Sox12 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sox12
Entrez Gene ID	20667
Full Name	SRY (sex determining region Y)-box 12
Synonyms	2010205A02Rik
General protein information	Preferred Names SRY (sex determining region Y)-box 12 Names transcription factor SOX-12 SRY-box containing gene 12
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 G3

mRNA and Protein(s)

mRNA	Protein	Name
NM_011438.2	NP_035568.1	transcription factor SOX-12

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sox12	NP_001162121.1
Homo sapiens (human)	SOX12	NP_008874.2
Pan troglodytes (chimpanzee)	SOX12	XP_003316841.1
Mus musculus (house mouse)	Sox12	NP_035568.1
Canis lupus familiaris (dog)	SOX12	XP_005634963.1
Gallus gallus (chicken)	LOC777179	XP_003642514.2

Gene Ontology
Bibliography

Related articles in PubMed

Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development.
Chang KC, Hertz J, Zhang X, Jin XL, Shaw P, Derosa BA, Li JY, Venugopalan P, Valenzuela DA, Patel RD, Russano KR, Alshamekh SA, Sun C, Tenerelli K, Li C, Velmeshev D, Cheng Y, Boyce TM, Dreyfuss A, Uddin MS, Muller KJ, Dykxhoorn DM, Goldberg JL
The Journal of neuroscience : the official journal of the Society for Neuroscience37(19)4967-4981(2017 May)

SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System.
Kuwajima T, Soares CA, Sitko AA, Lefebvre V, Mason C
Neuron93(5)1110-1125.e5(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SOXC proteins act cell- and non-cell-autonomously in perichondrocytes and chondrocytes to establish noncanonical WNT signaling crosstalk essential for growth plate induction and control
Title: SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling.

Study show that the survival of neural and mesenchymal progenitor cells critically relies on the redundantly acting SoxC transcription factors Sox4, Sox11 and Sox12.
Title: Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.

Sox4 and Sox11 function redundantly with Sox12 and can compensate its loss during mouse development.
Title: Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.

The following Sox12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sox12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58185	NM_011438.2 Latest version!	Mus musculus SRY (sex determining region Y)-box 12 (Sox12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sox12 ( NM_011438.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035568.1 Mus musculus SRY (sex determining region Y)-box 12 (Sox12), mRNA.

Price & Availability↑

CloneID	OMu58185
Clone ID Related Accession (Same CDS sequence)	NM_011438.2
Accession Version	NM_011438.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	transcription factor SOX-12
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB245116.1, BQ180104.1, BG228657.1, CA749985.1 and AL928568.17. On Mar 9, 2007 this sequence version replaced NM_011438.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGTGCAGC AGCGGGGCGC GCGGGCCAAG CGGGACGGCG GGCCGCCGCC CCCGGGGCCC 
GGGCCGGCCG CCGAGGGGGC GCGCGAGCCA GGCTGGTGCA AGACCCCGAG CGGCCACATT 
AAGCGGCCGA TGAACGCGTT CATGGTGTGG TCGCAGCACG AGCGGAGAAA AATCATGGAC 
CAGTGGCCCG ACATGCACAA CGCTGAGATC TCCAAGCGCC TGGGCCGCCG CTGGCAGCTG 
CTGCAGGACT CGGAGAAGAT CCCGTTCGTG CGGGAGGCGG AGCGGCTGCG CCTCAAGCAC 
ATGGCGGACT ACCCGGACTA CAAGTACCGG CCTCGCAAGA AGAGCAAGGG GGCGCCCGCC 
AAGGCGCGGC CCCGCCCCCC CGGAGGCGGC GGTGGTGGCA GTCGGCTGAA ACCCGGGCCA 
CAGCTGCCGG GCCGCGGGGG CCGCCGAGCG TCGGGAGGAC CTCTGGGGGG CGGCGCGGCG 
GCGCCGGAGG ACGACGACGA AGACGAAGAG GAGGAGCTGC TGGAAGTACG CCTGCTGGAG 
ACCCCCGGGC GCGAGCTGTG GAGGATGGTC CCGGCGGGGC GCGCCGCCCG CGGACCCGCG 
GAGCGCGCGC AGGGGCCATC CGGCGAGGGG GCGGCCGCCA GCGCCGCCTC TCCGACCCTG 
TCCGAGGACG AGGAGCCGGA GGAAGAGGAG GAGGAGGCGG CTACAGCAGA GGAGGGCGAA 
GAGGAGACGG TGGTATCTGG GGAGGAGCCA CTGGGCTTTC TGTCCAGGAT GCCCCCGGGC 
CCCGCCGGCC TGGACTGCAG TGCCCTGGAC CGTGACCCGG ACCTGCTGCC CCCTTCGGGC 
ACGTCACATT TCGAATTCCC GGACTATTGC ACCCCCGAGG TTACCGAGAT GATCGCAGGG 
GACTGGCGCT CGTCTAGTAT CGCCGACCTG GTTTTCACCT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035568.1
CDS	349..1293
Translation	MVQQRGARAKRDGGPPPPGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRASGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSGEGAAASAASPTLSEDEEPEEEEEEAATAEEGEEETVVSGEEPLGFLSRMPPGPAGLDCSALDRDPDLLPPSGTSHFEFPDYCTPEVTEMIAGDWRSSSIADLVFTY

