Ccl8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccl8
Entrez Gene ID	20307
Full Name	chemokine (C-C motif) ligand 8
Synonyms	1810063B20Rik,AB023418,HC14,MCP-2,Mcp2,Scya8
General protein information	Preferred Names chemokine (C-C motif) ligand 8 Names C-C motif chemokine 8 monocyte chemoattractant protein-2 monocyte chemotactic protein 2 small-inducible cytokine A8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 C\|11 49.91 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_021443.3	NP_067418.1	C-C motif chemokine 8 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia.
Sones JL, Merriam AA, Seffens A, Brown-Grant DA, Butler SD, Zhao AM, Xu X, Shawber CJ, Grenier JK, Douglas NC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Dec)

Cutting Edge: Origins, Recruitment, and Regulation of CD11c
Klementowicz JE, Mahne AE, Spence A, Nguyen V, Satpathy AT, Murphy KM, Tang Q
Journal of immunology (Baltimore, Md. : 1950)199(1)27-32(2017 Jul)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Sterile Inflammation Enhances ECM Degradation in Integrin ?1 KO Embryonic Skin.
Kurbet AS, Hegde S, Bhattacharjee O, Marepally S, Vemula PK, Raghavan S
Cell reports16(12)3334-3347(2016 09)

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1? Activation.
Yan D, Wang HW, Bowman RL, Joyce JA
Cell reports16(11)2914-2927(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings exemplify how gradients of chemoattractive factors such as CCL8, drive metastasis and suggest that interference with their operation may provide means for breast cancer management.
Title: A CCL8 gradient drives breast cancer cell dissemination.

tumours are characterized by expression of inflammatory chemokines (CCL2, CCL5, CCL7, CCL8, CCL12, CXCL9, CXCL10 and CX3CL1), reflected by an enrichment of activated Foxp3(-) and Foxp3(+) T cells
Title: A distinct chemokine axis does not account for enrichment of Foxp3(+) ?CD4(+) T cells in carcinogen-induced fibrosarcomas.

these data reveal an important role for BLIMP1 in modulating host defenses by suppressing expression of the chemokine CCL8.
Title: The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.

Results indicate that the induction of MCP-2/CCL8 by mycobacteria is dependent on the activation of TLR2/PI3K/Akt signaling pathway.
Title: Induction of CCL8/MCP-2 by mycobacteria through the activation of TLR2/PI3K/Akt signaling pathway.

Data indicate mRNA upregulation of CCR2 and CCR2 ligands CCL2, CCL7, CCL8, and CCL12 in aortas from DOCA/salt-treated hypertension.
Title: Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice.

The following Ccl8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccl8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22539	NM_021443.3 Latest version!	Mus musculus chemokine (C-C motif) ligand 8 (Ccl8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccl8 ( NM_021443.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067418.1 Mus musculus chemokine (C-C motif) ligand 8 (Ccl8), mRNA.

Price & Availability↑

CloneID	OMu22539
Clone ID Related Accession (Same CDS sequence)	NM_021443.3
Accession Version	NM_021443.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	C-C motif chemokine 8 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY707942.1, BC117101.1, BX639248.1 and AI449326.1. On Aug 11, 2009 this sequence version replaced NM_021443.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CK793037.1, CJ137042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGATCT ACGCAGTGCT TCTTTGCCTG CTGCTCATAG CTGTCCCTGT CAGCCCAGAG 
AAGCTGACTG GGCCAGATAA GGCTCCAGTC ACCTGCTGCT TTCATGTACT AAAGCTGAAG 
ATCCCCCTTC GGGTGCTGAA AAGCTACGAG AGAATCAACA ATATCCAGTG CCCCATGGAA 
GCTGTGGTTT TCCAGACCAA GCAGGGTATG TCTCTCTGTG TAGACCCCAC ACAGAAGTGG 
GTCAGTGAGT ACATGGAGAT CCTTGACCAG AAGTCTCAAA TTCTGCAGCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067418.1
CDS	53..346
Translation	MKIYAVLLCLLLIAVPVSPEKLTGPDKAPVTCCFHVLKLKIPLRVLKSYERINNIQCPMEAVVFQTKQGMSLCVDPTQKWVSEYMEILDQKSQILQP

Target ORF information:

RefSeq Version	NM_021443.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-C motif) ligand 8 (Ccl8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021443.3

ORF Insert Sequence:

ATGAAGATCT ACGCAGTGCT TCTTTGCCTG CTGCTCATAG CTGTCCCTGT CAGCCCAGAG 
AAGCTGACTG GGCCAGATAA GGCTCCAGTC ACCTGCTGCT TTCATGTACT AAAGCTGAAG 
ATCCCCCTTC GGGTGCTGAA AAGCTACGAG AGAATCAACA ATATCCAGTG CCCCATGGAA 
GCTGTGGTTT TCCAGACCAA GCAGGGTATG TCTCTCTGTG TAGACCCCAC ACAGAAGTGG 
GTCAGTGAGT ACATGGAGAT CCTTGACCAG AAGTCTCAAA TTCTGCAGCC TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Dec)
Sones JL,Merriam AA,Seffens A,Brown-Grant DA,Butler SD,Zhao AM,Xu X,Shawber CJ,Grenier JK,Douglas NC

Cutting Edge: Origins, Recruitment, and Regulation of CD11c
Journal of immunology (Baltimore, Md. : 1950)199(1)27-32(2017 Jul)
Klementowicz JE,Mahne AE,Spence A,Nguyen V,Satpathy AT,Murphy KM,Tang Q

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Sterile Inflammation Enhances ECM Degradation in Integrin ?1 KO Embryonic Skin.
Cell reports16(12)3334-3347(2016 09)
Kurbet AS,Hegde S,Bhattacharjee O,Marepally S,Vemula PK,Raghavan S

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1? Activation.
Cell reports16(11)2914-2927(2016 09)
Yan D,Wang HW,Bowman RL,Joyce JA

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Ccl8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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