Frzb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Frzb
Entrez Gene ID	20378
Full Name	frizzled-related protein
Synonyms	Frp,Sfrp3,frezzled,fritz,frzb-1
General protein information	Preferred Names frizzled-related protein Names secreted frizzled-related protein 3 frizzled-related protein 1 sFRP-3 secreted frizzled-related sequence protein 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 C3\|2 48.13 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011356.4	NP_035486.1	secreted frizzled-related protein 3 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	frzb	NP_571018.1
Homo sapiens (human)	FRZB	NP_001454.2
	FRZB	XP_001102583.1
Mus musculus (house mouse)	Frzb	NP_035486.1
Xenopus tropicalis (tropical clawed frog)	frzb	NP_001005438.1
Canis lupus familiaris (dog)	FRZB	XP_005640438.1
Gallus gallus (chicken)	FRZB	NP_990103.1
Pan troglodytes (chimpanzee)	FRZB	XP_001159997.1
Bos taurus (cattle)	FRZB	NP_776484.1
Rattus norvegicus (Norway rat)	Frzb	NP_001093997.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-130b Promotes Wear Particle-Induced Osteolysis via Downregulating Frizzled-Related Protein (FRZB).
Zheng DZ, Bu YM, Wang L, Liu J
Current neurovascular research14(1)32-38(2017)

Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche.
Amin S, Neijts R, Simmini S, van Rooijen C, Tan SC, Kester L, van Oudenaarden A, Creyghton MP, Deschamps J
Cell reports17(12)3165-3177(2016 12)

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.
L?dtke TH, Rudat C, Wojahn I, Weiss AC, Kleppa MJ, Kurz J, Farin HF, Moon A, Christoffels VM, Kispert A
Developmental cell39(2)239-253(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

particle-induced inhibition on cell proliferation, differentiation and FRZB expression were all reversed by miR-130b silence
Title: MicroRNA-130b Promotes Wear Particle-Induced Osteolysis via Downregulating Frizzled-Related Protein (FRZB).

Stable overexpression of Frzb in MC3T3-E1 cells increased calcium deposition and osteoblast markers compared with control. Western blot analysis showed that the increased osteogenesis was associated with reduced canonical, but increased non-canonical Wnt signaling.
Title: Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain.

an inverse septal-to-temporal increase in the expression of sfrp3 that emerges during postnatal development, is reported.
Title: A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation.

Our results suggest that FrzB may have a protective role on cartilage degradation and matrix metalloproteinase induction in mouse chondrocytes
Title: Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes.

left ventricles from post-MI mice showed an increased sFRP3 mRNA level, particularly in cardiac fibroblasts, and (iv) mechanical stretch enhanced sFRP3 expression and release in myocardial fibroblasts
Title: The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure.

The following Frzb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Frzb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16555	NM_011356.4 Latest version!	Mus musculus frizzled-related protein (Frzb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Frzb ( NM_011356.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035486.1 Mus musculus frizzled-related protein (Frzb), mRNA.

Price & Availability↑

CloneID	OMu16555
Clone ID Related Accession (Same CDS sequence)	NM_011356.4
Accession Version	NM_011356.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	secreted frizzled-related protein 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL928578.6. On Apr 28, 2007 this sequence version replaced NM_011356.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029941.1, BC016884.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTCTGCT GCGGCCCGGG ACGGATGCTG CTAGGATGGG CCGGGTTGCT AGTCCTGGCT 
GCTCTCTGCC TGCTCCAGGT GCCCGGAGCT CAGGCTGCAG CCTGTGAGCC TGTCCGCATC 
CCGCTGTGCA AGTCCCTTCC CTGGAACATG ACCAAGATGC CCAACCACCT GCACCACAGC 
ACCCAGGCTA ACGCCATCCT GGCCATGGAA CAGTTCGAAG GGCTGCTGGG CACCCACTGC 
AGCCCGGATC TTCTCTTCTT CCTCTGTGCA ATGTACGCAC CCATTTGCAC CATCGACTTC 
CAGCACGAGC CCATCAAGCC CTGCAAGTCT GTGTGTGAGC GCGCCCGACA GGGCTGCGAG 
CCCATTCTCA TCAAGTACCG CCACTCGTGG CCGGAAAGCT TGGCCTGCGA CGAGCTGCCG 
GTGTACGACC GCGGCGTGTG CATCTCTCCT GAGGCCATCG TCACCGCGGA CGGAGCGGAT 
TTTCCTATGG ATTCAAGTAC TGGACACTGC AGAGGGGCAA GCAGCGAACG TTGCAAATGT 
AAGCCTGTCA GAGCTACACA GAAGACCTAT TTCCGGAACA ATTACAACTA TGTCATCCGG 
GCTAAAGTTA AAGAGGTAAA GATGAAATGT CATGATGTGA CCGCCGTTGT GGAAGTGAAG 
GAAATTCTAA AGGCATCACT GGTAAACATT CCAAGGGACA CCGTCAATCT TTATACCACC 
TCTGGCTGCC TCTGTCCTCC ACTTACTGTC AATGAGGAAT ATGTCATCAT GGGCTATGAA 
GACGAGGAAC GTTCCAGGTT ACTCTTGGTA GAAGGCTCTA TAGCTGAGAA GTGGAAGGAT 
CGGCTTGGTA AGAAAGTCAA GCGCTGGGAT ATGAAACTCC GACACCTTGG ACTGGGTAAA 
ACTGATGCTA GCGATTCCAC TCAGAATCAG AAGTCTGGCA GGAACTCTAA TCCCCGGCCA 
GCACGCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035486.1
CDS	557..1528
Translation	MVCCGPGRMLLGWAGLLVLAALCLLQVPGAQAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPESLACDELPVYDRGVCISPEAIVTADGADFPMDSSTGHCRGASSERCKCKPVRATQKTYFRNNYNYVIRAKVKEVKMKCHDVTAVVEVKEILKASLVNIPRDTVNLYTTSGCLCPPLTVNEEYVIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLGKTDASDSTQNQKSGRNSNPRPARS