Target ORF information:

RefSeq Version	NM_011438.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SRY (sex determining region Y)-box 12 (Sox12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011438.2

ORF Insert Sequence:

ATGGTGCAGC AGCGGGGCGC GCGGGCCAAG CGGGACGGCG GGCCGCCGCC CCCGGGGCCC 
GGGCCGGCCG CCGAGGGGGC GCGCGAGCCA GGCTGGTGCA AGACCCCGAG CGGCCACATT 
AAGCGGCCGA TGAACGCGTT CATGGTGTGG TCGCAGCACG AGCGGAGAAA AATCATGGAC 
CAGTGGCCCG ACATGCACAA CGCTGAGATC TCCAAGCGCC TGGGCCGCCG CTGGCAGCTG 
CTGCAGGACT CGGAGAAGAT CCCGTTCGTG CGGGAGGCGG AGCGGCTGCG CCTCAAGCAC 
ATGGCGGACT ACCCGGACTA CAAGTACCGG CCTCGCAAGA AGAGCAAGGG GGCGCCCGCC 
AAGGCGCGGC CCCGCCCCCC CGGAGGCGGC GGTGGTGGCA GTCGGCTGAA ACCCGGGCCA 
CAGCTGCCGG GCCGCGGGGG CCGCCGAGCG TCGGGAGGAC CTCTGGGGGG CGGCGCGGCG 
GCGCCGGAGG ACGACGACGA AGACGAAGAG GAGGAGCTGC TGGAAGTACG CCTGCTGGAG 
ACCCCCGGGC GCGAGCTGTG GAGGATGGTC CCGGCGGGGC GCGCCGCCCG CGGACCCGCG 
GAGCGCGCGC AGGGGCCATC CGGCGAGGGG GCGGCCGCCA GCGCCGCCTC TCCGACCCTG 
TCCGAGGACG AGGAGCCGGA GGAAGAGGAG GAGGAGGCGG CTACAGCAGA GGAGGGCGAA 
GAGGAGACGG TGGTATCTGG GGAGGAGCCA CTGGGCTTTC TGTCCAGGAT GCCCCCGGGC 
CCCGCCGGCC TGGACTGCAG TGCCCTGGAC CGTGACCCGG ACCTGCTGCC CCCTTCGGGC 
ACGTCACATT TCGAATTCCC GGACTATTGC ACCCCCGAGG TTACCGAGAT GATCGCAGGG 
GACTGGCGCT CGTCTAGTAT CGCCGACCTG GTTTTCACCT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(19)4967-4981(2017 May)
Chang KC,Hertz J,Zhang X,Jin XL,Shaw P,Derosa BA,Li JY,Venugopalan P,Valenzuela DA,Patel RD,Russano KR,Alshamekh SA,Sun C,Tenerelli K,Li C,Velmeshev D,Cheng Y,Boyce TM,Dreyfuss A,Uddin MS,Muller KJ,Dykxhoorn DM,Goldberg JL

SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System.
Neuron93(5)1110-1125.e5(2017 Mar)
Kuwajima T,Soares CA,Sitko AA,Lefebvre V,Mason C