Tcl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tcl1
Entrez Gene ID	21432
Full Name	T cell lymphoma breakpoint 1
Synonyms	Tcl1a
General protein information	Preferred Names T cell lymphoma breakpoint 1 Names T-cell leukemia/lymphoma protein 1A TCL-1 oncogene TCL-1 oncogene TCL1 protein p14 TCL1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 E\|12 55.28 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001309484.1	NP_001296413.1	T-cell leukemia/lymphoma protein 1A isoform 3
NM_009337.3	NP_033363.1	T-cell leukemia/lymphoma protein 1A isoform 1
NM_001289468.1	NP_001276397.1	T-cell leukemia/lymphoma protein 1A isoform 2
NM_001309485.1	NP_001296414.1	T-cell leukemia/lymphoma protein 1A isoform 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TCL1A	XP_001154719.1
Homo sapiens (human)	TCL1A	NP_068801.1
Mus musculus (house mouse)	Tcl1	NP_033363.1
Rattus norvegicus (Norway rat)	Tcl1a	NP_001103071.1
Bos taurus (cattle)	TCL1A	XP_002696811.2
	LOC703349	XP_001101341.1

Gene Ontology
Bibliography

Related articles in PubMed

The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia.
Herman SEM, Montraveta A, Niemann CU, Mora-Jensen H, Gulrajani M, Krantz F, Mantel R, Smith LL, McClanahan F, Harrington BK, Colomer D, Covey T, Byrd JC, Izumi R, Kaptein A, Ulrich R, Johnson AJ, Lannutti BJ, Wiestner A, Woyach JA
Clinical cancer research : an official journal of the American Association for Cancer Research23(11)2831-2841(2017 Jun)

A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation.
Nishimura K, Aizawa S, Nugroho FL, Shiomitsu E, Tran YT, Bui PL, Borisova E, Sakuragi Y, Takada H, Kurisaki A, Hayashi Y, Fukuda A, Nakanishi M, Hisatake K
Stem cell reports8(3)787-801(2017 03)

CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.
Kocher T, Asslaber D, Zaborsky N, Flenady S, Denk U, Reinthaler P, Ablinger M, Geisberger R, Bauer JW, Seiffert M, Hartmann TN, Greil R, Egle A, Pi??n Hofbauer J
Leukemia30(6)1409-13(2016 Jun)

Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse.
Yu C, Ji SY, Dang YJ, Sha QQ, Yuan YF, Zhou JJ, Yan LY, Qiao J, Tang F, Fan HY
Cell research26(3)275-87(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we revealed that one of the key functions of KLF4-induced TCL1 during reprogramming is to promote the metabolic shift from oxidative phosphorylation to glycolysis.
Title: A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation.

results indicate that decreased Cav-1 in Emu-TCL1 mice significantly delays the onset of CLL and decreases leukemic progression by inhibiting MAPK-Erk signaling, suggesting a role for Cav-1 in the proliferation and progression of CLL
Title: Absence of caveolin-1 leads to delayed development of chronic lymphocytic leukemia in E?-TCL1 mouse model.

This review discusses the main features of the original TCL1 models and the different lines of research successively developed with particular attention to genetically compound mice and the therapeutic applications in drug development.
Title: The long journey of TCL1 transgenic mice: lessons learned in the last 15 years.

Data indicate that APRIL expression accelerates the onset of TCL1-driven leukemia formation mainly through TACI activation.
Title: Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model.

Tcl1 expression downregulated a distinct group of genes, including Ndp52, whose expression is very high in blastocysts but reduced in the primitive ectoderm.
Title: Functional analysis of Tcl1 using Tcl1-deficient mouse embryonic stem cells.