Target ORF information:

RefSeq Version	NM_011356.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus frizzled-related protein (Frzb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011356.4

ORF Insert Sequence:

ATGGTCTGCT GCGGCCCGGG ACGGATGCTG CTAGGATGGG CCGGGTTGCT AGTCCTGGCT 
GCTCTCTGCC TGCTCCAGGT GCCCGGAGCT CAGGCTGCAG CCTGTGAGCC TGTCCGCATC 
CCGCTGTGCA AGTCCCTTCC CTGGAACATG ACCAAGATGC CCAACCACCT GCACCACAGC 
ACCCAGGCTA ACGCCATCCT GGCCATGGAA CAGTTCGAAG GGCTGCTGGG CACCCACTGC 
AGCCCGGATC TTCTCTTCTT CCTCTGTGCA ATGTACGCAC CCATTTGCAC CATCGACTTC 
CAGCACGAGC CCATCAAGCC CTGCAAGTCT GTGTGTGAGC GCGCCCGACA GGGCTGCGAG 
CCCATTCTCA TCAAGTACCG CCACTCGTGG CCGGAAAGCT TGGCCTGCGA CGAGCTGCCG 
GTGTACGACC GCGGCGTGTG CATCTCTCCT GAGGCCATCG TCACCGCGGA CGGAGCGGAT 
TTTCCTATGG ATTCAAGTAC TGGACACTGC AGAGGGGCAA GCAGCGAACG TTGCAAATGT 
AAGCCTGTCA GAGCTACACA GAAGACCTAT TTCCGGAACA ATTACAACTA TGTCATCCGG 
GCTAAAGTTA AAGAGGTAAA GATGAAATGT CATGATGTGA CCGCCGTTGT GGAAGTGAAG 
GAAATTCTAA AGGCATCACT GGTAAACATT CCAAGGGACA CCGTCAATCT TTATACCACC 
TCTGGCTGCC TCTGTCCTCC ACTTACTGTC AATGAGGAAT ATGTCATCAT GGGCTATGAA 
GACGAGGAAC GTTCCAGGTT ACTCTTGGTA GAAGGCTCTA TAGCTGAGAA GTGGAAGGAT 
CGGCTTGGTA AGAAAGTCAA GCGCTGGGAT ATGAAACTCC GACACCTTGG ACTGGGTAAA 
ACTGATGCTA GCGATTCCAC TCAGAATCAG AAGTCTGGCA GGAACTCTAA TCCCCGGCCA 
GCACGCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-130b Promotes Wear Particle-Induced Osteolysis via Downregulating Frizzled-Related Protein (FRZB).
Current neurovascular research14(1)32-38(2017)
Zheng DZ,Bu YM,Wang L,Liu J

Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche.
Cell reports17(12)3165-3177(2016 12)
Amin S,Neijts R,Simmini S,van Rooijen C,Tan SC,Kester L,van Oudenaarden A,Creyghton MP,Deschamps J

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.
Developmental cell39(2)239-253(2016 10)
L?dtke TH,Rudat C,Wojahn I,Weiss AC,Kleppa MJ,Kurz J,Farin HF,Moon A,Christoffels VM,Kispert A

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Frzb cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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