Dsg1c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dsg1c
Entrez Gene ID	211924
Full Name	desmoglein 1 gamma
Synonyms	Dsg1gamma,Dsg6,dsg1g
General protein information	Preferred Names desmoglein 1 gamma Names desmoglein-1-gamma desmoglein 6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18 A2\|18 11.26 cM
Summary	This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_181680.2	NP_859008.1	desmoglein-1-gamma preproprotein

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.
Inoue SI, Takahara S, Yoshikawa T, Niihori T, Yanai K, Matsubara Y, Aoki Y
Human molecular genetics26(23)4715-4727(2017 Dec)

PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.
Pichery M, Huchenq A, Sandhoff R, Severino-Freire M, Zaafouri S, Op?lka L, Levade T, Soldan V, Bertrand-Michel J, Lhuillier E, Serre G, Maruani A, Mazereeuw-Hautier J, Jonca N
Human molecular genetics26(10)1787-1800(2017 05)

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R
PLoS genetics13(1)e1006566(2017 Jan)

Sgk1 regulates desmoglein 1 expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure.
Miyata S, Yoshikawa K, Taniguchi M, Ishikawa T, Tanaka T, Shimizu S, Tohyama M
Biochemical and biophysical research communications464(1)76-82(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sgk1 regulates Dsg1c expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure.
Title: Sgk1 regulates desmoglein 1 expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure.

Desmogleins 4, 5, and 6 are all expressed in the epidermis but are expressed during different times of mouse development.
Title: Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6.

Expressed in brain, skeletal muscle, and liver, among other tissues. Similar to Dsg2 in its tissue distribution. Orthologous Dsg1 gamma was not found in human genome, suggesting desmosomal cadherin gene cluster contracted during mammalian evolution.
Title: A novel mouse desmosomal cadherin family member, desmoglein 1 gamma.

The following Dsg1c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dsg1c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08138	NM_181680.2 Latest version!	Mus musculus desmoglein 1 gamma (Dsg1c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dsg1c ( NM_181680.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_859008.1 Mus musculus desmoglein 1 gamma (Dsg1c), mRNA.

Price & Availability↑

CloneID	OMu08138
Clone ID Related Accession (Same CDS sequence)	NM_181680.2
Accession Version	NM_181680.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2736bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	desmoglein-1-gamma preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY192159.1, AK034104.1 and AC108943.4. On Jan 29, 2016 this sequence version replaced NM_181680.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY192159.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849376 [ECO:0000350] ##Evidence-Data-END##

