RGS4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RGS4
Entrez Gene ID	5999
Full Name	regulator of G protein signaling 4
Synonyms	RGP4,SCZD9
General protein information	Preferred Names regulator of G protein signaling 4 Names regulator of G-protein signaling 4 schizophrenia disorder 9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.3
Summary	Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	602516

mRNA and Protein(s)

mRNA	Protein	Name
NM_001113381.1	NP_001106852.1	regulator of G-protein signaling 4 isoform 4
NM_001113380.1	NP_001106851.1	regulator of G-protein signaling 4 isoform 3
NM_001102445.2	NP_001095915.1	regulator of G-protein signaling 4 isoform 1
NM_005613.5	NP_005604.1	regulator of G-protein signaling 4 isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RGS4	NP_001040065.1
	RGS4	XP_001082467.1
Canis lupus familiaris (dog)	RGS4	XP_545783.2
Gallus gallus (chicken)	RGS4	NP_989716.1
Danio rerio (zebrafish)	rgs4	NP_954968.1
Pan troglodytes (chimpanzee)	RGS4	XP_513957.2
Mus musculus (house mouse)	Rgs4	NP_033088.2
Rattus norvegicus (Norway rat)	Rgs4	NP_058910.1
Xenopus tropicalis (tropical clawed frog)	rgs4	NP_989295.2
Homo sapiens (human)	RGS4	NP_001095915.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel regulatory role of RGS4 in STAT5B activation, neurite outgrowth and neuronal differentiation.
Pallaki P, Georganta EM, Serafimidis I, Papakonstantinou MP, Papanikolaou V, Koutloglou S, Papadimitriou E, Agalou A, Tserga A, Simeonof A, Thomaidou D, Gaitanou M, Georgoussi Z
Neuropharmacology117408-421(2017 May)

Association between RGS4 variants and psychotic-like experiences in nonclinical individuals.
de Castro-Catala M, Crist?bal-Narv?ez P, Kwapil TR, Sheinbaum T, Pe?a E, Barrantes-Vidal N, Rosa A
European archives of psychiatry and clinical neuroscience267(1)19-24(2017 Feb)

Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at G?i/o.
Jeon JP, Thakur DP, Tian JB, So I, Zhu MX
The Biochemical journal473(10)1379-90(2016 05)

Regulator of G-protein signaling 4: A novel tumor suppressor with prognostic significance in non-small cell lung cancer.
Cheng C, Yue W, Li L, Li S, Gao C, Si L, Tian H
Biochemical and biophysical research communications469(3)384-91(2016 Jan)

Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner.
Santhappan R, Crowder AT, Gouty S, Cox BM, C?t? TE
Journal of neurochemistry135(1)76-87(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of this study demonstrated the association between the variation in the regulator of G-protein signaling 4 (RGS4) gene, a putative candidate gene for psychosis previously associated with schizophrenia endophenotypes, and psychotic-like experiences (PLEs).
Title: Association between RGS4 variants and psychotic-like experiences in nonclinical individuals.

Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS4 in fine-tuning TRPC4 activities.
Title: Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at G?i/o.

All of these results confirmed the critical role of RGS4 in NSCLC progression.
Title: Regulator of G-protein signaling 4: A novel tumor suppressor with prognostic significance in non-small cell lung cancer.

After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR
Title: Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner.

RGS4 deletion results in a predisposition to atrial fibrillation from enhanced activity in the G-protein pathway, resulting in abnormal calcium release and corresponding electrical events.
Title: Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling.

The following RGS4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RGS4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23259	NM_001113380.1 Latest version!	Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu23270	NM_001102445.2 Latest version!	Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23870	NM_005613.5 Latest version!	Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu24172	NM_001113381.1 Latest version!	Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RGS4 ( NM_001113380.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001106851.1 Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu23259
Clone ID Related Accession (Same CDS sequence)	NM_001113380.1
Accession Version	NM_001113380.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 4 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EF054877.1 and AL583850.5. Transcript Variant: This variant (3) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF054877.1, SRR1660809.262232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAACATC GGCTAGGTTT CCTGCTGCAA AAATCTGATT CCTGTGAACA CAATTCTTCC 
CACAACAAGA AGGACAAAGT GGTTATTTGC CAGAGAGTGA GCCAAGAGGA AGTCAAGAAA 
TGGGCTGAAT CACTGGAAAA CCTGATTAGT CATGAATGTG GGCTGGCAGC TTTCAAAGCT 
TTCTTGAAGT CTGAATATAG TGAGGAGAAT ATTGACTTCT GGATCAGCTG TGAAGAGTAC 
AAGAAAATCA AATCACCATC TAAACTAAGT CCCAAGGCCA AAAAGATCTA TAATGAATTC 
ATCTCAGTCC AGGCAACCAA AGAGGTGAAC CTGGATTCTT GCACCAGGGA AGAGACAAGC 
CGGAACATGC TAGAGCCTAC AATAACCTGC TTTGATGAGG CCCAGAAGAA GATTTTCAAC 
CTGATGGAGA AGGATTCCTA CCGCCGCTTC CTCAAGTCTC GATTCTATCT TGATTTGGTC 
AACCCGTCCA GCTGTGGGGC AGAAAAGCAG AAAGGAGCCA AGAGTTCAGC AGACTGTGCT 
TCCCTGGTCC CTCAGTGTGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106851.1
CDS	250..813
Translation	MKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA

Target ORF information:

RefSeq Version	NM_001113380.1
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001113380.1

ORF Insert Sequence:

ATGAAACATC GGCTAGGTTT CCTGCTGCAA AAATCTGATT CCTGTGAACA CAATTCTTCC 
CACAACAAGA AGGACAAAGT GGTTATTTGC CAGAGAGTGA GCCAAGAGGA AGTCAAGAAA 
TGGGCTGAAT CACTGGAAAA CCTGATTAGT CATGAATGTG GGCTGGCAGC TTTCAAAGCT 
TTCTTGAAGT CTGAATATAG TGAGGAGAAT ATTGACTTCT GGATCAGCTG TGAAGAGTAC 
AAGAAAATCA AATCACCATC TAAACTAAGT CCCAAGGCCA AAAAGATCTA TAATGAATTC 
ATCTCAGTCC AGGCAACCAA AGAGGTGAAC CTGGATTCTT GCACCAGGGA AGAGACAAGC 
CGGAACATGC TAGAGCCTAC AATAACCTGC TTTGATGAGG CCCAGAAGAA GATTTTCAAC 
CTGATGGAGA AGGATTCCTA CCGCCGCTTC CTCAAGTCTC GATTCTATCT TGATTTGGTC 
AACCCGTCCA GCTGTGGGGC AGAAAAGCAG AAAGGAGCCA AGAGTTCAGC AGACTGTGCT 
TCCCTGGTCC CTCAGTGTGC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS4 ( NM_001102445.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001095915.1 Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23270
Clone ID Related Accession (Same CDS sequence)	NM_001102445.2
Accession Version	NM_001102445.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC334933.1, DQ346664.1 and AL583850.5. This sequence is a reference standard in the RefSeqGene project. On Jan 13, 2008 this sequence version replaced NM_001102445.1. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ346664.1, SRR1803613.10650.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145240, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END##

ATGTATAATA TGATGCTTCT AATCCAAAAG AGGAAAGGCA TTGGGAGTCA GCTCCTAAGG 
GCTGGAGAGG CAGAGGGAGA CAGAGGAGCT GGTACTGCAG AGCGGTCGTC TGATTGGCTG 
GACGGTCGTA GCTGGGCTAT AAAAGAGACC CCTACAGGCT TAGCAGGAAG ACGCTCAGAG 
GATTCTGACA ATATCTTTAC CGGAGAAGAG GCAAAGTACG CTCAAAGCCG AAGCCACAGC 
TCCTCCTGCC GCATTTCTTT CCTGCTTGCG AATTCCAAGC TGTTAAATAA GATGTGCAAA 
GGGCTTGCAG GTCTGCCGGC TTCTTGCTTG AGGAGTGCAA AAGATATGAA ACATCGGCTA 
GGTTTCCTGC TGCAAAAATC TGATTCCTGT GAACACAATT CTTCCCACAA CAAGAAGGAC 
AAAGTGGTTA TTTGCCAGAG AGTGAGCCAA GAGGAAGTCA AGAAATGGGC TGAATCACTG 
GAAAACCTGA TTAGTCATGA ATGTGGGCTG GCAGCTTTCA AAGCTTTCTT GAAGTCTGAA 
TATAGTGAGG AGAATATTGA CTTCTGGATC AGCTGTGAAG AGTACAAGAA AATCAAATCA 
CCATCTAAAC TAAGTCCCAA GGCCAAAAAG ATCTATAATG AATTCATCTC AGTCCAGGCA 
ACCAAAGAGG TGAACCTGGA TTCTTGCACC AGGGAAGAGA CAAGCCGGAA CATGCTAGAG 
CCTACAATAA CCTGCTTTGA TGAGGCCCAG AAGAAGATTT TCAACCTGAT GGAGAAGGAT 
TCCTACCGCC GCTTCCTCAA GTCTCGATTC TATCTTGATT TGGTCAACCC GTCCAGCTGT 
GGGGCAGAAA AGCAGAAAGG AGCCAAGAGT TCAGCAGACT GTGCTTCCCT GGTCCCTCAG 
TGTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001095915.1
CDS	330..1238
Translation	MYNMMLLIQKRKGIGSQLLRAGEAEGDRGAGTAERSSDWLDGRSWAIKETPTGLAGRRSEDSDNIFTGEEAKYAQSRSHSSSCRISFLLANSKLLNKMCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA

Target ORF information:

RefSeq Version	NM_001102445.2
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001102445.2

ORF Insert Sequence:

ATGTATAATA TGATGCTTCT AATCCAAAAG AGGAAAGGCA TTGGGAGTCA GCTCCTAAGG 
GCTGGAGAGG CAGAGGGAGA CAGAGGAGCT GGTACTGCAG AGCGGTCGTC TGATTGGCTG 
GACGGTCGTA GCTGGGCTAT AAAAGAGACC CCTACAGGCT TAGCAGGAAG ACGCTCAGAG 
GATTCTGACA ATATCTTTAC CGGAGAAGAG GCAAAGTACG CTCAAAGCCG AAGCCACAGC 
TCCTCCTGCC GCATTTCTTT CCTGCTTGCG AATTCCAAGC TGTTAAATAA GATGTGCAAA 
GGGCTTGCAG GTCTGCCGGC TTCTTGCTTG AGGAGTGCAA AAGATATGAA ACATCGGCTA 
GGTTTCCTGC TGCAAAAATC TGATTCCTGT GAACACAATT CTTCCCACAA CAAGAAGGAC 
AAAGTGGTTA TTTGCCAGAG AGTGAGCCAA GAGGAAGTCA AGAAATGGGC TGAATCACTG 
GAAAACCTGA TTAGTCATGA ATGTGGGCTG GCAGCTTTCA AAGCTTTCTT GAAGTCTGAA 
TATAGTGAGG AGAATATTGA CTTCTGGATC AGCTGTGAAG AGTACAAGAA AATCAAATCA 
CCATCTAAAC TAAGTCCCAA GGCCAAAAAG ATCTATAATG AATTCATCTC AGTCCAGGCA 
ACCAAAGAGG TGAACCTGGA TTCTTGCACC AGGGAAGAGA CAAGCCGGAA CATGCTAGAG 
CCTACAATAA CCTGCTTTGA TGAGGCCCAG AAGAAGATTT TCAACCTGAT GGAGAAGGAT 
TCCTACCGCC GCTTCCTCAA GTCTCGATTC TATCTTGATT TGGTCAACCC GTCCAGCTGT 
GGGGCAGAAA AGCAGAAAGG AGCCAAGAGT TCAGCAGACT GTGCTTCCCT GGTCCCTCAG 
TGTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS4 ( NM_005613.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005604.1 Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23870
Clone ID Related Accession (Same CDS sequence)	NM_005613.5
Accession Version	NM_005613.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-15
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC318279.1, DQ346663.1 and AL583850.5. On Jan 13, 2008 this sequence version replaced NM_005613.4. Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ346663.1, SRR1803611.66227.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGCAAAG GGCTTGCAGG TCTGCCGGCT TCTTGCTTGA GGAGTGCAAA AGATATGAAA 
CATCGGCTAG GTTTCCTGCT GCAAAAATCT GATTCCTGTG AACACAATTC TTCCCACAAC 
AAGAAGGACA AAGTGGTTAT TTGCCAGAGA GTGAGCCAAG AGGAAGTCAA GAAATGGGCT 
GAATCACTGG AAAACCTGAT TAGTCATGAA TGTGGGCTGG CAGCTTTCAA AGCTTTCTTG 
AAGTCTGAAT ATAGTGAGGA GAATATTGAC TTCTGGATCA GCTGTGAAGA GTACAAGAAA 
ATCAAATCAC CATCTAAACT AAGTCCCAAG GCCAAAAAGA TCTATAATGA ATTCATCTCA 
GTCCAGGCAA CCAAAGAGGT GAACCTGGAT TCTTGCACCA GGGAAGAGAC AAGCCGGAAC 
ATGCTAGAGC CTACAATAAC CTGCTTTGAT GAGGCCCAGA AGAAGATTTT CAACCTGATG 
GAGAAGGATT CCTACCGCCG CTTCCTCAAG TCTCGATTCT ATCTTGATTT GGTCAACCCG 
TCCAGCTGTG GGGCAGAAAA GCAGAAAGGA GCCAAGAGTT CAGCAGACTG TGCTTCCCTG 
GTCCCTCAGT GTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005604.1
CDS	512..1129
Translation	MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA

Target ORF information:

RefSeq Version	NM_005613.5
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005613.5

ORF Insert Sequence:

ATGTGCAAAG GGCTTGCAGG TCTGCCGGCT TCTTGCTTGA GGAGTGCAAA AGATATGAAA 
CATCGGCTAG GTTTCCTGCT GCAAAAATCT GATTCCTGTG AACACAATTC TTCCCACAAC 
AAGAAGGACA AAGTGGTTAT TTGCCAGAGA GTGAGCCAAG AGGAAGTCAA GAAATGGGCT 
GAATCACTGG AAAACCTGAT TAGTCATGAA TGTGGGCTGG CAGCTTTCAA AGCTTTCTTG 
AAGTCTGAAT ATAGTGAGGA GAATATTGAC TTCTGGATCA GCTGTGAAGA GTACAAGAAA 
ATCAAATCAC CATCTAAACT AAGTCCCAAG GCCAAAAAGA TCTATAATGA ATTCATCTCA 
GTCCAGGCAA CCAAAGAGGT GAACCTGGAT TCTTGCACCA GGGAAGAGAC AAGCCGGAAC 
ATGCTAGAGC CTACAATAAC CTGCTTTGAT GAGGCCCAGA AGAAGATTTT CAACCTGATG 
GAGAAGGATT CCTACCGCCG CTTCCTCAAG TCTCGATTCT ATCTTGATTT GGTCAACCCG 
TCCAGCTGTG GGGCAGAAAA GCAGAAAGGA GCCAAGAGTT CAGCAGACTG TGCTTCCCTG 
GTCCCTCAGT GTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RGS4 ( NM_001113381.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001106852.1 Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu24172
Clone ID Related Accession (Same CDS sequence)	NM_001113381.1
Accession Version	NM_001113381.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 282bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	regulator of G-protein signaling 4 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA660695.1, AK093959.1 and AL583850.5. Transcript Variant: This variant (4) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an internal coding exon in the 3' region, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK093959.1, SRR1803612.108879.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCAAAG GGCTTGCAGG TCTGCCGGCT TCTTGCTTGA GGAGTGCAAA AGATATGAAA 
CATCGGCTAG GTTTCCTGCT GCAAAAATCT GATTCCTGTG AACACAATTC TTCCCACAAC 
AAGAAGGACA AAGTGGTTAT TTGCCAGAGA GTGAGCCAAG AGGAAGTCAA GAAATGGGCT 
GAATCACTGG AAAACCTGAT TAGTCATGAA TGTGAACCTG GATTCTTGCA CCAGGGAAGA 
GACAAGCCGG AACATGCTAG AGCCTACAAT AACCTGCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106852.1
CDS	232..513
Translation	MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHECEPGFLHQGRDKPEHARAYNNLL

Target ORF information:

RefSeq Version	NM_001113381.1
Organism	Homo sapiens(human)
Definition	Homo sapiens regulator of G protein signaling 4 (RGS4), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001113381.1

ORF Insert Sequence:

ATGTGCAAAG GGCTTGCAGG TCTGCCGGCT TCTTGCTTGA GGAGTGCAAA AGATATGAAA 
CATCGGCTAG GTTTCCTGCT GCAAAAATCT GATTCCTGTG AACACAATTC TTCCCACAAC 
AAGAAGGACA AAGTGGTTAT TTGCCAGAGA GTGAGCCAAG AGGAAGTCAA GAAATGGGCT 
GAATCACTGG AAAACCTGAT TAGTCATGAA TGTGAACCTG GATTCTTGCA CCAGGGAAGA 
GACAAGCCGG AACATGCTAG AGCCTACAAT AACCTGCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel regulatory role of RGS4 in STAT5B activation, neurite outgrowth and neuronal differentiation.
Neuropharmacology117408-421(2017 May)
Pallaki P,Georganta EM,Serafimidis I,Papakonstantinou MP,Papanikolaou V,Koutloglou S,Papadimitriou E,Agalou A,Tserga A,Simeonof A,Thomaidou D,Gaitanou M,Georgoussi Z

Association between RGS4 variants and psychotic-like experiences in nonclinical individuals.
European archives of psychiatry and clinical neuroscience267(1)19-24(2017 Feb)
de Castro-Catala M,Crist?bal-Narv?ez P,Kwapil TR,Sheinbaum T,Pe?a E,Barrantes-Vidal N,Rosa A

Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at G?i/o.
The Biochemical journal473(10)1379-90(2016 05)
Jeon JP,Thakur DP,Tian JB,So I,Zhu MX

Regulator of G-protein signaling 4: A novel tumor suppressor with prognostic significance in non-small cell lung cancer.
Biochemical and biophysical research communications469(3)384-91(2016 Jan)
Cheng C,Yue W,Li L,Li S,Gao C,Si L,Tian H

Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner.
Journal of neurochemistry135(1)76-87(2015 Oct)
Santhappan R,Crowder AT,Gouty S,Cox BM,C?t? TE

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RGS4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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