin O, as an upstream regulator of MPF, plays an important role in oocyte meiotic resumption in mouse oocytes.
Title: Cyclin O regulates germinal vesicle breakdown in mouse oocytes.

Results show uracil-N-glycosylase (UNG) as a new molecular layer that shapes the specificity of activation-induced deaminase (AID)-induced mutations and may provide new insights into the role of AID in cancer development.
Title: UNG shapes the specificity of AID-induced somatic hypermutation.

Cyclin O activation correlates with apoptosis induction in vivo.
Title: Identification of a novel cyclin required for the intrinsic apoptosis pathway in lymphoid cells.

The following Ccno gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccno cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01625	NM_001081062.1 Latest version!	Mus musculus cyclin O (Ccno), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccno ( NM_001081062.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001074531.1 Mus musculus cyclin O (Ccno), mRNA.

Price & Availability↑

CloneID	OMu01625
Clone ID Related Accession (Same CDS sequence)	NM_001081062.1
Accession Version	NM_001081062.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	cyclin-O
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC165265.2. On Feb 6, 2007 this sequence version replaced XM_127523.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK086507.1, SRR1660821.3918.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTTACCC CTTGCCCTGC CAGCCCGGGC AGCCCCGCCG CGGGAGCCGG GAGGCGAGAC 
AGCCACCAGA ACCTCCGCGC CCCAGTGAAG AAGAGCAGAC GCCCGTGCCT CCGGAGAAAG 
AAGCCGCTGC GGCCGCTGAA CGCGTGTTCG CTCCCGGGAG ACTCGGGCGT CTGTGACCTT 
TTCGAGTCCC CCAGCTCCAG CTCGGACGGC GCCGACAGCC CCGCAGTGTC TGCGGCGCGG 
GACTGCAGCT CCCTACTCAA CCCTGCCCAG CCCTTGACAG CGCTGGATCT CCAGACCTTC 
CGAGAATACG GCCAGAGCTG CTACGACTTC CGAAAGGCGC AGGAGAATCT TTTCCACCCG 
CGGGAGTCGC TGGCGCGCCA GCCACAAGTG ACTGCCGAAT CGCGCTGTAA ACTGCTCAGC 
TGGCTCCTGC AAGTCCACCG CCAGTTCGGC CTCTCTTTCG AGTCGCTGTG TCTGACCGTG 
AATACTCTGG ACCGTTTTCT CCTCACGACC CCTGTTGCTG CAGACTGCTT CCAGCTGCTC 
GGGGTCACCT GTCTGCTCAT CGCTTGCAAG CAGGTAGAGG TGCACCCACC TCGCTTGAAA 
CAGCTCCTGG CCCTGTGCGG CGGTGCGTTC TCCCGGCAGC AGCTGTGCAA CCTGGAGTGC 
ATCGTGCTGC ATAAGCTCCA CTTCAGCCTG GGCGCGCCCA CCATCAACTT CTTCCTGGAG 
CACTTCACTC AGTGGCGCAT GGAAGCCGGC CAGGCTGAGG TCACCGAAGC TCTAGAGGCT 
CAAACCCTGG CCCGGGGAGT GGCGGAGCTG AGCCTAACGG ATTACGCGTT CACTACCTAC 
ACGCCGTCCC TGATGGCTAT CTGCTGCCTG GCGCTGGCTG ACGGATTGCT GCAGCACCAG 
CACGAGATGG ACCTGCGCCT GGGAGAGCAC CCAGAGGCCA CACTGCAAGA CTGTCTGGGC 
AAGCTGCAGA CGCTAGTGTC CATCAATAGC AGCTCCCTGC CTCGCATTCT GCCTCCCCAG 
ATCTGGGAGA GGTGCAGCCT GCCCCAGAGT TGGCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074531.1
CDS	97..1155
Translation	MVTPCPASPGSPAAGAGRRDSHQNLRAPVKKSRRPCLRRKKPLRPLNACSLPGDSGVCDLFESPSSSSDGADSPAVSAARDCSSLLNPAQPLTALDLQTFREYGQSCYDFRKAQENLFHPRESLARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTVNTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNLECIVLHKLHFSLGAPTINFFLEHFTQWRMEAGQAEVTEALEAQTLARGVAELSLTDYAFTTYTPSLMAICCLALADGLLQHQHEMDLRLGEHPEATLQDCLGKLQTLVSINSSSLPRILPPQIWERCSLPQSWQ