ATGGACTGGC ACTCCTTCAG GATAGCTGCC CTGCTGCTCA CTTCCCTGGT GGTGCTTGAA 
GTTAACAGTG AATTTCAAAT CCAGGTAAGA GATCATAACG CCAAAAATGG TACCATCAAG 
TGGCATTCCA TCAGAAGGCA GAAACGAGAA TGGATCAAGT TTGCTGCAGC CTGTCGCGAA 
GGTGAAGACA ACTCAAAGAG AAACCCAATT GCCAAAATTC ATTCAGACTG TGCTGCAAAC 
CAACCAGTGA CATACCGCAT CTCGGGAGTG GGAATTGACC AGCCACCTTA TGGAATCTTC 
ATTATTAACC AAAAAACTGG TGAAATCAAT ATAACATCCA TTGTTGATCG TGAAGTCACC 
CCCTTTTTCA TTATCTATTG CCGAGCACTG AATGCACAAG GTCAAGACTT GGAGAATCCA 
CTGGAGCTTA GAGTTAGAGT GATGGATATA AACGACAACC CTCCTGTGTT TTCAATGACT 
ACATTTCTAG GACAAATAGA AGAAAATTCT AATGCAAACA CACTGGTAAT GAAACTCAAT 
GCTACCGATG CCGATGAGCC AAATAACTTG AACTCAATGA TAGCCTTCAA GATCATAAGA 
CAGGAGCCTT CTGACTCACC AATGTTCACC ATCAACAGGA AAACTGGAGA AATCAGAACA 
ATGAATAACT TTCTAGACAG AGAGCAATAT AGCCAGTATT CCCTTGTGGT GAGAGGCTCA 
GACCGGGACG GTGGAGCAGA CGGCATGTCT GCAGAGAGCG AGTGCAGCAT CACCATCCTG 
GATGTCAATG ACAACATCCC ATACTTGGAG CAGTCATCTT ATGACATCAC AATTGAAGAA 
AACACACTTC ACTCCCAACT ATTGCAGATC AGAGTCATTG ATTTGGATGA AGAATTCTCA 
GACAACTGGA AGGCAATCAT TTTCTTTATC TCTGGAAATG AGGGAAATTG GTTTGAAATA 
GAAATGAATG AAAGAACAAA TGTAGGAACT CTGAAGGTTG TCAAGCCCCT AGATTATGAA 
GCCGTGAAGA ATCTACAGCT TTGTATTGGT GTTCGAAATG TAGCTGAATT CCACCAGTCA 
ATTATTTCTC AATATAGACT CACAGTAACT TTGATCACTG TGACTGTGTT AAATGTTGTC 
AAGGGCTGTG TGTTCCAGCC AGGTTCAAAG ACATTTATAG TAGACAGTAG AATGGAAGCA 
AATCACACAG TGGGAGAGTT TTTAGCTACA GACTGTGAAA CAGGTCAAGC TACAAACAAG 
TTCAAAAATG TTAGATACAG ATATGTAATG GGAAATAACC CAGAGAACCT GCTGGTTGTT 
GACTCAGGCA TAATAACTTT AAGAAACAGA GTTACTATGG AACAATACGA AAGGCTTAAT 
AAGAGATATG AAGGAACAGT GCTATCAATA CATGATTCCC TTCAGAGGAC CTGCACAGGG 
ACAATCATCA TGGTACTTTG TGGCTTCTGG ACAACTACTG AACATCCCAC AACATCCACT 
GAGAAACCTG TGACTCTATC CATCACTCCA AACGTAGACA ATGTTCACTT CGGTCCTGCA 
GGCATCGGGC TGCTCATCAT GGGGTTCCTA GTCTTAGGAT TGGTTCCATT CCTGCTGATC 
TCCTGTGATT GTGGAGGGGC CCCTGGTGGT GGAGCTGGAT TTGAACCTGT TCCAGAATGT 
TCTGATGGAG CAATTCACAC GTGGGCTGTA GAAGGGCCAC AGCCTGGTGG GATAACCACC 
ATCTGTGTGC CACAAATGCC ACCTGGTAAT GCCAATGTTA TAGAATATAT TGACAACTCA 
GGAGTTTATA CAAATGAATA TTGTGGCAGA GAAATGCAAG ATCTGGGAGG AGGAGAACGA 
ACCACAGGAT TTGAACTAAT GGATGGAGTT AAAACATCAG CTGCACCTGA GATATGCCAA 
GAATATTCAG GAACATTAAG AAGAAATTCA ATGAGAGAAT GTAGAGATGG GGGTCTCAAC 
ATGAATTTTA TGGAAAGTTA CTTCTGCCAG AAAGCCTATG CTTATGCGGA TGAAGATGAA 
GGACGTCCAT CCAATGACTG TTTGCTCATC TATGACATCG AAGGTGTGGG TTCCCCTGCA 
GGCTCCGTGG GCTGTTGCAG TTTCATTGAA GATCTAGATG AGAGTTTCCT GGATACCTTG 
GGGCCCAAGT TTAAGAAGTT GGCAGATATC AGCCTGGGAA AAGAAATAGA CTCATACCCA 
GATCCTGATC CTTCTTGGCC TCCTCAGAGC ACTGAACCAA TTTGCCCACA GCATATGGAG 
CAACTTGCTA GTGGACACCC AAGCATATCC CCACATTTTG GCAAGACCAC AGTAATTTCT 
GAGAATGCCT ACCCCTCTGG CCCTGGAGTA CAGCATCCTA TGCTAATTCC TGATCCTCTG 
GGCTATGGTA ATATCACTGT GAGGGAGTCC TATACTACCT CTGGCACTCT GAAACCCTCT 
GTCCACTTTC ATGATAACCA GCAAGCTTCA AATGTGGTGG TGACAGAGAG AGTGGTGGGC 
CCCATCTCTG GTGCTGATTT GCATGGCATG TTAGAGATAC CTGCCTTAAG AGATGGAACA 
AATGTTATAG TGACAGAAAG GGTAATAGCA CCAGGCTCAA GTTTACCCAA TTCTCTAACC 
ATTCCTAACC CTCGAGAGAC CTCAAATGTA GTTGTGACAG AAAGAGTGAT CCAACCAACC 
TCTGGCATGA TAGGCAACCT GAGCATCCCC CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_859008.1
CDS	101..2836
Translation	MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFTINRKTGEIRTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDITIEENTLHSQLLQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYEAVKNLQLCIGVRNVAEFHQSIISQYRLTVTLITVTVLNVVKGCVFQPGSKTFIVDSRMEANHTVGEFLATDCETGQATNKFKNVRYRYVMGNNPENLLVVDSGIITLRNRVTMEQYERLNKRYEGTVLSIHDSLQRTCTGTIIMVLCGFWTTTEHPTTSTEKPVTLSITPNVDNVHFGPAGIGLLIMGFLVLGLVPFLLISCDCGGAPGGGAGFEPVPECSDGAIHTWAVEGPQPGGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIEDLDESFLDTLGPKFKKLADISLGKEIDSYPDPDPSWPPQSTEPICPQHMEQLASGHPSISPHFGKTTVISENAYPSGPGVQHPMLIPDPLGYGNITVRESYTTSGTLKPSVHFHDNQQASNVVVTERVVGPISGADLHGMLEIPALRDGTNVIVTERVIAPGSSLPNSLTIPNPRETSNVVVTERVIQPTSGMIGNLSIPP

