Mkx cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mkx
Entrez Gene ID	210719
Full Name	mohawk homeobox
Synonyms	9430023B20Rik,Irxl1
General protein information	Preferred Names mohawk homeobox Names homeobox protein Mohawk iroquois homeobox protein-like 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18 A1\|18 4.53 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_177595.4	NP_808263.2	homeobox protein Mohawk

Pathways from BioSystems

Homologies

Homo sapiens (human)	MKX	NP_001229631.1
Rattus norvegicus (Norway rat)	Mkx	XP_006254203.1
Xenopus tropicalis (tropical clawed frog)	mkx	XP_004915507.1
	LOC715306	XP_001105456.2
Bos taurus (cattle)	MKX	NP_001179463.1
Danio rerio (zebrafish)	mkxa	NP_001092203.2
Pan troglodytes (chimpanzee)	MKX	XP_001160740.1
Canis lupus familiaris (dog)	MKX	XP_544207.5
Mus musculus (house mouse)	Mkx	NP_808263.2
Gallus gallus (chicken)	MKX	XP_001233726.3

Gene Ontology
Bibliography

Related articles in PubMed

Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system.
Yoshimoto Y, Takimoto A, Watanabe H, Hiraki Y, Kondoh G, Shukunami C
Scientific reports745010(2017 Mar)

The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament.
Koda N, Sato T, Shinohara M, Ichinose S, Ito Y, Nakamichi R, Kayama T, Kataoka K, Suzuki H, Moriyama K, Asahara H
Development (Cambridge, England)144(2)313-320(2017 01)

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.
Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz MK, Sakai D, Masuda K, Ozaki T, Asahara H
Nature communications712503(2016 Aug)

Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.
Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H
Proceedings of the National Academy of Sciences of the United States of America113(28)7840-5(2016 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mkx prevents periodontal ligament degeneration by regulating osteogenesis.
Title: The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament.

accelerates tendon differentiation and prevents chondrogenic/osteogenic differentiation
Title: Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.

Gtf2ird1 is essential for Mkx transcription, while also linking mechanical forces to Mkx-mediated tendon homeostasis and regeneration.
Title: Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon.

these data shed light on previously unrecognized roles of Mkx in tendinopathy, tenogenesis, and tendon repair as well as in regulating the TGFbeta pathway.
Title: Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGF? signaling pathway.

Mkx is an important regulator of the differentiation of VPs and pulleys, as well as of tendon differentiation.
Title: The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates.

The following Mkx gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mkx cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18637	NM_177595.4 Latest version!	Mus musculus mohawk homeobox (Mkx), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mkx ( NM_177595.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_808263.2 Mus musculus mohawk homeobox (Mkx), mRNA.

Price & Availability↑

CloneID	OMu18637
Clone ID Related Accession (Same CDS sequence)	NM_177595.4
Accession Version	NM_177595.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	homeobox protein Mohawk
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB856607.1, AK034675.1, CD544112.1 and BY644476.1. On Oct 25, 2007 this sequence version replaced NM_177595.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK034675.1, BC137728.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGAACACCA TCGTCTTCAA CAAGCTCGGG GGAGCCGTGC TTTTTGAAGA CCGAGGCACT 
CCAGATCGGG AACGTGGCAG CCGGACGTTC AGTGGTTTCC TGGACAATCC ACACACAGGG 
CCGGAGGTGG GCATACCAGA CGGCCCGCCC CTCAAGGACA ACCTCAGCCT GAGACACCGG 
AGGACAGGGG CCCGGCAGAA TGGAGGGAAG GTAAGGCATA AGCGACAGGC CCTGCAAGAC 
ATGGCGCGTC CTCTTAAGCA GTGGCTTTAC AAGCACCGTG ACAACCCGTA CCCTACGAAG 
ACTGAGAAGA TACTCTTGGC CCTAGGCTCG CAGATGACGC TAGTGCAGGT GTCAAATTGG 
TTCGCTAATG CTAGACGTCG GCTGAAGAAC ACTGTCCGGC AGCCAGATTT AAGTTGGGCC 
TTAAGAATAA AGTTATACAA CAAGTATGTT CAGGGCAACG CTGAACGGCT GAGTGTGAGC 
AGCGATGGCG ACTCCTGCTC TGAAGATGGA GAAAATCCCC CAAGAAATCA CATGAACGAA 
GAAGGCTACA GCACCCCCGC CCACCACACT GTGATTAAAG GGGAAAGCTC AGCGATAAAA 
GCTGGCGGCA GACCGGAGTC GAGGGCTGCC GAGGATTATG TGTCACCGCC CAAGTATAAG 
AGCAGCTTGT TGAACCGTTA CCTTAACGAC TCCTTGAGAC ATGTCATGGC CACCAGCACT 
GCCATGATGG GGAAAACAAG GCGAAGGAAC CATTCGGGGT CTTTTAGCTC CAACGAATTT 
GAAGAAGAGT TGGTGTCTCC ATCATCATCA GAAACTGAAG GCACCTTTGT CTATCGCACA 
GACACCCCGG ACATCGGATC TACTAAGGGT GACAGTGCTG CTAACAGAAG GGGACCAAGC 
AAAGATGACA CATACTGGAA GGAGATCAAT GCAGCCATGG CCTTAACAAA CCTTGCCCAA 
GGAAAAGATG AAGTGCAGGG GACGACCACC AGTTGCATCA TCCAGAAGTC TTCCCACATA 
GCAGAAGTAA AGACAGTCAA GCTGCCACTG GTGCAGCGCT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808263.2
CDS	238..1302
Translation	MNTIVFNKLGGAVLFEDRGTPDRERGSRTFSGFLDNPHTGPEVGIPDGPPLKDNLSLRHRRTGARQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDGDSCSEDGENPPRNHMNEEGYSTPAHHTVIKGESSAIKAGGRPESRAAEDYVSPPKYKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFSSNEFEEELVSPSSSETEGTFVYRTDTPDIGSTKGDSAANRRGPSKDDTYWKEINAAMALTNLAQGKDEVQGTTTSCIIQKSSHIAEVKTVKLPLVQRF

