SOX12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOX12
Entrez Gene ID	6666
Full Name	SRY-box 12
Synonyms	SOX22
General protein information	Preferred Names SRY-box 12 Names transcription factor SOX-12 SOX-22 protein SRY (sex determining region Y)-box 12 SRY-related HMG-box gene 22
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p13
Summary	Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013].
Disorder MIM:	601947

mRNA and Protein(s)

mRNA	Protein	Name
NM_006943.3	NP_008874.2	transcription factor SOX-12

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Sox12	NP_001162121.1
Homo sapiens (human)	SOX12	NP_008874.2
Pan troglodytes (chimpanzee)	SOX12	XP_003316841.1
Mus musculus (house mouse)	Sox12	NP_035568.1
Canis lupus familiaris (dog)	SOX12	XP_005634963.1
Gallus gallus (chicken)	LOC777179	XP_003642514.2

Gene Ontology
Bibliography

Related articles in PubMed

Sox12 Is a Cancer Stem-Like Cell Marker in Hepatocellular Carcinoma.
Zou S, Wang C, Liu J, Wang Q, Zhang D, Zhu S, Xu S, Kang M, He S
Molecules and cells40(11)847-854(2017 Nov)

SOX12 upregulation is associated with metastasis of hepatocellular carcinoma and increases CDK4 and IGF2BP1 expression.
Yuan P, Meng L, Wang N
European review for medical and pharmacological sciences21(17)3821-3826(2017 Oct)

SOX12: a novel potential target for acute myeloid leukaemia.
Wan H, Cai J, Chen F, Zhu J, Zhong J, Zhong H
British journal of haematology176(3)421-430(2017 Feb)

SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma.
Roisman A, Huam?n Garaicoa F, Metrebian F, Narbaitz M, Kohan D, Garc?a Rivello H, Fernandez I, Pavlovsky A, Pavlovsky M, Hern?ndez L, Slavutsky I
Genes, chromosomes & cancer55(6)531-40(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SOX12 may be involved in leukemia progression by regulating the expression of beta-catenin and then interfering with TCF/Wnt pathway, which may be a target for AML.
Title: SOX12: a novel potential target for acute myeloid leukaemia.

In this study we screened the transcriptional profiles of 70 MCL patients for SOXC cluster and miR17, miR18a, miR19b and miR92a, from the miR-17-92 cluster. Gene expression analysis showed higher SOX11 and SOX12 levels compared to SOX4 (P
Title: SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma.

Up-regulated Sox12 induced by FoxQ1 promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 and FGFBP1 expression.
Title: Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1.

This genome-wide screen has identified two novel metastatic suppressors: TMED3 and SOX12, the knockdown of which increases metastatic growth after direct seeding.
Title: A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12.

SOX12 and NRSN2 were identified as candidate genes that may be involved in the developmental defects in 20p13 microdeletion.
Title: SOX12 and NRSN2 are candidate genes for 20p13 subtelomeric deletions associated with developmental delay.

The following SOX12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOX12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu11053	NM_006943.3 Latest version!	Homo sapiens SRY-box transcription factor 12 (SOX12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOX12 ( NM_006943.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_008874.2 Homo sapiens SRY-box transcription factor 12 (SOX12), mRNA.

Price & Availability↑

CloneID	OHu11053
Clone ID Related Accession (Same CDS sequence)	NM_006943.3
Accession Version	NM_006943.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	transcription factor SOX-12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC067361.1, HY104751.1, AL034548.25 and BU078462.1. On Jan 16, 2013 this sequence version replaced NM_006943.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGCAGC AGCGGGGCGC GAGGGCCAAG CGGGACGGCG GGCCGCCGCC CCCGGGACCC 
GGGCCGGCCG AGGAGGGGGC GCGCGAGCCC GGCTGGTGCA AGACCCCGAG CGGCCACATC 
AAGAGGCCGA TGAACGCATT CATGGTGTGG TCGCAGCACG AACGGCGGAA GATCATGGAC 
CAGTGGCCCG ACATGCACAA CGCCGAGATC TCCAAGCGCC TGGGCCGCCG CTGGCAGCTG 
CTGCAGGACT CGGAGAAGAT CCCGTTCGTG CGGGAGGCGG AGCGGCTGCG GCTCAAGCAC 
ATGGCGGATT ACCCGGACTA CAAGTACCGG CCGCGCAAAA AGAGCAAGGG GGCGCCCGCC 
AAGGCGCGGC CCCGCCCCCC CGGTGGTAGC GGTGGCGGCA GCCGGCTCAA GCCCGGGCCG 
CAGCTGCCTG GCCGCGGGGG CCGCCGAGCA GCGGGAGGGC CTTTGGGGGG CGGGGCGGCG 
GCGCCCGAGG ACGACGATGA AGACGACGAC GAGGAGCTGC TGGAAGTGCG CCTGGTCGAG 
ACCCCGGGGC GGGAGCTGTG GAGGATGGTC CCGGCGGGAC GGGCCGCTCG GGGACAAGCG 
GAGCGCGCCC AAGGGCCGTC GGGCGAGGGG GCGGCCGCCG CCGCCGCCGC CTCCCCGACA 
CCGTCGGAGG ACGAGGAGCC GGAGGAAGAG GAGGAGGAGG CGGCAGCGGC TGAGGAAGGT 
GAAGAGGAGA CGGTGGCGTC GGGGGAGGAG TCGCTGGGCT TTCTGTCCAG GCTGCCCCCT 
GGCCCGGCCG GCCTGGACTG CAGCGCCCTG GATCGCGACC CGGACCTGCA GCCTCCCTCG 
GGCACGTCGC ACTTCGAGTT CCCGGACTAC TGCACCCCCG AGGTTACCGA GATGATCGCG 
GGGGACTGGC GCCCGTCTAG CATCGCAGAC CTGGTTTTCA CCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008874.2
CDS	355..1302
Translation	MVQQRGARAKRDGGPPPPGPGPAEEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRGGRRAAGGPLGGGAAAPEDDDEDDDEELLEVRLVETPGRELWRMVPAGRAARGQAERAQGPSGEGAAAAAAASPTPSEDEEPEEEEEEAAAAEEGEEETVASGEESLGFLSRLPPGPAGLDCSALDRDPDLQPPSGTSHFEFPDYCTPEVTEMIAGDWRPSSIADLVFTY