Target ORF information:

RefSeq Version	NM_181680.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmoglein 1 gamma (Dsg1c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181680.2

ORF Insert Sequence:

ATGGACTGGC ACTCCTTCAG GATAGCTGCC CTGCTGCTCA CTTCCCTGGT GGTGCTTGAA 
GTTAACAGTG AATTTCAAAT CCAGGTAAGA GATCATAACG CCAAAAATGG TACCATCAAG 
TGGCATTCCA TCAGAAGGCA GAAACGAGAA TGGATCAAGT TTGCTGCAGC CTGTCGCGAA 
GGTGAAGACA ACTCAAAGAG AAACCCAATT GCCAAAATTC ATTCAGACTG TGCTGCAAAC 
CAACCAGTGA CATACCGCAT CTCGGGAGTG GGAATTGACC AGCCACCTTA TGGAATCTTC 
ATTATTAACC AAAAAACTGG TGAAATCAAT ATAACATCCA TTGTTGATCG TGAAGTCACC 
CCCTTTTTCA TTATCTATTG CCGAGCACTG AATGCACAAG GTCAAGACTT GGAGAATCCA 
CTGGAGCTTA GAGTTAGAGT GATGGATATA AACGACAACC CTCCTGTGTT TTCAATGACT 
ACATTTCTAG GACAAATAGA AGAAAATTCT AATGCAAACA CACTGGTAAT GAAACTCAAT 
GCTACCGATG CCGATGAGCC AAATAACTTG AACTCAATGA TAGCCTTCAA GATCATAAGA 
CAGGAGCCTT CTGACTCACC AATGTTCACC ATCAACAGGA AAACTGGAGA AATCAGAACA 
ATGAATAACT TTCTAGACAG AGAGCAATAT AGCCAGTATT CCCTTGTGGT GAGAGGCTCA 
GACCGGGACG GTGGAGCAGA CGGCATGTCT GCAGAGAGCG AGTGCAGCAT CACCATCCTG 
GATGTCAATG ACAACATCCC ATACTTGGAG CAGTCATCTT ATGACATCAC AATTGAAGAA 
AACACACTTC ACTCCCAACT ATTGCAGATC AGAGTCATTG ATTTGGATGA AGAATTCTCA 
GACAACTGGA AGGCAATCAT TTTCTTTATC TCTGGAAATG AGGGAAATTG GTTTGAAATA 
GAAATGAATG AAAGAACAAA TGTAGGAACT CTGAAGGTTG TCAAGCCCCT AGATTATGAA 
GCCGTGAAGA ATCTACAGCT TTGTATTGGT GTTCGAAATG TAGCTGAATT CCACCAGTCA 
ATTATTTCTC AATATAGACT CACAGTAACT TTGATCACTG TGACTGTGTT AAATGTTGTC 
AAGGGCTGTG TGTTCCAGCC AGGTTCAAAG ACATTTATAG TAGACAGTAG AATGGAAGCA 
AATCACACAG TGGGAGAGTT TTTAGCTACA GACTGTGAAA CAGGTCAAGC TACAAACAAG 
TTCAAAAATG TTAGATACAG ATATGTAATG GGAAATAACC CAGAGAACCT GCTGGTTGTT 
GACTCAGGCA TAATAACTTT AAGAAACAGA GTTACTATGG AACAATACGA AAGGCTTAAT 
AAGAGATATG AAGGAACAGT GCTATCAATA CATGATTCCC TTCAGAGGAC CTGCACAGGG 
ACAATCATCA TGGTACTTTG TGGCTTCTGG ACAACTACTG AACATCCCAC AACATCCACT 
GAGAAACCTG TGACTCTATC CATCACTCCA AACGTAGACA ATGTTCACTT CGGTCCTGCA 
GGCATCGGGC TGCTCATCAT GGGGTTCCTA GTCTTAGGAT TGGTTCCATT CCTGCTGATC 
TCCTGTGATT GTGGAGGGGC CCCTGGTGGT GGAGCTGGAT TTGAACCTGT TCCAGAATGT 
TCTGATGGAG CAATTCACAC GTGGGCTGTA GAAGGGCCAC AGCCTGGTGG GATAACCACC 
