Tac2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tac2
Entrez Gene ID	21334
Full Name	tachykinin 2
Synonyms	PPT-B,Tac3
General protein information	Preferred Names tachykinin 2 Names tachykinin-3 neurokinin 2 neurokinin A neurokinin B-like protein Zneurok1 neurokinin alpha neuromedin L neuropeptide K preprotachykinin-B substance K
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D3
Summary	This gene encodes a member of the tachykinin family of signaling peptides that is widely expressed in the central nervous system and plays a role in diverse processes such as water homeostasis, pulmonary inflammation, cognition, fear memory consolidation and preeclampsia. The encoded protein is enzymatically processed to generate the mature neuropeptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_009312.2	NP_033338.2	tachykinin-3 preproprotein
NM_001199971.1	NP_001186900.1	tachykinin-3 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TAC3	XP_001168338.1
	TAC3	XP_001115535.1
Rattus norvegicus (Norway rat)	Tac3	NP_062035.1
Bos taurus (cattle)	TAC3	NP_851360.1
Canis lupus familiaris (dog)	TAC3	XP_005625588.1
Homo sapiens (human)	TAC3	NP_037383.1
Mus musculus (house mouse)	Tac2	NP_033338.2

Gene Ontology
Bibliography

Related articles in PubMed

Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors.
Kim J, Zhang X, Muralidhar S, LeBlanc SA, Tonegawa S
Neuron93(6)1464-1479.e5(2017 Mar)

Diverse Central Projection Patterns of Retinal Ganglion Cells.
Martersteck EM, Hirokawa KE, Evarts M, Bernard A, Duan X, Li Y, Ng L, Oh SW, Ouellette B, Royall JJ, Stoecklin M, Wang Q, Zeng H, Sanes JR, Harris JA
Cell reports18(8)2058-2072(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

steroidal environment and energy state negatively regulate kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) gene expression.
Title: The interaction of fasting, caloric restriction, and diet-induced obesity with 17?-estradiol on the expression of KNDy neuropeptides and their receptors in the female mouse.

This study showed a new evidence that furthers our understanding for the mechanisms underlying Tac2-dependent cellular pathways in fear learning.
Title: Amygdala-Dependent Molecular Mechanisms of the Tac2 Pathway in Fear Learning.

Data show that estrogen receptor alpha (ERalpha) in tachykinin 2 protein (Tac2) neurons typically restrains pubertal onset and hypothalamic reproductive drive.
Title: ER? in Tac2 Neurons Regulates Puberty Onset in Female Mice.

Tac2-/- females had delays in sexual maturation, with time to vaginal opening and first estrus occurring later than controls. However, cycling recovered in adulthood and Tac2-/- females were fertile, although they produced fewer pups per litter.
Title: Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice.

Increased Tac2 expression, through a stress-induced PTSD-like model, or following lentiviral CeA overexpression, are sufficient to enhance fear consolidation.
Title: A role for Tac2, NkB, and Nk3 receptor in normal and dysregulated fear memory consolidation.

The following Tac2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tac2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13684	NM_001199971.1 Latest version!	Mus musculus tachykinin 2 (Tac2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu13684	NM_009312.2 Latest version!	Mus musculus tachykinin 2 (Tac2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tac2 ( NM_009312.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033338.2 Mus musculus tachykinin 2 (Tac2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13684
Clone ID Related Accession (Same CDS sequence)	NM_009312.2 , NM_001199971.1
Accession Version	NM_009312.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	tachykinin-3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC160970.7 and BC031348.1. On Jan 31, 2008 this sequence version replaced NM_009312.1. Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ175657.1, AA051164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGAGCG CCATGCTGTT TGCGGCTGTC CTCGCCCTCA GCTTGGCTTG GACCTTCGGG 
GCTGTGTGTG AGGAGCCACA GGGGCAGGGA GGGAGGCTCA GTAAGGACTC TGATCTCTAT 
CAGCTGCCTC CGTCCCTGCT TCGGAGACTC TACGACAGCC GCCCTGTCTC TCTGGAAGGA 
TTGCTGAAAG TGCTGAGCAA GGCTAGCGTG GGACCAAAGG AGACATCACT TCCACAGAAA 
CGTGACATGC ACGACTTCTT TGTGGGACTT ATGGGCAAGA GGAACAGCCA ACCAGACACT 
CCCACCGACG TGGTTGAAGA GAACACCCCC AGCTTTGGCA TCCTCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033338.2
CDS	93..443
Translation	MRSAMLFAAVLALSLAWTFGAVCEEPQGQGGRLSKDSDLYQLPPSLLRRLYDSRPVSLEGLLKVLSKASVGPKETSLPQKRDMHDFFVGLMGKRNSQPDTPTDVVEENTPSFGILK

