Slc31a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc31a1
Entrez Gene ID	171135
Full Name	solute carrier family 31 member 1
Synonyms	Ctr1,LRRGT00200
General protein information	Preferred Names solute carrier family 31 member 1 Names high affinity copper uptake protein 1 Copper uptake transporter 1 copper transporter 1 liver regeneration-related protein LRRGT00200 rCTR1 solute carrier family 31 (copper transporter), member 1 solute carrier family 31 (copper transporters), member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q24
Summary	high-affinity copper uptake gene; esential for intracellular copper metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133600.1	NP_598284.1	high affinity copper uptake protein 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC31A1	XP_538800.1
	SLC31A1	XP_001103110.1
Mus musculus (house mouse)	Slc31a1	NP_780299.2
Drosophila melanogaster (fruit fly)	Ctr1A	NP_001245552.1
Gallus gallus (chicken)	SLC31A1	XP_004945826.1
Danio rerio (zebrafish)	slc31a1	NP_991280.1
Homo sapiens (human)	SLC31A1	NP_001850.1
Rattus norvegicus (Norway rat)	Slc31a1	NP_598284.1
Pan troglodytes (chimpanzee)	SLC31A1	XP_520197.2
Bos taurus (cattle)	SLC31A1	NP_001093851.1

Gene Ontology
Bibliography

Related articles in PubMed

Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu) accumulation in choroidal epithelial cells.
Zheng G, Zhang J, Xu Y, Shen X, Song H, Jing J, Luo W, Zheng W, Chen J
Toxicology letters225(1)110-8(2014 Feb)

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
?hrvik H, Nose Y, Wood LK, Kim BE, Gleber SC, Ralle M, Thiele DJ
Proceedings of the National Academy of Sciences of the United States of America110(46)E4279-88(2013 Nov)

Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons.
Liu JJ, Kim Y, Yan F, Ding Q, Ip V, Jong NN, Mercer JF, McKeage MJ
Biochemical pharmacology85(2)207-15(2013 Jan)

Subcellular targets of cisplatin cytotoxicity: an integrated view.
Sancho-Mart?nez SM, Prieto-Garc?a L, Prieto M, L?pez-Novoa JM, L?pez-Hern?ndez FJ
Pharmacology & therapeutics136(1)35-55(2012 Oct)

Membrane transporters as mediators of Cisplatin effects and side effects.
Ciarimboli G
Scientifica2012473829(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CTR1 and ATP7A play important roles in Cu transport in choroidal epithelial cells, and the Pb-induced intracellular Cu accumulation appears to be mediated, at least in part, via the alteration of CTR1 and ATP7A expression levels following Pb exposure.
Title: Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu) accumulation in choroidal epithelial cells.

Data suggest that Ctr1 is responsible for transport (and accumulation) of copper salts (CuCl2; CuSO4) and organoplatinum compounds in dorsal root ganglion neurons; Ctr1 is thus involved in neurotoxicity of such antineoplastic drugs.
Title: Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons.

These data indicate that CTR1, but not DMT1, plays an essential role in transporting Cu by the blood-CSF barrier in the choroid plexus
Title: Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: implication in manganese-induced neurotoxicity.

these results suggest that Ctr1, DMT1, ATOX1 and ATP7A contribute to Cu transport at the blood-CSF barrier
Title: Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model.

Adult rat DRG tissue exhibits a specific pattern of expression of copper transporters with distinct subsets of peripheral sensory neurons intensely expressing either ATP7A or CTR1, but not both or ATP7B.
Title: Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue.

The following Slc31a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc31a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12809	NM_133600.1 Latest version!	Rattus norvegicus solute carrier family 31 member 1 (Slc31a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc31a1 ( NM_133600.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598284.1 Rattus norvegicus solute carrier family 31 member 1 (Slc31a1), mRNA.