The following Tcl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tcl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu68854	NM_001309484.1 Latest version!	Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu18255	NM_001289468.1 Latest version!	Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu68853	NM_001309485.1 Latest version!	Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu18143	NM_009337.3 Latest version!	Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tcl1 ( NM_001309484.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001296413.1 Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OMu68854
Clone ID Related Accession (Same CDS sequence)	NM_001309484.1
Accession Version	NM_001309484.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	T-cell leukemia/lymphoma protein 1A isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV653827.1, CJ087217.1, DV649899.1, DV646075.1 and DV660020.1. On Jun 8, 2015 this sequence version replaced NR_110340.1. Transcript Variant: This variant (5) lacks an alternate internal exon and contains an alternate internal exon, resulting in the use of an alternate start codon, compared to variant 2. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DV649899.1, AV588090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATAACC CAGACCCGGT CCTGCAGCTC CTGTCTGCCT TGCCCAGGCC TGGCCCCACA 
GGGGAGATGT TGGTACTTAT GTTCTGTCTG TTCGCTAGTC ATGTCCTTTT TCCTCTACAC 
TGGGCTCCAA GAAGAAAACT CTGGCCAGAC GCTGCCCCTT CCCATGCTGC TGTTGCCTGC 
TCGGCTGCCT TGGTTGGTCC CTCAGCTCTG CTGACTCCCT GGCAAGGGGC TCCAGAGAAG 
ATCCCAGTTC TCCTCACCTC CTCTAGGTGC TCAGTGGTGT CTGTGCCTCT GATGATCTTA 
GCTGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001296413.1
CDS	258..566
Translation	MNNPDPVLQLLSALPRPGPTGEMLVLMFCLFASHVLFPLHWAPRRKLWPDAAPSHAAVACSAALVGPSALLTPWQGAPEKIPVLLTSSRCSVVSVPLMILAD

Target ORF information:

RefSeq Version	NM_001309484.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001309484.1

ORF Insert Sequence:

ATGAATAACC CAGACCCGGT CCTGCAGCTC CTGTCTGCCT TGCCCAGGCC TGGCCCCACA 
GGGGAGATGT TGGTACTTAT GTTCTGTCTG TTCGCTAGTC ATGTCCTTTT TCCTCTACAC 
TGGGCTCCAA GAAGAAAACT CTGGCCAGAC GCTGCCCCTT CCCATGCTGC TGTTGCCTGC 
TCGGCTGCCT TGGTTGGTCC CTCAGCTCTG CTGACTCCCT GGCAAGGGGC TCCAGAGAAG 
ATCCCAGTTC TCCTCACCTC CTCTAGGTGC TCAGTGGTGT CTGTGCCTCT GATGATCTTA 
GCTGATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tcl1 ( NM_001289468.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001276397.1 Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18255
Clone ID Related Accession (Same CDS sequence)	NM_001289468.1
Accession Version	NM_001289468.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	T-cell leukemia/lymphoma protein 1A isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV653827.1, AK149361.1 and DV660020.1. On Jan 23, 2014 this sequence version replaced XM_006515666.1. Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a longer and distinct C-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149361.1, CO803295.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTACCC AGCGGGCACA CAGGGCAGAG ACACCTGCAC ACCCCAACCG CCTGTGGATC 
TGGGAGAAGC ACGTGTACTT GGATGAGTTT CGTCGAAGCT GGCTGCCCGT AGTCATCAAG 
AGTAATGAAA AATTCCAGGT GATCTTGCGC CAGGAAGATG TCACCTTGGG GGAAGCTATG 
TCCCCCAGTC AGCTGGTGCC TTACGAGCTG CCTTTAATGT GGCAACTGTA CCCCAAGGAC 
AGGTACCGAA GCTGCGACTC CATGTATTGG CAGATCCTGT ACCATATCAA GGTCCTGCAG 
CTCCTGTCTG CCTTGCCCAG GCCTGGCCCC ACAGGGGAGA TGTTGGTACT TATGTTCTGT 
CTGTTCGCTA GTCATGTCCT TTTTCCTCTA CACTGGGCTC CAAGAAGAAA ACTCTGGCCA 
GACGCTGCCC CTTCCCATGC TGCTGTTGCC TGCTCGGCTG CCTTGGTTGG TCCCTCAGCT 
CTGCTGACTC CCTGGCAAGG GGCTCCAGAG AAGATCCCAG TTCTCCTCAC CTCCTCTAGG 
TGCTCAGTGG TGTCTGTGCC TCTGATGATC TTAGCTGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276397.1
CDS	86..667
Translation	MATQRAHRAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEKFQVILRQEDVTLGEAMSPSQLVPYELPLMWQLYPKDRYRSCDSMYWQILYHIKVLQLLSALPRPGPTGEMLVLMFCLFASHVLFPLHWAPRRKLWPDAAPSHAAVACSAALVGPSALLTPWQGAPEKIPVLLTSSRCSVVSVPLMILAD

