Rgs4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rgs4
Entrez Gene ID	19736
Full Name	regulator of G-protein signaling 4
Synonyms	AA004315,AA597169,ESTM48,ESTM50
General protein information	Preferred Names regulator of G-protein signaling 4 Names regulator of G-protein signaling 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H2.3\|1 76.84 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009062.3	NP_033088.2	regulator of G-protein signaling 4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RGS4	NP_001040065.1
	RGS4	XP_001082467.1
Canis lupus familiaris (dog)	RGS4	XP_545783.2
Gallus gallus (chicken)	RGS4	NP_989716.1
Danio rerio (zebrafish)	rgs4	NP_954968.1
Pan troglodytes (chimpanzee)	RGS4	XP_513957.2
Mus musculus (house mouse)	Rgs4	NP_033088.2
Rattus norvegicus (Norway rat)	Rgs4	NP_058910.1
Xenopus tropicalis (tropical clawed frog)	rgs4	NP_989295.2
Homo sapiens (human)	RGS4	NP_001095915.1

Gene Ontology
Bibliography

Related articles in PubMed

RGS4 Overexpression in Lung Attenuates Airway Hyperresponsiveness in Mice.
Madigan LA, Wong GS, Gordon EM, Chen WS, Balenga N, Koziol-White CJ, Panettieri RA Jr, Levine SJ, Druey KM
American journal of respiratory cell and molecular biology58(1)89-98(2018 Jan)

Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.
Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B
The American journal of pathology187(7)1496-1511(2017 Jul)

The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development.
Inoue K, Hirose M, Inoue H, Hatanaka Y, Honda A, Hasegawa A, Mochida K, Ogura A
Cell reports19(5)949-956(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RGS4 in the paraventricular nucleus regulates blood corticosteroid-related GABAB receptor signaling during the acute stress response.
Title: Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response.

Thus, RGS4 expression, specific to renal vascular smooth muscle cells, inhibits angiotensin II-mediated cytokine signaling and macrophage recruitment during reperfusion, distinct from vasomotor regulation.
Title: RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm.

Spinal RGS4 inhibited the endogenous or exogenous OR-mediated antinociceptive effect in the formalin pain test.
Title: Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.

RGS6-Gbeta5, but not RGS4, is the primary RGS modulator of parasympathetic HR regulation and SAN M2R-IKACh signaling in mice.
Title: RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate.

dramatic up-regulation of RGS4 expression in the nucleus accumbens of mice treated with monoamine-directed antidepressants
Title: Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models.

The following Rgs4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rgs4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16005	NM_009062.3 Latest version!	Mus musculus regulator of G-protein signaling 4 (Rgs4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rgs4 ( NM_009062.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033088.2 Mus musculus regulator of G-protein signaling 4 (Rgs4), mRNA.

Price & Availability↑

CloneID	OMu16005
Clone ID Related Accession (Same CDS sequence)	NM_009062.3
Accession Version	NM_009062.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Mus musculus(house mouse)
Product	regulator of G-protein signaling 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK030536.1, BB459021.2 and CD741379.1. On Apr 17, 2007 this sequence version replaced NM_009062.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ346661.1, SRR1660813.182966.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END##

ATGTGCAAAG GACTTGCAGG TCTGCCGGCT TCCTGCCTGA GGAGTGCAAA GGACATGAAA 
CATCGGCTGG GGTTCCTGCT GCAGAAGTCA GATTCCTGCG AACACAGTTC TTCACACAGC 
AAGAAGGACA AAGTAGTAAC TTGCCAGAGG GTAAGCCAAG AAGAAGTCAA GAAATGGGCT 
GAATCGTTGG AAAACCTGAT TCACCATGAA TGTGGACTGG CAGCTTTCAA AGCTTTCCTG 
AAGTCGGAAT ACAGCGAGGA GAACATTGAC TTCTGGATCA GCTGTGAGGA GTACAAGAAG 
ATCAAGTCAC CTTCTAAACT AAGTCCCAAA GCCAAGAAGA TCTACAACGA GTTCATCTCA 
GTGCAAGCAA CAAAAGAGGT GAACCTGGAC TCTTGCACCA GAGAGGAGAC AAGCCGGAAC 
ATGTTACAGC CCACAATAAC CTGTTTTGAT GAAGCCCAGA AGAAGATTTT CAACCTGATG 
GAAAAGGATT CCTACCGCCG CTTCCTCAAG TCTCGATTCT ATCTTGACCT GACCAATCCT 
TCCAGCTGCG GGGCAGAGAA GCAGAAAGGA GCCAAGAGTT CTGCAGACTG CACTTCCCTG 
GTCTCCCAGT GTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033088.2
CDS	120..737
Translation	MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHSSSHSKKDKVVTCQRVSQEEVKKWAESLENLIHHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLQPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLTNPSSCGAEKQKGAKSSADCTSLVSQCA

Target ORF information:

RefSeq Version	NM_009062.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus regulator of G-protein signaling 4 (Rgs4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009062.3

ORF Insert Sequence:

ATGTGCAAAG GACTTGCAGG TCTGCCGGCT TCCTGCCTGA GGAGTGCAAA GGACATGAAA 
CATCGGCTGG GGTTCCTGCT GCAGAAGTCA GATTCCTGCG AACACAGTTC TTCACACAGC 
AAGAAGGACA AAGTAGTAAC TTGCCAGAGG GTAAGCCAAG AAGAAGTCAA GAAATGGGCT 
GAATCGTTGG AAAACCTGAT TCACCATGAA TGTGGACTGG CAGCTTTCAA AGCTTTCCTG 
AAGTCGGAAT ACAGCGAGGA GAACATTGAC TTCTGGATCA GCTGTGAGGA GTACAAGAAG 
ATCAAGTCAC CTTCTAAACT AAGTCCCAAA GCCAAGAAGA TCTACAACGA GTTCATCTCA 
GTGCAAGCAA CAAAAGAGGT GAACCTGGAC TCTTGCACCA GAGAGGAGAC AAGCCGGAAC 
ATGTTACAGC CCACAATAAC CTGTTTTGAT GAAGCCCAGA AGAAGATTTT CAACCTGATG 
GAAAAGGATT CCTACCGCCG CTTCCTCAAG TCTCGATTCT ATCTTGACCT GACCAATCCT 
TCCAGCTGCG GGGCAGAGAA GCAGAAAGGA GCCAAGAGTT CTGCAGACTG CACTTCCCTG 
GTCTCCCAGT GTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RGS4 Overexpression in Lung Attenuates Airway Hyperresponsiveness in Mice.
American journal of respiratory cell and molecular biology58(1)89-98(2018 Jan)
Madigan LA,Wong GS,Gordon EM,Chen WS,Balenga N,Koziol-White CJ,Panettieri RA Jr,Levine SJ,Druey KM

Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.
The American journal of pathology187(7)1496-1511(2017 Jul)
Gerl K,Steppan D,Fuchs M,Wagner C,Willam C,Kurtz A,Kurt B

The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development.
Cell reports19(5)949-956(2017 May)
Inoue K,Hirose M,Inoue H,Hatanaka Y,Honda A,Hasegawa A,Mochida K,Ogura A

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Rgs4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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