FRZB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FRZB
Entrez Gene ID	2487
Full Name	frizzled related protein
Synonyms	FRE,FRITZ,FRP-3,FRZB-1,FRZB-PEN,FRZB1,FZRB,OS1,SFRP3,SRFP3,hFIZ
General protein information	Preferred Names frizzled related protein Names secreted frizzled-related protein 3 frezzled frizzled homolog-related frizzled-related protein 1 sFRP-3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q32.1
Summary	The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010].
Disorder MIM:	605083
Disorder Html:	{Osteoarthritis susceptibility 1}, 165720 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001463.3	NP_001454.2	secreted frizzled-related protein 3 precursor
NM_001463.4	NP_001454.2	secreted frizzled-related protein 3 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	frzb	NP_571018.1
Homo sapiens (human)	FRZB	NP_001454.2
	FRZB	XP_001102583.1
Mus musculus (house mouse)	Frzb	NP_035486.1
Xenopus tropicalis (tropical clawed frog)	frzb	NP_001005438.1
Canis lupus familiaris (dog)	FRZB	XP_005640438.1
Gallus gallus (chicken)	FRZB	NP_990103.1
Pan troglodytes (chimpanzee)	FRZB	XP_001159997.1
Bos taurus (cattle)	FRZB	NP_776484.1
Rattus norvegicus (Norway rat)	Frzb	NP_001093997.1

Gene Ontology
Bibliography

Related articles in PubMed

Negative regulators of Wnt signaling pathway SFRP1 and SFRP3 expression in preterm and term pathologic placentas.
Zmijanac Partl J, Karin V, Skrtic A, Nikuseva-Martic T, Serman A, Mlinarec J, Curkovic-Perica M, Vranic S, Serman L
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians1-9(2017 Aug)

sFRP3 and DKK1 Regulate Fibroblast-Like Synoviocytes Markers and Wnt Elements Expression Depending on Cellular Context.
Elhaj Mahmoud D, Sassi N, Drissi G, Barsaoui M, Zitouna K, Sahli H, Kallel-Sellami M, Kanoun L, Cheour E, Laadhar L
Immunological investigations46(3)314-328(2017 Apr)

FRZB and melusin, overexpressed in LGMD2A, regulate integrin ?1D isoform replacement altering myoblast fusion and the integrin-signalling pathway.
Jaka O, Casas-Fraile L, Azpitarte M, Aiastui A, L?pez de Munain A, S?enz A
Expert reviews in molecular medicine19e2(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that sFRP3 regulates fibroblast-like synociocyte transformation
Title: sFRP3 and DKK1 Regulate Fibroblast-Like Synoviocytes Markers and Wnt Elements Expression Depending on Cellular Context.

endogenous expression of the WNT antagonists DKK1 and FRZB is necessary for multiple steps during chondrogenesis
Title: Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells.

The secreted frizzled-related protein and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
Title: The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors.

This may suggest that SFRP3 acts as an agonist of Wnt signaling and promotes invasive behavior.
Title: Expression patterns of Wnt signaling component, secreted frizzled?related protein 3 in astrocytoma and glioblastoma.

FRZB expression was up-regulated in hepatocellular carcinoma bone metastasis tissue, which suggested that FRZB might play a key role in the HCC bone metastasis.
Title: FRZB up-regulated in hepatocellular carcinoma bone metastasis.

The following FRZB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FRZB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22540	NM_001463.4 Latest version!	Homo sapiens frizzled related protein (FRZB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu22540	NM_001463.3	Homo sapiens frizzled related protein (FRZB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FRZB ( NM_001463.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001454.2 Homo sapiens frizzled related protein (FRZB), mRNA.

