Rad9a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rad9a
Entrez Gene ID	19367
Full Name	RAD9 checkpoint clamp component A
Synonyms	Rad9
General protein information	Preferred Names RAD9 checkpoint clamp component A Names cell cycle checkpoint control protein RAD9A DNA repair exonuclease rad9 homolog A RAD9 homolog A Rad9-like protein mRAD9
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 A

mRNA and Protein(s)

mRNA	Protein	Name
NM_011237.2	NP_035367.1	cell cycle checkpoint control protein RAD9A

Pathways from BioSystems

Homologies

Homo sapiens (human)	RAD9A	NP_004575.1
Bos taurus (cattle)	RAD9A	NP_001014848.1
Mus musculus (house mouse)	Rad9a	NP_035367.1
Rattus norvegicus (Norway rat)	Rad9a	XP_002728900.1
	RAD9A	XP_001106622.1
Canis lupus familiaris (dog)	RAD9A	XP_540817.3
Drosophila melanogaster (fruit fly)	Rad9	NP_001097639.2
Xenopus tropicalis (tropical clawed frog)	rad9a	NP_001005810.1
Gallus gallus (chicken)	RAD9A	NP_998748.1
Magnaporthe oryzae (rice blast fungus)	MGG_05278	XP_003712837.1

Gene Ontology
Bibliography

Related articles in PubMed

Rad9a is required for spermatogonia differentiation in mice.
Huang L, Wang ZB, Qi ST, Ma XS, Liang QX, Lei G, Meng TG, Liang LF, Xian YX, Hou Y, Sun XF, Zhao Y, Wang WH, Sun QY
Oncotarget7(52)86350-86358(2016 Dec)

Three-dimensional microCT imaging of mouse development from early post-implantation to early postnatal stages.
Hsu CW, Wong L, Rasmussen TL, Kalaga S, McElwee ML, Keith LC, Bohat R, Seavitt JR, Beaudet AL, Dickinson ME
Developmental biology419(2)229-236(2016 11)

Regulation of ATRIP protein abundance by RAD9 in the DNA damage repair pathway.
Peng XJ, Liu SJ, Bao CM, Liu YZ, Xie HW, Cai YH, Li BM, Hang HY, Ding X
Cellular and molecular biology (Noisy-le-Grand, France)61(8)31-6(2015 Dec)

RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal response.
Ghandhi SA, Ponnaiya B, Panigrahi SK, Hopkins KM, Cui Q, Hei TK, Amundson SA, Lieberman HB
Radiation oncology (London, England)9206(2014 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RAD9 has a prominent role in the ATR-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
Title: Regulation of ATRIP protein abundance by RAD9 in the DNA damage repair pathway.

We demonstrated that Mrad9 null enhances chromatid aberration frequency induced by radiation in bystander mouse embryonic stem cells
Title: RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal response.

RAD9A is essential for male fertility and for repair of DNA double-strand breaks during meiotic prophase I.
Title: The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse.

HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 and TOPBP1 respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1.
Title: Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.

A review of the many activities assigned to Rad9, and speculation as to which influence its function in tumor development.
Title: Contributions of Rad9 to tumorigenesis.

The following Rad9a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rad9a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18874	NM_011237.2 Latest version!	Mus musculus RAD9 checkpoint clamp component A (Rad9a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rad9a ( NM_011237.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035367.1 Mus musculus RAD9 checkpoint clamp component A (Rad9a), mRNA.