ATCTGTGTGC CACAAATGCC ACCTGGTAAT GCCAATGTTA TAGAATATAT TGACAACTCA 
GGAGTTTATA CAAATGAATA TTGTGGCAGA GAAATGCAAG ATCTGGGAGG AGGAGAACGA 
ACCACAGGAT TTGAACTAAT GGATGGAGTT AAAACATCAG CTGCACCTGA GATATGCCAA 
GAATATTCAG GAACATTAAG AAGAAATTCA ATGAGAGAAT GTAGAGATGG GGGTCTCAAC 
ATGAATTTTA TGGAAAGTTA CTTCTGCCAG AAAGCCTATG CTTATGCGGA TGAAGATGAA 
GGACGTCCAT CCAATGACTG TTTGCTCATC TATGACATCG AAGGTGTGGG TTCCCCTGCA 
GGCTCCGTGG GCTGTTGCAG TTTCATTGAA GATCTAGATG AGAGTTTCCT GGATACCTTG 
GGGCCCAAGT TTAAGAAGTT GGCAGATATC AGCCTGGGAA AAGAAATAGA CTCATACCCA 
GATCCTGATC CTTCTTGGCC TCCTCAGAGC ACTGAACCAA TTTGCCCACA GCATATGGAG 
CAACTTGCTA GTGGACACCC AAGCATATCC CCACATTTTG GCAAGACCAC AGTAATTTCT 
GAGAATGCCT ACCCCTCTGG CCCTGGAGTA CAGCATCCTA TGCTAATTCC TGATCCTCTG 
GGCTATGGTA ATATCACTGT GAGGGAGTCC TATACTACCT CTGGCACTCT GAAACCCTCT 
GTCCACTTTC ATGATAACCA GCAAGCTTCA AATGTGGTGG TGACAGAGAG AGTGGTGGGC 
CCCATCTCTG GTGCTGATTT GCATGGCATG TTAGAGATAC CTGCCTTAAG AGATGGAACA 
AATGTTATAG TGACAGAAAG GGTAATAGCA CCAGGCTCAA GTTTACCCAA TTCTCTAACC 
ATTCCTAACC CTCGAGAGAC CTCAAATGTA GTTGTGACAG AAAGAGTGAT CCAACCAACC 
TCTGGCATGA TAGGCAACCT GAGCATCCCC CCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.
Human molecular genetics26(23)4715-4727(2017 Dec)
Inoue SI,Takahara S,Yoshikawa T,Niihori T,Yanai K,Matsubara Y,Aoki Y

PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.
Human molecular genetics26(10)1787-1800(2017 05)
Pichery M,Huchenq A,Sandhoff R,Severino-Freire M,Zaafouri S,Op?lka L,Levade T,Soldan V,Bertrand-Michel J,Lhuillier E,Serre G,Maruani A,Mazereeuw-Hautier J,Jonca N

KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
PLoS genetics13(1)e1006566(2017 Jan)
Kasparek P,Ileninova Z,Zbodakova O,Kanchev I,Benada O,Chalupsky K,Brattsand M,Beck IM,Sedlacek R

Sgk1 regulates desmoglein 1 expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure.
Biochemical and biophysical research communications464(1)76-82(2015 Aug)
Miyata S,Yoshikawa K,Taniguchi M,Ishikawa T,Tanaka T,Shimizu S,Tohyama M

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Dsg1c cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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