Target ORF information:

RefSeq Version	NM_001081062.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus cyclin O (Ccno), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001081062.1

ORF Insert Sequence:

ATGGTTACCC CTTGCCCTGC CAGCCCGGGC AGCCCCGCCG CGGGAGCCGG GAGGCGAGAC 
AGCCACCAGA ACCTCCGCGC CCCAGTGAAG AAGAGCAGAC GCCCGTGCCT CCGGAGAAAG 
AAGCCGCTGC GGCCGCTGAA CGCGTGTTCG CTCCCGGGAG ACTCGGGCGT CTGTGACCTT 
TTCGAGTCCC CCAGCTCCAG CTCGGACGGC GCCGACAGCC CCGCAGTGTC TGCGGCGCGG 
GACTGCAGCT CCCTACTCAA CCCTGCCCAG CCCTTGACAG CGCTGGATCT CCAGACCTTC 
CGAGAATACG GCCAGAGCTG CTACGACTTC CGAAAGGCGC AGGAGAATCT TTTCCACCCG 
CGGGAGTCGC TGGCGCGCCA GCCACAAGTG ACTGCCGAAT CGCGCTGTAA ACTGCTCAGC 
TGGCTCCTGC AAGTCCACCG CCAGTTCGGC CTCTCTTTCG AGTCGCTGTG TCTGACCGTG 
AATACTCTGG ACCGTTTTCT CCTCACGACC CCTGTTGCTG CAGACTGCTT CCAGCTGCTC 
GGGGTCACCT GTCTGCTCAT CGCTTGCAAG CAGGTAGAGG TGCACCCACC TCGCTTGAAA 
CAGCTCCTGG CCCTGTGCGG CGGTGCGTTC TCCCGGCAGC AGCTGTGCAA CCTGGAGTGC 
ATCGTGCTGC ATAAGCTCCA CTTCAGCCTG GGCGCGCCCA CCATCAACTT CTTCCTGGAG 
CACTTCACTC AGTGGCGCAT GGAAGCCGGC CAGGCTGAGG TCACCGAAGC TCTAGAGGCT 
CAAACCCTGG CCCGGGGAGT GGCGGAGCTG AGCCTAACGG ATTACGCGTT CACTACCTAC 
ACGCCGTCCC TGATGGCTAT CTGCTGCCTG GCGCTGGCTG ACGGATTGCT GCAGCACCAG 
CACGAGATGG ACCTGCGCCT GGGAGAGCAC CCAGAGGCCA CACTGCAAGA CTGTCTGGGC 
AAGCTGCAGA CGCTAGTGTC CATCAATAGC AGCTCCCTGC CTCGCATTCT GCCTCCCCAG 
ATCTGGGAGA GGTGCAGCCT GCCCCAGAGT TGGCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility.
Oncotarget8(59)99261-99273(2017 Nov)
N?nez-Oll? M,Jung C,Terr? B,Balsiger NA,Plata C,Roset R,Pardo-Pastor C,Garrido M,Rojas S,Alameda F,Lloreta J,Mart?n-Caballero J,Flores JM,Stracker TH,Valverde MA,Mu?oz FJ,Gil-G?mez G

Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit.
Proceedings of the National Academy of Sciences of the United States of America114(40)10660-10665(2017 Oct)
Otto T,Candido SV,Pilarz MS,Sicinska E,Bronson RT,Bowden M,Lachowicz IA,Mulry K,Fassl A,Han RC,Jecrois ES,Sicinski P

The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis.
Nature communications712652(2016 Aug)
Villa M,Crotta S,Dingwell KS,Hirst EM,Gialitakis M,Ahlfors H,Smith JC,Stockinger B,Wack A

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Ccno cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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