Target ORF information:

RefSeq Version	NM_009312.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus tachykinin 2 (Tac2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009312.2

ORF Insert Sequence:

ATGAGGAGCG CCATGCTGTT TGCGGCTGTC CTCGCCCTCA GCTTGGCTTG GACCTTCGGG 
GCTGTGTGTG AGGAGCCACA GGGGCAGGGA GGGAGGCTCA GTAAGGACTC TGATCTCTAT 
CAGCTGCCTC CGTCCCTGCT TCGGAGACTC TACGACAGCC GCCCTGTCTC TCTGGAAGGA 
TTGCTGAAAG TGCTGAGCAA GGCTAGCGTG GGACCAAAGG AGACATCACT TCCACAGAAA 
CGTGACATGC ACGACTTCTT TGTGGGACTT ATGGGCAAGA GGAACAGCCA ACCAGACACT 
CCCACCGACG TGGTTGAAGA GAACACCCCC AGCTTTGGCA TCCTCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tac2 ( NM_001199971.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001186900.1 Mus musculus tachykinin 2 (Tac2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13684
Clone ID Related Accession (Same CDS sequence)	NM_009312.2 , NM_001199971.1
Accession Version	NM_001199971.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Mus musculus(house mouse)
Product	tachykinin-3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC160970.7 and BC031348.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D14423.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGAGCG CCATGCTGTT TGCGGCTGTC CTCGCCCTCA GCTTGGCTTG GACCTTCGGG 
GCTGTGTGTG AGGAGCCACA GGGGCAGGGA GGGAGGCTCA GTAAGGACTC TGATCTCTAT 
CAGCTGCCTC CGTCCCTGCT TCGGAGACTC TACGACAGCC GCCCTGTCTC TCTGGAAGGA 
TTGCTGAAAG TGCTGAGCAA GGCTAGCGTG GGACCAAAGG AGACATCACT TCCACAGAAA 
CGTGACATGC ACGACTTCTT TGTGGGACTT ATGGGCAAGA GGAACAGCCA ACCAGACACT 
CCCACCGACG TGGTTGAAGA GAACACCCCC AGCTTTGGCA TCCTCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186900.1
CDS	265..615
Translation	MRSAMLFAAVLALSLAWTFGAVCEEPQGQGGRLSKDSDLYQLPPSLLRRLYDSRPVSLEGLLKVLSKASVGPKETSLPQKRDMHDFFVGLMGKRNSQPDTPTDVVEENTPSFGILK

Target ORF information:

RefSeq Version	NM_001199971.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus tachykinin 2 (Tac2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199971.1

ORF Insert Sequence:

ATGAGGAGCG CCATGCTGTT TGCGGCTGTC CTCGCCCTCA GCTTGGCTTG GACCTTCGGG 
GCTGTGTGTG AGGAGCCACA GGGGCAGGGA GGGAGGCTCA GTAAGGACTC TGATCTCTAT 
CAGCTGCCTC CGTCCCTGCT TCGGAGACTC TACGACAGCC GCCCTGTCTC TCTGGAAGGA 
TTGCTGAAAG TGCTGAGCAA GGCTAGCGTG GGACCAAAGG AGACATCACT TCCACAGAAA 
CGTGACATGC ACGACTTCTT TGTGGGACTT ATGGGCAAGA GGAACAGCCA ACCAGACACT 
CCCACCGACG TGGTTGAAGA GAACACCCCC AGCTTTGGCA TCCTCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors.
Neuron93(6)1464-1479.e5(2017 Mar)
Kim J,Zhang X,Muralidhar S,LeBlanc SA,Tonegawa S

Diverse Central Projection Patterns of Retinal Ganglion Cells.
Cell reports18(8)2058-2072(2017 Feb)
Martersteck EM,Hirokawa KE,Evarts M,Bernard A,Duan X,Li Y,Ng L,Oh SW,Ouellette B,Royall JJ,Stoecklin M,Wang Q,Zeng H,Sanes JR,Harris JA

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Tac2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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