Price & Availability↑

CloneID	OMu18874
Clone ID Related Accession (Same CDS sequence)	NM_011237.2
Accession Version	NM_011237.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1170bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	cell cycle checkpoint control protein RAD9A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC109138.10. On Mar 21, 2007 this sequence version replaced NM_011237.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF045663.1, AK165833.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164142 [ECO:0000348] ##Evidence-Data-END##

ATGAAGTGCC TGATCACCGG GGGCAACGTG AAGGTGCTGG GCAAGGCTGT CCATTCGCTA 
TCCCGAATCG GGGACGAGCT CTATCTGGAA CCCTTGAAGG ACGGGCTCTC CCTACGGACT 
GTGAACTCGT CCCGTTCTGC CTATGCCTGC TTCCTTTTTG CCCCACTCTT CTTCCAGCAG 
TACCAGGCGG CTTCCCCTGG TCAGGACCTG CTGCGCTGTA AGATCCTGAT GAAGGCCTTC 
CTGTCCGTCT TCCGCTCTCT GGCAATTGTG GAGAAGTCTG TGGAGAAGTG CTGTATCTCC 
CTCAGTGGCA GCCACAGCCA CCTGGTGGTC CAGCTCCACT GCAAGTATGG GGTCAAGAAG 
ACACACAACC TCTCCTTCCA GGACTGTGAG TCCCTGCAGG CTGTCTTCGA CCCAGCCTCA 
TGCCCTCACT TATTGCGCAC CCCAGCACGG GTTCTGGCAG AGGCTGTTCT GTCCTTTCCC 
CTTGCATTGA CTGAGGTGAC ACTGGGCATT GGCCGTGGCC GGCGGGTCAT CCTGCGCAGC 
TACCAGGAAG AGGAGGCAGA CAGCACCAGC AAAGCCATGG TGACTGAGAC CAGCATTGGG 
GATGAGGACT TCCAGCAGCT GCATGCCCCA GAAGGGATAG CTGTCACCTT CTGCCTCAAG 
GAATTTCGGG GGCTCCTGAG CTTTGCAGAG TCAGCGAATT TGCCTCTTAC TATCCACTTC 
GATGTTCCAG GCAGGCCAGT CATCTTTACT ATTGAGGATT CCTTGCTGGA TGCCCACTTT 
GTCTTGGCCA CACTCTTAGA GCAAGACTCA TGTTCCCAGG GCCCGTGTTC CCCAAAACCC 
CACCAGCCAG TGCCTCAGAA GCAGGCACAC AGCACACCCC ACTTAGATGA CTTTACCAGT 
GATGACATTG ACTGTTACAT GATTGCCATG GAAACCACTG GAGGCAATGA GGGCTCCGGG 
GCACAGCCTT CCACATCCCT CCCACCTGTC TCCCTGGCCT CCCATGACCT TGCCCCCACC 
TCAGAGGAGG AAGCTGAGCC CAGTACAGTG CCTGGGACTC CCCCACCCAA GAAGTTTCGT 
TCACTGTTCT TTGGCTCCAT CCTGGCCCCT GTACACTCCC CGCAGGGTCC CAACCCTGTG 
CTGGCTGAAG ACAGTGATGG TGAAGGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035367.1
CDS	88..1257
Translation	MKCLITGGNVKVLGKAVHSLSRIGDELYLEPLKDGLSLRTVNSSRSAYACFLFAPLFFQQYQAASPGQDLLRCKILMKAFLSVFRSLAIVEKSVEKCCISLSGSHSHLVVQLHCKYGVKKTHNLSFQDCESLQAVFDPASCPHLLRTPARVLAEAVLSFPLALTEVTLGIGRGRRVILRSYQEEEADSTSKAMVTETSIGDEDFQQLHAPEGIAVTFCLKEFRGLLSFAESANLPLTIHFDVPGRPVIFTIEDSLLDAHFVLATLLEQDSCSQGPCSPKPHQPVPQKQAHSTPHLDDFTSDDIDCYMIAMETTGGNEGSGAQPSTSLPPVSLASHDLAPTSEEEAEPSTVPGTPPPKKFRSLFFGSILAPVHSPQGPNPVLAEDSDGEG

Target ORF information:

RefSeq Version	NM_011237.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAD9 checkpoint clamp component A (Rad9a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011237.2

ORF Insert Sequence:

ATGAAGTGCC TGATCACCGG GGGCAACGTG AAGGTGCTGG GCAAGGCTGT CCATTCGCTA 
TCCCGAATCG GGGACGAGCT CTATCTGGAA CCCTTGAAGG ACGGGCTCTC CCTACGGACT 
GTGAACTCGT CCCGTTCTGC CTATGCCTGC TTCCTTTTTG CCCCACTCTT CTTCCAGCAG 
TACCAGGCGG CTTCCCCTGG TCAGGACCTG CTGCGCTGTA AGATCCTGAT GAAGGCCTTC 
CTGTCCGTCT TCCGCTCTCT GGCAATTGTG GAGAAGTCTG TGGAGAAGTG CTGTATCTCC 
CTCAGTGGCA GCCACAGCCA CCTGGTGGTC CAGCTCCACT GCAAGTATGG GGTCAAGAAG 
ACACACAACC TCTCCTTCCA GGACTGTGAG TCCCTGCAGG CTGTCTTCGA CCCAGCCTCA 
TGCCCTCACT TATTGCGCAC CCCAGCACGG GTTCTGGCAG AGGCTGTTCT GTCCTTTCCC 
CTTGCATTGA CTGAGGTGAC ACTGGGCATT GGCCGTGGCC GGCGGGTCAT CCTGCGCAGC 
TACCAGGAAG AGGAGGCAGA CAGCACCAGC AAAGCCATGG TGACTGAGAC CAGCATTGGG 
GATGAGGACT TCCAGCAGCT GCATGCCCCA GAAGGGATAG CTGTCACCTT CTGCCTCAAG 
GAATTTCGGG GGCTCCTGAG CTTTGCAGAG TCAGCGAATT TGCCTCTTAC TATCCACTTC 
GATGTTCCAG GCAGGCCAGT CATCTTTACT ATTGAGGATT CCTTGCTGGA TGCCCACTTT 
GTCTTGGCCA CACTCTTAGA GCAAGACTCA TGTTCCCAGG GCCCGTGTTC CCCAAAACCC 
CACCAGCCAG TGCCTCAGAA GCAGGCACAC AGCACACCCC ACTTAGATGA CTTTACCAGT 
GATGACATTG ACTGTTACAT GATTGCCATG GAAACCACTG GAGGCAATGA GGGCTCCGGG 
GCACAGCCTT CCACATCCCT CCCACCTGTC TCCCTGGCCT CCCATGACCT TGCCCCCACC 
TCAGAGGAGG AAGCTGAGCC CAGTACAGTG CCTGGGACTC CCCCACCCAA GAAGTTTCGT 
TCACTGTTCT TTGGCTCCAT CCTGGCCCCT GTACACTCCC CGCAGGGTCC CAACCCTGTG 
CTGGCTGAAG ACAGTGATGG TGAAGGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rad9a is required for spermatogonia differentiation in mice.
Oncotarget7(52)86350-86358(2016 Dec)
Huang L,Wang ZB,Qi ST,Ma XS,Liang QX,Lei G,Meng TG,Liang LF,Xian YX,Hou Y,Sun XF,Zhao Y,Wang WH,Sun QY

Three-dimensional microCT imaging of mouse development from early post-implantation to early postnatal stages.
Developmental biology419(2)229-236(2016 11)
Hsu CW,Wong L,Rasmussen TL,Kalaga S,McElwee ML,Keith LC,Bohat R,Seavitt JR,Beaudet AL,Dickinson ME

Regulation of ATRIP protein abundance by RAD9 in the DNA damage repair pathway.
Cellular and molecular biology (Noisy-le-Grand, France)61(8)31-6(2015 Dec)
Peng XJ,Liu SJ,Bao CM,Liu YZ,Xie HW,Cai YH,Li BM,Hang HY,Ding X

RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal response.
Radiation oncology (London, England)9206(2014 Sep)
Ghandhi SA,Ponnaiya B,Panigrahi SK,Hopkins KM,Cui Q,Hei TK,Amundson SA,Lieberman HB

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Rad9a cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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