Price & Availability↑

CloneID	OHu22540
Clone ID Related Accession (Same CDS sequence)	NM_001463.3 , NM_001463.4
Accession Version	NM_001463.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-25
Organism	Homo sapiens(human)
Product	secreted frizzled-related protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU117730.1, U24163.1, U91903.1, BF058813.1, BE549700.1 and AC105396.2. This sequence is a reference standard in the RefSeqGene project. On Apr 25, 2010 this sequence version replaced NM_001463.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.235601.1, SRR1660807.264009.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTCTGCG GCAGCCCGGG AGGGATGCTG CTGCTGCGGG CCGGGCTGCT TGCCCTGGCT 
GCTCTCTGCC TGCTCCGGGT GCCCGGGGCT CGGGCTGCAG CCTGTGAGCC CGTCCGCATC 
CCCCTGTGCA AGTCCCTGCC CTGGAACATG ACTAAGATGC CCAACCACCT GCACCACAGC 
ACTCAGGCCA ACGCCATCCT GGCCATCGAG CAGTTCGAAG GTCTGCTGGG CACCCACTGC 
AGCCCCGATC TGCTCTTCTT CCTCTGTGCC ATGTACGCGC CCATCTGCAC CATTGACTTC 
CAGCACGAGC CCATCAAGCC CTGTAAGTCT GTGTGCGAGC GGGCCCGGCA GGGCTGTGAG 
CCCATACTCA TCAAGTACCG CCACTCGTGG CCGGAGAACC TGGCCTGCGA GGAGCTGCCA 
GTGTACGACA GGGGCGTGTG CATCTCTCCC GAGGCCATCG TTACTGCGGA CGGAGCTGAT 
TTTCCTATGG ATTCTAGTAA CGGAAACTGT AGAGGGGCAA GCAGTGAACG CTGTAAATGT 
AAGCCTATTA GAGCTACACA GAAGACCTAT TTCCGGAACA ATTACAACTA TGTCATTCGG 
GCTAAAGTTA AAGAGATAAA GACTAAGTGC CATGATGTGA CTGCAGTAGT GGAGGTGAAG 
GAGATTCTAA AGTCCTCTCT GGTAAACATT CCACGGGACA CTGTCAACCT CTATACCAGC 
TCTGGCTGCC TCTGCCCTCC ACTTAATGTT AATGAGGAAT ATATCATCAT GGGCTATGAA 
GATGAGGAAC GTTCCAGATT ACTCTTGGTG GAAGGCTCTA TAGCTGAGAA GTGGAAGGAT 
CGACTCGGTA AAAAAGTTAA GCGCTGGGAT ATGAAGCTTC GTCATCTTGG ACTCAGTAAA 
AGTGATTCTA GCAATAGTGA TTCCACTCAG AGTCAGAAGT CTGGCAGGAA CTCGAACCCC 
CGGCAAGCAC GCAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001454.2
CDS	219..1196
Translation	MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN

Target ORF information:

RefSeq Version	NM_001463.3
Organism	Homo sapiens(human)
Definition	Homo sapiens frizzled related protein (FRZB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001463.3

ORF Insert Sequence:

