Casc3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casc3
Entrez Gene ID	192160
Full Name	cancer susceptibility candidate 3
Synonyms	Btz,Mln51
General protein information	Preferred Names cancer susceptibility candidate 3 Names protein CASC3 Barentsz MLN 51 homolog cancer susceptibility candidate gene 3 protein homolog mBtz metastatic lymph node 51 metastatic lymph node gene 51 protein homolog protein barentsz
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_138660.2	NP_619601.2	protein CASC3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CASC3	XP_511470.3
Bos taurus (cattle)	CASC3	NP_001091538.1
Homo sapiens (human)	CASC3	NP_031385.2
Mus musculus (house mouse)	Casc3	NP_619601.2
Rattus norvegicus (Norway rat)	Casc3	NP_671485.1
	CASC3	XP_001096548.1
Gallus gallus (chicken)	CASC3	XP_423806.4
Canis lupus familiaris (dog)	CASC3	XP_537649.2
Xenopus tropicalis (tropical clawed frog)	casc3	NP_001012670.1

Gene Ontology
Bibliography

Related articles in PubMed

Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.
Mao H, Brown HE, Silver DL
RNA (New York, N.Y.)23(1)23-31(2017 01)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner.
Macchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B, Ambrosino C, Goetze B, Lupas A, St Johnston D, Kiebler M
The Journal of neuroscience : the official journal of the Society for Neuroscience23(13)5778-88(2003 Jul)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that the mRNA transport machinery is conserved during evolution, and that mammalian Btz is an additional component of the dendritic ribonucleoprotein particles in hippocampal neurons
Title: Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner.

The following Casc3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casc3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21118	NM_138660.2 Latest version!	Mus musculus cancer susceptibility candidate 3 (Casc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casc3 ( NM_138660.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_619601.2 Mus musculus cancer susceptibility candidate 3 (Casc3), mRNA.