Target ORF information:

RefSeq Version	NM_006943.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SRY-box transcription factor 12 (SOX12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006943.3

ORF Insert Sequence:

ATGGTGCAGC AGCGGGGCGC GAGGGCCAAG CGGGACGGCG GGCCGCCGCC CCCGGGACCC 
GGGCCGGCCG AGGAGGGGGC GCGCGAGCCC GGCTGGTGCA AGACCCCGAG CGGCCACATC 
AAGAGGCCGA TGAACGCATT CATGGTGTGG TCGCAGCACG AACGGCGGAA GATCATGGAC 
CAGTGGCCCG ACATGCACAA CGCCGAGATC TCCAAGCGCC TGGGCCGCCG CTGGCAGCTG 
CTGCAGGACT CGGAGAAGAT CCCGTTCGTG CGGGAGGCGG AGCGGCTGCG GCTCAAGCAC 
ATGGCGGATT ACCCGGACTA CAAGTACCGG CCGCGCAAAA AGAGCAAGGG GGCGCCCGCC 
AAGGCGCGGC CCCGCCCCCC CGGTGGTAGC GGTGGCGGCA GCCGGCTCAA GCCCGGGCCG 
CAGCTGCCTG GCCGCGGGGG CCGCCGAGCA GCGGGAGGGC CTTTGGGGGG CGGGGCGGCG 
GCGCCCGAGG ACGACGATGA AGACGACGAC GAGGAGCTGC TGGAAGTGCG CCTGGTCGAG 
ACCCCGGGGC GGGAGCTGTG GAGGATGGTC CCGGCGGGAC GGGCCGCTCG GGGACAAGCG 
GAGCGCGCCC AAGGGCCGTC GGGCGAGGGG GCGGCCGCCG CCGCCGCCGC CTCCCCGACA 
CCGTCGGAGG ACGAGGAGCC GGAGGAAGAG GAGGAGGAGG CGGCAGCGGC TGAGGAAGGT 
GAAGAGGAGA CGGTGGCGTC GGGGGAGGAG TCGCTGGGCT TTCTGTCCAG GCTGCCCCCT 
GGCCCGGCCG GCCTGGACTG CAGCGCCCTG GATCGCGACC CGGACCTGCA GCCTCCCTCG 
GGCACGTCGC ACTTCGAGTT CCCGGACTAC TGCACCCCCG AGGTTACCGA GATGATCGCG 
GGGGACTGGC GCCCGTCTAG CATCGCAGAC CTGGTTTTCA CCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sox12 Is a Cancer Stem-Like Cell Marker in Hepatocellular Carcinoma.
Molecules and cells40(11)847-854(2017 Nov)
Zou S,Wang C,Liu J,Wang Q,Zhang D,Zhu S,Xu S,Kang M,He S

SOX12 upregulation is associated with metastasis of hepatocellular carcinoma and increases CDK4 and IGF2BP1 expression.
European review for medical and pharmacological sciences21(17)3821-3826(2017 Oct)
Yuan P,Meng L,Wang N

SOX12: a novel potential target for acute myeloid leukaemia.
British journal of haematology176(3)421-430(2017 Feb)
Wan H,Cai J,Chen F,Zhu J,Zhong J,Zhong H

SOXC and MiR17-92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma.
Genes, chromosomes & cancer55(6)531-40(2016 06)
Roisman A,Huam?n Garaicoa F,Metrebian F,Narbaitz M,Kohan D,Garc?a Rivello H,Fernandez I,Pavlovsky A,Pavlovsky M,Hern?ndez L,Slavutsky I

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SOX12 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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