Target ORF information:

RefSeq Version	NM_001289468.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001289468.1

ORF Insert Sequence:

ATGGCTACCC AGCGGGCACA CAGGGCAGAG ACACCTGCAC ACCCCAACCG CCTGTGGATC 
TGGGAGAAGC ACGTGTACTT GGATGAGTTT CGTCGAAGCT GGCTGCCCGT AGTCATCAAG 
AGTAATGAAA AATTCCAGGT GATCTTGCGC CAGGAAGATG TCACCTTGGG GGAAGCTATG 
TCCCCCAGTC AGCTGGTGCC TTACGAGCTG CCTTTAATGT GGCAACTGTA CCCCAAGGAC 
AGGTACCGAA GCTGCGACTC CATGTATTGG CAGATCCTGT ACCATATCAA GGTCCTGCAG 
CTCCTGTCTG CCTTGCCCAG GCCTGGCCCC ACAGGGGAGA TGTTGGTACT TATGTTCTGT 
CTGTTCGCTA GTCATGTCCT TTTTCCTCTA CACTGGGCTC CAAGAAGAAA ACTCTGGCCA 
GACGCTGCCC CTTCCCATGC TGCTGTTGCC TGCTCGGCTG CCTTGGTTGG TCCCTCAGCT 
CTGCTGACTC CCTGGCAAGG GGCTCCAGAG AAGATCCCAG TTCTCCTCAC CTCCTCTAGG 
TGCTCAGTGG TGTCTGTGCC TCTGATGATC TTAGCTGATT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tcl1 ( NM_001309485.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001296414.1 Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu68853
Clone ID Related Accession (Same CDS sequence)	NM_001309485.1
Accession Version	NM_001309485.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 276bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	T-cell leukemia/lymphoma protein 1A isoform 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV653827.1, CA558861.1, DV655843.1, DV646075.1 and DV660020.1. On Jun 6, 2015 this sequence version replaced NR_110341.1. Transcript Variant: This variant (4) uses an alternate splice site in its 3' coding region and contains an alternate internal exon, resulting in a frameshift and an early stop codon, compared to variant 2. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DV655843.1, CA558861.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTACCC AGCGGGCACA CAGGGCAGAG ACACCTGCAC ACCCCAACCG CCTGTGGATC 
TGGGAGAAGC ACGTGTACTT GGATGAGTTT CGTCGAAGCT GGCTGCCCGT AGTCATCAAG 
AGTAATGAAA AATTCCAGGT GATCTTGCGC CAGGAAGATG TCACCTTGGG GGAAGCTATG 
TCCCCCAGTC AGCTGGTGCC TTACGAGCTG CCTTTAATGT GGCAACTGTA CCCCAAGGAC 
AGTTTAGAGA CGTGGAGGAC ATGTTGCTTG AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001296414.1
CDS	86..361
Translation	MATQRAHRAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEKFQVILRQEDVTLGEAMSPSQLVPYELPLMWQLYPKDSLETWRTCCLN

Target ORF information:

RefSeq Version	NM_001309485.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001309485.1

ORF Insert Sequence:

ATGGCTACCC AGCGGGCACA CAGGGCAGAG ACACCTGCAC ACCCCAACCG CCTGTGGATC 
TGGGAGAAGC ACGTGTACTT GGATGAGTTT CGTCGAAGCT GGCTGCCCGT AGTCATCAAG 
AGTAATGAAA AATTCCAGGT GATCTTGCGC CAGGAAGATG TCACCTTGGG GGAAGCTATG 
TCCCCCAGTC AGCTGGTGCC TTACGAGCTG CCTTTAATGT GGCAACTGTA CCCCAAGGAC 
AGTTTAGAGA CGTGGAGGAC ATGTTGCTTG AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tcl1 ( NM_009337.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033363.1 Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18143
Clone ID Related Accession (Same CDS sequence)	NM_009337.3
Accession Version	NM_009337.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	T-cell leukemia/lymphoma protein 1A isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV653827.1, BC052336.1 and AK163387.1. On Aug 13, 2009 this sequence version replaced NM_009337.2. Transcript Variant: This variant (1) encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052336.1, AK163387.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTACCC AGCGGGCACA CAGGGCAGAG ACACCTGCAC ACCCCAACCG CCTGTGGATC 
TGGGAGAAGC ACGTGTACTT GGATGAGTTT CGTCGAAGCT GGCTGCCCGT AGTCATCAAG 
AGTAATGAAA AATTCCAGGT GATCTTGCGC CAGGAAGATG TCACCTTGGG GGAAGCTATG 
TCCCCCAGTC AGCTGGTGCC TTACGAGCTG CCTTTAATGT GGCAACTGTA CCCCAAGGAC 
AGGTACCGAA GCTGCGACTC CATGTATTGG CAGATCCTGT ACCATATCAA GTTTAGAGAC 
GTGGAGGACA TGTTGCTTGA ACTGATAGAC TCGGAGTCCA ACGATGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033363.1
CDS	86..436
Translation	MATQRAHRAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEKFQVILRQEDVTLGEAMSPSQLVPYELPLMWQLYPKDRYRSCDSMYWQILYHIKFRDVEDMLLELIDSESNDE

Target ORF information:

RefSeq Version	NM_009337.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009337.3

ORF Insert Sequence:

ATGGCTACCC AGCGGGCACA CAGGGCAGAG ACACCTGCAC ACCCCAACCG CCTGTGGATC 
TGGGAGAAGC ACGTGTACTT GGATGAGTTT CGTCGAAGCT GGCTGCCCGT AGTCATCAAG 
AGTAATGAAA AATTCCAGGT GATCTTGCGC CAGGAAGATG TCACCTTGGG GGAAGCTATG 
TCCCCCAGTC AGCTGGTGCC TTACGAGCTG CCTTTAATGT GGCAACTGTA CCCCAAGGAC 
AGGTACCGAA GCTGCGACTC CATGTATTGG CAGATCCTGT ACCATATCAA GTTTAGAGAC 
GTGGAGGACA TGTTGCTTGA ACTGATAGAC TCGGAGTCCA ACGATGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research23(11)2831-2841(2017 Jun)
Herman SEM,Montraveta A,Niemann CU,Mora-Jensen H,Gulrajani M,Krantz F,Mantel R,Smith LL,McClanahan F,Harrington BK,Colomer D,Covey T,Byrd JC,Izumi R,Kaptein A,Ulrich R,Johnson AJ,Lannutti BJ,Wiestner A,Woyach JA

A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation.
Stem cell reports8(3)787-801(2017 03)
Nishimura K,Aizawa S,Nugroho FL,Shiomitsu E,Tran YT,Bui PL,Borisova E,Sakuragi Y,Takada H,Kurisaki A,Hayashi Y,Fukuda A,Nakanishi M,Hisatake K

CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.
Leukemia30(6)1409-13(2016 Jun)
Kocher T,Asslaber D,Zaborsky N,Flenady S,Denk U,Reinthaler P,Ablinger M,Geisberger R,Bauer JW,Seiffert M,Hartmann TN,Greil R,Egle A,Pi??n Hofbauer J

Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse.
Cell research26(3)275-87(2016 Mar)
Yu C,Ji SY,Dang YJ,Sha QQ,Yuan YF,Zhou JJ,Yan LY,Qiao J,Tang F,Fan HY

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Tcl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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