Slc31a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc31a1
Entrez Gene ID	20529
Full Name	solute carrier family 31, member 1
Synonyms	4930445G01Rik,AI787263,AU016967,Ctr1
General protein information	Preferred Names solute carrier family 31, member 1 Names high affinity copper uptake protein 1 copper transporter 1 solute carrier family 13 (sodium/sulphate symporters), member 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 B3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006537711.2	XP_006537774.1	high affinity copper uptake protein 1 isoform X1
XM_006537711.3	XP_006537774.1	high affinity copper uptake protein 1 isoform X1
NM_175090.4	NP_780299.2	high affinity copper uptake protein 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC31A1	XP_538800.1
	SLC31A1	XP_001103110.1
Mus musculus (house mouse)	Slc31a1	NP_780299.2
Drosophila melanogaster (fruit fly)	Ctr1A	NP_001245552.1
Gallus gallus (chicken)	SLC31A1	XP_004945826.1
Danio rerio (zebrafish)	slc31a1	NP_991280.1
Homo sapiens (human)	SLC31A1	NP_001850.1
Rattus norvegicus (Norway rat)	Slc31a1	NP_598284.1
Pan troglodytes (chimpanzee)	SLC31A1	XP_520197.2
Bos taurus (cattle)	SLC31A1	NP_001093851.1

Gene Ontology
Bibliography

Related articles in PubMed

The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.
Baker ZN, Jett K, Boulet A, Hossain A, Cobine PA, Kim BE, El Zawily AM, Lee L, Tibbits GF, Petris MJ, Leary SC
Human molecular genetics26(23)4617-4628(2017 Dec)

Copper Chelation Inhibits BRAF
Brady DC, Crowe MS, Greenberg DN, Counter CM
Cancer research77(22)6240-6252(2017 Nov)

Sexual congruency in the connectome and translatome of VTA dopamine neurons.
Chung AS, Miller SM, Sun Y, Xu X, Zweifel LS
Scientific reports7(1)11120(2017 Sep)

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.
Logeman BL, Wood LK, Lee J, Thiele DJ
The Journal of biological chemistry292(27)11531-11546(2017 07)

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1.
Srivastava S, Panda S, Li Z, Fuhs SR, Hunter T, Thiele DJ, Hubbard SR, Skolnik EY
eLife5(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2
Title: Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.

studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) and cisplatin acquisition
Title: Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.

conclude that Y103 is required for the internalization of hCTR1 in response to Cu, that this occurs by a mechanism other than phosphorylation and that mutation of Y103 modulates the interaction with IRS-4
Title: Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4.

CTR1, ATP7A, and lysyl oxidase were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.
Title: Upregulated copper transporters in hypoxia-induced pulmonary hypertension.

A key regulatory mechanism for mammalian copper transport is through Ctr2-dependent accumulation of a Ctr1 variant lacking the copper- and cisplatin-binding ecto-domain.
Title: Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.

The following Slc31a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc31a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu22485	NM_175090.4 Latest version!	Mus musculus solute carrier family 31, member 1 (Slc31a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu22485	XM_006537711.3 Latest version!	Mus musculus solute carrier family 31, member 1 (Slc31a1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu22485	XM_006537711.2	Mus musculus solute carrier family 31, member 1 (Slc31a1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc31a1 ( NM_175090.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780299.2 Mus musculus solute carrier family 31, member 1 (Slc31a1), mRNA.

Price & Availability↑

CloneID	OMu22485
Clone ID Related Accession (Same CDS sequence)	XM_006537711.2 , XM_006537711.3 , NM_175090.4
Accession Version	NM_175090.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	high affinity copper uptake protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY097629.1, BC058227.1 and BC065147.1. On Apr 21, 2009 this sequence version replaced NM_175090.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK151337.1, BC058227.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAACCATA TGGGGATGAA CCATATGGAG ATGCACCACC ATATGGGTAT GAACCACACG 
GACGACAACA TTACCATGCC ACCTCACCAC CACCCGACCA CCTCAGCCTC ACACTCCCAC 
GGTGGAGGGG ACAGCATGAT GATGATGCCT ATGACCTTCT ACTTTGACTT TAAGAATGTG 
AATCTATTGT TTTCCGGTTT GGTAATCAAT ACACCTGGAG AAATGGCTGG AGCCTTCGTG 
GCAGTGTTTT TACTAGCAAT GTTTTATGAA GGACTCAAGA TAGCCCGAGA GGGTCTGCTT 
CGAAAGTCTC AAGTCAGCAT TCGCTACAAT TCCATGCCTG TCCCAGGACC AAATGGAACC 
ATCCTAATGG AGACACACAA AACTGTTGGG CAGCAGATGC TGAGCTTCCC CCACCTCCTG 
CAGACAGTGC TGCACATCAT CCAGGTAGTC ATCAGCTACT TCCTCATGCT CATCTTCATG 
ACCTACAATG GGTACCTATG CATTGCAGTA GCAGCAGGGG CTGGGACGGG ATACTTTCTC 
TTCAGCTGGA AGAAGGCAGT GGTGGTGGAC ATCACAGAGC ACTGCCATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780299.2
CDS	184..774
Translation	MNHMGMNHMEMHHHMGMNHTDDNITMPPHHHPTTSASHSHGGGDSMMMMPMTFYFDFKNVNLLFSGLVINTPGEMAGAFVAVFLLAMFYEGLKIAREGLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH

Target ORF information:

RefSeq Version	NM_175090.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 31, member 1 (Slc31a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175090.4

ORF Insert Sequence:

ATGAACCATA TGGGGATGAA CCATATGGAG ATGCACCACC ATATGGGTAT GAACCACACG 
GACGACAACA TTACCATGCC ACCTCACCAC CACCCGACCA CCTCAGCCTC ACACTCCCAC 
GGTGGAGGGG ACAGCATGAT GATGATGCCT ATGACCTTCT ACTTTGACTT TAAGAATGTG 
AATCTATTGT TTTCCGGTTT GGTAATCAAT ACACCTGGAG AAATGGCTGG AGCCTTCGTG 
GCAGTGTTTT TACTAGCAAT GTTTTATGAA GGACTCAAGA TAGCCCGAGA GGGTCTGCTT 
CGAAAGTCTC AAGTCAGCAT TCGCTACAAT TCCATGCCTG TCCCAGGACC AAATGGAACC 
ATCCTAATGG AGACACACAA AACTGTTGGG CAGCAGATGC TGAGCTTCCC CCACCTCCTG 
CAGACAGTGC TGCACATCAT CCAGGTAGTC ATCAGCTACT TCCTCATGCT CATCTTCATG 
ACCTACAATG GGTACCTATG CATTGCAGTA GCAGCAGGGG CTGGGACGGG ATACTTTCTC 
TTCAGCTGGA AGAAGGCAGT GGTGGTGGAC ATCACAGAGC ACTGCCATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc31a1 ( XM_006537711.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006537774.1 Mus musculus solute carrier family 31, member 1 (Slc31a1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu22485
Clone ID Related Accession (Same CDS sequence)	XM_006537711.2 , XM_006537711.3 , NM_175090.4
Accession Version	XM_006537711.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	high affinity copper uptake protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006537711.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCATA TGGGGATGAA CCATATGGAG ATGCACCACC ATATGGGTAT GAACCACACG 
GACGACAACA TTACCATGCC ACCTCACCAC CACCCGACCA CCTCAGCCTC ACACTCCCAC 
GGTGGAGGGG ACAGCATGAT GATGATGCCT ATGACCTTCT ACTTTGACTT TAAGAATGTG 
AATCTATTGT TTTCCGGTTT GGTAATCAAT ACACCTGGAG AAATGGCTGG AGCCTTCGTG 
GCAGTGTTTT TACTAGCAAT GTTTTATGAA GGACTCAAGA TAGCCCGAGA GGGTCTGCTT 
CGAAAGTCTC AAGTCAGCAT TCGCTACAAT TCCATGCCTG TCCCAGGACC AAATGGAACC 
ATCCTAATGG AGACACACAA AACTGTTGGG CAGCAGATGC TGAGCTTCCC CCACCTCCTG 
CAGACAGTGC TGCACATCAT CCAGGTAGTC ATCAGCTACT TCCTCATGCT CATCTTCATG 
ACCTACAATG GGTACCTATG CATTGCAGTA GCAGCAGGGG CTGGGACGGG ATACTTTCTC 
TTCAGCTGGA AGAAGGCAGT GGTGGTGGAC ATCACAGAGC ACTGCCATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006537774.1
CDS	62..652
Translation	MNHMGMNHMEMHHHMGMNHTDDNITMPPHHHPTTSASHSHGGGDSMMMMPMTFYFDFKNVNLLFSGLVINTPGEMAGAFVAVFLLAMFYEGLKIAREGLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH

Target ORF information:

RefSeq Version	XM_006537711.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 31, member 1 (Slc31a1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006537711.2

ORF Insert Sequence:

ATGAACCATA TGGGGATGAA CCATATGGAG ATGCACCACC ATATGGGTAT GAACCACACG 
GACGACAACA TTACCATGCC ACCTCACCAC CACCCGACCA CCTCAGCCTC ACACTCCCAC 
GGTGGAGGGG ACAGCATGAT GATGATGCCT ATGACCTTCT ACTTTGACTT TAAGAATGTG 
AATCTATTGT TTTCCGGTTT GGTAATCAAT ACACCTGGAG AAATGGCTGG AGCCTTCGTG 
GCAGTGTTTT TACTAGCAAT GTTTTATGAA GGACTCAAGA TAGCCCGAGA GGGTCTGCTT 
CGAAAGTCTC AAGTCAGCAT TCGCTACAAT TCCATGCCTG TCCCAGGACC AAATGGAACC 
ATCCTAATGG AGACACACAA AACTGTTGGG CAGCAGATGC TGAGCTTCCC CCACCTCCTG 
CAGACAGTGC TGCACATCAT CCAGGTAGTC ATCAGCTACT TCCTCATGCT CATCTTCATG 
ACCTACAATG GGTACCTATG CATTGCAGTA GCAGCAGGGG CTGGGACGGG ATACTTTCTC 
TTCAGCTGGA AGAAGGCAGT GGTGGTGGAC ATCACAGAGC ACTGCCATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc31a1 ( XM_006537711.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006537774.1 Mus musculus solute carrier family 31, member 1 (Slc31a1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu22485
Clone ID Related Accession (Same CDS sequence)	XM_006537711.2 , XM_006537711.3 , NM_175090.4
Accession Version	XM_006537711.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	high affinity copper uptake protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006537711.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACCATA TGGGGATGAA CCATATGGAG ATGCACCACC ATATGGGTAT GAACCACACG 
GACGACAACA TTACCATGCC ACCTCACCAC CACCCGACCA CCTCAGCCTC ACACTCCCAC 
GGTGGAGGGG ACAGCATGAT GATGATGCCT ATGACCTTCT ACTTTGACTT TAAGAATGTG 
AATCTATTGT TTTCCGGTTT GGTAATCAAT ACACCTGGAG AAATGGCTGG AGCCTTCGTG 
GCAGTGTTTT TACTAGCAAT GTTTTATGAA GGACTCAAGA TAGCCCGAGA GGGTCTGCTT 
CGAAAGTCTC AAGTCAGCAT TCGCTACAAT TCCATGCCTG TCCCAGGACC AAATGGAACC 
ATCCTAATGG AGACACACAA AACTGTTGGG CAGCAGATGC TGAGCTTCCC CCACCTCCTG 
CAGACAGTGC TGCACATCAT CCAGGTAGTC ATCAGCTACT TCCTCATGCT CATCTTCATG 
ACCTACAATG GGTACCTATG CATTGCAGTA GCAGCAGGGG CTGGGACGGG ATACTTTCTC 
TTCAGCTGGA AGAAGGCAGT GGTGGTGGAC ATCACAGAGC ACTGCCATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006537774.1
CDS	61..651
Translation	MNHMGMNHMEMHHHMGMNHTDDNITMPPHHHPTTSASHSHGGGDSMMMMPMTFYFDFKNVNLLFSGLVINTPGEMAGAFVAVFLLAMFYEGLKIAREGLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH

Target ORF information:

RefSeq Version	XM_006537711.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 31, member 1 (Slc31a1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006537711.3

ORF Insert Sequence:

ATGAACCATA TGGGGATGAA CCATATGGAG ATGCACCACC ATATGGGTAT GAACCACACG 
GACGACAACA TTACCATGCC ACCTCACCAC CACCCGACCA CCTCAGCCTC ACACTCCCAC 
GGTGGAGGGG ACAGCATGAT GATGATGCCT ATGACCTTCT ACTTTGACTT TAAGAATGTG 
AATCTATTGT TTTCCGGTTT GGTAATCAAT ACACCTGGAG AAATGGCTGG AGCCTTCGTG 
GCAGTGTTTT TACTAGCAAT GTTTTATGAA GGACTCAAGA TAGCCCGAGA GGGTCTGCTT 
CGAAAGTCTC AAGTCAGCAT TCGCTACAAT TCCATGCCTG TCCCAGGACC AAATGGAACC 
ATCCTAATGG AGACACACAA AACTGTTGGG CAGCAGATGC TGAGCTTCCC CCACCTCCTG 
CAGACAGTGC TGCACATCAT CCAGGTAGTC ATCAGCTACT TCCTCATGCT CATCTTCATG 
ACCTACAATG GGTACCTATG CATTGCAGTA GCAGCAGGGG CTGGGACGGG ATACTTTCTC 
TTCAGCTGGA AGAAGGCAGT GGTGGTGGAC ATCACAGAGC ACTGCCATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.
Human molecular genetics26(23)4617-4628(2017 Dec)
Baker ZN,Jett K,Boulet A,Hossain A,Cobine PA,Kim BE,El Zawily AM,Lee L,Tibbits GF,Petris MJ,Leary SC

Copper Chelation Inhibits BRAF
Cancer research77(22)6240-6252(2017 Nov)
Brady DC,Crowe MS,Greenberg DN,Counter CM

Sexual congruency in the connectome and translatome of VTA dopamine neurons.
Scientific reports7(1)11120(2017 Sep)
Chung AS,Miller SM,Sun Y,Xu X,Zweifel LS

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.
The Journal of biological chemistry292(27)11531-11546(2017 07)
Logeman BL,Wood LK,Lee J,Thiele DJ

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1.
eLife5(2016 08)
Srivastava S,Panda S,Li Z,Fuhs SR,Hunter T,Thiele DJ,Hubbard SR,Skolnik EY

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Slc31a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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