Target ORF information:

RefSeq Version	NM_177595.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus mohawk homeobox (Mkx), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177595.4

ORF Insert Sequence:

ATGAACACCA TCGTCTTCAA CAAGCTCGGG GGAGCCGTGC TTTTTGAAGA CCGAGGCACT 
CCAGATCGGG AACGTGGCAG CCGGACGTTC AGTGGTTTCC TGGACAATCC ACACACAGGG 
CCGGAGGTGG GCATACCAGA CGGCCCGCCC CTCAAGGACA ACCTCAGCCT GAGACACCGG 
AGGACAGGGG CCCGGCAGAA TGGAGGGAAG GTAAGGCATA AGCGACAGGC CCTGCAAGAC 
ATGGCGCGTC CTCTTAAGCA GTGGCTTTAC AAGCACCGTG ACAACCCGTA CCCTACGAAG 
ACTGAGAAGA TACTCTTGGC CCTAGGCTCG CAGATGACGC TAGTGCAGGT GTCAAATTGG 
TTCGCTAATG CTAGACGTCG GCTGAAGAAC ACTGTCCGGC AGCCAGATTT AAGTTGGGCC 
TTAAGAATAA AGTTATACAA CAAGTATGTT CAGGGCAACG CTGAACGGCT GAGTGTGAGC 
AGCGATGGCG ACTCCTGCTC TGAAGATGGA GAAAATCCCC CAAGAAATCA CATGAACGAA 
GAAGGCTACA GCACCCCCGC CCACCACACT GTGATTAAAG GGGAAAGCTC AGCGATAAAA 
GCTGGCGGCA GACCGGAGTC GAGGGCTGCC GAGGATTATG TGTCACCGCC CAAGTATAAG 
AGCAGCTTGT TGAACCGTTA CCTTAACGAC TCCTTGAGAC ATGTCATGGC CACCAGCACT 
GCCATGATGG GGAAAACAAG GCGAAGGAAC CATTCGGGGT CTTTTAGCTC CAACGAATTT 
GAAGAAGAGT TGGTGTCTCC ATCATCATCA GAAACTGAAG GCACCTTTGT CTATCGCACA 
GACACCCCGG ACATCGGATC TACTAAGGGT GACAGTGCTG CTAACAGAAG GGGACCAAGC 
AAAGATGACA CATACTGGAA GGAGATCAAT GCAGCCATGG CCTTAACAAA CCTTGCCCAA 
GGAAAAGATG AAGTGCAGGG GACGACCACC AGTTGCATCA TCCAGAAGTC TTCCCACATA 
GCAGAAGTAA AGACAGTCAA GCTGCCACTG GTGCAGCGCT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system.
Scientific reports745010(2017 Mar)
Yoshimoto Y,Takimoto A,Watanabe H,Hiraki Y,Kondoh G,Shukunami C

The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament.
Development (Cambridge, England)144(2)313-320(2017 01)
Koda N,Sato T,Shinohara M,Ichinose S,Ito Y,Nakamichi R,Kayama T,Kataoka K,Suzuki H,Moriyama K,Asahara H

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.
Nature communications712503(2016 Aug)
Nakamichi R,Ito Y,Inui M,Onizuka N,Kayama T,Kataoka K,Suzuki H,Mori M,Inagawa M,Ichinose S,Lotz MK,Sakai D,Masuda K,Ozaki T,Asahara H

Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.
Proceedings of the National Academy of Sciences of the United States of America113(28)7840-5(2016 07)
Suzuki H,Ito Y,Shinohara M,Yamashita S,Ichinose S,Kishida A,Oyaizu T,Kayama T,Nakamichi R,Koda N,Yagishita K,Lotz MK,Okawa A,Asahara H

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Mkx cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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