Price & Availability↑

CloneID	OMu21118
Clone ID Related Accession (Same CDS sequence)	NM_138660.2
Accession Version	NM_138660.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2097bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	protein CASC3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK139608.1, AK145886.1, AK037399.1 and BQ548016.1. On Nov 15, 2007 this sequence version replaced NM_138660.1. ##Evidence-Data-START## Transcript exon combination :: AK139608.1, BC141296.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACC GGCGGCGGCA GCGCGCTTCC CAGGACACGG AGGACGAGGA ATCCGGGGCT 
TCGGGTTCCG ACAGCGGCTC TCCGGCGCGG GGCGGCGGCA GCTGCAGCGG GAGCGTCGGA 
GGCGGCGGCA GTGGCTCGCT GCCTTCTCAG CGCGGCGGCC GCGGCGGGGG CCTTCACCTG 
CGGCGGGTGG AGAGCGGGGG CGCCAAGAGC GCCGAGGAGT CTGAGTGTGA GAGTGAAGAT 
GGCATGGAAG GAGATGCTGT TCTTTCCGAT TATGAAAGTG CAGAAGATTC AGAAGGTGAA 
GAAGACTACA GTGAAGAGGA GAATTCCAAG GTGGAGCTGA AATCAGAAGC TAACGATGCT 
GCTGATTCCT CTGCGAAAGA AAAGGGAGAG GAAAAGCCTG AGTCTAAAGG CACGGTGACT 
GGGGAGAGGC AGAGCGGCGA TGGGCAGGAG AGCACAGAGC CTGTGGAGAA CAAAGTGGGG 
AAAAAAGGCC CTAAGCACTT GGATGACGAT GAGGATCGGA AAAACCCAGC CTACATCCCC 
AGGAAAGGGC TCTTCTTTGA GCACGATCTT CGAGGACAGA CTCAGGAGGA GGAAGTCCGA 
CCCAAGGGAC GGCAGCGAAA GCTATGGAAA GATGAGGGTC GCTGGGAACA TGATAAGTTC 
CGTGAGGATG AACAGGCCCC GAAATCTCGG CAGGAGCTAA TTGCACTTTA TGGTTATGAC 
ATTCGGTCTG CTCACAATCC TGATGACATC AAACCCCGAA GAATCCGGAA ACCTCGATTT 
GGAAGTTCCC CACAAAGAGA TCCAAACTGG ATTGGTGATC GATCAAGCAA ATCCCATCGC 
CACCAGGGTC CTGGGGGCAA TCTACCACCT AGGACATTTA TTAACAGGAA CACGGCAGGT 
ACTGGCCGCA TGTCTGCATC CAGGAATTAC TCTCGATCTG GGGGCTTCAA GGATGGCCGC 
ACTAGTTTCA GGCCTGTGGA GGTTGCTGGG CAGCATGGTG GCCGGTCTGC TGAGACTCTT 
AAGCATGAAG CTAGTTACCG GTCACGGCGT CTAGAGCAGA CTCCTGTGAG GGATCCATCT 
CCAGAGCCAG ATGCTCCATT GCTTGGAAGT CCTGAGAAAG AAGAGGTGGC CTCAGAGACG 
CCAGCTGCTG TACCCGACAT CACCCCACCA GCTCCTGACA GGCCCATTGA GAAGAAGTCC 
TATTCCCGGG CAAGAAGGAC CAGGACCAAA GTTGGGGATG CAGTCAAAGC TGCTGAGGAG 
GTTCCTCCTC CATCTGAAGG GCTGGCCTCA ACAGCCACAG TCCCCGAAAC GACTCCAGCT 
GCTAAGACTG GGAACTGGGA GGCTCCAGTA GACTCTACCA CAGGTGGACT TGAGCAAGAT 
GTGGCGCAGC TAAATATAGC AGAACAAAGT TGGAGTCCAA GCCAGCCTTC ATTCTTGCAG 
CCACGGGAAC TTCGAGGTGT GCCTAACCAC ATCCACATGG GAGCAGGACC CCCACCTCAG 
TTTAACCGGA TGGAAGAAAT GGGCGTCCAG AGTGGTCGAG CTAAGCGTTA CTCATCCCAG 
CGGCAGAGAC CTGTGCCAGA GCCCCCTGCT CCTCCTGTGC ATATCAGTAT CATGGAGGGA 
CATTACTATG ATCCATTGCA GTTCCAGGGA CCAATCTATA CCCATGGTGA CAGCCCTGCC 
CCACTGCCCC CACAGGGCAT GATCGTACAG CCGGAAATGC ACCTTCCCCA CCCAGGTTTA 
CATCCCCACC AGTCACCAGG ACCTCTGCCC AACCCGGGTC TCTACCCACC ACCAGTGTCC 
ATGTCCCCAG GACAGCCACC GCCCCAGCAA CTGCTTGCTC CTACCTACTT TTCTGCTCCG 
GGTGTCATGA ATTTTGGTAA CCCCAATTAC CCTTATGCTC CGGGAGCATT GCCACCTCCT 
CCACCTCCTC ATCTGTATCC TAACACGCAG GCTCCACCAC AGGTGTATGG AGGAGTGACT 
TACTATAACC CCGCCCAGCA GCAGGTGCAG CCCAAGCCCT CCCCACCCCG GAGGACTCCC 
CAGCCGGTCT CCATCAAGCC CCCCCCACCT GAGGTTGTAA GCAGGGGTTC CAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_619601.2
CDS	57..2153
Translation	MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSVGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEDYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSSPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNTAGTGRMSASRNYSRSGGFKDGRTSFRPVEVAGQHGGRSAETLKHEASYRSRRLEQTPVRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLASTATVPETTPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQSWSPSQPSFLQPRELRGVPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPGPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPNYPYAPGALPPPPPPHLYPNTQAPPQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPPEVVSRGSS

Target ORF information:

RefSeq Version	NM_138660.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus cancer susceptibility candidate 3 (Casc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138660.2

ORF Insert Sequence:

ATGGCGGACC GGCGGCGGCA GCGCGCTTCC CAGGACACGG AGGACGAGGA ATCCGGGGCT 
TCGGGTTCCG ACAGCGGCTC TCCGGCGCGG GGCGGCGGCA GCTGCAGCGG GAGCGTCGGA 
GGCGGCGGCA GTGGCTCGCT GCCTTCTCAG CGCGGCGGCC GCGGCGGGGG CCTTCACCTG 
CGGCGGGTGG AGAGCGGGGG CGCCAAGAGC GCCGAGGAGT CTGAGTGTGA GAGTGAAGAT 
GGCATGGAAG GAGATGCTGT TCTTTCCGAT TATGAAAGTG CAGAAGATTC AGAAGGTGAA 
GAAGACTACA GTGAAGAGGA GAATTCCAAG GTGGAGCTGA AATCAGAAGC TAACGATGCT 
GCTGATTCCT CTGCGAAAGA AAAGGGAGAG GAAAAGCCTG AGTCTAAAGG CACGGTGACT 
GGGGAGAGGC AGAGCGGCGA TGGGCAGGAG AGCACAGAGC CTGTGGAGAA CAAAGTGGGG 
AAAAAAGGCC CTAAGCACTT GGATGACGAT GAGGATCGGA AAAACCCAGC CTACATCCCC 
AGGAAAGGGC TCTTCTTTGA GCACGATCTT CGAGGACAGA CTCAGGAGGA GGAAGTCCGA 
CCCAAGGGAC GGCAGCGAAA GCTATGGAAA GATGAGGGTC GCTGGGAACA TGATAAGTTC 
CGTGAGGATG AACAGGCCCC GAAATCTCGG CAGGAGCTAA TTGCACTTTA TGGTTATGAC 
ATTCGGTCTG CTCACAATCC TGATGACATC AAACCCCGAA GAATCCGGAA ACCTCGATTT 
GGAAGTTCCC CACAAAGAGA TCCAAACTGG ATTGGTGATC GATCAAGCAA ATCCCATCGC 
CACCAGGGTC CTGGGGGCAA TCTACCACCT AGGACATTTA TTAACAGGAA CACGGCAGGT 
ACTGGCCGCA TGTCTGCATC CAGGAATTAC TCTCGATCTG GGGGCTTCAA GGATGGCCGC 
ACTAGTTTCA GGCCTGTGGA GGTTGCTGGG CAGCATGGTG GCCGGTCTGC TGAGACTCTT 
AAGCATGAAG CTAGTTACCG GTCACGGCGT CTAGAGCAGA CTCCTGTGAG GGATCCATCT 
CCAGAGCCAG ATGCTCCATT GCTTGGAAGT CCTGAGAAAG AAGAGGTGGC CTCAGAGACG 
CCAGCTGCTG TACCCGACAT CACCCCACCA GCTCCTGACA GGCCCATTGA GAAGAAGTCC 
TATTCCCGGG CAAGAAGGAC CAGGACCAAA GTTGGGGATG CAGTCAAAGC TGCTGAGGAG 
GTTCCTCCTC CATCTGAAGG GCTGGCCTCA ACAGCCACAG TCCCCGAAAC GACTCCAGCT 
GCTAAGACTG GGAACTGGGA GGCTCCAGTA GACTCTACCA CAGGTGGACT TGAGCAAGAT 
GTGGCGCAGC TAAATATAGC AGAACAAAGT TGGAGTCCAA GCCAGCCTTC ATTCTTGCAG 
CCACGGGAAC TTCGAGGTGT GCCTAACCAC ATCCACATGG GAGCAGGACC CCCACCTCAG 
TTTAACCGGA TGGAAGAAAT GGGCGTCCAG AGTGGTCGAG CTAAGCGTTA CTCATCCCAG 
CGGCAGAGAC CTGTGCCAGA GCCCCCTGCT CCTCCTGTGC ATATCAGTAT CATGGAGGGA 
CATTACTATG ATCCATTGCA GTTCCAGGGA CCAATCTATA CCCATGGTGA CAGCCCTGCC 
CCACTGCCCC CACAGGGCAT GATCGTACAG CCGGAAATGC ACCTTCCCCA CCCAGGTTTA 
CATCCCCACC AGTCACCAGG ACCTCTGCCC AACCCGGGTC TCTACCCACC ACCAGTGTCC 
ATGTCCCCAG GACAGCCACC GCCCCAGCAA CTGCTTGCTC CTACCTACTT TTCTGCTCCG 
GGTGTCATGA ATTTTGGTAA CCCCAATTAC CCTTATGCTC CGGGAGCATT GCCACCTCCT 
CCACCTCCTC ATCTGTATCC TAACACGCAG GCTCCACCAC AGGTGTATGG AGGAGTGACT 
TACTATAACC CCGCCCAGCA GCAGGTGCAG CCCAAGCCCT CCCCACCCCG GAGGACTCCC 
CAGCCGGTCT CCATCAAGCC CCCCCCACCT GAGGTTGTAA GCAGGGGTTC CAGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.
RNA (New York, N.Y.)23(1)23-31(2017 01)
Mao H,Brown HE,Silver DL

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner.
The Journal of neuroscience : the official journal of the Society for Neuroscience23(13)5778-88(2003 Jul)
Macchi P,Kroening S,Palacios IM,Baldassa S,Grunewald B,Ambrosino C,Goetze B,Lupas A,St Johnston D,Kiebler M

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research31(1)278-81(2003 Jan)
Stryke D,Kawamoto M,Huang CC,Johns SJ,King LA,Harper CA,Meng EC,Lee RE,Yee A,L'Italien L,Chuang PT,Young SG,Skarnes WC,Babbitt PC,Ferrin TE

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Casc3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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