Price & Availability↑

CloneID	ORa12809
Clone ID Related Accession (Same CDS sequence)	NM_133600.1
Accession Version	NM_133600.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	high affinity copper uptake protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF268030.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF268030.1, FQ223114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGGATGA ACCACATGGA GATGCATCAT ATGGGGATGA ACCACACGGA CGACAACATC 
ACCATGCCAC CCCACCAGCA CCCCACCACC TCGGCCTCAC ACTCCCACGA GATGATGATG 
CCTATGACCT TCTACTTTGG CTTTAAGAAT GTGGACCTAT TGTTTTCCAG TTTGGTAATC 
AACACACCTG GAGAAATGGC TGGAGCTTTT GTGGCAGTGT TTTTACTAGC AATGTTTTAT 
GAAGGACTCA AGATAGCCCG AGAGGGTCTG CTTCGAAAGT CTCAAGTCAG CATTCGCTAC 
AATTCCATGC CTGTGCCAGG ACCAAATGGA ACCATCCTTA TGGAGACACA CAAAACTGTT 
GGGCAGCAGA TGCTGAGCTT CCCCCACCTC CTGCAGACAG TGCTGCACAT CATCCAAGTA 
GTCATCAGCT ACTTCCTCAT GCTCATCTTC ATGACCTACA ATGGGTACCT ATGCATTGCA 
GTAGCCGCAG GGGCTGGGAC AGGATACTTT CTCTTCAGCT GGAAGAAGGC TGTGGTGGTG 
GACATCACAG AGCACTGCCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598284.1
CDS	169..732
Translation	MRMNHMEMHHMGMNHTDDNITMPPHQHPTTSASHSHEMMMPMTFYFGFKNVDLLFSSLVINTPGEMAGAFVAVFLLAMFYEGLKIAREGLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH

Target ORF information:

RefSeq Version	NM_133600.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 31 member 1 (Slc31a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133600.1

ORF Insert Sequence:

ATGAGGATGA ACCACATGGA GATGCATCAT ATGGGGATGA ACCACACGGA CGACAACATC 
ACCATGCCAC CCCACCAGCA CCCCACCACC TCGGCCTCAC ACTCCCACGA GATGATGATG 
CCTATGACCT TCTACTTTGG CTTTAAGAAT GTGGACCTAT TGTTTTCCAG TTTGGTAATC 
AACACACCTG GAGAAATGGC TGGAGCTTTT GTGGCAGTGT TTTTACTAGC AATGTTTTAT 
GAAGGACTCA AGATAGCCCG AGAGGGTCTG CTTCGAAAGT CTCAAGTCAG CATTCGCTAC 
AATTCCATGC CTGTGCCAGG ACCAAATGGA ACCATCCTTA TGGAGACACA CAAAACTGTT 
GGGCAGCAGA TGCTGAGCTT CCCCCACCTC CTGCAGACAG TGCTGCACAT CATCCAAGTA 
GTCATCAGCT ACTTCCTCAT GCTCATCTTC ATGACCTACA ATGGGTACCT ATGCATTGCA 
GTAGCCGCAG GGGCTGGGAC AGGATACTTT CTCTTCAGCT GGAAGAAGGC TGTGGTGGTG 
GACATCACAG AGCACTGCCA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu) accumulation in choroidal epithelial cells.
Toxicology letters225(1)110-8(2014 Feb)
Zheng G,Zhang J,Xu Y,Shen X,Song H,Jing J,Luo W,Zheng W,Chen J

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
Proceedings of the National Academy of Sciences of the United States of America110(46)E4279-88(2013 Nov)
?hrvik H,Nose Y,Wood LK,Kim BE,Gleber SC,Ralle M,Thiele DJ

Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons.
Biochemical pharmacology85(2)207-15(2013 Jan)
Liu JJ,Kim Y,Yan F,Ding Q,Ip V,Jong NN,Mercer JF,McKeage MJ

Subcellular targets of cisplatin cytotoxicity: an integrated view.
Pharmacology & therapeutics136(1)35-55(2012 Oct)
Sancho-Mart?nez SM,Prieto-Garc?a L,Prieto M,L?pez-Novoa JM,L?pez-Hern?ndez FJ

Membrane transporters as mediators of Cisplatin effects and side effects.
Scientifica2012473829(2012)
Ciarimboli G

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Slc31a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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