ATGGTCTGCG GCAGCCCGGG AGGGATGCTG CTGCTGCGGG CCGGGCTGCT TGCCCTGGCT 
GCTCTCTGCC TGCTCCGGGT GCCCGGGGCT CGGGCTGCAG CCTGTGAGCC CGTCCGCATC 
CCCCTGTGCA AGTCCCTGCC CTGGAACATG ACTAAGATGC CCAACCACCT GCACCACAGC 
ACTCAGGCCA ACGCCATCCT GGCCATCGAG CAGTTCGAAG GTCTGCTGGG CACCCACTGC 
AGCCCCGATC TGCTCTTCTT CCTCTGTGCC ATGTACGCGC CCATCTGCAC CATTGACTTC 
CAGCACGAGC CCATCAAGCC CTGTAAGTCT GTGTGCGAGC GGGCCCGGCA GGGCTGTGAG 
CCCATACTCA TCAAGTACCG CCACTCGTGG CCGGAGAACC TGGCCTGCGA GGAGCTGCCA 
GTGTACGACA GGGGCGTGTG CATCTCTCCC GAGGCCATCG TTACTGCGGA CGGAGCTGAT 
TTTCCTATGG ATTCTAGTAA CGGAAACTGT AGAGGGGCAA GCAGTGAACG CTGTAAATGT 
AAGCCTATTA GAGCTACACA GAAGACCTAT TTCCGGAACA ATTACAACTA TGTCATTCGG 
GCTAAAGTTA AAGAGATAAA GACTAAGTGC CATGATGTGA CTGCAGTAGT GGAGGTGAAG 
GAGATTCTAA AGTCCTCTCT GGTAAACATT CCACGGGACA CTGTCAACCT CTATACCAGC 
TCTGGCTGCC TCTGCCCTCC ACTTAATGTT AATGAGGAAT ATATCATCAT GGGCTATGAA 
GATGAGGAAC GTTCCAGATT ACTCTTGGTG GAAGGCTCTA TAGCTGAGAA GTGGAAGGAT 
CGACTCGGTA AAAAAGTTAA GCGCTGGGAT ATGAAGCTTC GTCATCTTGG ACTCAGTAAA 
AGTGATTCTA GCAATAGTGA TTCCACTCAG AGTCAGAAGT CTGGCAGGAA CTCGAACCCC 
CGGCAAGCAC GCAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FRZB ( NM_001463.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001454.2 Homo sapiens frizzled related protein (FRZB), mRNA.

Price & Availability↑

CloneID	OHu22540
Clone ID Related Accession (Same CDS sequence)	NM_001463.3 , NM_001463.4
Accession Version	NM_001463.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	secreted frizzled-related protein 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU117730.1, U24163.1, U91903.1, BF058813.1, BE549700.1 and AC105396.2. This sequence is a reference standard in the RefSeqGene project. On Nov 24, 2018 this sequence version replaced NM_001463.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.126961.1, SRR1660807.264009.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144, SAMEA2467148 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000295113.5/ ENSP00000295113.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTCTGCG GCAGCCCGGG AGGGATGCTG CTGCTGCGGG CCGGGCTGCT TGCCCTGGCT 
GCTCTCTGCC TGCTCCGGGT GCCCGGGGCT CGGGCTGCAG CCTGTGAGCC CGTCCGCATC 
CCCCTGTGCA AGTCCCTGCC CTGGAACATG ACTAAGATGC CCAACCACCT GCACCACAGC 
ACTCAGGCCA ACGCCATCCT GGCCATCGAG CAGTTCGAAG GTCTGCTGGG CACCCACTGC 
AGCCCCGATC TGCTCTTCTT CCTCTGTGCC ATGTACGCGC CCATCTGCAC CATTGACTTC 
CAGCACGAGC CCATCAAGCC CTGTAAGTCT GTGTGCGAGC GGGCCCGGCA GGGCTGTGAG 
CCCATACTCA TCAAGTACCG CCACTCGTGG CCGGAGAACC TGGCCTGCGA GGAGCTGCCA 
GTGTACGACA GGGGCGTGTG CATCTCTCCC GAGGCCATCG TTACTGCGGA CGGAGCTGAT 
TTTCCTATGG ATTCTAGTAA CGGAAACTGT AGAGGGGCAA GCAGTGAACG CTGTAAATGT 
AAGCCTATTA GAGCTACACA GAAGACCTAT TTCCGGAACA ATTACAACTA TGTCATTCGG 
GCTAAAGTTA AAGAGATAAA GACTAAGTGC CATGATGTGA CTGCAGTAGT GGAGGTGAAG 
GAGATTCTAA AGTCCTCTCT GGTAAACATT CCACGGGACA CTGTCAACCT CTATACCAGC 
TCTGGCTGCC TCTGCCCTCC ACTTAATGTT AATGAGGAAT ATATCATCAT GGGCTATGAA 
GATGAGGAAC GTTCCAGATT ACTCTTGGTG GAAGGCTCTA TAGCTGAGAA GTGGAAGGAT 
CGACTCGGTA AAAAAGTTAA GCGCTGGGAT ATGAAGCTTC GTCATCTTGG ACTCAGTAAA 
AGTGATTCTA GCAATAGTGA TTCCACTCAG AGTCAGAAGT CTGGCAGGAA CTCGAACCCC 
CGGCAAGCAC GCAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001454.2
CDS	86..1063
Translation	MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN

Target ORF information:

RefSeq Version	NM_001463.4
Organism	Homo sapiens(human)
Definition	Homo sapiens frizzled related protein (FRZB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001463.4

ORF Insert Sequence:

ATGGTCTGCG GCAGCCCGGG AGGGATGCTG CTGCTGCGGG CCGGGCTGCT TGCCCTGGCT 
GCTCTCTGCC TGCTCCGGGT GCCCGGGGCT CGGGCTGCAG CCTGTGAGCC CGTCCGCATC 
CCCCTGTGCA AGTCCCTGCC CTGGAACATG ACTAAGATGC CCAACCACCT GCACCACAGC 
ACTCAGGCCA ACGCCATCCT GGCCATCGAG CAGTTCGAAG GTCTGCTGGG CACCCACTGC 
AGCCCCGATC TGCTCTTCTT CCTCTGTGCC ATGTACGCGC CCATCTGCAC CATTGACTTC 
CAGCACGAGC CCATCAAGCC CTGTAAGTCT GTGTGCGAGC GGGCCCGGCA GGGCTGTGAG 
CCCATACTCA TCAAGTACCG CCACTCGTGG CCGGAGAACC TGGCCTGCGA GGAGCTGCCA 
GTGTACGACA GGGGCGTGTG CATCTCTCCC GAGGCCATCG TTACTGCGGA CGGAGCTGAT 
TTTCCTATGG ATTCTAGTAA CGGAAACTGT AGAGGGGCAA GCAGTGAACG CTGTAAATGT 
AAGCCTATTA GAGCTACACA GAAGACCTAT TTCCGGAACA ATTACAACTA TGTCATTCGG 
GCTAAAGTTA AAGAGATAAA GACTAAGTGC CATGATGTGA CTGCAGTAGT GGAGGTGAAG 
GAGATTCTAA AGTCCTCTCT GGTAAACATT CCACGGGACA CTGTCAACCT CTATACCAGC 
TCTGGCTGCC TCTGCCCTCC ACTTAATGTT AATGAGGAAT ATATCATCAT GGGCTATGAA 
GATGAGGAAC GTTCCAGATT ACTCTTGGTG GAAGGCTCTA TAGCTGAGAA GTGGAAGGAT 
CGACTCGGTA AAAAAGTTAA GCGCTGGGAT ATGAAGCTTC GTCATCTTGG ACTCAGTAAA 
AGTGATTCTA GCAATAGTGA TTCCACTCAG AGTCAGAAGT CTGGCAGGAA CTCGAACCCC 
CGGCAAGCAC GCAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Negative regulators of Wnt signaling pathway SFRP1 and SFRP3 expression in preterm and term pathologic placentas.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians1-9(2017 Aug)
Zmijanac Partl J,Karin V,Skrtic A,Nikuseva-Martic T,Serman A,Mlinarec J,Curkovic-Perica M,Vranic S,Serman L

sFRP3 and DKK1 Regulate Fibroblast-Like Synoviocytes Markers and Wnt Elements Expression Depending on Cellular Context.
Immunological investigations46(3)314-328(2017 Apr)
Elhaj Mahmoud D,Sassi N,Drissi G,Barsaoui M,Zitouna K,Sahli H,Kallel-Sellami M,Kanoun L,Cheour E,Laadhar L

FRZB and melusin, overexpressed in LGMD2A, regulate integrin ?1D isoform replacement altering myoblast fusion and the integrin-signalling pathway.
Expert reviews in molecular medicine19e2(2017 Mar)
Jaka O,Casas-Fraile L,Azpitarte M,Aiastui A,L?pez de Munain A,S?enz A

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FRZB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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